Styrene-Maleic Acid Copolymer Nanodiscs to Determine the Shape of Membrane Proteins.

Lipid Bilayers / chemistry Maleates / chemistry Membrane Proteins / chemistry Nanostructures / chemistry Scattering, Small Angle

Journal

The journal of physical chemistry. B
ISSN: 1520-5207
Titre abrégé: J Phys Chem B
Pays: United States
ID NLM: 101157530

Informations de publication

Date de publication:
10 02 2022
Historique:
pubmed: 29 1 2022
medline: 22 2 2022
entrez: 28 1 2022
Statut: ppublish

Résumé

Lipid nanodiscs can be used to solubilize functional membrane proteins (MPs) in nativelike environments. Thus, they are promising reagents that have been proven useful to characterize MPs. Both protein and non-protein molecular belts have shown promise to maintain the structural integrity of MPs in lipid nanodiscs. Small-angle neutron scattering (SANS) can be used to determine low-resolution structures of proteins in solution, which can be enhanced through the use of contrast variation methods. We present theoretical contrast variation SANS results for protein and styrene-maleic acid copolymer (SMA) belt 1,2-dimyristoyl-

Identifiants

DOI: 10.1021/acs.jpcb.1c05050 PMID: 35089036
pubmed: 35089036
doi: 10.1021/acs.jpcb.1c05050
doi:

Substances chimiques

Lipid Bilayers 0
Maleates 0
Membrane Proteins 0
maleic acid 91XW058U2C

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1034-1044

Auteurs

Cheol Jeong (C)

NIST Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, Maryland 20899, United States.
Department of Chemistry, The University of Tennessee, Knoxville, Tennessee 37996-1600, United States.

Ryan Franklin (R)

NIST Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, Maryland 20899, United States.

Karen J Edler (KJ)

Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
ORCID: 0000-0001-5822-0127

Kenno Vanommeslaeghe (K)

Department of Analytical Chemistry, Applied Chemometrics and Molecular Modelling─FABI, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium.

Susan Krueger (S)

NIST Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, Maryland 20899, United States.

Joseph E Curtis (JE)

NIST Center for Neutron Research, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 6102, Gaithersburg, Maryland 20899, United States.
ORCID: 0000-0001-5818-295X

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Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Double couche lipidique › Styrene-Maleic Acid Copolymer Nanodiscs to...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Diacides carboxyliques › Maléates › Styrene-Maleic Acid Copolymer Nanodiscs to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Styrene-Maleic Acid Copolymer Nanodiscs to...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Styrene-Maleic Acid Copolymer Nanodiscs to...
questionsmedicales.fr › Phénomènes physiques › Diffusion de rayonnements › Diffusion aux petits angles › Styrene-Maleic Acid Copolymer Nanodiscs to...