questionsmedicales.fr
Facteurs biologiques
Toxines biologiques
Toxines bactériennes
Endotoxines
Endotoxines : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Tests de laboratoire
Endotoxines
Culture bactérienne
Endotoxines
Symptômes
5
Système immunitaire
Choc septique
Choc septique
Hypotension
Prévention
5
Sécurité en laboratoire
Équipements de protection
Infections nosocomiales
Hygiène hospitalière
Traitements
5
Antibiotiques
Soins de soutien
Corticostéroïdes
Inflammation
Choc septique
Vasopresseurs
Antidotes
Traitement symptomatique
Prise en charge précoce
Complications
Complications
5
Choc septique
Insuffisance organique
Défaillance organique
Inflammation
Syndrome de détresse respiratoire
Inflammation pulmonaire
Dommages neurologiques
Inflammation systémique
Facteurs de risque
5
Facteurs de risque
Immunodépression
Infections bactériennes
Gram-négatif
Interventions chirurgicales
Infections
Diabète
Système immunitaire
Conditions de vie
Bactéries
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"name": "Comment diagnostiquer une intoxication par endotoxines ?",
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"text": "Le diagnostic repose sur des tests sanguins, cultures et évaluation clinique."
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{
"@type": "Question",
"name": "Quels tests sont utilisés pour détecter les endotoxines ?",
"position": 2,
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"@type": "Question",
"name": "Quels signes cliniques indiquent une exposition aux endotoxines ?",
"position": 3,
"acceptedAnswer": {
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"@type": "Question",
"name": "Quel rôle joue la culture bactérienne dans le diagnostic ?",
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"@type": "Question",
"name": "Quels sont les symptômes d'une intoxication par endotoxines ?",
"position": 6,
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"@type": "Question",
"name": "Comment les endotoxines affectent-elles le système immunitaire ?",
"position": 7,
"acceptedAnswer": {
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"text": "Elles provoquent une réponse inflammatoire excessive, pouvant mener à un choc."
}
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"@type": "Question",
"name": "Les endotoxines causent-elles des douleurs ?",
"position": 8,
"acceptedAnswer": {
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"text": "Oui, elles peuvent provoquer des douleurs abdominales et musculaires."
}
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{
"@type": "Question",
"name": "Quels signes indiquent un choc septique dû aux endotoxines ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Hypotension, tachycardie, confusion et peau froide sont des signes clés."
}
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{
"@type": "Question",
"name": "Les symptômes varient-ils selon l'exposition ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'intensité des symptômes dépend de la dose et de la durée d'exposition."
}
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{
"@type": "Question",
"name": "Comment prévenir l'exposition aux endotoxines ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les environnements contaminés et respecter les protocoles d'hygiène."
}
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{
"@type": "Question",
"name": "Les vaccins peuvent-ils prévenir les infections à endotoxines ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de vaccin spécifique contre les endotoxines, mais contre certaines bactéries."
}
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{
"@type": "Question",
"name": "Quelles mesures de sécurité en laboratoire sont nécessaires ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Utiliser des équipements de protection individuelle et des procédures de désinfection."
}
},
{
"@type": "Question",
"name": "Les antibiotiques préventifs sont-ils efficaces ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent être utilisés dans certains cas à risque, mais pas systématiquement."
}
},
{
"@type": "Question",
"name": "Comment réduire le risque d'infections nosocomiales ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Améliorer l'hygiène hospitalière et le contrôle des infections est essentiel."
}
},
{
"@type": "Question",
"name": "Quel est le traitement principal pour une intoxication par endotoxines ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement inclut des antibiotiques et des soins de soutien pour stabiliser le patient."
}
},
{
"@type": "Question",
"name": "Les corticostéroïdes sont-ils efficaces contre les endotoxines ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent réduire l'inflammation, mais leur utilisation est controversée."
}
},
{
"@type": "Question",
"name": "Comment traiter le choc septique causé par des endotoxines ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement nécessite des fluides intraveineux et des vasopresseurs."
}
},
{
"@type": "Question",
"name": "Les antidotes existent-ils pour les endotoxines ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas d'antidote spécifique, le traitement est symptomatique."
}
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{
"@type": "Question",
"name": "Quelle est l'importance de la prise en charge précoce ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une prise en charge rapide améliore les chances de survie et réduit les complications."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles d'une intoxication par endotoxines ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent le choc septique, l'insuffisance organique et la mort."
