questionsmedicales.fr
Technologie, industrie et agriculture
Industrie
Secteur secondaire
Industrie pharmaceutique
Industrie pharmaceutique : Questions médicales fréquentes
Termes MeSH sélectionnés :
17-alpha-Hydroxyprogesterone
Diagnostic
5
Essais cliniques
Efficacité des médicaments
Essais cliniques
Phase III
Critères d'inclusion
Essais cliniques
Effets secondaires
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Symptômes
5
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Effets indésirables
Allergie médicamenteuse
Réactions allergiques
Overdose
Intoxication médicamenteuse
Interaction médicamenteuse
Effets indésirables
Effets secondaires
Pharmacovigilance
Prévention
5
Effets indésirables
Pharmacovigilance
Prescription médicale
Pratiques cliniques
Sensibilisation
Éducation à la santé
Interactions médicamenteuses
Conseils médicaux
Polymédication
Gestion des médicaments
Traitements
5
Développement de médicaments
Essais cliniques
Médicaments génériques
Pharmacie
Thérapie ciblée
Oncologie
Médicaments orphelins
Maladies rares
Mise sur le marché
Réglementation des médicaments
Complications
5
Complications médicamenteuses
Effets indésirables
Réaction allergique
Urgences médicales
Surdosage
Intoxication médicamenteuse
Médicaments anticancéreux
Effets indésirables
Facteurs de risque
5
Facteurs de risque
Effets indésirables
Alcool
Interactions médicamenteuses
Médicaments à risque
Personnes âgées
Maladies chroniques
Pharmacologie
Automédication
Risques médicaux
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 07/04/2025
Contenu vérifié selon les dernières recommandations médicales
6 publications dans cette catégorie
Affiliations :
KRISP, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.
6 publications dans cette catégorie
Affiliations :
School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, South Africa.
CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain.
3 publications dans cette catégorie
Affiliations :
Small Molecules Pharmaceutical Development, Drug Product Development, Biopharmaceutics, Janssen Research and Development, Beerse, Belgium.
Publications dans "Industrie pharmaceutique" :
3 publications dans cette catégorie
Affiliations :
Department of PK Sciences, PBPK and Biopharmaceutics Section, Novartis Institutes for BioMedical Research, East Hanover, New Jersey 07936.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
School of Health Policy and Management, York University, Toronto, ON, Canada.
Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
School of Journalism and Communication, Carleton University, Ottawa, ON, Canada.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
School of Public Policy & Administration, Carleton University, Ottawa, ON, Canada.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
School of Public Policy & Administration, Carleton University, Ottawa, ON, Canada.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
Pharmaceutical Sciences, Pharmaceutical Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
Medicinal Science and Technology, GlaxoSmithKline R&D, Ware, Hertfordshire, UK.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
Pharmaceutical Sciences, Merck & Co., Inc., Kenilworth, New Jersey 07033. Electronic address: filippos_kesisoglou@merck.com.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
Pfizer, Inc, BioTherapeutics PharmSci, 1 Burtt Road, Andover MA 01810, USA.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
Genentech (A Member of the Roche Group), Pharmaceutical Development, 1 DNA Way, South San Francisco, CA 94080, USA.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
Pfizer PGRD, Sandwich CT13 9NJ, UK.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
AstraZeneca UK Limited, Macclesfield SK10 2NA, UK.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
School of Pharmacy and Biomedical Sciences, University of Portsmouth, St. Michael's Building, White Swan Road, Portsmouth PO1 2DT, UK.
Publications dans "Industrie pharmaceutique" :
2 publications dans cette catégorie
Affiliations :
Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California, USA.
Publications dans "Industrie pharmaceutique" :
1 publication dans cette catégorie
Affiliations :
Boehringer Ingelheim Vetmedica GmbH, Ingelheim am Rhein, Germany.
Publications dans "Industrie pharmaceutique" :
1 publication dans cette catégorie
Affiliations :
Department of Poultry Science, University of Arkansas, Fayetteville, AR, USA.
Publications dans "Industrie pharmaceutique" :
1 publication dans cette catégorie
Affiliations :
Boehringer Ingelheim Vetmedica GmbH, Ingelheim am Rhein, Germany. paul.selzer@boehringer-ingelheim.com.
Publications dans "Industrie pharmaceutique" :
Disorders of sex development (DSD) have complex pathogenesis, and evidence suggests an association between MAMLD1 defects and DSD. MAMLD1 is expressed in gonadal tissues and affected males exhibit hyp...
Genetic testing of the proband and parents was conducted using whole-exome and Sanger sequencing. The identified variant was transfected into HEK293T cells to assess mutant protein expression using we...
A novel heterozygous variant was identified in the proband's MAMLD1, NM_005491.5: c.1619_1637del (p.Gln540Alafs*72), inherited from the mother. In transfected cells, the wild-type and mutant proteins ...
Severe hypospadias in the proband may be attributed to a novel MAMLD1 variant, whereas the 17α-OH elevation might be related to interference with CYP17A1 transcriptional activation. This study expands...
To describe regional differences in utilization of 17α-hydroxyprogesterone caproate (17-OHP)....
Retrospective cohort study of a large, US commercial managed care plan claims database with pharmacy coverage from 2008 to 2018. Singleton pregnancies with at least one prior spontaneous preterm birth...
