S Spisak

Affiliations

Molecular Medicine Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary.

Publications (28)

A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures.

NPJ precision oncology

Avec: Miklos Diossy , Zsofia Sztupinszki , Judit Borcsok , Marcin Krzystanek , Viktoria Tisza , Sandor Spisak , Orsolya Rusz , Jozsef Timar , István Csabai , Janos Fillinger , Judit Moldvay , Anders Gorm Pedersen , David Szuts , Zoltan Szallasi

A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer.

Cancer research

Avec: Agostina Nardone , Xintao Qiu , Sandor Spisak , Zsuzsanna Nagy , Ariel Feiglin , Avery Feit , Gabriela Cohen Feit , Yingtian Xie , Alba Font-Tello , Cristina Guarducci , Francisco Hermida-Prado , Sudeepa Syamala , Klothilda Lim , Miguel Munoz Gomez , Matthew Pun , MacIntosh Cornwell , Weihan Liu , Aysegul Ors , Hisham Mohammed , Paloma Cejas , Jane B Brock , Matthew L Freedman , Eric P Winer , Xiaoyong Fu , Rachel Schiff , Henry W Long , Otto Metzger Filho , Rinath Jeselsohn

Circulating Cell-Free DNA in Renal Cell Carcinoma: The New Era of Precision Medicine.

Cancers

Avec: Edoardo Francini , Giuseppe Nicolò Fanelli , Filippo Pederzoli , Sandor Spisak , Erika Minonne , Massimiliano Raffo , Hubert Pakula , Viktoria Tisza , Cristian Scatena , Antonio Giuseppe Naccarato , Massimo Loda , Pier Vitale Nuzzo

Replicative stress in gastroesophageal cancer is associated with chromosomal instability and sensitivity to DNA damage response inhibitors.

iScience

Avec: Pranshu Sahgal , Deepa T Patil , Pratyusha Bala , Zsofia M Sztupinszki , Viktoria Tisza , Sandor Spisak , Anna G Luong , Brandon Huffman , Aurel Prosz , Harshabad Singh , Jean-Bernard Lazaro , Zoltan Szallasi , James M Cleary , Nilay S Sethi

Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression.

NPJ precision oncology

Avec: Miklos Diossy , Viktoria Tisza , Hua Li , Pranshu Sahgal , Jia Zhou , Zsofia Sztupinszki , Denise Young , Darryl Nousome , Claire Kuo , Jiji Jiang , Yongmei Chen , Reinhard Ebner , Isabell A Sesterhenn , Joel T Moncur , Gregory T Chesnut , Gyorgy Petrovics , Gregory T Klus , Gabor Valcz , Pier Vitale Nuzzo , Dezso Ribli , Judit Börcsök , Aurel Prosz , Marcin Krzystanek , Thomas Ried , David Szuts , Kinza Rizwan , Salma Kaochar , Shailja Pathania , Alan D D'Andrea , Istvan Csabai , Shiv Srivastava , Matthew L Freedman , Albert Dobi , Sandor Spisak , Zoltan Szallasi

Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors.

bioRxiv : the preprint server for biology

Avec: Pranshu Sahgal , Deepa T Patil , Zsofia M Sztupinszki , Viktoria Tisza , Sandor Spisak , Brandon Huffman , Aurel Prosz , Harshabad Singh , Jean-Bernard Lazaro , Zoltan Szallasi , James M Cleary , Nilay S Sethi

An Enhancer-Driven Stem Cell-Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer.

Gastroenterology

Avec: Xiaoyan Liang , Gina N Duronio , Yaying Yang , Pratyusha Bala , Prajna Hebbar , Sandor Spisak , Pranshu Sahgal , Harshabad Singh , Yanxi Zhang , Yingtian Xie , Paloma Cejas , Henry W Long , Adam J Bass , Nilay S Sethi

HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer.

