Martin Pacesa

Affiliations

EPFL.

ORCID: 0000-0003-1560-5769

Publications (11)

PAM-Flexible Genome Editing with an Engineered Chimeric Cas9.

Research square

Avec: Sabrina Koseki , Lauren Hong , Vivian Yudistyra , Teodora Stan , Emma Tysinger , Rachel Silverstein , Christian Kramme , Nadia Amrani , Natasha Savic , Martin Pacesa , Tomás Rodriguez , Manvitha Ponnapati , Joseph Jacobson , George Church , Ray Truant , Martin Jinek , Benjamin Kleinstiver , Erik Sontheimer , Pranam Chatterjee

Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells.

Molecular cell

Avec: Paul D Donohoue , Martin Pacesa , Elaine Lau , Bastien Vidal , Matthew J Irby , David B Nyer , Tomer Rotstein , Lynda Banh , Mckenzi S Toh , Jason Gibson , Bryan Kohrs , Kevin Baek , Arthur L G Owen , Euan M Slorach , Megan van Overbeek , Christopher K Fuller , Andrew P May , Martin Jinek , Peter Cameron

De novo design of protein interactions with learned surface fingerprints.

Nature

Avec: Pablo Gainza , Sarah Wehrle , Alexandra Van Hall-Beauvais , Anthony Marchand , Andreas Scheck , Zander Harteveld , Stephen Buckley , Dongchun Ni , Shuguang Tan , Freyr Sverrisson , Casper Goverde , Priscilla Turelli , Charlène Raclot , Alexandra Teslenko , Martin Pacesa , Stéphane Rosset , Sandrine Georgeon , Jane Marsden , Aaron Petruzzella , Kefang Liu , Zepeng Xu , Yan Chai , Pu Han , George F Gao , Elisa Oricchio , Beat Fierz , Didier Trono , Henning Stahlberg , Michael Bronstein , Bruno E Correia

Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR-Cas9.

Nature catalysis

Avec: Łukasz Nierzwicki , Kyle W East , Jonas M Binz , Rohaine V Hsu , Mohd Ahsan , Pablo R Arantes , Erin Skeens , Martin Pacesa , Martin Jinek , George P Lisi , Giulia Palermo

R-loop formation and conformational activation mechanisms of Cas9.

Nature

Avec: Martin Pacesa , Luuk Loeff , Irma Querques , Lena M Muckenfuss , Marta Sawicka , Martin Jinek

Structural basis for Cas9 off-target activity.

Cell

Avec: Martin Pacesa , Chun-Han Lin , Antoine Cléry , Aakash Saha , Pablo R Arantes , Katja Bargsten , Matthew J Irby , Frédéric H-T Allain , Giulia Palermo , Peter Cameron , Paul D Donohoue , Martin Jinek

PAM-flexible genome editing with an engineered chimeric Cas9.

Nature communications

Avec: Lin Zhao , Sabrina R T Koseki , Rachel A Silverstein , Nadia Amrani , Christina Peng , Christian Kramme , Natasha Savic , Martin Pacesa , Tomás C Rodríguez , Teodora Stan , Emma Tysinger , Lauren Hong , Vivian Yudistyra , Manvitha R Ponnapati , Joseph M Jacobson , George M Church , Noah Jakimo , Ray Truant , Martin Jinek , Benjamin P Kleinstiver , Erik J Sontheimer , Pranam Chatterjee

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.

Nature biotechnology

Avec: Tanja Rothgangl , Melissa K Dennis , Paulo J C Lin , Rurika Oka , Dominik Witzigmann , Lukas Villiger , Weihong Qi , Martina Hruzova , Lucas Kissling , Daniela Lenggenhager , Costanza Borrelli , Sabina Egli , Nina Frey , Noëlle Bakker , John A Walker , Anastasia P Kadina , Denis V Victorov , Martin Pacesa , Susanne Kreutzer , Zacharias Kontarakis , Andreas Moor , Martin Jinek , Drew Weissman , Markus Stoffel , Ruben van Boxtel , Kevin Holden , Norbert Pardi , Beat Thöny , Johannes Häberle , Ying K Tam , Sean C Semple , Gerald Schwank

An atlas of protein homo-oligomerization across domains of life.

Cell

Avec: Hugo Schweke , Martin Pacesa , Tal Levin , Casper A Goverde , Prasun Kumar , Yoan Duhoo , Lars J Dornfeld , Benjamin Dubreuil , Sandrine Georgeon , Sergey Ovchinnikov , Derek N Woolfson , Bruno E Correia , Sucharita Dey , Emmanuel D Levy

Past, present, and future of CRISPR genome editing technologies.

Cell

Avec: Martin Pacesa , Oana Pelea , Martin Jinek

Computational design of soluble and functional membrane protein analogues.

