I Amit

Affiliations

Centre for Graphene Science, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4QF, UK.

ORCID: 0000-0002-4747-7020

Publications (20)

Single-cell genomic approaches for developing the next generation of immunotherapies.

Nature medicine

Avec: Ido Yofe , Rony Dahan , Ido Amit

Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program.

Cell

Avec: Laufey Geirsdottir , Eyal David , Hadas Keren-Shaul , Assaf Weiner , Stefan Cornelius Bohlen , Jana Neuber , Adam Balic , Amir Giladi , Fadi Sheban , Charles-Antoine Dutertre , Christine Pfeifle , Francesca Peri , Antonella Raffo-Romero , Jacopo Vizioli , Kaspar Matiasek , Christian Scheiwe , Stephan Meckel , Kerstin Mätz-Rensing , Franziska van der Meer , Finnbogi Rutur Thormodsson , Christine Stadelmann , Noga Zilkha , Tali Kimchi , Florent Ginhoux , Igor Ulitsky , Daniel Erny , Ido Amit , Marco Prinz

LifeTime and improving European healthcare through cell-based interceptive medicine.

Nature

Avec: Nikolaus Rajewsky , Geneviève Almouzni , Stanislaw A Gorski , Stein Aerts , Ido Amit , Michela G Bertero , Christoph Bock , Annelien L Bredenoord , Giacomo Cavalli , Susanna Chiocca , Hans Clevers , Bart De Strooper , Angelika Eggert , Jan Ellenberg , Xosé M Fernández , Marek Figlerowicz , Susan M Gasser , Norbert Hubner , Jørgen Kjems , Jürgen A Knoblich , Grietje Krabbe , Peter Lichter , Sten Linnarsson , Jean-Christophe Marine , John C Marioni , Marc A Marti-Renom , Mihai G Netea , Dörthe Nickel , Marcelo Nollmann , Halina R Novak , Helen Parkinson , Stefano Piccolo , Inês Pinheiro , Ana Pombo , Christian Popp , Wolf Reik , Sergio Roman-Roman , Philip Rosenstiel , Joachim L Schultze , Oliver Stegle , Amos Tanay , Giuseppe Testa , Dimitris Thanos , Fabian J Theis , Maria-Elena Torres-Padilla , Alfonso Valencia , Céline Vallot , Alexander van Oudenaarden , Marie Vidal , Thierry Voet , Auteur inconnu

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.

Nature medicine

Avec: Mingfeng Liao , Yang Liu , Jing Yuan , Yanling Wen , Gang Xu , Juanjuan Zhao , Lin Cheng , Jinxiu Li , Xin Wang , Fuxiang Wang , Lei Liu , Ido Amit , Shuye Zhang , Zheng Zhang

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner.

Cell

Avec: Diego Adhemar Jaitin , Lorenz Adlung , Christoph A Thaiss , Assaf Weiner , Baoguo Li , Hélène Descamps , Patrick Lundgren , Camille Bleriot , Zhaoyuan Liu , Aleksandra Deczkowska , Hadas Keren-Shaul , Eyal David , Niv Zmora , Shai Meron Eldar , Nir Lubezky , Oren Shibolet , David A Hill , Mitchell A Lazar , Marco Colonna , Florent Ginhoux , Hagit Shapiro , Eran Elinav , Ido Amit

Laser-writable high-k dielectric for van der Waals nanoelectronics.

Science advances

Avec: N Peimyoo , M D Barnes , J D Mehew , A De Sanctis , I Amit , J Escolar , K Anastasiou , A P Rooney , S J Haigh , S Russo , M F Craciun , F Withers

DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node.

Frontiers in immunology

Avec: Caterina Curato , Biana Bernshtein , Eva Zupancič , Almut Dufner , Diego Jaitin , Amir Giladi , Eyal David , Louise Chappell-Maor , Dena Leshkowitz , Klaus-Peter Knobeloch , Ido Amit , Helena F Florindo , Steffen Jung

MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing.

Nature protocols

Avec: Hadas Keren-Shaul , Ephraim Kenigsberg , Diego Adhemar Jaitin , Eyal David , Franziska Paul , Amos Tanay , Ido Amit

Cell composition analysis of bulk genomics using single-cell data.