}
},
{
"@type": "Question",
"name": "Comment les endotoxines affectent-elles les organes ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent provoquer une défaillance multi-organique en raison de l'inflammation."
}
},
{
"@type": "Question",
"name": "Le syndrome de détresse respiratoire est-il lié aux endotoxines ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'inflammation pulmonaire peut entraîner un syndrome de détresse respiratoire."
}
},
{
"@type": "Question",
"name": "Les endotoxines peuvent-elles causer des dommages neurologiques ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent provoquer des troubles neurologiques en raison de l'inflammation systémique."
}
},
{
"@type": "Question",
"name": "Quel est le pronostic après une exposition aux endotoxines ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le pronostic dépend de la rapidité du traitement et de la gravité de l'exposition."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque d'intoxication par endotoxines ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les patients immunodéprimés, les personnes âgées et les hospitalisés sont à risque."
}
},
{
"@type": "Question",
"name": "Les infections bactériennes augmentent-elles le risque d'endotoxines ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les infections par des bactéries Gram-négatives sont un facteur de risque majeur."
}
},
{
"@type": "Question",
"name": "Les interventions chirurgicales augmentent-elles le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les interventions chirurgicales peuvent exposer à des endotoxines, surtout en cas d'infection."
}
},
{
"@type": "Question",
"name": "Le diabète est-il un facteur de risque pour les endotoxines ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le diabète peut affaiblir le système immunitaire et augmenter le risque d'infections."
}
},
{
"@type": "Question",
"name": "Les conditions de vie insalubres augmentent-elles le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles favorisent la prolifération bactérienne et l'exposition aux endotoxines."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 06/02/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Microcoat Biotechnologie GmbH, Am Neuland 3, 82347 Bernried am Stanberger See, Germany. j.reich@microcoat.de.
Publications dans "Endotoxines" :
3 publications dans cette catégorie
Affiliations :
Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK. gcb3@cam.ac.uk.
Publications dans "Endotoxines" :
3 publications dans cette catégorie
Affiliations :
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Spectral Medical Inc., Toronto, Ontario, Canada.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Nanomedicine and Molecular Imaging Group, Department of Clinical Medicine, Trinity Translational Medicine Institute, Dublin, Ireland.
Laboratory of Biological Characterization of Advanced Materials (LBCAM), Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Nanomedicine and Molecular Imaging Group, Department of Clinical Medicine, Trinity Translational Medicine Institute, Dublin, Ireland.
Laboratory of Biological Characterization of Advanced Materials (LBCAM), Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Advanced Materials and Bioengineering Research (AMBER) Centre, CRANN institute, Trinity College Dublin, Dublin, Ireland.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Biophotonics and Advanced Microscopy, Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Biophotonics and Advanced Microscopy, Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Innate Immunity, Inflammation and Immuno-nanosafety, IBBC-CNR, Napoli, Italy.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Innate Immunity, Inflammation and Immuno-nanosafety, IBBC-CNR, Napoli, Italy.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Biophotonics and Advanced Microscopy, Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Toray Medical Co., Ltd., Tokyo, Japan.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Microbial Solutions, Charles River Laboratories, 1023 Wappoo Road, Suite 43-B, Charleston, SC 29407, United States.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States.
Publications dans "Endotoxines" :
1 publication dans cette catégorie
Affiliations :
Microcoat Biotechnologie GmbH, Am Neuland 3, 82347 Bernried am Stanberger See, Germany. f.weyer@microcoat.de.
Publications dans "Endotoxines" :
1 publication dans cette catégorie
Affiliations :
LPS (Laboratory Program Support) Consulting Office, Tokyo 160-0023, Japan. htamura@lpsct.com.
Department of Host Defense and Biochemical Research, Juntendo University Graduate School of Medicine, Tokyo 113-8431, Japan. htamura@lpsct.com.
Publications dans "Endotoxines" :
1 publication dans cette catégorie
Affiliations :
Department of Host Defense and Biochemical Research, Juntendo University Graduate School of Medicine, Tokyo 113-8431, Japan. nagaokai@juntendo.ac.jp.
Publications dans "Endotoxines" :
1 publication dans cette catégorie
Affiliations :
Institute of Physical and Theoretical Chemistry, University of Regensburg, 93040 Regensburg, Germany. Hubert.Motschmann@chemie.uni-regensburg.de.
