A Candidate Gene Cluster for the Bioactive Natural Product Gyrophoric Acid in Lichen-Forming Fungi.
PKS phylogeny
Umbilicaria
biosynthetic genes
depsides
fungi
genome mining
genomics
lichen compounds
long-read sequencing
microbial biotechnology
nonreducing PKSs
pharmaceutically relevant natural products
secondary metabolites
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
31 08 2022
31 08 2022
Historique:
pubmed:
23
7
2022
medline:
9
9
2022
entrez:
22
7
2022
Statut:
ppublish
Résumé
Natural products of lichen-forming fungi are structurally diverse and have a variety of medicinal properties. Despite this, they have limited implementation in industry mostly because the corresponding genes are unknown for most of their natural products. Here, we implement a long-read sequencing and bioinformatic approach to identify the putative biosynthetic gene cluster of the bioactive natural product gyrophoric acid (GA). Using 15 high-quality genomes representing nine GA-producing species of the lichen-forming fungal genus
Identifiants
pubmed: 35867425
doi: 10.1128/spectrum.00109-22
pmc: PMC9430680
doi:
Substances chimiques
Benzoates
0
Biological Products
0
Polyketide Synthases
79956-01-7
gyrophoric acid
BAQ44A6C6H
Banques de données
figshare
['10.6084/m9.figshare.19625997']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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