Genomic variants affecting homoeologous gene expression dosage contribute to agronomic trait variation in allopolyploid wheat.

Alleles Chromosome Mapping Gene Expression Gene Expression Regulation, Plant Genome, Plant Genomics Phenotype Plant Breeding Polyploidy Quantitative Trait Loci Triticum / genetics

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
11 02 2022

Historique:

received: 02 04 2021

accepted: 26 01 2022

entrez: 12 2 2022

pubmed: 13 2 2022

medline: 5 3 2022

Statut: epublish

Résumé

Allopolyploidy greatly expands the range of possible regulatory interactions among functionally redundant homoeologous genes. However, connection between the emerging regulatory complexity and expression and phenotypic diversity in polyploid crops remains elusive. Here, we use diverse wheat accessions to map expression quantitative trait loci (eQTL) and evaluate their effects on the population-scale variation in homoeolog expression dosage. The relative contribution of cis- and trans-eQTL to homoeolog expression variation is strongly affected by both selection and demographic events. Though trans-acting effects play major role in expression regulation, the expression dosage of homoeologs is largely influenced by cis-acting variants, which appear to be subjected to selection. The frequency and expression of homoeologous gene alleles showing strong expression dosage bias are predictive of variation in yield-related traits, and have likely been impacted by breeding for increased productivity. Our study highlights the importance of genomic variants affecting homoeolog expression dosage in shaping agronomic phenotypes and points at their potential utility for improving yield in polyploid crops.

Identifiants

DOI: 10.1038/s41467-022-28453-y PMID: 35149708 PMC: PMC8837796

pubmed: 35149708

doi: 10.1038/s41467-022-28453-y

pii: 10.1038/s41467-022-28453-y

pmc: PMC8837796

doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

Pagination

826

Informations de copyright

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