Adam Hedley

Affiliations

Cadham Provincial Laboratory (Bullard, Dust, Hedley, Alexander, Van Caeseele), Manitoba Health; Department of Pediatrics & Child Health (Bullard, Strong, Lee, Van Caeseele, Poliquin), University of Manitoba; National Microbiology Laboratory (Funk, Garnett, Tran, Bello, Strong, Poliquin), Public Health Agency of Canada; Departments of Anesthesiology and Medicine (Funk), Section of Critical Care, University of Manitoba; Department of Medical Microbiology & Infectious Diseases (Garnett, Tran, Bello, Alexander), University of Manitoba; Communicable Disease Control, Public Health (Lee), Manitoba Health; Epidemiology and Surveillance Unit (Waruk, Loeppky), Manitoba Health; Department of Community Health Science (Loeppky), University of Manitoba. Winnipeg, Man.

Publications (13)

Infectivity of severe acute respiratory syndrome coronavirus 2 in children compared with adults.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

Avec: Jared Bullard , Duane Funk , Kerry Dust , Lauren Garnett , Kaylie Tran , Alex Bello , James E Strong , Santina J Lee , Jillian Waruk , Adam Hedley , David Alexander , Paul Van Caeseele , Carla Loeppky , Guillaume Poliquin

Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung Adenocarcinoma.

Cancers

Avec: Sarah Neidler , Björn Kruspig , Kay Hewit , Tiziana Monteverde , Katarina Gyuraszova , Attila Braun , William Clark , Daniel James , Ann Hedley , Bernhard Nieswandt , Emma Shanks , Craig Dick , Daniel J Murphy

Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma.

Cancer discovery

Avec: Nathiya Muthalagu , Tiziana Monteverde , Ximena Raffo-Iraolagoitia , Robert Wiesheu , Declan Whyte , Ann Hedley , Sarah Laing , Björn Kruspig , Rosanna Upstill-Goddard , Robin Shaw , Sarah Neidler , Curtis Rink , Saadia A Karim , Katarina Gyuraszova , Colin Nixon , William Clark , Andrew V Biankin , Leo M Carlin , Seth B Coffelt , Owen J Sansom , Jennifer P Morton , Daniel J Murphy

Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix.

Nature metabolism

Avec: Emily J Kay , Karla Paterson , Carla Riera-Domingo , David Sumpton , J Henry M Däbritz , Saverio Tardito , Claudia Boldrini , Juan R Hernandez-Fernaud , Dimitris Athineos , Sandeep Dhayade , Ekaterina Stepanova , Enio Gjerga , Lisa J Neilson , Sergio Lilla , Ann Hedley , Grigorios Koulouras , Grace McGregor , Craig Jamieson , Radia Marie Johnson , Morag Park , Kristina Kirschner , Crispin Miller , Jurre J Kamphorst , Fabricio Loayza-Puch , Julio Saez-Rodriguez , Massimiliano Mazzone , Karen Blyth , Michele Zagnoni , Sara Zanivan

Differential Infectivity of Original and Delta Variants of SARS-CoV-2 in Children Compared to Adults.

Microbiology spectrum

Avec: Lauren Garnett , Carmen Tse , Duane Funk , Kerry Dust , Kaylie N Tran , Adam Hedley , Guillaume Poliquin , Jared Bullard , James E Strong

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer.

British journal of cancer

Avec: Jessica C Casciano , Caroline Perry , Adam J Cohen-Nowak , Katelyn D Miller , Johan Vande Voorde , Qifeng Zhang , Susan Chalmers , Mairi E Sandison , Qin Liu , Ann Hedley , Tony McBryan , Hsin-Yao Tang , Nicole Gorman , Thomas Beer , David W Speicher , Peter D Adams , Xuefeng Liu , Richard Schlegel , John G McCarron , Michael J O Wakelam , Eyal Gottlieb , Andrew V Kossenkov , Zachary T Schug

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.

Nature communications

Avec: David M Gay , Rachel A Ridgway , Miryam Müller , Michael C Hodder , Ann Hedley , William Clark , Joshua D Leach , Rene Jackstadt , Colin Nixon , David J Huels , Andrew D Campbell , Thomas G Bird , Owen J Sansom

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer.

