T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10.

Adult Aged Brain Neoplasms / drug therapy Cell Communication / immunology Cell Line, Tumor Female Glioblastoma / drug therapy Healthy Volunteers Heme Oxygenase-1 / metabolism Humans Immunotherapy / methods Interleukin-10 / metabolism Janus Kinase Inhibitors / pharmacology Janus Kinases / antagonists & inhibitors Male Middle Aged Myeloid Cells / metabolism Neocortex / cytology Primary Cell Culture RNA-Seq STAT Transcription Factors / metabolism Signal Transduction / drug effects Single-Cell Analysis T-Lymphocytes / drug effects Tissue Culture Techniques Tumor Escape Tumor Microenvironment / immunology

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
17 02 2022

Historique:

received: 26 02 2021

accepted: 26 01 2022

entrez: 18 2 2022

pubmed: 19 2 2022

medline: 4 3 2022

Statut: epublish

Résumé

Despite recent advances in cancer immunotherapy, certain tumor types, such as Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti-tumor immune response. Here we show, by applying an in-silico multidimensional model integrating spatially resolved and single-cell gene expression data of 45,615 immune cells from 12 tumor samples, that a subset of Interleukin-10-releasing HMOX1

Identifiants

DOI: 10.1038/s41467-022-28523-1 PMID: 35177622 PMC: PMC8854421

pubmed: 35177622

doi: 10.1038/s41467-022-28523-1

pii: 10.1038/s41467-022-28523-1

pmc: PMC8854421

doi:

Substances chimiques

IL10 protein, human 0

Janus Kinase Inhibitors 0

STAT Transcription Factors 0

Interleukin-10 130068-27-8

HMOX1 protein, human EC 1.14.14.18

Heme Oxygenase-1 EC 1.14.14.18

Janus Kinases EC 2.7.10.2

Types de publication

Journal Article Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

925

Informations de copyright

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