Nature genetics

Avec: Xiaodong Lu , Ka-Wing Fong , Galina Gritsina , Fang Wang , Sylvan C Baca , Lourdes T Brea , Jacob E Berchuck , Sandor Spisak , Jenny Ross , Colm Morrissey , Eva Corey , Navdeep S Chandel , William J Catalona , Ximing Yang , Matthew L Freedman , Jonathan C Zhao , Jindan Yu

Epigenomic charting and functional annotation of risk loci in renal cell carcinoma.

Nature communications

Avec: Amin H Nassar , Sarah Abou Alaiwi , Sylvan C Baca , Elio Adib , Rosario I Corona , Ji-Heui Seo , Marcos A S Fonseca , Sandor Spisak , Talal El Zarif , Viktoria Tisza , David A Braun , Heng Du , Monica He , Abdallah Flaifel , Michel Alchoueiry , Thomas Denize , Sayed G Matar , Andres Acosta , Sachet Shukla , Yue Hou , John Steinharter , Gabrielle Bouchard , Jacob E Berchuck , Edward O'Connor , Connor Bell , Pier Vitale Nuzzo , Gwo-Shu Mary Lee , Sabina Signoretti , Michelle S Hirsch , Mark Pomerantz , Elizabeth Henske , Alexander Gusev , Kate Lawrenson , Toni K Choueiri , David J Kwiatkowski , Matthew L Freedman

A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus.

Nature communications

Avec: Sandor Spisak , Viktoria Tisza , Pier Vitale Nuzzo , Ji-Heui Seo , Balint Pataki , Dezso Ribli , Zsofia Sztupinszki , Connor Bell , Mersedeh Rohanizadegan , David R Stillman , Sarah Abou Alaiwi , Alan H Bartels , Marton Papp , Anamay Shetty , Forough Abbasi , Xianzhi Lin , Kate Lawrenson , Simon A Gayther , Mark Pomerantz , Sylvan Baca , Norbert Solymosi , Istvan Csabai , Zoltan Szallasi , Alexander Gusev , Matthew L Freedman

Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system.

Nature communications

Avec: Sandor Spisak , David Chen , Pornlada Likasitwatanakul , Paul Doan , Zhixin Li , Pratyusha Bala , Laura Vizkeleti , Viktoria Tisza , Pushpamali De Silva , Marios Giannakis , Brian Wolpin , Jun Qi , Nilay S Sethi

Detection of Molecular Signatures of Homologous Recombination Deficiency in Prostate Cancer with or without BRCA1/2 Mutations.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Zsofia Sztupinszki , Miklos Diossy , Marcin Krzystanek , Judit Borcsok , Mark M Pomerantz , Viktoria Tisza , Sandor Spisak , Orsolya Rusz , István Csabai , Matthew L Freedman , Zoltan Szallasi

Detection of Molecular Signatures of Homologous Recombination Deficiency in Bladder Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Judit Börcsök , Miklos Diossy , Zsofia Sztupinszki , Aurel Prosz , Viktoria Tisza , Sandor Spisak , Orsolya Rusz , Dag R Stormoen , Helle Pappot , Istvan Csabai , Søren Brunak , Kent W Mouw , Zoltan Szallasi

Androgen receptor and MYC equilibration centralizes on developmental super-enhancer.

Nature communications

Avec: Haiyang Guo , Yiming Wu , Mannan Nouri , Sandor Spisak , Joshua W Russo , Adam G Sowalsky , Mark M Pomerantz , Zhao Wei , Keegan Korthauer , Ji-Heui Seo , Liyang Wang , Seiji Arai , Matthew L Freedman , Housheng Hansen He , Shaoyong Chen , Steven P Balk

Detecting Neuroendocrine Prostate Cancer Through Tissue-Informed Cell-Free DNA Methylation Analysis.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Jacob E Berchuck , Sylvan C Baca , Heather M McClure , Keegan Korthauer , Harrison K Tsai , Pier Vitale Nuzzo , Kaitlin M Kelleher , Monica He , John A Steinharter , Soumya Zacharia , Sandor Spisak , Ji-Heui Seo , Vincenza Conteduca , Olivier Elemento , Joonghoon Auh , Michael Sigouros , Eva Corey , Michelle S Hirsch , Mary-Ellen Taplin , Toni K Choueiri , Mark M Pomerantz , Himisha Beltran , Matthew L Freedman

The minimal structure for iodotyrosine deiodinase function is defined by an outlier protein from the thermophilic bacterium Thermotoga neapolitana.