Publications dans "Endotoxines" :
We aimed to determine foetal losses for DCDA and MCDA twins following transabdominal CVS or amniocentesis performed <22+...
Retrospective cohort study conducted in the UK and Belgium 01/01/00-01/06/20. Cases with unknown chorionicity, monochorionic complications or complex procedures were excluded. Uncomplicated DCDA and M...
Outcomes were compared for DCDA foetuses; 258 after CVS with 3406 controls, 406 after amniocentesis with 3390 controls plus MCDA foetuses, 98 after CVS with 1124 controls, and 160 after amniocentesis ...
This study indicates increased foetal losses for DCDA and MCDA twins following CVS and amniocentesis with uncertain risk to normal foetuses....
Dysregulation of transcriptional programs that are tightly regulated by DNA methylation during placental and fetal development at different gestational stages, may cause recurrent miscarriage. Here, w...
The direction of blood movement in normal and abnormal placenta is curious from a morphometric point of view. Once pregnancy is compromised by an illness like hypertension, maternal and foetal distres...
Measurements used a computerized morphometry system and a Vascular Medicine Institute (VMI) calculator....
Our data showed a significant decrease in vessel area (VA), wall area (WA), lumen area (LA), mean wall thickness-boundary (MWTB), mean wall thickness-rosette (MWTR), mean diameter-rosette (MDR), mean ...
We concluded that preeclamptic chorion and chorionic villi vessels are linked with significant structural discrepancies; future studies should address morphological events that occur throughout pregna...
We aimed to compare cell-based NIPT (cbNIPT) to chorionic villus sampling (CVS) and to examine the test characteristics of cbNIPT in the first clinical validation study of cbNIPT compared to cell-free...
Study 1: Women (N = 92) who accepted CVS were recruited for cbNIPT (53 normal and 39 abnormal). Samples were analyzed with chromosomal microarray (CMA). Study 2: Women (N = 282) who accepted cfNIPT we...
Study 1: cbNIPT detected all aberrations (32/32) found in CVS: trisomies 13, 18 and 21 (23/23), pathogenic copy number variations (CNVs) (6/6) and sex chromosome aberrations (3/3). cbNIPT detected 3/8...
Circulating trophoblasts in the maternal circulation provide the potential of screening for aneuploidies and pathogenic CNVs covering the entire fetal genome....
To investigate the expression of autophagy mediated by the hypoxia-inducible factor 1α (HIF-1α)/BNIP3 signaling pathway in villus tissues of missed abortion and HTR-8/SVneo cells and to elucidate the ...
Villus tissues from 30 healthy women with induced abortion and 35 patients with missed abortion were collected, and HTR-8/SVneo cells were cultured under hypoxia and transfected with HIF-1α-siRNA. Rea...
The mRNA levels of HIF-1α and BNIP3 were significantly lower in the missed abortion villi than in the induced abortion samples. The protein levels of HIF-1α, BNIP3, Beclin 1, and LC3II/I were signific...
Autophagy mediated by the HIF-1α/BNIP3 signaling pathway in villous trophoblast cells may be associated with the progression and development of missed abortion....
An important step in the proteomic analysis of missing proteins is the use of a wide range of tissues, optimal extraction, and the processing of protein material in order to ensure the highest sensiti...
The placenta is important for fetal development in mammals, and spatial transcriptomic profiling of placenta helps to resolve its structure and function. In this study, we described the landscape of s...
Growing data suggest a role of Treg cells in placentation. The aim of the study was to evaluate Treg cells (FOXP3-positive cells) placental bed infiltration in patients with placenta accrete syndrome ...
The study group included 13 patients with PAS and the control group consisted of 66 women who had caesarean (CD) delivery of whom, 44 patients with elective caesarean (EC) delivery, and 22 patients wi...
We observed significant difference in the degree of FOXP3-positive cell CV infiltration between studied groups (p = 0.04). FOXP3-positive cells were the most commonly observed in PAS patients, while, ...
Our study provides further evidence that abnormal invasive placentation is an associated disturbance of the maternal immune response. Accordingly, we have theorized that alteration of the FOXP3-positi...
The relationship between fertility and maternal body weight is shaped like an inverted "U," meaning that fertility is negatively affected in overweight or underweight women. Timely and appropriate mat...
Mosaic chromosomal anomalies arising in the product of conception and the final fetal chromosomal arrangement are expression of complex biological mechanisms. The rescue of unbalanced chromosome with ...