M Wuhrer

Affiliations

Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands.

Publications (93)

ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab.

Oncogene

Avec: Henrique O Duarte , Joana G Rodrigues , Catarina Gomes , Paul J Hensbergen , Agnes L Hipgrave Ederveen , Arnoud H de Ru , Stefan Mereiter , António Polónia , Elisabete Fernandes , José A Ferreira , Peter A van Veelen , Lúcio L Santos , Manfred Wuhrer , Joana Gomes , Celso A Reis

Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry.

The Journal of biological chemistry

Avec: Katarzyna Szymczak-Kulus , Sascha Weidler , Anna Bereznicka , Krzysztof Mikolajczyk , Radoslaw Kaczmarek , Bartosz Bednarz , Tao Zhang , Anna Urbaniak , Mariusz Olczak , Enoch Y Park , Edyta Majorczyk , Katarzyna Kapczynska , Jolanta Lukasiewicz , Manfred Wuhrer , Carlo Unverzagt , Marcin Czerwinski

Site-Specific

Journal of proteome research

Avec: Laura Pont , Valeriia Kuzyk , Fernando Benavente , Victoria Sanz-Nebot , Oleg A Mayboroda , Manfred Wuhrer , Guinevere S M Lageveen-Kammeijer

Unique patterns of glycosylation in immunoglobulin subclass G4-related disease and primary sclerosing cholangitis.

Journal of gastroenterology and hepatology

Avec: Emma L Culver , Fleur S van de Bovenkamp , Ninotska I L Derksen , Jana Koers , Tamsin Cargill , Eleanor Barnes , Louise A de Neef , Carolien A M Koeleman , Rob C Aalberse , Manfred Wuhrer , Theo Rispens

A Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Assay for the Relative Quantitation of Antennary Fucosylated

Frontiers in chemistry

Avec: Osmond D Rebello , Simone Nicolardi , Guinevere S M Lageveen-Kammeijer , Jan Nouta , Richard A Gardner , Wilma E Mesker , Rob A E M Tollenaar , Daniel I R Spencer , Manfred Wuhrer , David Falck

Monoclonal immunoglobulins promote bone loss in multiple myeloma.

Blood

Avec: Marita Westhrin , Vlado Kovcic , Zejian Zhang , Siv H Moen , Tonje Marie Vikene Nedal , Albert Bondt , Stephanie Holst , Kristine Misund , Glenn Buene , Anders Sundan , Anders Waage , Tobias S Slørdahl , Manfred Wuhrer , Therese Standal

Serum N-Glycome analysis reveals pancreatic cancer disease signatures.

Cancer medicine

Avec: Gerda C M Vreeker , Randa G Hanna-Sawires , Yassene Mohammed , Marco R Bladergroen , Simone Nicolardi , Viktoria Dotz , Jan Nouta , Bert A Bonsing , Wilma E Mesker , Yuri E M van der Burgt , Manfred Wuhrer , Rob A E M Tollenaar

IgA subclasses have different effector functions associated with distinct glycosylation profiles.

Nature communications

Avec: Ulrike Steffen , Carolien A Koeleman , Maria V Sokolova , Holger Bang , Arnd Kleyer , Jürgen Rech , Harald Unterweger , Martin Schicht , Fabian Garreis , Jonas Hahn , Fabian T Andes , Fabian Hartmann , Madelaine Hahn , Aparna Mahajan , Friedrich Paulsen , Markus Hoffmann , Günter Lochnit , Luis E Muñoz , Manfred Wuhrer , David Falck , Martin Herrmann , Georg Schett

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases.

Science advances

Avec: Lucija Klarić , Yakov A Tsepilov , Chloe M Stanton , Massimo Mangino , Timo Tõnis Sikka , Tõnu Esko , Eugene Pakhomov , Perttu Salo , Joris Deelen , Stuart J McGurnaghan , Toma Keser , Frano Vučković , Ivo Ugrina , Jasminka Krištić , Ivan Gudelj , Jerko Štambuk , Rosina Plomp , Maja Pučić-Baković , Tamara Pavić , Marija Vilaj , Irena Trbojević-Akmačić , Camilla Drake , Paula Dobrinić , Jelena Mlinarec , Barbara Jelušić , Anne Richmond , Maria Timofeeva , Alexander K Grishchenko , Julia Dmitrieva , Mairead L Bermingham , Sodbo Zh Sharapov , Susan M Farrington , Evropi Theodoratou , Hae-Won Uh , Marian Beekman , Eline P Slagboom , Edouard Louis , Michel Georges , Manfred Wuhrer , Helen M Colhoun , Malcolm G Dunlop , Markus Perola , Krista Fischer , Ozren Polasek , Harry Campbell , Igor Rudan , James F Wilson , Vlatka Zoldoš , Veronique Vitart , Tim Spector , Yurii S Aulchenko , Gordan Lauc , Caroline Hayward

Afucosylated IgG Targets FcγRIV for Enhanced Tumor Therapy in Mice.