The Journal of biological chemistry

Avec: Zuodong Sun , Bing Xu , Shaun Spisak , Jennifer M Kavran , Steven E Rokita

A bacterial dual positive and negative selection system for dCas9 activity.

PloS one

Avec: Shaun Spisak , Brett O'Brien , Marc Ostermeier

Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma.

bioRxiv : the preprint server for biology

Avec: Aurel Prosz , Haohui Duan , Viktoria Tisza , Pranshu Sahgal , Sabine Topka , Gregory T Klus , Judit Börcsök , Zsofia Sztupinszki , Timothy Hanlon , Miklos Diossy , Laura Vizkeleti , Dag Rune Stormoen , Istvan Csabai , Helle Pappot , Joseph Vijai , Kenneth Offit , Thomas Ried , Nilay Sethi , Kent W Mouw , Sandor Spisak , Shailja Pathania , Zoltan Szallasi

Biologically informed deep learning for explainable epigenetic clocks.

Scientific reports

Avec: Aurel Prosz , Orsolya Pipek , Judit Börcsök , Gergely Palla , Zoltan Szallasi , Sandor Spisak , István Csabai

Utilizing a dual endogenous reporter system to identify functional regulators of aberrant stem cell and differentiation activity in colorectal cancer.

bioRxiv : the preprint server for biology

Avec: Sandor Spisak , David Chen , Pornlada Likasitwatanakul , Paul Doan , Zhixin Li , Pratyusha Bala , Laura Vizkeleti , Viktoria Tisza , Pushpamail De Silva , Marios Giannakis , Brian Wolpin , Jun Qi , Nilay S Sethi

Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes.

Nature medicine

Avec: Pier Vitale Nuzzo , Jacob E Berchuck , Keegan Korthauer , Sandor Spisak , Amin H Nassar , Sarah Abou Alaiwi , Ankur Chakravarthy , Shu Yi Shen , Ziad Bakouny , Francesco Boccardo , John Steinharter , Gabrielle Bouchard , Catherine R Curran , Wenting Pan , Sylvan C Baca , Ji-Heui Seo , Gwo-Shu Mary Lee , M Dror Michaelson , Steven L Chang , Sushrut S Waikar , Guru Sonpavde , Rafael A Irizarry , Mark Pomerantz , Daniel D De Carvalho , Toni K Choueiri , Matthew L Freedman

Limitations of high throughput methods for miRNA expression profiles in non-functioning pituitary adenomas.

Pathology oncology research : POR

Avec: O Darvasi , P M Szabo , K Nemeth , K Szabo , S Spisak , I Liko , S Czirjak , K Racz , P Igaz , A Patocs , Henriett Butz

Author Correction: Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes.

Nature medicine

Engineered protein switches for exogenous control of gene expression.

Biochemical Society transactions

Avec: Shaun Spisak , Marc Ostermeier

H3K27ac HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility.

American journal of human genetics

Avec: Claudia Giambartolomei , Ji-Heui Seo , Tommer Schwarz , Malika Kumar Freund , Ruth Dolly Johnson , Sandor Spisak , Sylvan C Baca , Alexander Gusev , Nicholas Mancuso , Bogdan Pasaniuc , Matthew L Freedman

Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting.

