E Ikonen

Affiliations

Department of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Minerva Foundation Institute for Medical Research, Helsinki, Finland.

Publications (35)

Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase.

Journal of internal medicine

Avec: P Simonen , S Li , N K Chua , A-M Lampi , V Piironen , J Lommi , J Sinisalo , A J Brown , E Ikonen , H Gylling

Machine learning of human plasma lipidomes for obesity estimation in a large population cohort.

PLoS biology

Avec: Mathias J Gerl , Christian Klose , Michal A Surma , Celine Fernandez , Olle Melander , Satu Männistö , Katja Borodulin , Aki S Havulinna , Veikko Salomaa , Elina Ikonen , Carlo V Cannistraci , Kai Simons

ORP2, a cholesterol transporter, regulates angiogenic signaling in endothelial cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Annika Koponen , Guoping Pan , Annukka M Kivelä , Arthur Ralko , Juuso H Taskinen , Amita Arora , Riikka Kosonen , Otto K Kari , Joseph Ndika , Elina Ikonen , Wonhwa Cho , Daoguang Yan , Vesa M Olkkonen

Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes.

Cell reports

Avec: Yoann Combot , Veijo T Salo , Gilliane Chadeuf , Maarit Hölttä , Katharina Ven , Ilari Pulli , Simon Ducheix , Claire Pecqueur , Ophélie Renoult , Behnam Lak , Shiqian Li , Leena Karhinen , Ilya Belevich , Cedric Le May , Jennifer Rieusset , Soazig Le Lay , Mikael Croyal , Karim Si Tayeb , Helena Vihinen , Eija Jokitalo , Kid Törnquist , Corinne Vigouroux , Bertrand Cariou , Jocelyne Magré , Abdelhalim Larhlimi , Elina Ikonen , Xavier Prieur

Cholesterol transport in the late endocytic pathway: Roles of ORP family proteins.

The Journal of steroid biochemistry and molecular biology

Avec: Vesa M Olkkonen , Elina Ikonen

LAPTM4B controls the sphingolipid and ether lipid signature of small extracellular vesicles.

Biochimica et biophysica acta. Molecular and cell biology of lipids

Avec: Andrea Dichlberger , Kecheng Zhou , Nils Bäck , Thomas Nyholm , Anders Backman , Peter Mattjus , Elina Ikonen , Tomas Blom

Photoacoustic characteristics of carbon-based infrared absorbers.

Photoacoustics

Avec: Jussi Rossi , Juho Uotila , Sucheta Sharma , Toni Laurila , Roland Teissier , Alexei Baranov , Erkki Ikonen , Markku Vainio

ATPase activity of DFCP1 controls selective autophagy.

Nature communications

Avec: Viola Nähse , Camilla Raiborg , Kia Wee Tan , Sissel Mørk , Maria Lyngaas Torgersen , Eva Maria Wenzel , Mireia Nager , Veijo T Salo , Terje Johansen , Elina Ikonen , Kay Oliver Schink , Harald Stenmark

Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex.

bioRxiv : the preprint server for biology

Avec: Chao Li , Xue-Nan Sun , Jan-Bernd Funcke , Lauri Vanharanta , Nolwenn Joffin , Yan Li , Xavier Prasanna , Megan Paredes , Chanmin Joung , Ruth Gordillo , Csaba Vörös , Waldemar Kulig , Leon Straub , Shuiwei Chen , Joselin Velasco , Ayanna Cobb , Davide La Padula , May-Yun Wang , Toshiharu Onodera , Oleg Varlamov , Yang Li , Chen Liu , Andrea R Nawrocki , Shangang Zhao , Da Young Oh , Zhao V Wang , Joel M Goodman , R Max Wynn , Ilpo Vattulainen , Yan Han , Elina Ikonen , Philipp E Scherer

Real-time measurement of metals in submicron aerosols with particle-into-liquid sampler combined with micro-discharge optical emission spectroscopy.

Environmental monitoring and assessment

Avec: Sudatta Das , Kimmo Teinilä , Hilkka Timonen , Erkki Ikonen , Toni Laurila

Long-term outcomes of extracapsular tonsillectomy in the treatment of obstructive sleep apnoea in adults.

Acta oto-laryngologica

Avec: Jenny Knubb , Henrik M Sjöblom , Ella Ikonen , Miika Suomela , Jaakko M Piitulainen

Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling.

