Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
11
2021
accepted:
24
01
2022
entrez:
16
2
2022
pubmed:
17
2
2022
medline:
25
2
2022
Statut:
epublish
Résumé
Meiotic DNA double-strand breaks produce reciprocally exchanged DNA strands, which mature into chiasmata that hold homologous chromosomes together as bivalents. These bivalents are subsequently separated in the first meiotic division. In a mutant lacking the newly identified Tetrahymena gene APRO1 (Anaphase promoting 1), meiosis is arrested by the end of prophase. Mature chiasmata are not formed but bivalents are connected via a molecular precursor structure. In-depth analysis of this arrested intermediate structure may help to elucidate the noncanonical molecular recombination pathway in Tetrahymena.
Identifiants
pubmed: 35171923
doi: 10.1371/journal.pone.0263691
pii: PONE-D-21-35764
pmc: PMC8849441
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0263691Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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