NPJ precision oncology

Avec: Aurel Prosz , Pranshu Sahgal , Brandon M Huffman , Zsofia Sztupinszki , Clare X Morris , David Chen , Judit Börcsök , Miklos Diossy , Viktoria Tisza , Sandor Spisak , Pornlada Likasitwatanakul , Orsolya Rusz , Istvan Csabai , Michael Cecchini , Yasmine Baca , Andrew Elliot , Peter Enzinger , Harshabad Singh , Jessalyn Ubellaker , Jean-Bernard Lazaro , James M Cleary , Zoltan Szallasi , Nilay S Sethi

Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency.

Research square

Avec: Zoltan Szallasi , Miklos Diossy , Viktoria Tisza , Hua Li , Pranshu Sahgal , Jia Zhou , Zsofia Sztupinszki , Denise Young , Darryl Nuosome , Claire Kuo , Jiji Jiang , Yongmei Chen , Reinhard Ebner , Isabell Sesterhenn , Joel Moncur , Gregory Chesnut , Gyorgy Petrovics , Gregory T Klus , Gábor Valcz , Pier Nuzzo , Dezso Ribli , Judit Börcsök , Aurél Prósz , Marcin Krzystanek , Thomas Ried , Dávid Szüts , Kinza Rizwan , Salma Kaochar , Shailja Pathania , Alan D'Andrea , István Csabai , Shib Srivast , Matthew Freedman , Albert Dobi , Sandor Spisak

Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma.