Cancers

Avec: Rens Braster , Marijn Bögels , Hreinn Benonisson , Manfred Wuhrer , Rosina Plomp , Arthur E H Bentlage , Rianne Korthouwer , Remco Visser , J Sjef Verbeek , Marjolein van Egmond , Gestur Vidarsson

Clinical Perspective on Proteomic and Glycomic Biomarkers for Diagnosis, Prognosis, and Prediction of Pancreatic Cancer.

International journal of molecular sciences

Avec: Randa G Hanna-Sawires , Jorinde H Schiphuis , Manfred Wuhrer , Hans F A Vasen , Monique E van Leerdam , Bert A Bonsing , Wilma E Mesker , Yuri E M van der Burgt , Rob A E M Tollenaar

Plasma protein

BMJ open diabetes research & care

Avec: Elham Memarian , Leen M 't Hart , Roderick C Slieker , Roosmarijn F L Lemmers , Amber A van der Heijden , Femke Rutters , Giel Nijpels , Emma Schoep , Aloysius G Lieverse , Eric J G Sijbrands , Manfred Wuhrer , Mandy van Hoek , Viktoria Dotz

Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors.

Frontiers in immunology

Avec: Andrew R Crowley , Nana Yaw Osei-Owusu , Gillian Dekkers , Wenda Gao , Manfred Wuhrer , Diogo M Magnani , Keith A Reimann , Seth H Pincus , Gestur Vidarsson , Margaret E Ackerman

Antibody glycosylation in COVID-19.

Glycoconjugate journal

Avec: Tamas Pongracz , Gestur Vidarsson , Manfred Wuhrer

High-Throughput Glycomic Methods.

Chemical reviews

Avec: Irena Trbojević-Akmačić , Guinevere S M Lageveen-Kammeijer , Bram Heijs , Tea Petrović , Helena Deriš , Manfred Wuhrer , Gordan Lauc

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis.

Nature

Avec: Matteo Rossi , Patricia Altea-Manzano , Margherita Demicco , Ginevra Doglioni , Laura Bornes , Marina Fukano , Anke Vandekeere , Alejandro M Cuadros , Juan Fernández-García , Carla Riera-Domingo , Cristina Jauset , Mélanie Planque , H Furkan Alkan , David Nittner , Dongmei Zuo , Lindsay A Broadfield , Sweta Parik , Antonino Alejandro Pane , Francesca Rizzollo , Gianmarco Rinaldi , Tao Zhang , Shao Thing Teoh , Arin B Aurora , Panagiotis Karras , Ines Vermeire , Dorien Broekaert , Joke Van Elsen , Maximilian M L Knott , Martin F Orth , Sofie Demeyer , Guy Eelen , Lacey E Dobrolecki , Ayse Bassez , Thomas Van Brussel , Karl Sotlar , Michael T Lewis , Harald Bartsch , Manfred Wuhrer , Peter van Veelen , Peter Carmeliet , Jan Cools , Sean J Morrison , Jean-Christophe Marine , Diether Lambrechts , Massimiliano Mazzone , Gregory J Hannon , Sophia Y Lunt , Thomas G P Grünewald , Morag Park , Jacco van Rheenen , Sarah-Maria Fendt

Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples.

Glycobiology

Avec: Noortje de Haan , Maja Pučić-Baković , Mislav Novokmet , David Falck , Guinevere Lageveen-Kammeijer , Genadij Razdorov , Frano Vučković , Irena Trbojević-Akmačić , Olga Gornik , Maja Hanić , Manfred Wuhrer , Gordan Lauc , Auteur inconnu

Afucosylated broadly neutralizing antibodies enhance clearance of HIV-1 infected cells through cell-mediated killing.

Communications biology

Avec: Steven W de Taeye , Angela I Schriek , Jeffrey C Umotoy , Marloes Grobben , Judith A Burger , Rogier W Sanders , Gestur Vidarsson , Manfred Wuhrer , David Falck , Neeltje A Kootstra , Marit J van Gils

IgG Fab Glycans Hinder FcRn-Mediated Placental Transport.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Mikhail Volkov , Maximilian Brinkhaus , Karin A van Schie , Albert Bondt , Theresa Kissel , Elvera J van der Kooi , Arthur E H Bentlage , Carolien A M Koeleman , Steven W de Taeye , Ninotska I Derksen , Radboud J E M Dolhain , Ute Braig-Scherer , Tom W J Huizinga , Manfred Wuhrer , René E M Toes , Gestur Vidarsson , Diane van der Woude

Glycobiology of rheumatic diseases.

Nature reviews. Rheumatology

Avec: Theresa Kissel , René E M Toes , Thomas W J Huizinga , Manfred Wuhrer

Analysis of Immunogenic Galactose-α-1,3-galactose-Containing

Journal of agricultural and food chemistry

Avec: Rui-Rui Guo , Guinevere S M Lageveen-Kammeijer , Wenjun Wang , Hans Dalebout , Wangang Zhang , Manfred Wuhrer , Li Liu , Bram Heijs , Josef Voglmeir

Transcriptionally imprinted glycomic signatures of acute myeloid leukemia.