Nature methods

Avec: Amit Frishberg , Naama Peshes-Yaloz , Ofir Cohn , Diana Rosentul , Yael Steuerman , Liran Valadarsky , Gal Yankovitz , Michal Mandelboim , Fuad A Iraqi , Ido Amit , Lior Mayo , Eran Bacharach , Irit Gat-Viks

Early antitumor activity of oral Langerhans cells is compromised by a carcinogen.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Yasmin Saba , Itay Aizenbud , Daniela Matanes , Noam Koren , Or Barel , Khalid Zubeidat , Tal Capucha , Eyal David , Luba Eli-Berchoer , Patrizia Stoitzner , Asaf Wilensky , Ido Amit , Rakefet Czerninski , Simon Yona , Avi-Hai Hovav

Dichotomous metabolic networks govern human ILC2 proliferation and function.

Nature immunology

Avec: Laura Surace , Jean-Marc Doisne , Carys A Croft , Anna Thaller , Pedro Escoll , Solenne Marie , Natalia Petrosemoli , Vincent Guillemot , Valerie Dardalhon , Davide Topazio , Antonia Cama , Carmen Buchrieser , Naomi Taylor , Ido Amit , Olimpia Musumeci , James P Di Santo

Acute liver failure is regulated by MYC- and microbiome-dependent programs.

Nature medicine

Avec: Aleksandra A Kolodziejczyk , Sara Federici , Niv Zmora , Gayatree Mohapatra , Mally Dori-Bachash , Shanni Hornstein , Avner Leshem , Debby Reuveni , Ehud Zigmond , Ana Tobar , Tomer Meir Salame , Alon Harmelin , Amir Shlomai , Hagit Shapiro , Ido Amit , Eran Elinav

Single-cell analysis of regions of interest (SCARI) using a photosensitive tag.

Nature chemical biology

Avec: Anne M van der Leun , Mirjam E Hoekstra , Luuk Reinalda , Colinda L G J Scheele , Mireille Toebes , Michel J van de Graaff , Linda Y Y Chen , Hanjie Li , Akhiad Bercovich , Yaniv Lubling , Eyal David , Daniela S Thommen , Amos Tanay , Jacco van Rheenen , Ido Amit , Sander I van Kasteren , Ton N Schumacher

Tumor cells in light-chain amyloidosis and myeloma show distinct transcriptional rewiring of normal plasma cell development.

Blood

Avec: Daniel Alameda , Ibai Goicoechea , Marco Vicari , Elena Arriazu , Alice Nevone , Sara Rodriguez , Marta Lasa , Noemi Puig , Maria Teresa Cedena , Diego Alignani , Sonia Garate , David Lara-Astiaso , Amaia Vilas-Zornoza , Sarai Sarvide , Enrique M Ocio , Ramon Lecumberri , Alfonso Garcia de Coca , Jorge Labrador , Maria-Esther Gonzalez , Luis Palomera , Mercedes Gironella , Valentin Cabañas , Maria Casanova , Albert Oriol , Isabel Krsnik , Albert Perez-Montaña , Javier de la Rubia , Jose-Enrique de la Puerta , Felipe de Arriba , Vito Michele Fazio , Joaquin Martinez-Lopez , Juan-Jose Lahuerta , Maria-Victoria Mateos , Maria-Dolores Odero , Felipe Prosper , Assaf Weiner , Ido Amit , Mario Nuvolone , Jesus F San Miguel , Bruno Paiva

Brain metastases: Not all tumors are created equal.

Neuron

Avec: Daniel Kirschenbaum , Ido Amit

Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary.

Cancer discovery

Avec: Ido Yofe , Tamar Shami , Noam Cohen , Tomer Landsberger , Fadi Sheban , Liat Stoler-Barak , Adam Yalin , Truong San Phan , Baoguo Li , Lea Monteran , Ye'ela Scharff , Amir Giladi , Miriam Elbaz , Eyal David , Anna Gurevich-Shapiro , Chamutal Gur , Ziv Shulman , Neta Erez , Ido Amit

Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma.

