DOCK2 is involved in the host genetics and biology of severe COVID-19.
Alleles
Animals
COVID-19
/ complications
Disease Models, Animal
GTPase-Activating Proteins
/ antagonists & inhibitors
Genetic Predisposition to Disease
Genome-Wide Association Study
Guanine Nucleotide Exchange Factors
/ antagonists & inhibitors
Host Microbial Interactions
/ genetics
Humans
Interferon Type I
/ genetics
Japan
Lung
/ pathology
Macrophages
Mesocricetus
Middle Aged
Pneumonia
/ complications
Pyrazoles
/ pharmacology
RNA-Seq
SARS-CoV-2
/ pathogenicity
Viral Load
Weight Loss
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
26
10
2021
accepted:
28
07
2022
pubmed:
9
8
2022
medline:
24
9
2022
entrez:
8
8
2022
Statut:
ppublish
Résumé
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge
Identifiants
pubmed: 35940203
doi: 10.1038/s41586-022-05163-5
pii: 10.1038/s41586-022-05163-5
pmc: PMC9492544
doi:
Substances chimiques
4-(3'-(2'-chlorophenyl)-2'-propen-1'-ylidene)-1-phenyl-3,5-pyrazolidinedione
0
DOCK2 protein, human
0
GTPase-Activating Proteins
0
Guanine Nucleotide Exchange Factors
0
Interferon Type I
0
Pyrazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
754-760Investigateurs
Koichi Matsuda
(K)
Yuji Yamanashi
(Y)
Yoichi Furukawa
(Y)
Takayuki Morisaki
(T)
Yoshinori Murakami
(Y)
Yoichiro Kamatani
(Y)
Kaori Muto
(K)
Akiko Nagai
(A)
Wataru Obara
(W)
Ken Yamaji
(K)
Kazuhisa Takahashi
(K)
Satoshi Asai
(S)
Yasuo Takahashi
(Y)
Takao Suzuki
(T)
Nobuaki Sinozaki
(N)
Hiroki Yamaguchi
(H)
Shiro Minami
(S)
Shigeo Murayama
(S)
Kozo Yoshimori
(K)
Satoshi Nagayama
(S)
Daisuke Obata
(D)
Masahiko Higashiyama
(M)
Akihide Masumoto
(A)
Yukihiro Koretsune
(Y)
Informations de copyright
© 2022. The Author(s).
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