Cell & bioscience

Avec: Constantin Blöchl , Di Wang , Oleg A Mayboroda , Guinevere S M Lageveen-Kammeijer , Manfred Wuhrer

Dopant-enriched nitrogen gas to boost ionization of glycoproteins analyzed with native liquid chromatography coupled to nano-electrospray ionization.

Analytica chimica acta

Avec: Guusje van Schaick , Manfred Wuhrer , Elena Domínguez-Vega

Cellular surface plasmon resonance-based detection of anti-HPA-1a antibody glycosylation in fetal and neonatal alloimmune thrombocytopenia.

Frontiers in immunology

Avec: Zoltán Szittner , Arthur E H Bentlage , A Robin Temming , David E Schmidt , Remco Visser , Suzanne Lissenberg-Thunnissen , Juk Yee Mok , Wim J E van Esch , Myrthe E Sonneveld , Erik L de Graaf , Manfred Wuhrer , Leendert Porcelijn , Masja de Haas , C Ellen van der Schoot , Gestur Vidarsson

IgG glycosylation associates with risk of progression from latent to active tuberculosis.

The Journal of infection

Avec: Julie G Burel , Wenjun Wang , Manfred Wuhrer , Martin Dedicoat , Thomas E Fletcher , Adam F Cunningham , Matthew K O'Shea

IgG1 glycosylation highlights premature aging in Down syndrome.

Aging cell

Avec: Bianca M M Streng , Julie Van Coillie , Joanne G Wildenbeest , Rob S Binnendijk , Gaby Smits , Gerco den Hartog , Wenjun Wang , Jan Nouta , Federica Linty , Remco Visser , Manfred Wuhrer , Gestur Vidarsson , Louis J Bont , Auteur inconnu

CslA and GlxA from

Applied and environmental microbiology

Avec: Xiaobo Zhong , Simone Nicolardi , Ruochen Ouyang , Manfred Wuhrer , Chao Du , Gilles van Wezel , Erik Vijgenboom , Ariane Briegel , Dennis Claessen

Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics.

mAbs

Avec: Oksana Tyshchuk , Christoph Gstöttner , Dennis Funk , Simone Nicolardi , Stefan Frost , Stefan Klostermann , Tim Becker , Elena Jolkver , Felix Schumacher , Claudia Ferrara Koller , Hans Rainer Völger , Manfred Wuhrer , Patrick Bulau , Michael Mølhøj

Site-specific N- and O-glycosylation analysis of atacicept.

mAbs

Avec: Kathrin Stavenhagen , Rabah Gahoual , Elena Dominguez Vega , Angelo Palmese , Agnes L Hipgrave Ederveen , Francesca Cutillo , Wolf Palinsky , Horst Bierau , Manfred Wuhrer

N-Linked Glycans in the Variable Domain of IgG Anti-Citrullinated Protein Antibodies Predict the Development of Rheumatoid Arthritis.

Arthritis & rheumatology (Hoboken, N.J.)

Avec: Lise Hafkenscheid , Emma de Moel , Irene Smolik , Stacey Tanner , Xiaobo Meng , Bas C Jansen , Albert Bondt , Manfred Wuhrer , Tom W J Huizinga , Rene E M Toes , Hani El-Gabalawy , Hans U Scherer

Towards a standardized bioinformatics infrastructure for N- and O-glycomics.

Nature communications

Avec: Miguel A Rojas-Macias , Julien Mariethoz , Peter Andersson , Chunsheng Jin , Vignesh Venkatakrishnan , Nobuyuki P Aoki , Daisuke Shinmachi , Christopher Ashwood , Katarina Madunic , Tao Zhang , Rebecca L Miller , Oliver Horlacher , Weston B Struwe , Yu Watanabe , Shujiro Okuda , Fredrik Levander , Daniel Kolarich , Pauline M Rudd , Manfred Wuhrer , Carsten Kettner , Nicolle H Packer , Kiyoko F Aoki-Kinoshita , Frédérique Lisacek , Niclas G Karlsson

Molecular signatures of tumor progression in myxoid liposarcoma identified by N-glycan mass spectrometry imaging.

Laboratory investigation; a journal of technical methods and pathology

Avec: Bram Heijs , Stephanie Holst-Bernal , Marieke A de Graaff , Inge H Briaire-de Bruijn , Mar Rodriguez-Girondo , Michiel A J van de Sande , Manfred Wuhrer , Liam A McDonnell , Judith V M G Bovée

Development of a 96-well plate sample preparation method for integrated N- and O-glycomics using porous graphitized carbon liquid chromatography-mass spectrometry.

Molecular omics

Avec: Tao Zhang , Katarina Madunić , Stephanie Holst , Jing Zhang , Chunsheng Jin , Peter Ten Dijke , Niclas G Karlsson , Kathrin Stavenhagen , Manfred Wuhrer

Author Correction: Human DC-SIGN and CD23 do not interact with human IgG.