Molecular cancer research : MCR

Avec: Jin-Yih Low , W Nathaniel Brennen , Alan K Meeker , Elina Ikonen , Brian W Simons , Marikki Laiho

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact.

Developmental cell

Avec: Veijo T Salo , Shiqian Li , Helena Vihinen , Maarit Hölttä-Vuori , Abel Szkalisity , Peter Horvath , Ilya Belevich , Johan Peränen , Christoph Thiele , Pentti Somerharju , Hongxia Zhao , Alexandre Santinho , Abdou Rachid Thiam , Eija Jokitalo , Elina Ikonen

Author Correction: An efficient auxin-inducible degron system with low basal degradation in human cells.

Nature methods

Avec: Shiqian Li , Xavier Prasanna , Veijo T Salo , Ilpo Vattulainen , Elina Ikonen

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol.

Biochimie

Avec: Annika Koponen , Amita Arora , Kohta Takahashi , Henriikka Kentala , Annukka M Kivelä , Eeva Jääskeläinen , Johan Peränen , Pentti Somerharju , Elina Ikonen , Tapani Viitala , Vesa M Olkkonen

Lipid Droplet Nucleation.

Trends in cell biology

Avec: Abdou Rachid Thiam , Elina Ikonen

Membrane Curvature Catalyzes Lipid Droplet Assembly.

Current biology : CB

Avec: Alexandre Santinho , Veijo T Salo , Aymeric Chorlay , Shiqian Li , Xin Zhou , Mohyeddine Omrane , Elina Ikonen , Abdou Rachid Thiam

Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Xinbo Zhang , Jeffrey G McDonald , Binod Aryal , Alberto Canfrán-Duque , Emily L Goldberg , Elisa Araldi , Wen Ding , Yuhua Fan , Bonne M Thompson , Abhishek K Singh , Qian Li , George Tellides , Jose Ordovás-Montanes , Rolando García Milian , Vishwa Deep Dixit , Elina Ikonen , Yajaira Suárez , Carlos Fernández-Hernando

Lipid Metabolic Reprogramming Extends beyond Histologic Tumor Demarcations in Operable Human Pancreatic Cancer.

Cancer research

Avec: Juho Pirhonen , Ábel Szkalisity , Jaana Hagström , Yonghyo Kim , Ede Migh , Mária Kovács , Maarit Hölttä , Johan Peränen , Hanna Seppänen , Caj Haglund , Jeovanis Gil , Melinda Rezeli , Johan Malm , Peter Horvath , György Markó-Varga , Pauli Puolakkainen , Elina Ikonen

Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols.

Nature communications

Avec: Calvin Dumesnil , Lauri Vanharanta , Xavier Prasanna , Mohyeddine Omrane , Maxime Carpentier , Apoorva Bhapkar , Giray Enkavi , Veijo T Salo , Ilpo Vattulainen , Elina Ikonen , Abdou Rachid Thiam

Intracellular Cholesterol Trafficking.

Cold Spring Harbor perspectives in biology

Avec: Elina Ikonen , Vesa M Olkkonen

Cholesterol transport between cellular membranes: A balancing act between interconnected lipid fluxes.

Developmental cell

Avec: Elina Ikonen , Xin Zhou

Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane.

PLoS biology

Avec: Xavier Prasanna , Veijo T Salo , Shiqian Li , Katharina Ven , Helena Vihinen , Eija Jokitalo , Ilpo Vattulainen , Elina Ikonen

HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo.

Molecular metabolism

Avec: Burcin Gungor , Lauri Vanharanta , Maarit Hölttä-Vuori , Juho Pirhonen , Nikolaj H T Petersen , Silvia Gramolelli , Päivi M Ojala , Thomas Kirkegaard , Elina Ikonen

An efficient auxin-inducible degron system with low basal degradation in human cells.

Nature methods

Avec: Shiqian Li , Xavier Prasanna , Veijo T Salo , Ilpo Vattulainen , Elina Ikonen

Moving out but keeping in touch: contacts between endoplasmic reticulum and lipid droplets.

Current opinion in cell biology

Avec: Veijo T Salo , Elina Ikonen

Lysosome Associated Protein Transmembrane 4B-24 Is the Predominant Protein Isoform in Human Tissues and Undergoes Rapid, Nutrient-Regulated Turnover.