Nature genetics

Avec: Arafath K Najumudeen , Fatih Ceteci , Sigrid K Fey , Gregory Hamm , Rory T Steven , Holly Hall , Chelsea J Nikula , Alex Dexter , Teresa Murta , Alan M Race , David Sumpton , Nikola Vlahov , David M Gay , John R P Knight , Rene Jackstadt , Joshua D G Leach , Rachel A Ridgway , Emma R Johnson , Colin Nixon , Ann Hedley , Kathryn Gilroy , William Clark , Sudhir B Malla , Philip D Dunne , Giovanny Rodriguez-Blanco , Susan E Critchlow , Agata Mrowinska , Gaurav Malviya , Dmitry Solovyev , Gavin Brown , David Y Lewis , Gillian M Mackay , Douglas Strathdee , Saverio Tardito , Eyal Gottlieb , Auteur inconnu , Zoltan Takats , Simon T Barry , Richard J A Goodwin , Josephine Bunch , Martin Bushell , Andrew D Campbell , Owen J Sansom

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

Nature

Avec: Dustin J Flanagan , Nalle Pentinmikko , Kalle Luopajärvi , Nicky J Willis , Kathryn Gilroy , Alexander P Raven , Lynn Mcgarry , Johanna I Englund , Anna T Webb , Sandra Scharaw , Nadia Nasreddin , Michael C Hodder , Rachel A Ridgway , Emma Minnee , Nathalie Sphyris , Ella Gilchrist , Arafath K Najumudeen , Beatrice Romagnolo , Christine Perret , Ann C Williams , Hans Clevers , Pirjo Nummela , Marianne Lähde , Kari Alitalo , Ville Hietakangas , Ann Hedley , William Clark , Colin Nixon , Kristina Kirschner , E Yvonne Jones , Ari Ristimäki , Simon J Leedham , Paul V Fish , Jean-Paul Vincent , Pekka Katajisto , Owen J Sansom

Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis.

Molecular metabolism

Avec: Giuseppe Taurino , Ruhi Deshmukh , Victor H Villar , Martina Chiu , Robin Shaw , Ann Hedley , Engy Shokry , David Sumpton , Erica Dander , Giovanna D'Amico , Ovidio Bussolati , Saverio Tardito

Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging.

Nature communications

Avec: Eva C Freckmann , Emma Sandilands , Erin Cumming , Matthew Neilson , Alvaro Román-Fernández , Konstantina Nikolatou , Marisa Nacke , Tamsin R M Lannagan , Ann Hedley , David Strachan , Mark Salji , Jennifer P Morton , Lynn McGarry , Hing Y Leung , Owen J Sansom , Crispin J Miller , David M Bryant

Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.

Nature communications

Avec: Dustin J Flanagan , Raheleh Amirkhah , David F Vincent , Nuray Gunduz , Pauline Gentaz , Patrizia Cammareri , Aoife J McCooey , Amy M B McCorry , Natalie C Fisher , Hayley L Davis , Rachel A Ridgway , Jeroen Lohuis , Joshua D G Leach , Rene Jackstadt , Kathryn Gilroy , Elisa Mariella , Colin Nixon , William Clark , Ann Hedley , Elke K Markert , Douglas Strathdee , Laurent Bartholin , Keara L Redmond , Emma M Kerr , Daniel B Longley , Fiona Ginty , Sanghee Cho , Helen G Coleman , Maurice B Loughrey , Alberto Bardelli , Timothy S Maughan , Andrew D Campbell , Mark Lawler , Simon J Leedham , Simon T Barry , Gareth J Inman , Jacco van Rheenen , Philip D Dunne , Owen J Sansom

Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration.

Journal of hepatology

Avec: Stephanie May , Miryam Müller , Callum R Livingstone , George L Skalka , Peter J Walsh , Colin Nixon , Ann Hedley , Robin Shaw , William Clark , Johan Vande Voorde , Leah Officer-Jones , Fiona Ballantyne , Ian R Powley , Thomas M Drake , Christos Kiourtis , Andrew Keith , Ana Sofia Rocha , Saverio Tardito , David Sumpton , John Le Quesne , Martin Bushell , Owen J Sansom , Thomas G Bird