Scientific reports

Avec: A Robin Temming , Gillian Dekkers , Fleur S van de Bovenkamp , H Rosina Plomp , Arthur E H Bentlage , Zoltán Szittner , Ninotska I L Derksen , Manfred Wuhrer , Theo Rispens , Gestur Vidarsson

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown.

Nature communications

Avec: Lucy I Crouch , Marcelo V Liberato , Paulina A Urbanowicz , Arnaud Baslé , Christopher A Lamb , Christopher J Stewart , Katie Cooke , Mary Doona , Stephanie Needham , Richard R Brady , Janet E Berrington , Katarina Madunic , Manfred Wuhrer , Peter Chater , Jeffery P Pearson , Robert Glowacki , Eric C Martens , Fuming Zhang , Robert J Linhardt , Daniel I R Spencer , David N Bolam

Sheathless CE-MS as a tool for monitoring exchange efficiency and stability of bispecific antibodies.

Electrophoresis

Avec: Christoph Gstöttner , Dana L E Vergoossen , Manfred Wuhrer , Maartje G M Huijbers , Elena Domínguez-Vega

Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.

The EMBO journal

Avec: Martina Pigoni , Hung-En Hsia , Jana Hartmann , Jasenka Rudan Njavro , Merav D Shmueli , Stephan A Müller , Gökhan Güner , Johanna Tüshaus , Peer-Hendrik Kuhn , Rohit Kumar , Pan Gao , Mai Ly Tran , Bulat Ramazanov , Birgit Blank , Agnes L Hipgrave Ederveen , Julia Von Blume , Christophe Mulle , Jenny M Gunnersen , Manfred Wuhrer , Gerhard Rammes , Marc Aurel Busche , Thomas Koeglsperger , Stefan F Lichtenthaler

IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants.

The Journal of allergy and clinical immunology

Avec: Yannic C Bartsch , Simon Eschweiler , Alexei Leliavski , Hanna B Lunding , Sander Wagt , Janina Petry , Gina-Maria Lilienthal , Johann Rahmöller , Noortje de Haan , Alexandra Hölscher , Raghu Erapaneedi , Anastasios D Giannou , Lilian Aly , Ryota Sato , Louise A de Neef , André Winkler , Dominique Braumann , Juliane Hobusch , Kyra Kuhnigk , Vanessa Krémer , Moritz Steinhaus , Véronique Blanchard , Timo Gemoll , Jens K Habermann , Mattias Collin , Gabriela Salinas , Rudolf A Manz , Hidehiro Fukuyama , Thomas Korn , Ari Waisman , Nir Yogev , Samuel Huber , Björn Rabe , Stefan Rose-John , Hauke Busch , Friederike Berberich-Siebelt , Christoph Hölscher , Manfred Wuhrer , Marc Ehlers

Site-Specific Glycosylation Mapping of Fc Gamma Receptor IIIb from Neutrophils of Individual Healthy Donors.

Analytical chemistry

Avec: Iwona Wojcik , Thomas Sénard , Erik L de Graaf , George M C Janssen , Arnoud H de Ru , Yassene Mohammed , Peter A van Veelen , Gestur Vidarsson , Manfred Wuhrer , David Falck

Evaluation of Sibling and Twin Fragment Ions Improves the Structural Characterization of Proteins by Top-Down MALDI In-Source Decay Mass Spectrometry.

Analytical chemistry

Avec: Simone Nicolardi , David P A Kilgour , Natasja Dolezal , Jan W Drijfhout , Manfred Wuhrer , Yuri E M van der Burgt

Lipopolysaccharide O-antigen molecular and supramolecular modifications of plant root microbiota are pivotal for host recognition.

Carbohydrate polymers

Avec: Adele Vanacore , Giuseppe Vitiello , Alan Wanke , Domenico Cavasso , Luke A Clifton , Lisa Mahdi , María Asunción Campanero-Rhodes , Dolores Solís , Manfred Wuhrer , Simone Nicolardi , Antonio Molinaro , Roberta Marchetti , Alga Zuccaro , Luigi Paduano , Alba Silipo

Serum N-glycan profiles differ for various breast cancer subtypes.

Glycoconjugate journal

Avec: Gerda C M Vreeker , Kiki M H Vangangelt , Marco R Bladergroen , Simone Nicolardi , Wilma E Mesker , Manfred Wuhrer , Yuri E M van der Burgt , Rob A E M Tollenaar

Targeting Glycans and Heavily Glycosylated Proteins for Tumor Imaging.

Cancers

Avec: Ruben D Houvast , Mireille Vankemmelbeke , Lindy G Durrant , Manfred Wuhrer , Victor M Baart , Peter J K Kuppen , Lioe-Fee de Geus-Oei , Alexander L Vahrmeijer , Cornelis F M Sier

Large-Scale Analysis of Apolipoprotein CIII Glycosylation by Ultrahigh Resolution Mass Spectrometry.