Of the 4,514 individuals with an indication for 17-OHP, 580 (12.8%) were prescribed 17-OHP. Regional and state-based differences in 17-OHP utilization were identified; Northeast 15.7%, Midwest 13.7%, ...
While significant regional differences in 17-OHP utilization were demonstrated, 17-OHP utilization remained low despite this cohort having insurance through a US commercial managed care plan. Suboptim...
We present an intriguing case of primary adrenal lymphoma, with associated primary adrenal insufficiency (PAI), in a patient presenting a transitory partial 21-hydroxylase deficiency during the active...
An 85-years old woman was referred because of worsening asthenia, lumbar pain, generalized myalgia and arthralgia. During investigations a computed tomography (CT) scan evidenced two large bilateral a...
In the presence of bilateral adrenal disease and/or in the presence of signs and symptoms of PAI clinicians must exclude the presence of PAL. The evidence of elevated ACTH-stimulated 17-OHP levels als...
The effectiveness of 17-hydroxyprogesterone caproate is unclear as trials have provided conflicting results. With the absence of fundamental pharmacologic studies addressing dosing or the relationship...
This study aimed to evaluate the relationship between plasma concentrations of 17-hydroxyprogesterone caproate and preterm birth rates and gestational age at preterm delivery and to assess the safety ...
This study recruited 2 cohorts with previous spontaneous preterm birth; 1 cohort (n=143) was randomly assigned to either 250-mg or 500-mg 17-hydroxyprogesterone caproate, and the other cohort (n=16) w...
There was a dose proportional increase in trough plasma concentrations with the 250-mg (median, 8.6 ng/m; n=66) and 500-mg (median, 16.2 ng/mL; n=55) doses. In 116 compliant participants with blood sa...
In this pharmacodynamic study, trough plasma 17-hydroxyprogesterone caproate concentrations were significantly associated with gestational age at preterm birth but not with the preterm birth rate. Pos...
A history of spontaneous preterm birth (sPTB) is a significant risk factor for recurrence. Intra-muscular-7α-hydroxyprogesterone caproate (17P) has been the preventive treatment of choice until the re...
To determine the benefit of (17P) treatment in preventing reoccurrence of sPTB, by evaluating two presenting symptoms of the first sPTB: premature contractions (PMC) and preterm premature rupture of m...
This retrospective study included 342 women with a previous singleton sPTB followed by a subsequent pregnancy. sPTB were either due to PMC (n = 145) or pPROM (n = 197). During the subsequent pregnancy...
Patients treated with 17P in the subsequent pregnancy had delivered earlier in the previous pregnancy (33.4w vs. 35.3w in the PMC group, and 34.1w vs. 35.7w in the pPROM group, p<0.001). In the follow...
17P might delay preterm delivery in patients with a previous sPTB on an individual level (prolongation of the pregnancy for each patient compared to her previous delivery). Therefore, our results impl...
The US preterm birth rate varies dramatically by race and ethnicity yet the racial and ethnic representation within studies evaluating 17-hydroxprogesterone caproate (17-P) for preterm birth preventio...
We systematically reviewed US studies published between January 2000 and December 2019. Study participant's race and ethnicity were reported using descriptive statistics then compared to US 2017//2018...
Eighteen studies met the inclusion criteria, 17 studies reported race, 11 studies reported ethnicity, and yet none of the studies followed the NIH criteria. Compared to 2017/2018 US preterm births, th...
More detailed reporting of race and ethnicity is needed in 17-P literature. Black women appear to be well represented while other racial and ethnic groups may be understudied....
The IPOP trial demonstrated a reduced risk of severe small for gestational age among infants born to women with HIV who received weekly intramuscular 17 alpha-hydroxyprogesterone caproate. This second...
Children with classical congenital adrenal hyperplasia (CAH) have an impaired steroid synthesis due to 21-hydroxylase dysfunction and require glucocorticoid replacement. Therapy management in children...
In this retrospective and longitudinal study of 22 patients with CAH, we analyzed 546 saliva samples for 17-hydroxyprogesterone (s17-OHP) in prepubertal/pubertal patients. Additionally, we correlated ...
We analyzed a median observation period of 5.5 years per patient. No precocious pubertal development, abnormal vital signs, or Addison crises occurred. 57.1% of the samples were collected in prepubert...
The measurement of s17-OHP is an important sub-aspect in the overall assessment of treatment response in CAH. It can provide an indication of over-/undertreatment and allows the assessment of day prof...
Newborn screening for congenital adrenal hyperplasia (CAH) has benefits with a high adoption rate worldwide. It also has problems of high false positives, which can cause stress to the patient's famil...
Newborns (n=1,071) born between October 2020 and January 2022 were screened for CAH. Samples from neonates were collected on filter paper with the heel prick method. 17-OHP concentration was measured ...
The median age of newborns at neonatal sample collection was 6 days. 17-OHP concentration showed a statistically significant negative correlation with BW (...
This study presents new 17-OHP cutoff values for preterm, LBW, and sick newborns. These data in our laboratory can be used as a reference by other laboratories for establishing new cutoff criteria to ...
Quantifying small amounts of the 17-hydroxyprogesterone in various matrix is crucial for different purposes. In this study, a commercial polydimethylsiloxane stir bar was used to extract hormone from ...