Cell

Avec: Daniel Kirschenbaum , Ken Xie , Florian Ingelfinger , Yonatan Katzenelenbogen , Kathleen Abadie , Thomas Look , Fadi Sheban , Truong San Phan , Baoguo Li , Pascale Zwicky , Ido Yofe , Eyal David , Kfir Mazuz , Jinchao Hou , Yun Chen , Hila Shaim , Mayra Shanley , Soeren Becker , Jiawen Qian , Marco Colonna , Florent Ginhoux , Katayoun Rezvani , Fabian J Theis , Nir Yosef , Tobias Weiss , Assaf Weiner , Ido Amit

Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration.

Immunity

Avec: Aymeric Silvin , Stefan Uderhardt , Cecile Piot , Sandro Da Mesquita , Katharine Yang , Laufey Geirsdottir , Kevin Mulder , David Eyal , Zhaoyuan Liu , Cecile Bridlance , Morgane Sonia Thion , Xiao Meng Zhang , Wan Ting Kong , Marc Deloger , Vasco Fontes , Assaf Weiner , Rachel Ee , Regine Dress , Jing Wen Hang , Akhila Balachander , Svetoslav Chakarov , Benoit Malleret , Garett Dunsmore , Olivier Cexus , Jinmiao Chen , Sonia Garel , Charles Antoine Dutertre , Ido Amit , Jonathan Kipnis , Florent Ginhoux

The CD8

Immunity

Avec: Willem Van Der Byl , Simone Nüssing , Timothy J Peters , Antonio Ahn , Hanjie Li , Guy Ledergor , Eyal David , Andrew S Koh , Mayura V Wagle , Christian Deo T Deguit , Maria N de Menezes , Avraham Travers , Shienny Sampurno , Kelly M Ramsbottom , Rui Li , Axel Kallies , Paul A Beavis , Ralf Jungmann , Maartje M C Bastings , Gabrielle T Belz , Shom Goel , Joseph A Trapani , Gerald R Crabtree , Howard Y Chang , Ido Amit , Chris C Goodnow , Fabio Luciani , Ian A Parish

Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4

Nature immunology

Avec: Marco De Giovanni , Valeria Cutillo , Amir Giladi , Eleonora Sala , Carmela G Maganuco , Chiara Medaglia , Pietro Di Lucia , Elisa Bono , Claudia Cristofani , Eleonora Consolo , Leonardo Giustini , Alessandra Fiore , Sarah Eickhoff , Wolfgang Kastenmüller , Ido Amit , Mirela Kuka , Matteo Iannacone