Frontiers in chemistry

Avec: Daniel Demus , Annemieke Naber , Viktoria Dotz , Bas C Jansen , Marco R Bladergroen , Jan Nouta , Eric J G Sijbrands , Mandy Van Hoek , Simone Nicolardi , Manfred Wuhrer

Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Dana L E Vergoossen , Jaap J Plomp , Christoph Gstöttner , Yvonne E Fillié-Grijpma , Roy Augustinus , Robyn Verpalen , Manfred Wuhrer , Paul W H I Parren , Elena Dominguez-Vega , Silvère M van der Maarel , Jan J Verschuuren , Maartje G Huijbers

Journal of the American Society of Nephrology : JASN

Avec: Viktoria Dotz , Alessia Visconti , Hannah J Lomax-Browne , Florent Clerc , Agnes L Hipgrave Ederveen , Nicholas R Medjeral-Thomas , H Terence Cook , Matthew C Pickering , Manfred Wuhrer , Mario Falchi

A semi-automated, high throughput approach for O-glycosylation profiling of in vitro established cancer cell lines by MALDI-FT-ICR MS.

Glycoconjugate journal

Avec: Maximilianos Kotsias , Katarina Madunić , Simone Nicolardi , Radoslaw P Kozak , Richard A Gardner , Bas C Jansen , Daniel I R Spencer , Manfred Wuhrer

Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability.

ACS omega

Avec: Ingrid Grunert , Katrin Heinrich , Juliane Ernst , Michael Hingar , Alexandre Briguet , Michael Leiss , Manfred Wuhrer , Dietmar Reusch , Patrick Bulau

IgG Anti-Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross-Sectional Study Encompassing ~1,500 Samples.

Arthritis & rheumatology (Hoboken, N.J.)

Avec: Theresa Kissel , Lise Hafkenscheid , Tineke J Wesemael , Mami Tamai , Shin-Ya Kawashiri , Atsushi Kawakami , Hani S El-Gabalawy , Dirkjan van Schaardenburg , Solbritt Rantapää-Dahlqvist , Manfred Wuhrer , Annette H M van der Helm-van Mil , Cornelia F Allaart , Diane van der Woude , Hans U Scherer , Rene E M Toes , Tom W J Huizinga

Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination.

Nature communications

Avec: Mads Delbo Larsen , Mary Lopez-Perez , Emmanuel Kakra Dickson , Paulina Ampomah , Nicaise Tuikue Ndam , Jan Nouta , Carolien A M Koeleman , Agnes L Hipgrave Ederveen , Benjamin Mordmüller , Ali Salanti , Morten Agertoug Nielsen , Achille Massougbodji , C Ellen van der Schoot , Michael F Ofori , Manfred Wuhrer , Lars Hviid , Gestur Vidarsson

Fc galactosylation of anti-platelet human IgG1 alloantibodies enhances complement activation on platelets.

Haematologica

Avec: Thijs L J Van Osch , Janita J Oosterhoff , Arthur E H Bentlage , Jan Nouta , Carolien A M Koeleman , Dionne M Geerdes , Juk Yee Mok , Sebastiaan Heidt , Arend Mulder , Wim J E Van Esch , Rick Kapur , Leendert Porcelijn , C Ellen Van der Schoot , Masja De Haas , Manfred Wuhrer , Jan Voorberg , Gestur Vidarsson

Longitudinal changes of serum protein N-Glycan levels for earlier detection of pancreatic cancer in high-risk individuals.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Avec: I J M Levink , D C F Klatte , R G Hanna-Sawires , G C M Vreeker , I S Ibrahim , Y E M van der Burgt , K A Overbeek , B D M Koopmann , D L Cahen , G M Fuhler , M Wuhrer , B A Bonsing , R A E M Tollenaar , F P Vleggaar , H F A Vasen , M E van Leerdam , M J Bruno , W E Mesker

Glycan and Protein Analysis of Glycoengineered Bacterial

Analytical chemistry

Avec: Simone Nicolardi , Renzo Danuser , Viktoria Dotz , Elena Domínguez-Vega , Ali Al Kaabi , Michel Beurret , Chakkumkal Anish , Manfred Wuhrer

mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine.

Frontiers in immunology

Avec: Jana Sophia Buhre , Tamas Pongracz , Inga Künsting , Anne S Lixenfeld , Wenjun Wang , Jan Nouta , Selina Lehrian , Franziska Schmelter , Hanna B Lunding , Lara Dühring , Carsten Kern , Janina Petry , Emily L Martin , Bandik Föh , Moritz Steinhaus , Vera von Kopylow , Christian Sina , Tobias Graf , Johann Rahmöller , Manfred Wuhrer , Marc Ehlers

Studying protein structure and function by native separation-mass spectrometry.

Nature reviews. Chemistry

Avec: Guusje van Schaick , Rob Haselberg , Govert W Somsen , Manfred Wuhrer , Elena Domínguez-Vega

Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation.