Réseau de co-auteurs

Ann Hedley 11 collaborations

William Clark 7 collaborations

Owen J Sansom 7 collaborations

Colin Nixon 6 collaborations

David Sumpton 4 collaborations

Saverio Tardito 4 collaborations

Rachel A Ridgway 4 collaborations

Robin Shaw 3 collaborations

Rene Jackstadt 3 collaborations

Andrew D Campbell 3 collaborations

Kathryn Gilroy 3 collaborations

Jared Bullard 2 collaborations

Duane Funk 2 collaborations

Kerry Dust 2 collaborations

Lauren Garnett 2 collaborations

James E Strong 2 collaborations

Guillaume Poliquin 2 collaborations

Sarah Neidler 2 collaborations

Björn Kruspig 2 collaborations

Tiziana Monteverde 2 collaborations

Katarina Gyuraszova 2 collaborations

Daniel J Murphy 2 collaborations

Jennifer P Morton 2 collaborations

Kristina Kirschner 2 collaborations

Johan Vande Voorde 2 collaborations

Eyal Gottlieb 2 collaborations

David M Gay 2 collaborations

Miryam Müller 2 collaborations

Michael C Hodder 2 collaborations

Thomas G Bird 2 collaborations

Arafath K Najumudeen 2 collaborations

Joshua D G Leach 2 collaborations

Philip D Dunne 2 collaborations

Douglas Strathdee 2 collaborations

Simon T Barry 2 collaborations

Martin Bushell 2 collaborations

Dustin J Flanagan 2 collaborations

Simon J Leedham 2 collaborations

Kaylie Tran 1 collaboration

Alex Bello 1 collaboration

Santina J Lee 1 collaboration

Jillian Waruk 1 collaboration

David Alexander 1 collaboration

Paul Van Caeseele 1 collaboration

Carla Loeppky 1 collaboration

Kay Hewit 1 collaboration

Attila Braun 1 collaboration

Daniel James 1 collaboration

Bernhard Nieswandt 1 collaboration

Emma Shanks 1 collaboration

Craig Dick 1 collaboration

Nathiya Muthalagu 1 collaboration

Ximena Raffo-Iraolagoitia 1 collaboration

Robert Wiesheu 1 collaboration

Declan Whyte 1 collaboration

Sarah Laing 1 collaboration

Rosanna Upstill-Goddard 1 collaboration

Curtis Rink 1 collaboration

Saadia A Karim 1 collaboration

Andrew V Biankin 1 collaboration

Leo M Carlin 1 collaboration

Seth B Coffelt 1 collaboration

Emily J Kay 1 collaboration

Karla Paterson 1 collaboration

Carla Riera-Domingo 1 collaboration

J Henry M Däbritz 1 collaboration

Claudia Boldrini 1 collaboration

Juan R Hernandez-Fernaud 1 collaboration

Dimitris Athineos 1 collaboration

Sandeep Dhayade 1 collaboration

Ekaterina Stepanova 1 collaboration

Enio Gjerga 1 collaboration

Lisa J Neilson 1 collaboration

Sergio Lilla 1 collaboration

Grigorios Koulouras 1 collaboration

Grace McGregor 1 collaboration

Craig Jamieson 1 collaboration

Radia Marie Johnson 1 collaboration

Morag Park 1 collaboration

Crispin Miller 1 collaboration

Jurre J Kamphorst 1 collaboration

Fabricio Loayza-Puch 1 collaboration

Julio Saez-Rodriguez 1 collaboration

Massimiliano Mazzone 1 collaboration

Karen Blyth 1 collaboration

Michele Zagnoni 1 collaboration

Sara Zanivan 1 collaboration

Carmen Tse 1 collaboration

Kaylie N Tran 1 collaboration

Jessica C Casciano 1 collaboration

Caroline Perry 1 collaboration

Adam J Cohen-Nowak 1 collaboration

Katelyn D Miller 1 collaboration

Qifeng Zhang 1 collaboration

Susan Chalmers 1 collaboration

Mairi E Sandison 1 collaboration

Qin Liu 1 collaboration

Tony McBryan 1 collaboration

Hsin-Yao Tang 1 collaboration

Nicole Gorman 1 collaboration

Thomas Beer 1 collaboration

David W Speicher 1 collaboration

Peter D Adams 1 collaboration

Xuefeng Liu 1 collaboration

Richard Schlegel 1 collaboration

John G McCarron 1 collaboration

Michael J O Wakelam 1 collaboration

Andrew V Kossenkov 1 collaboration

Zachary T Schug 1 collaboration

