Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19.

Adult Aged COVID-19 / complications Cell Communication Chromatography, Liquid Cytokines / immunology Dexamethasone / therapeutic use Down-Regulation Female Gene Regulatory Networks Glucocorticoids / therapeutic use Humans Immunity, Innate / immunology Interferons / immunology Male Middle Aged Neutrophils / immunology Pneumonia, Bacterial / complications Prostaglandins / immunology Proteomics RNA-Seq Respiratory Distress Syndrome / drug therapy SARS-CoV-2 Severity of Illness Index Sex Factors Single-Cell Analysis Tandem Mass Spectrometry COVID-19 Drug Treatment

Journal

Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015

Informations de publication

Date de publication:
01 2022
Historique:
received: 04 08 2021
accepted: 12 10 2021
pubmed: 17 11 2021
medline: 4 2 2022
entrez: 16 11 2021
Statut: ppublish

Résumé

Although critical for host defense, innate immune cells are also pathologic drivers of acute respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus Disease 2019 (COVID-19) ARDS, compared to ARDS from other respiratory pathogens, is unclear. Moreover, mechanisms underlying the beneficial effects of dexamethasone during severe COVID-19 remain elusive. Using single-cell RNA sequencing and plasma proteomics, we discovered that, compared to bacterial ARDS, COVID-19 was associated with expansion of distinct neutrophil states characterized by interferon (IFN) and prostaglandin signaling. Dexamethasone during severe COVID-19 affected circulating neutrophils, altered IFN

Identifiants

DOI: 10.1038/s41591-021-01576-3 PMID: 34782790 PMC: PMC8799469
pubmed: 34782790
doi: 10.1038/s41591-021-01576-3
pii: 10.1038/s41591-021-01576-3
pmc: PMC8799469
doi:

Substances chimiques

Cytokines 0
Glucocorticoids 0
Prostaglandins 0
Dexamethasone 7S5I7G3JQL
Interferons 9008-11-1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

201-211

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2021. The Author(s).

Références

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Auteurs

Sarthak Sinha (S)

Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
ORCID: 0000-0002-0770-3150

Nicole L Rosin (NL)

Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada. nicole.rosin@ucalgary.ca.
ORCID: 0000-0003-3030-1704

Rohit Arora (R)

Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.

Elodie Labit (E)

Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
ORCID: 0000-0002-7659-6248

Arzina Jaffer (A)

Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
ORCID: 0000-0002-9197-9060

Leslie Cao (L)

Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
ORCID: 0000-0002-7075-0443

Raquel Farias (R)

Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Angela P Nguyen (AP)

Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
ORCID: 0000-0002-7453-2232

Luiz G N de Almeida (LGN)

Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.
McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada.

Antoine Dufour (A)

Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.
McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada.
ORCID: 0000-0002-3429-4188

Amy Bromley (A)

Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.

Braedon McDonald (B)

Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Mark R Gillrie (MR)

Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada.
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
ORCID: 0000-0002-5836-5833

Marvin J Fritzler (MJ)

Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
ORCID: 0000-0003-1652-6608

Bryan G Yipp (BG)

Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. bgyipp@ucalgary.ca.
Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. bgyipp@ucalgary.ca.
ORCID: 0000-0002-5887-9551

Jeff Biernaskie (J)

Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada. jeff.biernaskie@ucalgary.ca.
Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. jeff.biernaskie@ucalgary.ca.
Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. jeff.biernaskie@ucalgary.ca.
Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada. jeff.biernaskie@ucalgary.ca.
ORCID: 0000-0002-0633-0698

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Dexamethasone modulates immature neutrophils...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Dexamethasone modulates immature neutrophils...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Dexamethasone modulates immature neutrophils...
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questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Syndrome de détresse respiratoire de l'adulte › Dexamethasone modulates immature neutrophils...
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