Cell reports. Medicine

Avec: Pranay Bharadwaj , Sweta Shrestha , Tamas Pongracz , Catalano Concetta , Shilpee Sharma , Alain Le Moine , Noortje de Haan , Naoka Murakami , Leonardo V Riella , Vanda Holovska , Manfred Wuhrer , Arnaud Marchant , Margaret E Ackerman

Assessment of Macro- and Microheterogeneity of Monoclonal Antibodies Using Capillary Zone Electrophoresis Hyphenated with Mass Spectrometry.

Methods in molecular biology (Clifton, N.J.)

Avec: Christoph Gstöttner , Rob Haselberg , Manfred Wuhrer , Govert W Somsen , Elena Domínguez-Vega

Phagocytosis of platelets opsonized with differently glycosylated anti-HLA hIgG1 by monocyte-derived macrophages.

Platelets

Avec: Thijs L J van Osch , Juulke Steuten , Jan Nouta , Carolien A M Koeleman , Arthur E H Bentlage , Sebastiaan Heidt , Arend Mulder , Jan Voorberg , S Marieke van Ham , Manfred Wuhrer , Anja Ten Brinke , Gestur Vidarsson

Software-Assisted Data Processing Workflow for Intact Glycoprotein Mass Spectrometry.

Journal of proteome research

Avec: Alan B Moran , Elena Domínguez-Vega , Manfred Wuhrer , Guinevere S M Lageveen-Kammeijer

IgG N-glycans are associated with prevalent and incident complications of type 2 diabetes.

Diabetes/metabolism research and reviews

Avec: Elham Memarian , Ralph Heijmans , Roderick C Slieker , Adriana Sierra , Olga Gornik , Joline W J Beulens , Maja Hanic , Petra Elders , Julio Pascual , Eric Sijbrands , Gordan Lauc , Viktoria Dotz , Clara Barrios , Leen M 't Hart , Manfred Wuhrer , Mandy van Hoek

A semi-automated hybrid HPLC-MS approach for in-depth characterization of intact non-covalent heterodimer glycoforms of gonadotropin biopharmaceuticals.

Analytica chimica acta

Avec: Fiammetta Di Marco , Gabriele Blümel , Constantin Blöchl , Manfred Wuhrer , Christian G Huber

A photoaffinity glycan-labeling approach to investigate immunoglobulin glycan-binding partners.

Glycobiology

Avec: Miles D Holborough-Kerkvliet , Greta Mucignato , Sam J Moons , Venetia Psomiadou , Rohit S R Konada , Nichole J Pedowitz , Matthew R Pratt , Theresa Kissel , Carolien A M Koeleman , Rayman T N Tjokrodirijo , Petrus A van Veelen , Thomas Huizinga , Karin A J van Schie , Manfred Wuhrer , Jennifer J Kohler , Kimberly M Bonger , Thomas J Boltje , Reinaldus E M Toes

Total serum

iScience

Avec: Gabriane Nascimento Porcino , Marco René Bladergroen , Viktoria Dotz , Simone Nicolardi , Elham Memarian , Luiz Gustavo Gardinassi , Carlos Henrique Nery Costa , Roque Pacheco de Almeida , Isabel Kinney Ferreira de Miranda Santos , Manfred Wuhrer

A robust nanoscale RP HPLC-MS approach for sensitive Fc proteoform profiling of IgG allotypes.

Analytica chimica acta

Avec: Constantin Blöchl , Christoph Gstöttner , Thomas Sénard , Eva Maria Stork , Hans Ulrich Scherer , Rene E M Toes , Manfred Wuhrer , Elena Domínguez-Vega

Apolipoprotein-CIII O-Glycosylation Is Associated with Micro- and Macrovascular Complications of Type 2 Diabetes.

International journal of molecular sciences

Avec: Annemieke Naber , Daniel Demus , Roderick C Slieker , Simone Nicolardi , Joline W J Beulens , Petra J M Elders , Aloysius G Lieverse , Eric J G Sijbrands , Leen M 't Hart , Manfred Wuhrer , Mandy van Hoek

Non-prime- and prime-side profiling of Pro-Pro endopeptidase specificity using synthetic combinatorial peptide libraries and mass spectrometry.

The FEBS journal

Avec: Bart Claushuis , Robert A Cordfunke , Arnoud H de Ru , Jordy van Angeren , Ulrich Baumann , Peter A van Veelen , Manfred Wuhrer , Jeroen Corver , Jan W Drijfhout , Paul J Hensbergen

The genetics and epidemiology of N- and O-immunoglobulin A glycomics.

Genome medicine

Avec: Alessia Visconti , Niccolò Rossi , Albert Bondt , Agnes Hipgrave Ederveen , Gaurav Thareja , Carolien A M Koeleman , Nisha Stephan , Anna Halama , Hannah J Lomax-Browne , Matthew C Pickering , Xu-Jie Zhou , Manfred Wuhrer , Karsten Suhre , Mario Falchi

Simultaneous Immunoglobulin A and G Glycopeptide Profiling for High-Throughput Applications.