Joshua D Leach 1 collaboration

David J Huels 1 collaboration

Fatih Ceteci 1 collaboration

Sigrid K Fey 1 collaboration

Gregory Hamm 1 collaboration

Rory T Steven 1 collaboration

Holly Hall 1 collaboration

Chelsea J Nikula 1 collaboration

Alex Dexter 1 collaboration

Teresa Murta 1 collaboration

Alan M Race 1 collaboration

Nikola Vlahov 1 collaboration

John R P Knight 1 collaboration

Emma R Johnson 1 collaboration

Sudhir B Malla 1 collaboration

Giovanny Rodriguez-Blanco 1 collaboration

Susan E Critchlow 1 collaboration

Agata Mrowinska 1 collaboration

Gaurav Malviya 1 collaboration

Dmitry Solovyev 1 collaboration

Gavin Brown 1 collaboration

David Y Lewis 1 collaboration

Gillian M Mackay 1 collaboration

None None 1 collaboration

Zoltan Takats 1 collaboration

Richard J A Goodwin 1 collaboration

Josephine Bunch 1 collaboration

Nalle Pentinmikko 1 collaboration

Kalle Luopajärvi 1 collaboration

Nicky J Willis 1 collaboration

Alexander P Raven 1 collaboration

Lynn Mcgarry 1 collaboration

Johanna I Englund 1 collaboration

Anna T Webb 1 collaboration

Sandra Scharaw 1 collaboration

Nadia Nasreddin 1 collaboration

Emma Minnee 1 collaboration

Nathalie Sphyris 1 collaboration

Ella Gilchrist 1 collaboration

Beatrice Romagnolo 1 collaboration

Christine Perret 1 collaboration

Ann C Williams 1 collaboration

Hans Clevers 1 collaboration

Pirjo Nummela 1 collaboration

Marianne Lähde 1 collaboration

Kari Alitalo 1 collaboration

Ville Hietakangas 1 collaboration

E Yvonne Jones 1 collaboration

Ari Ristimäki 1 collaboration

Paul V Fish 1 collaboration

Jean-Paul Vincent 1 collaboration

Pekka Katajisto 1 collaboration

Giuseppe Taurino 1 collaboration

Ruhi Deshmukh 1 collaboration

Victor H Villar 1 collaboration

Martina Chiu 1 collaboration

Engy Shokry 1 collaboration

Erica Dander 1 collaboration

Giovanna D'Amico 1 collaboration

Ovidio Bussolati 1 collaboration

Eva C Freckmann 1 collaboration

Emma Sandilands 1 collaboration

Erin Cumming 1 collaboration

Matthew Neilson 1 collaboration

Alvaro Román-Fernández 1 collaboration

Konstantina Nikolatou 1 collaboration

Marisa Nacke 1 collaboration

Tamsin R M Lannagan 1 collaboration

David Strachan 1 collaboration

Mark Salji 1 collaboration

Lynn McGarry 1 collaboration

Hing Y Leung 1 collaboration

Crispin J Miller 1 collaboration

David M Bryant 1 collaboration

Raheleh Amirkhah 1 collaboration

David F Vincent 1 collaboration

Nuray Gunduz 1 collaboration

Pauline Gentaz 1 collaboration

Patrizia Cammareri 1 collaboration

Aoife J McCooey 1 collaboration

Amy M B McCorry 1 collaboration

Natalie C Fisher 1 collaboration

Hayley L Davis 1 collaboration

Jeroen Lohuis 1 collaboration

Elisa Mariella 1 collaboration

Elke K Markert 1 collaboration

Laurent Bartholin 1 collaboration

Keara L Redmond 1 collaboration

Emma M Kerr 1 collaboration

Daniel B Longley 1 collaboration

Fiona Ginty 1 collaboration

Sanghee Cho 1 collaboration

Helen G Coleman 1 collaboration

Maurice B Loughrey 1 collaboration

Alberto Bardelli 1 collaboration

Timothy S Maughan 1 collaboration

Mark Lawler 1 collaboration

Gareth J Inman 1 collaboration

Jacco van Rheenen 1 collaboration

Stephanie May 1 collaboration

Callum R Livingstone 1 collaboration

George L Skalka 1 collaboration

Peter J Walsh 1 collaboration

Leah Officer-Jones 1 collaboration

Fiona Ballantyne 1 collaboration

Ian R Powley 1 collaboration

Thomas M Drake 1 collaboration

Christos Kiourtis 1 collaboration

Andrew Keith 1 collaboration

Ana Sofia Rocha 1 collaboration

John Le Quesne 1 collaboration