The American journal of pathology

Avec: Kecheng Zhou , Andrea Dichlberger , Elina Ikonen , Tomas Blom

High Performance Predictable Quantum Efficient Detector Based on Induced-Junction Photodiodes Passivated with SiO

Sensors (Basel, Switzerland)

Avec: Ozhan Koybasi , Ørnulf Nordseth , Trinh Tran , Marco Povoli , Mauro Rajteri , Carlo Pepe , Eivind Bardalen , Farshid Manoocheri , Anand Summanwar , Mikhail Korpusenko , Michael N Getz , Per Ohlckers , Erkki Ikonen , Jarle Gran

Terahertz radiation detection with a cantilever-based photoacoustic sensor.

Optics express

Avec: Sucheta Sharma , Mohsen Ahmadi , Jussi Rossi , Markku Vainio , Zhipei Sun , Andreas Steiger , Erkki Ikonen

Cholesterol binding to VCAM-1 promotes vascular inflammation.

bioRxiv : the preprint server for biology

Avec: John P Kennelly , Xu Xiao , Yajing Gao , Sumin Kim , Soon-Gook Hong , Miranda Villanueva , Alessandra Ferrari , Lauri Vanharanta , Alexander Nguyen , Rohith T Nagari , Nikolas R Burton , Marcus J Tol , Andrew P Becker , Min Jae Lee , Elina Ikonen , Keriann M Backus , Julia J Mack , Peter Tontonoz

GC-MS with photoionization of cold molecules in supersonic molecular beams-Approaching the softest ionization method.

Journal of mass spectrometry : JMS

Avec: Alexander B Fialkov , Elias Ikonen , Tiina Laaksonen , Aviv Amirav

Cryostat setup for measuring spectral and electrical properties of light-emitting diodes at junction temperatures from 81 K to 297 K.

The Review of scientific instruments

Avec: Elvira Martikainen , Anna Vaskuri , Timo Dönsberg , Erkki Ikonen

Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids.

JCI insight

Avec: Panu K Luukkonen , Auli Nick , Maarit Hölttä-Vuori , Christoph Thiele , Elina Isokuortti , Susanna Lallukka-Brück , You Zhou , Antti Hakkarainen , Nina Lundbom , Markku Peltonen , Marju Orho-Melander , Matej Orešič , Tuulia Hyötyläinen , Leanne Hodson , Elina Ikonen , Hannele Yki-Järvinen

Shuttling HDL Cholesterol to the Membrane via Metastable Receptor Multimers.

Developmental cell

Avec: Elina Ikonen , Kristiina Kanerva

Regression plane concept for analysing continuous cellular processes with machine learning.

Nature communications

Avec: Abel Szkalisity , Filippo Piccinini , Attila Beleon , Tamas Balassa , Istvan Gergely Varga , Ede Migh , Csaba Molnar , Lassi Paavolainen , Sanna Timonen , Indranil Banerjee , Elina Ikonen , Yohei Yamauchi , Istvan Ando , Jaakko Peltonen , Vilja Pietiäinen , Viktor Honti , Peter Horvath