Réseau de co-auteurs

Ido Amit 19 collaborations

Eyal David 9 collaborations

Assaf Weiner 5 collaborations

Amir Giladi 4 collaborations

Florent Ginhoux 4 collaborations

Ido Yofe 3 collaborations

Hadas Keren-Shaul 3 collaborations

Fadi Sheban 3 collaborations

Amos Tanay 3 collaborations

Baoguo Li 3 collaborations

Laufey Geirsdottir 2 collaborations

Fabian J Theis 2 collaborations

Diego Adhemar Jaitin 2 collaborations

Zhaoyuan Liu 2 collaborations

Niv Zmora 2 collaborations

Marco Colonna 2 collaborations

Hagit Shapiro 2 collaborations

Eran Elinav 2 collaborations

Hanjie Li 2 collaborations

Daniel Kirschenbaum 2 collaborations

Truong San Phan 2 collaborations

Rony Dahan 1 collaboration

Stefan Cornelius Bohlen 1 collaboration

Jana Neuber 1 collaboration

Adam Balic 1 collaboration

Charles-Antoine Dutertre 1 collaboration

Christine Pfeifle 1 collaboration

Francesca Peri 1 collaboration

Antonella Raffo-Romero 1 collaboration

Jacopo Vizioli 1 collaboration

Kaspar Matiasek 1 collaboration

Christian Scheiwe 1 collaboration

Stephan Meckel 1 collaboration

Kerstin Mätz-Rensing 1 collaboration

Franziska van der Meer 1 collaboration

Finnbogi Rutur Thormodsson 1 collaboration

Christine Stadelmann 1 collaboration

Noga Zilkha 1 collaboration

Tali Kimchi 1 collaboration

Igor Ulitsky 1 collaboration

Daniel Erny 1 collaboration

Marco Prinz 1 collaboration

Nikolaus Rajewsky 1 collaboration

Geneviève Almouzni 1 collaboration

Stanislaw A Gorski 1 collaboration

Stein Aerts 1 collaboration

Michela G Bertero 1 collaboration

Christoph Bock 1 collaboration

Annelien L Bredenoord 1 collaboration

Giacomo Cavalli 1 collaboration

Susanna Chiocca 1 collaboration

Hans Clevers 1 collaboration

Bart De Strooper 1 collaboration

Angelika Eggert 1 collaboration

Jan Ellenberg 1 collaboration

Xosé M Fernández 1 collaboration

Marek Figlerowicz 1 collaboration

Susan M Gasser 1 collaboration

Norbert Hubner 1 collaboration

Jørgen Kjems 1 collaboration

Jürgen A Knoblich 1 collaboration

Grietje Krabbe 1 collaboration

Peter Lichter 1 collaboration

Sten Linnarsson 1 collaboration

Jean-Christophe Marine 1 collaboration

John C Marioni 1 collaboration

Marc A Marti-Renom 1 collaboration

Mihai G Netea 1 collaboration

Dörthe Nickel 1 collaboration

Marcelo Nollmann 1 collaboration

Halina R Novak 1 collaboration

Helen Parkinson 1 collaboration

Stefano Piccolo 1 collaboration

Inês Pinheiro 1 collaboration

Ana Pombo 1 collaboration

Christian Popp 1 collaboration

Wolf Reik 1 collaboration

Sergio Roman-Roman 1 collaboration

Philip Rosenstiel 1 collaboration

Joachim L Schultze 1 collaboration

Oliver Stegle 1 collaboration

Giuseppe Testa 1 collaboration

Dimitris Thanos 1 collaboration

Maria-Elena Torres-Padilla 1 collaboration

Alfonso Valencia 1 collaboration

Céline Vallot 1 collaboration

Alexander van Oudenaarden 1 collaboration

Marie Vidal 1 collaboration

Thierry Voet 1 collaboration

None None 1 collaboration

Mingfeng Liao 1 collaboration

Yang Liu 1 collaboration

Jing Yuan 1 collaboration

Yanling Wen 1 collaboration

Gang Xu 1 collaboration

Juanjuan Zhao 1 collaboration

Lin Cheng 1 collaboration

Jinxiu Li 1 collaboration

Xin Wang 1 collaboration

Fuxiang Wang 1 collaboration

Lei Liu 1 collaboration

Shuye Zhang 1 collaboration

Zheng Zhang 1 collaboration

Lorenz Adlung 1 collaboration

Christoph A Thaiss 1 collaboration

Hélène Descamps 1 collaboration

Patrick Lundgren 1 collaboration

Camille Bleriot 1 collaboration

Aleksandra Deczkowska 1 collaboration

Shai Meron Eldar 1 collaboration