Scientific reports

Réseau de co-auteurs

Sandor Spisak 24 collaborations

Viktoria Tisza 15 collaborations

Zoltan Szallasi 12 collaborations

Matthew L Freedman 11 collaborations

Zsofia Sztupinszki 9 collaborations

Miklos Diossy 8 collaborations

Pranshu Sahgal 8 collaborations

Aurel Prosz 8 collaborations

Pier Vitale Nuzzo 7 collaborations

Judit Börcsök 7 collaborations

Ji-Heui Seo 7 collaborations

Nilay S Sethi 6 collaborations

Istvan Csabai 6 collaborations

Sylvan C Baca 6 collaborations

Jacob E Berchuck 5 collaborations

Marcin Krzystanek 4 collaborations

Orsolya Rusz 4 collaborations

István Csabai 4 collaborations

Pratyusha Bala 4 collaborations

Harshabad Singh 4 collaborations

Gregory T Klus 4 collaborations

Thomas Ried 4 collaborations

Shailja Pathania 4 collaborations

Sarah Abou Alaiwi 4 collaborations

Mark Pomerantz 4 collaborations

Toni K Choueiri 4 collaborations

Laura Vizkeleti 4 collaborations

Keegan Korthauer 4 collaborations

Jean-Bernard Lazaro 3 collaborations

James M Cleary 3 collaborations

Dezso Ribli 3 collaborations

Amin H Nassar 3 collaborations

John Steinharter 3 collaborations

Gabrielle Bouchard 3 collaborations

Gwo-Shu Mary Lee 3 collaborations

Alexander Gusev 3 collaborations

David Chen 3 collaborations

Pornlada Likasitwatanakul 3 collaborations

Mark M Pomerantz 3 collaborations

Helle Pappot 3 collaborations

Kent W Mouw 3 collaborations

Shaun Spisak 3 collaborations

Judit Borcsok 2 collaborations

David Szuts 2 collaborations

Yingtian Xie 2 collaborations

Paloma Cejas 2 collaborations

Henry W Long 2 collaborations

Deepa T Patil 2 collaborations

Zsofia M Sztupinszki 2 collaborations

Brandon Huffman 2 collaborations

Hua Li 2 collaborations

Jia Zhou 2 collaborations

Denise Young 2 collaborations

Claire Kuo 2 collaborations

Jiji Jiang 2 collaborations

Yongmei Chen 2 collaborations

Reinhard Ebner 2 collaborations

Gyorgy Petrovics 2 collaborations

Kinza Rizwan 2 collaborations

Salma Kaochar 2 collaborations

Albert Dobi 2 collaborations

Eva Corey 2 collaborations

Monica He 2 collaborations

Connor Bell 2 collaborations

Michelle S Hirsch 2 collaborations

Kate Lawrenson 2 collaborations

Paul Doan 2 collaborations

Zhixin Li 2 collaborations

Marios Giannakis 2 collaborations

Brian Wolpin 2 collaborations

Jun Qi 2 collaborations

Marc Ostermeier 2 collaborations

Haohui Duan 2 collaborations

Sabine Topka 2 collaborations

Timothy Hanlon 2 collaborations

Dag Rune Stormoen 2 collaborations

Joseph Vijai 2 collaborations

Kenneth Offit 2 collaborations

Nilay Sethi 2 collaborations

Ankur Chakravarthy 2 collaborations

Shu Yi Shen 2 collaborations

Ziad Bakouny 2 collaborations

Francesco Boccardo 2 collaborations

Catherine R Curran 2 collaborations

Wenting Pan 2 collaborations

M Dror Michaelson 2 collaborations

Steven L Chang 2 collaborations

Sushrut S Waikar 2 collaborations

Guru Sonpavde 2 collaborations

Rafael A Irizarry 2 collaborations

Daniel D De Carvalho 2 collaborations

Jozsef Timar 1 collaboration

Janos Fillinger 1 collaboration

Judit Moldvay 1 collaboration

Anders Gorm Pedersen 1 collaboration

Agostina Nardone 1 collaboration

Xintao Qiu 1 collaboration

Zsuzsanna Nagy 1 collaboration

Ariel Feiglin 1 collaboration

Avery Feit 1 collaboration

Gabriela Cohen Feit 1 collaboration

Alba Font-Tello 1 collaboration

Cristina Guarducci 1 collaboration

Francisco Hermida-Prado 1 collaboration

Sudeepa Syamala 1 collaboration

Klothilda Lim 1 collaboration

Miguel Munoz Gomez 1 collaboration

Matthew Pun 1 collaboration

MacIntosh Cornwell 1 collaboration

Weihan Liu 1 collaboration

Aysegul Ors 1 collaboration

Hisham Mohammed 1 collaboration

Jane B Brock 1 collaboration

Eric P Winer 1 collaboration

Xiaoyong Fu 1 collaboration

Rachel Schiff 1 collaboration

Otto Metzger Filho 1 collaboration

Rinath Jeselsohn 1 collaboration

Edoardo Francini 1 collaboration

Giuseppe Nicolò Fanelli 1 collaboration

Filippo Pederzoli 1 collaboration