Analytical chemistry

Avec: Ana Momčilović , Noortje de Haan , Agnes L Hipgrave Ederveen , Albert Bondt , Carolien A M Koeleman , David Falck , Louise A de Neef , Wilma E Mesker , Rob Tollenaar , Arnoud de Ru , Peter van Veelen , Manfred Wuhrer , Viktoria Dotz

Metformin and statin use associate with plasma protein

BMJ open diabetes research & care

Avec: Sunny S Singh , Annemieke Naber , Viktoria Dotz , Emma Schoep , Elham Memarian , Roderick C Slieker , Petra J M Elders , Gerda Vreeker , Simone Nicolardi , Manfred Wuhrer , Eric J G Sijbrands , Aloysius G Lieverse , Leen M 't Hart , Mandy van Hoek

International journal of molecular sciences

Avec: Martina Pirro , Yassene Mohammed , Sandra J van Vliet , Yoann Rombouts , Agnese Sciacca , Arnoud H de Ru , George M C Janssen , Rayman T N Tjokrodirijo , Manfred Wuhrer , Peter A van Veelen , Paul J Hensbergen

Biological and structural characterization of murine TRALI antibody reveals increased Fc-mediated complement activation.

Blood advances

Avec: Eveline A N Zeeuw van der Laan , Saskia van der Velden , Arthur E H Bentlage , Mads D Larsen , Thijs L J van Osch , Juk Yee Mok , Giso Brasser , Dionne M Geerdes , Carolien A M Koeleman , Jan Nouta , John W Semple , Leendert Porcelijn , Wim J E van Esch , Manfred Wuhrer , C Ellen van der Schoot , Gestur Vidarsson , Rick Kapur

Serum protein N-glycosylation changes in multiple myeloma.

Biochimica et biophysica acta. General subjects

Avec: Zejian Zhang , Marita Westhrin , Albert Bondt , Manfred Wuhrer , Therese Standal , Stephanie Holst

On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis.

Annals of the rheumatic diseases

Avec: Theresa Kissel , Karin Anna van Schie , Lise Hafkenscheid , Anders Lundquist , Heidi Kokkonen , Manfred Wuhrer , Tom Wj Huizinga , Hans Ulrich Scherer , René Toes , Solbritt Rantapää-Dahlqvist

Glycoform-resolved FcɣRIIIa affinity chromatography-mass spectrometry.

mAbs

Avec: Steffen Lippold , Simone Nicolardi , Elena Domínguez-Vega , Anna-Katharina Heidenreich , Gestur Vidarsson , Dietmar Reusch , Markus Haberger , Manfred Wuhrer , David Falck

Recombinant human monoclonal HLA antibodies of different IgG subclasses recognising the same epitope: Excellent tools to study differential effects of donor-specific antibodies.

HLA

Avec: Cynthia S M Kramer , Marry E I Franke-van Dijk , Ashley J Priddey , Tamás Pongrácz , Elena Gnudi , Helena Car , Gonca E Karahan , Els van Beelen , Chalana C C Zilvold-van den Oever , Hendrik J Rademaker , Noortje de Haan , Manfred Wuhrer , Vasilis Kosmoliaptsis , Paul W H I Parren , Arend Mulder , Dave L Roelen , Frans H J Claas , Sebastiaan Heidt

OGT Controls the Expression and the Glycosylation of E-cadherin, and Affects Glycosphingolipid Structures in Human Colon Cell Lines.

Proteomics

Avec: James Biwi , Charlotte Clarisse , Christophe Biot , Radoslaw Pawel Kozak , Katarina Madunic , Marlène Mortuaire , Manfred Wuhrer , Daniel Ian Richard Spencer , Céline Schulz , Yann Guerardel , Tony Lefebvre , Anne-Sophie Vercoutter-Edouart

Monitoring of immunoglobulin N- and O-glycosylation in health and disease.

Glycobiology

Avec: Noortje de Haan , David Falck , Manfred Wuhrer

Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples.

Nature communications

Avec: Guinevere S M Lageveen-Kammeijer , Noortje de Haan , Pablo Mohaupt , Sander Wagt , Mike Filius , Jan Nouta , David Falck , Manfred Wuhrer

Proteoform-Resolved FcɤRIIIa Binding Assay for Fab Glycosylated Monoclonal Antibodies Achieved by Affinity Chromatography Mass Spectrometry of Fc Moieties.

Frontiers in chemistry

Avec: Steffen Lippold , Simone Nicolardi , Manfred Wuhrer , David Falck

Improved and semi-automated reductive β-elimination workflow for higher throughput protein O-glycosylation analysis.

PloS one

Avec: Maximilianos Kotsias , Radoslaw P Kozak , Richard A Gardner , Manfred Wuhrer , Daniel I R Spencer

Oxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific

International journal of molecular sciences

Avec: Martina Pirro , Yassene Mohammed , Arnoud H de Ru , George M C Janssen , Rayman T N Tjokrodirijo , Katarina Madunić , Manfred Wuhrer , Peter A van Veelen , Paul J Hensbergen

Integrated

Cells

Avec: Constantin Blöchl , Di Wang , Katarina Madunić , Guinevere S M Lageveen-Kammeijer , Christian G Huber , Manfred Wuhrer , Tao Zhang

Mass spectrometry in clinical glycomics: The path from biomarker identification to clinical implementation.