Nir Lubezky 1 collaboration

Oren Shibolet 1 collaboration

David A Hill 1 collaboration

Mitchell A Lazar 1 collaboration

N Peimyoo 1 collaboration

M D Barnes 1 collaboration

J D Mehew 1 collaboration

A De Sanctis 1 collaboration

J Escolar 1 collaboration

K Anastasiou 1 collaboration

A P Rooney 1 collaboration

S J Haigh 1 collaboration

S Russo 1 collaboration

M F Craciun 1 collaboration

F Withers 1 collaboration

Caterina Curato 1 collaboration

Biana Bernshtein 1 collaboration

Eva Zupancič 1 collaboration

Almut Dufner 1 collaboration

Diego Jaitin 1 collaboration

Louise Chappell-Maor 1 collaboration

Dena Leshkowitz 1 collaboration

Klaus-Peter Knobeloch 1 collaboration

Helena F Florindo 1 collaboration

Steffen Jung 1 collaboration

Ephraim Kenigsberg 1 collaboration

Franziska Paul 1 collaboration

Amit Frishberg 1 collaboration

Naama Peshes-Yaloz 1 collaboration

Ofir Cohn 1 collaboration

Diana Rosentul 1 collaboration

Yael Steuerman 1 collaboration

Liran Valadarsky 1 collaboration

Gal Yankovitz 1 collaboration

Michal Mandelboim 1 collaboration

Fuad A Iraqi 1 collaboration

Lior Mayo 1 collaboration

Eran Bacharach 1 collaboration

Irit Gat-Viks 1 collaboration

Yasmin Saba 1 collaboration

Itay Aizenbud 1 collaboration

Daniela Matanes 1 collaboration

Noam Koren 1 collaboration

Or Barel 1 collaboration

Khalid Zubeidat 1 collaboration

Tal Capucha 1 collaboration

Luba Eli-Berchoer 1 collaboration

Patrizia Stoitzner 1 collaboration

Asaf Wilensky 1 collaboration

Rakefet Czerninski 1 collaboration

Simon Yona 1 collaboration

Avi-Hai Hovav 1 collaboration

Laura Surace 1 collaboration

Jean-Marc Doisne 1 collaboration

Carys A Croft 1 collaboration

Anna Thaller 1 collaboration

Pedro Escoll 1 collaboration

Solenne Marie 1 collaboration

Natalia Petrosemoli 1 collaboration

Vincent Guillemot 1 collaboration

Valerie Dardalhon 1 collaboration

Davide Topazio 1 collaboration

Antonia Cama 1 collaboration

Carmen Buchrieser 1 collaboration

Naomi Taylor 1 collaboration

Olimpia Musumeci 1 collaboration

James P Di Santo 1 collaboration

Aleksandra A Kolodziejczyk 1 collaboration

Sara Federici 1 collaboration

Gayatree Mohapatra 1 collaboration

Mally Dori-Bachash 1 collaboration

Shanni Hornstein 1 collaboration

Avner Leshem 1 collaboration

Debby Reuveni 1 collaboration

Ehud Zigmond 1 collaboration

Ana Tobar 1 collaboration

Tomer Meir Salame 1 collaboration

Alon Harmelin 1 collaboration

Amir Shlomai 1 collaboration

Anne M van der Leun 1 collaboration

Mirjam E Hoekstra 1 collaboration

Luuk Reinalda 1 collaboration

Colinda L G J Scheele 1 collaboration

Mireille Toebes 1 collaboration

Michel J van de Graaff 1 collaboration

Linda Y Y Chen 1 collaboration

Akhiad Bercovich 1 collaboration

Yaniv Lubling 1 collaboration

Daniela S Thommen 1 collaboration

Jacco van Rheenen 1 collaboration

Sander I van Kasteren 1 collaboration

Ton N Schumacher 1 collaboration

Daniel Alameda 1 collaboration

Ibai Goicoechea 1 collaboration

Marco Vicari 1 collaboration

Elena Arriazu 1 collaboration

Alice Nevone 1 collaboration

Sara Rodriguez 1 collaboration

Marta Lasa 1 collaboration

Noemi Puig 1 collaboration

Maria Teresa Cedena 1 collaboration

Diego Alignani 1 collaboration

Sonia Garate 1 collaboration

David Lara-Astiaso 1 collaboration

Amaia Vilas-Zornoza 1 collaboration

Sarai Sarvide 1 collaboration

Enrique M Ocio 1 collaboration

Ramon Lecumberri 1 collaboration

Alfonso Garcia de Coca 1 collaboration

Jorge Labrador 1 collaboration

Maria-Esther Gonzalez 1 collaboration

Luis Palomera 1 collaboration

