Probing the dynamic RNA structurome and its functions.
Journal
Nature reviews. Genetics
ISSN: 1471-0064
Titre abrégé: Nat Rev Genet
Pays: England
ID NLM: 100962779
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
accepted:
06
10
2022
pubmed:
9
11
2022
medline:
25
2
2023
entrez:
8
11
2022
Statut:
ppublish
Résumé
RNA is a key regulator of almost every cellular process, and the structures adopted by RNA molecules are thought to be central to their functions. The recent fast-paced evolution of high-throughput sequencing-based RNA structure mapping methods has enabled the rapid in vivo structural interrogation of entire cellular transcriptomes. Collectively, these studies are shedding new light on the long underestimated complexity of the structural organization of the transcriptome - the RNA structurome. Moreover, recent analyses are challenging the view that the RNA structurome is a static entity by revealing how RNA molecules establish intricate networks of alternative intramolecular and intermolecular interactions and that these ensembles of RNA structures are dynamically regulated to finely tune RNA functions in living cells. This new understanding of how RNA can shape cell phenotypes has important implications for the development of RNA-targeted therapeutic strategies.
Identifiants
pubmed: 36348050
doi: 10.1038/s41576-022-00546-w
pii: 10.1038/s41576-022-00546-w
pmc: PMC9644009
doi:
Substances chimiques
RNA
63231-63-0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
178-196Informations de copyright
© 2022. Springer Nature Limited.
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