Clinical mass spectrometry (Del Mar, Calif.)

Avec: N de Haan , M Wuhrer , L R Ruhaak

Glycoform analysis of intact erythropoietin by MALDI FT-ICR mass spectrometry.

Analytica chimica acta

Avec: Steffen Lippold , Raashina Thavarajah , Dietmar Reusch , Manfred Wuhrer , Simone Nicolardi

Glycation Interferes with the Expression of Sialyltransferases in Meningiomas.

Cells

Avec: Philipp Selke , Kaya Bork , Tao Zhang , Manfred Wuhrer , Christian Strauss , Rüdiger Horstkorte , Maximilian Scheer

Sugar Matters: Improving In Vivo Clearance Rate of Highly Glycosylated Recombinant Plasma Proteins for Therapeutic Use.

Pharmaceuticals (Basel, Switzerland)

Avec: Sacha Zeerleder , Ruchira Engel , Tao Zhang , Dorina Roem , Gerard van Mierlo , Ineke Wagenaar-Bos , Sija Marieke van Ham , Manfred Wuhrer , Diana Wouters , Ilse Jongerius

N-Glycomic Signature of Stage II Colorectal Cancer and Its Association With the Tumor Microenvironment.

Molecular & cellular proteomics : MCP

Avec: Fanny Boyaval , René van Zeijl , Hans Dalebout , Stephanie Holst , Gabi van Pelt , Arantza Fariña-Sarasqueta , Wilma Mesker , Rob Tollenaar , Hans Morreau , Manfred Wuhrer , Bram Heijs

High-throughput glycopeptide profiling of prostate-specific antigen from seminal plasma by MALDI-MS.

Talanta

Avec: Wei Wang , Anna Kałuża , Jan Nouta , Simone Nicolardi , Mirosława Ferens-Sieczkowska , Manfred Wuhrer , Guinevere S M Lageveen-Kammeijer , Noortje de Haan

Definition of IgG Subclass-Specific Glycopatterns in Idiopathic Membranous Nephropathy: Aberrant IgG Glycoforms in Blood.

International journal of molecular sciences

Avec: Clizia Chinello , Noortje de Haan , Giulia Capitoli , Barbara Trezzi , Antonella Radice , Lisa Pagani , Lucrezia Criscuolo , Stefano Signorini , Stefania Galimberti , Renato Alberto Sinico , Manfred Wuhrer , Fulvio Magni

Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation.

Science advances

Avec: Theresa Kissel , Changrong Ge , Lise Hafkenscheid , Joanneke C Kwekkeboom , Linda M Slot , Marco Cavallari , Yibo He , Karin A van Schie , Rochelle D Vergroesen , Arieke S B Kampstra , Sanne Reijm , Gerrie Stoeken-Rijsbergen , Carolien Koeleman , Lennard M Voortman , Laura H Heitman , Bingze Xu , Ger J M Pruijn , Manfred Wuhrer , Theo Rispens , Tom W J Huizinga , Hans Ulrich Scherer , Michael Reth , Rikard Holmdahl , Rene E M Toes

High Diversity of Glycosphingolipid Glycans of Colorectal Cancer Cell Lines Reflects the Cellular Differentiation Phenotype.

Molecular & cellular proteomics : MCP

Avec: Di Wang , Katarina Madunić , Tao Zhang , Oleg A Mayboroda , Guinevere S M Lageveen-Kammeijer , Manfred Wuhrer

High sensitivity glycomics in biomedicine.

Mass spectrometry reviews

Avec: Guinevere S M Lageveen-Kammeijer , Bernhard Kuster , Dietmar Reusch , Manfred Wuhrer

Native Structural and Functional Proteoform Characterization of the Prolyl-Alanyl-Specific Endoprotease EndoPro from

Journal of proteome research

Avec: Guusje van Schaick , Elena Domínguez-Vega , Christoph Gstöttner , Johanna H van den Berg-Verleg , Olaf Schouten , Michiel Akeroyd , Maurien M A Olsthoorn , Manfred Wuhrer , Albert J R Heck , Nicolas Abello , Vojtech Franc

Réseau de co-auteurs

Manfred Wuhrer 91 collaborations

Simone Nicolardi 17 collaborations

Gestur Vidarsson 14 collaborations

Guinevere S M Lageveen-Kammeijer 11 collaborations

Jan Nouta 11 collaborations

David Falck 10 collaborations

Carolien A M Koeleman 9 collaborations

Viktoria Dotz 9 collaborations

Noortje de Haan 9 collaborations

Elena Domínguez-Vega 9 collaborations

Tao Zhang 8 collaborations

Arthur E H Bentlage 7 collaborations

Agnes L Hipgrave Ederveen 6 collaborations

Albert Bondt 6 collaborations

Theresa Kissel 6 collaborations

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Daniel I R Spencer 4 collaborations

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Yassene Mohammed 4 collaborations

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