Mercedes Gironella 1 collaboration

Valentin Cabañas 1 collaboration

Maria Casanova 1 collaboration

Albert Oriol 1 collaboration

Isabel Krsnik 1 collaboration

Albert Perez-Montaña 1 collaboration

Javier de la Rubia 1 collaboration

Jose-Enrique de la Puerta 1 collaboration

Felipe de Arriba 1 collaboration

Vito Michele Fazio 1 collaboration

Joaquin Martinez-Lopez 1 collaboration

Juan-Jose Lahuerta 1 collaboration

Maria-Victoria Mateos 1 collaboration

Maria-Dolores Odero 1 collaboration

Felipe Prosper 1 collaboration

Mario Nuvolone 1 collaboration

Jesus F San Miguel 1 collaboration

Bruno Paiva 1 collaboration

Tamar Shami 1 collaboration

Noam Cohen 1 collaboration

Tomer Landsberger 1 collaboration

Liat Stoler-Barak 1 collaboration

Adam Yalin 1 collaboration

Lea Monteran 1 collaboration

Ye'ela Scharff 1 collaboration

Miriam Elbaz 1 collaboration

Anna Gurevich-Shapiro 1 collaboration

Chamutal Gur 1 collaboration

Ziv Shulman 1 collaboration

Neta Erez 1 collaboration

Ken Xie 1 collaboration

Florian Ingelfinger 1 collaboration

Yonatan Katzenelenbogen 1 collaboration

Kathleen Abadie 1 collaboration

Thomas Look 1 collaboration

Pascale Zwicky 1 collaboration

Kfir Mazuz 1 collaboration

Jinchao Hou 1 collaboration

Yun Chen 1 collaboration

Hila Shaim 1 collaboration

Mayra Shanley 1 collaboration

Soeren Becker 1 collaboration

Jiawen Qian 1 collaboration

Katayoun Rezvani 1 collaboration

Nir Yosef 1 collaboration

Tobias Weiss 1 collaboration

Aymeric Silvin 1 collaboration

Stefan Uderhardt 1 collaboration

Cecile Piot 1 collaboration

Sandro Da Mesquita 1 collaboration

Katharine Yang 1 collaboration

Kevin Mulder 1 collaboration

David Eyal 1 collaboration

Cecile Bridlance 1 collaboration

Morgane Sonia Thion 1 collaboration

Xiao Meng Zhang 1 collaboration

Wan Ting Kong 1 collaboration

Marc Deloger 1 collaboration

Vasco Fontes 1 collaboration

Rachel Ee 1 collaboration

Regine Dress 1 collaboration

Jing Wen Hang 1 collaboration

Akhila Balachander 1 collaboration

Svetoslav Chakarov 1 collaboration

Benoit Malleret 1 collaboration

Garett Dunsmore 1 collaboration

Olivier Cexus 1 collaboration

Jinmiao Chen 1 collaboration

Sonia Garel 1 collaboration

Charles Antoine Dutertre 1 collaboration

Jonathan Kipnis 1 collaboration

Willem Van Der Byl 1 collaboration

Simone Nüssing 1 collaboration

Timothy J Peters 1 collaboration

Antonio Ahn 1 collaboration

Guy Ledergor 1 collaboration

Andrew S Koh 1 collaboration

Mayura V Wagle 1 collaboration

Christian Deo T Deguit 1 collaboration

Maria N de Menezes 1 collaboration

Avraham Travers 1 collaboration

Shienny Sampurno 1 collaboration

Kelly M Ramsbottom 1 collaboration

Rui Li 1 collaboration

Axel Kallies 1 collaboration

Paul A Beavis 1 collaboration

Ralf Jungmann 1 collaboration

Maartje M C Bastings 1 collaboration

Gabrielle T Belz 1 collaboration

Shom Goel 1 collaboration

Joseph A Trapani 1 collaboration

Gerald R Crabtree 1 collaboration

Howard Y Chang 1 collaboration

Chris C Goodnow 1 collaboration

Fabio Luciani 1 collaboration

Ian A Parish 1 collaboration

Marco De Giovanni 1 collaboration

Valeria Cutillo 1 collaboration

Eleonora Sala 1 collaboration

Carmela G Maganuco 1 collaboration

Chiara Medaglia 1 collaboration

Pietro Di Lucia 1 collaboration

Elisa Bono 1 collaboration

Claudia Cristofani 1 collaboration

Eleonora Consolo 1 collaboration

Leonardo Giustini 1 collaboration

Alessandra Fiore 1 collaboration

Sarah Eickhoff 1 collaboration

Wolfgang Kastenmüller 1 collaboration

Mirela Kuka 1 collaboration

Matteo Iannacone 1 collaboration