Erika Minonne 1 collaboration

Massimiliano Raffo 1 collaboration

Hubert Pakula 1 collaboration

Cristian Scatena 1 collaboration

Antonio Giuseppe Naccarato 1 collaboration

Massimo Loda 1 collaboration

Anna G Luong 1 collaboration

Darryl Nousome 1 collaboration

Isabell A Sesterhenn 1 collaboration

Joel T Moncur 1 collaboration

Gregory T Chesnut 1 collaboration

Gabor Valcz 1 collaboration

Alan D D'Andrea 1 collaboration

Shiv Srivastava 1 collaboration

Xiaoyan Liang 1 collaboration

Gina N Duronio 1 collaboration

Yaying Yang 1 collaboration

Prajna Hebbar 1 collaboration

Yanxi Zhang 1 collaboration

Adam J Bass 1 collaboration

Xiaodong Lu 1 collaboration

Ka-Wing Fong 1 collaboration

Galina Gritsina 1 collaboration

Fang Wang 1 collaboration

Lourdes T Brea 1 collaboration

Jenny Ross 1 collaboration

Colm Morrissey 1 collaboration

Navdeep S Chandel 1 collaboration

William J Catalona 1 collaboration

Ximing Yang 1 collaboration

Jonathan C Zhao 1 collaboration

Jindan Yu 1 collaboration

Elio Adib 1 collaboration

Rosario I Corona 1 collaboration

Marcos A S Fonseca 1 collaboration

Talal El Zarif 1 collaboration

David A Braun 1 collaboration

Heng Du 1 collaboration

Abdallah Flaifel 1 collaboration

Michel Alchoueiry 1 collaboration

Thomas Denize 1 collaboration

Sayed G Matar 1 collaboration

Andres Acosta 1 collaboration

Sachet Shukla 1 collaboration

Yue Hou 1 collaboration

Edward O'Connor 1 collaboration

Sabina Signoretti 1 collaboration

Elizabeth Henske 1 collaboration

David J Kwiatkowski 1 collaboration

Balint Pataki 1 collaboration

Mersedeh Rohanizadegan 1 collaboration

David R Stillman 1 collaboration

Alan H Bartels 1 collaboration

Marton Papp 1 collaboration

Anamay Shetty 1 collaboration

Forough Abbasi 1 collaboration

Xianzhi Lin 1 collaboration

Simon A Gayther 1 collaboration

Sylvan Baca 1 collaboration

Norbert Solymosi 1 collaboration

Pushpamali De Silva 1 collaboration

Dag R Stormoen 1 collaboration

Søren Brunak 1 collaboration

Haiyang Guo 1 collaboration

Yiming Wu 1 collaboration

Mannan Nouri 1 collaboration

Joshua W Russo 1 collaboration

Adam G Sowalsky 1 collaboration

Zhao Wei 1 collaboration

Liyang Wang 1 collaboration

Seiji Arai 1 collaboration

Housheng Hansen He 1 collaboration

Shaoyong Chen 1 collaboration

Steven P Balk 1 collaboration

Heather M McClure 1 collaboration

Harrison K Tsai 1 collaboration

Kaitlin M Kelleher 1 collaboration

John A Steinharter 1 collaboration

Soumya Zacharia 1 collaboration

Vincenza Conteduca 1 collaboration

Olivier Elemento 1 collaboration

Joonghoon Auh 1 collaboration

Michael Sigouros 1 collaboration

Mary-Ellen Taplin 1 collaboration

Himisha Beltran 1 collaboration

Zuodong Sun 1 collaboration

Bing Xu 1 collaboration

Jennifer M Kavran 1 collaboration

Steven E Rokita 1 collaboration

Brett O'Brien 1 collaboration

Orsolya Pipek 1 collaboration

Gergely Palla 1 collaboration

Pushpamail De Silva 1 collaboration

O Darvasi 1 collaboration

P M Szabo 1 collaboration

K Nemeth 1 collaboration

K Szabo 1 collaboration

I Liko 1 collaboration

S Czirjak 1 collaboration

K Racz 1 collaboration

P Igaz 1 collaboration

A Patocs 1 collaboration

Henriett Butz 1 collaboration

Claudia Giambartolomei 1 collaboration

Tommer Schwarz 1 collaboration

Malika Kumar Freund 1 collaboration

Ruth Dolly Johnson 1 collaboration

Nicholas Mancuso 1 collaboration

Bogdan Pasaniuc 1 collaboration

Brandon M Huffman 1 collaboration

Clare X Morris 1 collaboration

Michael Cecchini 1 collaboration

Yasmine Baca 1 collaboration

Andrew Elliot 1 collaboration

Peter Enzinger 1 collaboration

Jessalyn Ubellaker 1 collaboration

Darryl Nuosome 1 collaboration

Isabell Sesterhenn 1 collaboration

Joel Moncur 1 collaboration

Gregory Chesnut 1 collaboration

Gábor Valcz 1 collaboration

Pier Nuzzo 1 collaboration

Aurél Prósz 1 collaboration

Dávid Szüts 1 collaboration

Alan D'Andrea 1 collaboration

Shib Srivast 1 collaboration

Matthew Freedman 1 collaboration