Réseau de co-auteurs

Elina Ikonen 27 collaborations

Veijo T Salo 9 collaborations

Shiqian Li 6 collaborations

Erkki Ikonen 5 collaborations

Xavier Prasanna 5 collaborations

Ilpo Vattulainen 5 collaborations

Vesa M Olkkonen 4 collaborations

Lauri Vanharanta 4 collaborations

Abdou Rachid Thiam 4 collaborations

Helena Vihinen 3 collaborations

Eija Jokitalo 3 collaborations

Maarit Hölttä-Vuori 3 collaborations

Peter Horvath 3 collaborations

Johan Peränen 3 collaborations

Annika Koponen 2 collaborations

Annukka M Kivelä 2 collaborations

Amita Arora 2 collaborations

Maarit Hölttä 2 collaborations

Katharina Ven 2 collaborations

Ilya Belevich 2 collaborations

Andrea Dichlberger 2 collaborations

Kecheng Zhou 2 collaborations

Tomas Blom 2 collaborations

Jussi Rossi 2 collaborations

Sucheta Sharma 2 collaborations

Toni Laurila 2 collaborations

Markku Vainio 2 collaborations

Abel Szkalisity 2 collaborations

Christoph Thiele 2 collaborations

Pentti Somerharju 2 collaborations

Alexandre Santinho 2 collaborations

Xin Zhou 2 collaborations

Mohyeddine Omrane 2 collaborations

Juho Pirhonen 2 collaborations

Ede Migh 2 collaborations

P Simonen 1 collaboration

S Li 1 collaboration

N K Chua 1 collaboration

A-M Lampi 1 collaboration

V Piironen 1 collaboration

J Lommi 1 collaboration

J Sinisalo 1 collaboration

A J Brown 1 collaboration

H Gylling 1 collaboration

Mathias J Gerl 1 collaboration

Christian Klose 1 collaboration

Michal A Surma 1 collaboration

Celine Fernandez 1 collaboration

Olle Melander 1 collaboration

Satu Männistö 1 collaboration

Katja Borodulin 1 collaboration

Aki S Havulinna 1 collaboration

Veikko Salomaa 1 collaboration

Carlo V Cannistraci 1 collaboration

Kai Simons 1 collaboration

Guoping Pan 1 collaboration

Arthur Ralko 1 collaboration

Juuso H Taskinen 1 collaboration

Riikka Kosonen 1 collaboration

Otto K Kari 1 collaboration

Joseph Ndika 1 collaboration

Wonhwa Cho 1 collaboration

Daoguang Yan 1 collaboration

Yoann Combot 1 collaboration

Gilliane Chadeuf 1 collaboration

Ilari Pulli 1 collaboration

Simon Ducheix 1 collaboration

Claire Pecqueur 1 collaboration

Ophélie Renoult 1 collaboration

Behnam Lak 1 collaboration

Leena Karhinen 1 collaboration

Cedric Le May 1 collaboration

Jennifer Rieusset 1 collaboration

Soazig Le Lay 1 collaboration

Mikael Croyal 1 collaboration

Karim Si Tayeb 1 collaboration

Kid Törnquist 1 collaboration

Corinne Vigouroux 1 collaboration

Bertrand Cariou 1 collaboration

Jocelyne Magré 1 collaboration

Abdelhalim Larhlimi 1 collaboration

Xavier Prieur 1 collaboration

Nils Bäck 1 collaboration

Thomas Nyholm 1 collaboration

Anders Backman 1 collaboration

Peter Mattjus 1 collaboration

Juho Uotila 1 collaboration

Roland Teissier 1 collaboration

Alexei Baranov 1 collaboration

Viola Nähse 1 collaboration

Camilla Raiborg 1 collaboration

Kia Wee Tan 1 collaboration

Sissel Mørk 1 collaboration

Maria Lyngaas Torgersen 1 collaboration

Eva Maria Wenzel 1 collaboration

Mireia Nager 1 collaboration

Terje Johansen 1 collaboration

Kay Oliver Schink 1 collaboration

Harald Stenmark 1 collaboration

Chao Li 1 collaboration

Xue-Nan Sun 1 collaboration

Jan-Bernd Funcke 1 collaboration

Nolwenn Joffin 1 collaboration

Yan Li 1 collaboration

Megan Paredes 1 collaboration

Chanmin Joung 1 collaboration

Ruth Gordillo 1 collaboration

Csaba Vörös 1 collaboration

Waldemar Kulig 1 collaboration

Leon Straub 1 collaboration

Shuiwei Chen 1 collaboration

Joselin Velasco 1 collaboration

Ayanna Cobb 1 collaboration

Davide La Padula 1 collaboration

May-Yun Wang 1 collaboration

Toshiharu Onodera 1 collaboration

Oleg Varlamov 1 collaboration

Yang Li 1 collaboration

Chen Liu 1 collaboration

Andrea R Nawrocki 1 collaboration

Shangang Zhao 1 collaboration

Da Young Oh 1 collaboration

Zhao V Wang 1 collaboration

Joel M Goodman 1 collaboration

R Max Wynn 1 collaboration

Yan Han 1 collaboration

