Pharmacological targeting of netrin-1 inhibits EMT in cancer.

Animals Humans Mice A549 Cells Carcinoma, Squamous Cell / drug therapy Cell Line, Tumor Epithelial-Mesenchymal Transition / drug effects Netrin Receptors / antagonists & inhibitors Netrin-1 / antagonists & inhibitors RNA, Small Interfering / genetics Disease Models, Animal Skin Neoplasms / drug therapy Antibodies, Monoclonal / pharmacology Neoplasm Metastasis / drug therapy Single-Cell Gene Expression Analysis RNA-Seq Epithelial Cell Adhesion Molecule / metabolism Xenograft Model Antitumor Assays Transforming Growth Factor beta1 / pharmacology

Journal

Nature

ISSN: 1476-4687

Titre abrégé: Nature

Pays: England

ID NLM: 0410462

Informations de publication

Date de publication:
Aug 2023

Historique:

received: 04 04 2022

accepted: 26 06 2023

pmc-release: 01 02 2024

medline: 11 8 2023

pubmed: 3 8 2023

entrez: 2 8 2023

Statut: ppublish

Résumé

Epithelial-to-mesenchymal transition (EMT) regulates tumour initiation, progression, metastasis and resistance to anti-cancer therapy

Identifiants

DOI: 10.1038/s41586-023-06372-2 PMID: 37532929 PMC: PMC7615210

pubmed: 37532929

doi: 10.1038/s41586-023-06372-2

pii: 10.1038/s41586-023-06372-2

pmc: PMC7615210

mid: EMS188994

doi:

Substances chimiques

Netrin Receptors 0

Netrin-1 158651-98-0

RNA, Small Interfering 0

Antibodies, Monoclonal 0

Unc5b protein, mouse 0

Epithelial Cell Adhesion Molecule 0

TGFB1 protein, human 0

Transforming Growth Factor beta1 0

Ntn1 protein, mouse 0

NTN1 protein, human 0

Banques de données

ClinicalTrials.gov

['NCT02977195']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

402-408

Subventions

Organisme : European Research Council

ID : 885093

Pays : International

Informations de copyright

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