[Semi-rational evolution of ω-transaminase from

Transaminases / genetics Molecular Docking Simulation Amines / chemistry Pyruvic Acid / metabolism Enzyme Stability
chiral amines molecular dynamic simulation semi-rational design thermostability α-helix ω-transaminases

Journal

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
ISSN: 1872-2075
Titre abrégé: Sheng Wu Gong Cheng Xue Bao
Pays: China
ID NLM: 9426463

Informations de publication

Date de publication:
25 Jun 2023
Historique:
medline: 5 7 2023
pubmed: 4 7 2023
entrez: 4 7 2023
Statut: ppublish

Résumé

ω-transaminase (ω-TA) is a natural biocatalyst that has good application potential in the synthesis of chiral amines. However, the poor stability and low activity of ω-TA in the process of catalyzing unnatural substrates greatly hampers its application. To overcome these shortcomings, the thermostability of (

Identifiants

DOI: 10.13345/j.cjb.220927 PMID: 37401586
pubmed: 37401586
doi: 10.13345/j.cjb.220927
doi:

Substances chimiques

Transaminases EC 2.6.1.-
Amines 0
Pyruvic Acid 8558G7RUTR

Types de publication

English Abstract Journal Article

Langues

chi

Sous-ensembles de citation

IM

Pagination

2126-2140

Auteurs

Tingting Cai (T)

School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, Zhejiang, China.

Jiaren Cao (J)

School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, Zhejiang, China.

Shuai Qiu (S)

School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, Zhejiang, China.

Changjiang Lyu (C)

School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, Zhejiang, China.

Fangfang Fan (F)

School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, Zhejiang, China.

Sheng Hu (S)

School of Biological and Chemical Engineering, Ningbo Tech University, Ningbo 315100, Zhejiang, China.

Weirui Zhao (W)

School of Biological and Chemical Engineering, Ningbo Tech University, Ningbo 315100, Zhejiang, China.

Lehe Mei (L)

School of Biological and Chemical Engineering, Ningbo Tech University, Ningbo 315100, Zhejiang, China.
College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China.
Jinhua Advanced Research Institute, Jinhua 321019, Zhejiang, China.

Jun Huang (J)

School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, Zhejiang, China.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › [Semi-rational evolution of ω-transaminase from
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › [Semi-rational evolution of ω-transaminase from
questionsmedicales.fr › Composés chimiques organiques › Amines › [Semi-rational evolution of ω-transaminase from
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Cétoacides › Pyruvates › Acide pyruvique › [Semi-rational evolution of ω-transaminase from
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité protéique › Stabilité enzymatique › [Semi-rational evolution of ω-transaminase from