Philipp E Scherer 1 collaboration

Sudatta Das 1 collaboration

Kimmo Teinilä 1 collaboration

Hilkka Timonen 1 collaboration

Jenny Knubb 1 collaboration

Henrik M Sjöblom 1 collaboration

Ella Ikonen 1 collaboration

Miika Suomela 1 collaboration

Jaakko M Piitulainen 1 collaboration

Jin-Yih Low 1 collaboration

W Nathaniel Brennen 1 collaboration

Alan K Meeker 1 collaboration

Brian W Simons 1 collaboration

Marikki Laiho 1 collaboration

Hongxia Zhao 1 collaboration

Kohta Takahashi 1 collaboration

Henriikka Kentala 1 collaboration

Eeva Jääskeläinen 1 collaboration

Tapani Viitala 1 collaboration

Aymeric Chorlay 1 collaboration

Xinbo Zhang 1 collaboration

Jeffrey G McDonald 1 collaboration

Binod Aryal 1 collaboration

Alberto Canfrán-Duque 1 collaboration

Emily L Goldberg 1 collaboration

Elisa Araldi 1 collaboration

Wen Ding 1 collaboration

Yuhua Fan 1 collaboration

Bonne M Thompson 1 collaboration

Abhishek K Singh 1 collaboration

Qian Li 1 collaboration

George Tellides 1 collaboration

Jose Ordovás-Montanes 1 collaboration

Rolando García Milian 1 collaboration

Vishwa Deep Dixit 1 collaboration

Yajaira Suárez 1 collaboration

Carlos Fernández-Hernando 1 collaboration

Ábel Szkalisity 1 collaboration

Jaana Hagström 1 collaboration

Yonghyo Kim 1 collaboration

Mária Kovács 1 collaboration

Hanna Seppänen 1 collaboration

Caj Haglund 1 collaboration

Jeovanis Gil 1 collaboration

Melinda Rezeli 1 collaboration

Johan Malm 1 collaboration

György Markó-Varga 1 collaboration

Pauli Puolakkainen 1 collaboration

Calvin Dumesnil 1 collaboration

Maxime Carpentier 1 collaboration

Apoorva Bhapkar 1 collaboration

Giray Enkavi 1 collaboration

Burcin Gungor 1 collaboration

Nikolaj H T Petersen 1 collaboration

Silvia Gramolelli 1 collaboration

Päivi M Ojala 1 collaboration

Thomas Kirkegaard 1 collaboration

Ozhan Koybasi 1 collaboration

Ørnulf Nordseth 1 collaboration

Trinh Tran 1 collaboration

Marco Povoli 1 collaboration

Mauro Rajteri 1 collaboration

Carlo Pepe 1 collaboration

Eivind Bardalen 1 collaboration

Farshid Manoocheri 1 collaboration

Anand Summanwar 1 collaboration

Mikhail Korpusenko 1 collaboration

Michael N Getz 1 collaboration

Per Ohlckers 1 collaboration

Jarle Gran 1 collaboration

Mohsen Ahmadi 1 collaboration

Zhipei Sun 1 collaboration

Andreas Steiger 1 collaboration

John P Kennelly 1 collaboration

Xu Xiao 1 collaboration

Yajing Gao 1 collaboration

Sumin Kim 1 collaboration

Soon-Gook Hong 1 collaboration

Miranda Villanueva 1 collaboration

Alessandra Ferrari 1 collaboration

Alexander Nguyen 1 collaboration

Rohith T Nagari 1 collaboration

Nikolas R Burton 1 collaboration

Marcus J Tol 1 collaboration

Andrew P Becker 1 collaboration

Min Jae Lee 1 collaboration

Keriann M Backus 1 collaboration

Julia J Mack 1 collaboration

Peter Tontonoz 1 collaboration

Alexander B Fialkov 1 collaboration

Elias Ikonen 1 collaboration

Tiina Laaksonen 1 collaboration

Aviv Amirav 1 collaboration

Elvira Martikainen 1 collaboration

Anna Vaskuri 1 collaboration

Timo Dönsberg 1 collaboration

Panu K Luukkonen 1 collaboration

Auli Nick 1 collaboration

Elina Isokuortti 1 collaboration

Susanna Lallukka-Brück 1 collaboration

You Zhou 1 collaboration

Antti Hakkarainen 1 collaboration

Nina Lundbom 1 collaboration

Markku Peltonen 1 collaboration

Marju Orho-Melander 1 collaboration

Matej Orešič 1 collaboration

Tuulia Hyötyläinen 1 collaboration

Leanne Hodson 1 collaboration

Hannele Yki-Järvinen 1 collaboration

Kristiina Kanerva 1 collaboration

Filippo Piccinini 1 collaboration

Attila Beleon 1 collaboration

Tamas Balassa 1 collaboration

Istvan Gergely Varga 1 collaboration

Csaba Molnar 1 collaboration

Lassi Paavolainen 1 collaboration

Sanna Timonen 1 collaboration

Indranil Banerjee 1 collaboration

Yohei Yamauchi 1 collaboration

Istvan Ando 1 collaboration

Jaakko Peltonen 1 collaboration

Vilja Pietiäinen 1 collaboration

Viktor Honti 1 collaboration