Nature

Avec: Casper A Goverde , Martin Pacesa , Nicolas Goldbach , Lars J Dornfeld , Petra E M Balbi , Sandrine Georgeon , Stéphane Rosset , Srajan Kapoor , Jagrity Choudhury , Justas Dauparas , Christian Schellhaas , Simon Kozlov , David Baker , Sergey Ovchinnikov , Alex J Vecchio , Bruno E Correia

Réseau de co-auteurs

Martin Jinek 8 collaborations

Sandrine Georgeon 3 collaborations

Bruno E Correia 3 collaborations

Lauren Hong 2 collaborations

Vivian Yudistyra 2 collaborations

Teodora Stan 2 collaborations

Emma Tysinger 2 collaborations

Christian Kramme 2 collaborations

Nadia Amrani 2 collaborations

Natasha Savic 2 collaborations

Ray Truant 2 collaborations

Pranam Chatterjee 2 collaborations

Paul D Donohoue 2 collaborations

Matthew J Irby 2 collaborations

Peter Cameron 2 collaborations

Stéphane Rosset 2 collaborations

Pablo R Arantes 2 collaborations

Giulia Palermo 2 collaborations

Casper A Goverde 2 collaborations

Lars J Dornfeld 2 collaborations

Sergey Ovchinnikov 2 collaborations

Sabrina Koseki 1 collaboration

Rachel Silverstein 1 collaboration

Tomás Rodriguez 1 collaboration

Manvitha Ponnapati 1 collaboration

Joseph Jacobson 1 collaboration

George Church 1 collaboration

Benjamin Kleinstiver 1 collaboration

Erik Sontheimer 1 collaboration

Elaine Lau 1 collaboration

Bastien Vidal 1 collaboration

David B Nyer 1 collaboration

Tomer Rotstein 1 collaboration

Lynda Banh 1 collaboration

Mckenzi S Toh 1 collaboration

Jason Gibson 1 collaboration

Bryan Kohrs 1 collaboration

Kevin Baek 1 collaboration

Arthur L G Owen 1 collaboration

Euan M Slorach 1 collaboration

Megan van Overbeek 1 collaboration

Christopher K Fuller 1 collaboration

Andrew P May 1 collaboration

Pablo Gainza 1 collaboration

Sarah Wehrle 1 collaboration

Alexandra Van Hall-Beauvais 1 collaboration

Anthony Marchand 1 collaboration

Andreas Scheck 1 collaboration

Zander Harteveld 1 collaboration

Stephen Buckley 1 collaboration

Dongchun Ni 1 collaboration

Shuguang Tan 1 collaboration

Freyr Sverrisson 1 collaboration

Casper Goverde 1 collaboration

Priscilla Turelli 1 collaboration

Charlène Raclot 1 collaboration

Alexandra Teslenko 1 collaboration

Jane Marsden 1 collaboration

Aaron Petruzzella 1 collaboration

Kefang Liu 1 collaboration

Zepeng Xu 1 collaboration

Yan Chai 1 collaboration

Pu Han 1 collaboration

George F Gao 1 collaboration

Elisa Oricchio 1 collaboration

Beat Fierz 1 collaboration

Didier Trono 1 collaboration

Henning Stahlberg 1 collaboration

Michael Bronstein 1 collaboration

Łukasz Nierzwicki 1 collaboration

Kyle W East 1 collaboration

Jonas M Binz 1 collaboration

Rohaine V Hsu 1 collaboration

Mohd Ahsan 1 collaboration

Erin Skeens 1 collaboration

George P Lisi 1 collaboration

Luuk Loeff 1 collaboration

Irma Querques 1 collaboration

Lena M Muckenfuss 1 collaboration

Marta Sawicka 1 collaboration

Chun-Han Lin 1 collaboration

Antoine Cléry 1 collaboration

Aakash Saha 1 collaboration

Katja Bargsten 1 collaboration

Frédéric H-T Allain 1 collaboration

Lin Zhao 1 collaboration

Sabrina R T Koseki 1 collaboration

Rachel A Silverstein 1 collaboration

Christina Peng 1 collaboration

Tomás C Rodríguez 1 collaboration

Manvitha R Ponnapati 1 collaboration

Joseph M Jacobson 1 collaboration

George M Church 1 collaboration

Noah Jakimo 1 collaboration

Benjamin P Kleinstiver 1 collaboration

Erik J Sontheimer 1 collaboration

Tanja Rothgangl 1 collaboration

Melissa K Dennis 1 collaboration

Paulo J C Lin 1 collaboration

Rurika Oka 1 collaboration

Dominik Witzigmann 1 collaboration

Lukas Villiger 1 collaboration

Weihong Qi 1 collaboration

Martina Hruzova 1 collaboration

Lucas Kissling 1 collaboration

Daniela Lenggenhager 1 collaboration

Costanza Borrelli 1 collaboration

Sabina Egli 1 collaboration

Nina Frey 1 collaboration

Noëlle Bakker 1 collaboration

John A Walker 1 collaboration

Anastasia P Kadina 1 collaboration

Denis V Victorov 1 collaboration

Susanne Kreutzer 1 collaboration

Zacharias Kontarakis 1 collaboration

Andreas Moor 1 collaboration

Drew Weissman 1 collaboration

Markus Stoffel 1 collaboration

Ruben van Boxtel 1 collaboration

Kevin Holden 1 collaboration

Norbert Pardi 1 collaboration

Beat Thöny 1 collaboration

Johannes Häberle 1 collaboration

Ying K Tam 1 collaboration

Sean C Semple 1 collaboration

Gerald Schwank 1 collaboration

Hugo Schweke 1 collaboration

Tal Levin 1 collaboration

Prasun Kumar 1 collaboration

Yoan Duhoo 1 collaboration

Benjamin Dubreuil 1 collaboration

Derek N Woolfson 1 collaboration

Sucharita Dey 1 collaboration

Emmanuel D Levy 1 collaboration

Oana Pelea 1 collaboration

Nicolas Goldbach 1 collaboration

Petra E M Balbi 1 collaboration

Srajan Kapoor 1 collaboration

Jagrity Choudhury 1 collaboration

Justas Dauparas 1 collaboration

Christian Schellhaas 1 collaboration

Simon Kozlov 1 collaboration

David Baker 1 collaboration

Alex J Vecchio 1 collaboration