Comment diagnostiquer une dysfonction mitochondriale ?

Un diagnostic peut inclure des tests génétiques, des biopsies musculaires et des analyses biochimiques.

Quels tests sanguins sont utilisés pour évaluer les protéines mitochondriales ?

Des tests de lactate, pyruvate et des enzymes spécifiques peuvent être effectués.

Quels symptômes indiquent une maladie mitochondriale ?

Fatigue, faiblesse musculaire, troubles neurologiques et problèmes cardiaques peuvent indiquer une maladie.

Les tests génétiques sont-ils fiables pour les maladies mitochondriales ?

Oui, les tests génétiques peuvent identifier des mutations spécifiques liées aux maladies mitochondriales.

Quel rôle joue l'imagerie dans le diagnostic mitochondrial ?

L'imagerie par résonance magnétique (IRM) peut aider à visualiser des anomalies cérébrales.

Quels sont les symptômes courants des maladies mitochondriales ?

Les symptômes incluent fatigue, douleurs musculaires, troubles de la vision et épilepsie.

Les troubles cognitifs sont-ils liés aux protéines mitochondriales ?

Oui, des troubles cognitifs peuvent survenir en raison de dysfonctionnements mitochondriaux.

Comment la myopathie mitochondriale se manifeste-t-elle ?

Elle se manifeste par une faiblesse musculaire, des crampes et une intolérance à l'exercice.

Les troubles cardiaques sont-ils fréquents dans les maladies mitochondriales ?

Oui, des cardiomyopathies peuvent se développer en raison de dysfonctionnements mitochondriaux.

Les symptômes varient-ils selon l'âge d'apparition ?

Oui, les symptômes peuvent varier considérablement selon l'âge d'apparition de la maladie.

Peut-on prévenir les maladies mitochondriales ?

Certaines maladies génétiques ne peuvent pas être prévenues, mais un mode de vie sain aide.

L'exercice physique peut-il réduire les risques ?

Oui, l'exercice régulier peut améliorer la santé mitochondriale et réduire les risques.

Les antioxydants jouent-ils un rôle préventif ?

Oui, les antioxydants peuvent protéger les mitochondries des dommages oxydatifs.

Une alimentation équilibrée est-elle importante ?

Oui, une alimentation riche en nutriments soutient la santé mitochondriale.

Les dépistages précoces sont-ils recommandés ?

Oui, le dépistage précoce peut aider à identifier les risques et à intervenir rapidement.

Quels traitements sont disponibles pour les maladies mitochondriales ?

Les traitements incluent des suppléments, des thérapies symptomatiques et des approches nutritionnelles.

Les coenzymes Q10 sont-elles bénéfiques ?

Oui, le coenzyme Q10 peut améliorer la fonction mitochondriale et réduire les symptômes.

La thérapie génique est-elle une option pour ces maladies ?

La thérapie génique est en recherche, mais elle pourrait offrir des solutions futures.

Les régimes alimentaires peuvent-ils aider ?

Oui, des régimes spécifiques peuvent soutenir la fonction mitochondriale et améliorer les symptômes.

Les traitements varient-ils selon le type de maladie mitochondriale ?

Oui, les traitements doivent être adaptés au type spécifique de maladie mitochondriale.

Quelles complications peuvent survenir avec les maladies mitochondriales ?

Les complications incluent des troubles neurologiques, cardiaques et endocriniens.

Les maladies mitochondriales peuvent-elles affecter la fertilité ?

Oui, certaines maladies mitochondriales peuvent entraîner des problèmes de fertilité.

Les complications peuvent-elles être gérées ?

Certaines complications peuvent être gérées avec des traitements symptomatiques appropriés.

Les maladies mitochondriales augmentent-elles le risque de cancer ?

Certaines études suggèrent un lien entre dysfonction mitochondriale et risque accru de cancer.

Les complications cardiovasculaires sont-elles fréquentes ?

Oui, les maladies mitochondriales peuvent entraîner des cardiomyopathies et d'autres complications.

Quels sont les facteurs de risque pour les maladies mitochondriales ?

Les facteurs incluent des antécédents familiaux, des mutations génétiques et des expositions environnementales.

L'âge est-il un facteur de risque ?

Oui, certaines maladies mitochondriales se manifestent plus fréquemment avec l'âge.

Les facteurs environnementaux influencent-ils les maladies mitochondriales ?

Oui, l'exposition à des toxines peut augmenter le risque de dysfonction mitochondriale.

Le stress oxydatif est-il un facteur de risque ?

Oui, le stress oxydatif peut endommager les mitochondries et contribuer à des maladies.

Les habitudes alimentaires peuvent-elles influencer le risque ?

Oui, une alimentation pauvre en nutriments peut augmenter le risque de dysfonction mitochondriale.

Protéines mitochondriales - Informations médicales vérifiées

Laparoscopic Appendectomy versus Open Appendectomy in Acute Appendicitis.

20 Jul 2023

DOI: 10.33314/jnhrc.v20i4.3681 PMID: 37489661

Appendectomy is the most common emergency surgical procedure performed. Appendectomy is performed by either open or laparoscopic methods. However, there is lack of consensus regarding the most appropr... Fifty-two patients undergoing appendectomy were analyzed in this prospective comparative study, with 26 patients each in laparoscopic and open group. The outcomes were measured in terms of operative t... Laparoscopic group had longer time after completion of surgery till exit from operation theatre (30 min in laparoscopic and 20 min in open, p<0.01) and significantly higher cost (Nrs. 26295 for laparo... The results suggest that laparoscopic appendectomy group had longer recovery time after operation and was costlier than open appendectomy. Thus, the decision of the operative procedure can be based on...

Humans Appendicitis Appendectomy Prospective Studies Nepal +4 autres

Isolated Appendectomy Technique Without Mesoappendix in Laparoscopic Appendectomy.

01 Dec 2022

DOI: 10.1097/SLE.0000000000001116 PMID: 36468896

Laparoscopic appendectomy is among the most common general surgical procedures performed in developed countries. Among the most critical steps in laparoscopic appendectomy is transection of the append... Patients who were operated on with the diagnosis of acute appendicits in our clinic between October 2021 and January 2022 were evaluated retrospectively. Patients were divided into 2 groups. In the fi... During the study, 157 patients were included in the study. Seventy-one (45.2%) of the patients were in group 1, and 86 (54.8%) were in group 2. There was no difference between the groups regarding age... Although there was no difference in postoperative complications between the isolated appendectomy technique and the mesoicular technique, the operation time was shorter, and the operation cost was low...

Humans Appendectomy Appendix Appendicitis Retrospective Studies +3 autres

Needlescopic appendectomy versus conventional laparoscopic appendectomy in young patients.

Apr 2023

DOI: 10.1111/ases.13146 PMID: 36426403

Several studies have reported that needlescopic appendectomy (NA) is a safe and effective procedure for appendicitis because of reduced trocar wounds and tissue trauma. The aim of this study was to ev... We retrospectively reviewed our database looking for patients under 40 years of age diagnosed with appendicitis who underwent NA or CLA from January 2013 to April 2017. Patients were divided into two ... Fifty-four patients underwent NA and 53 patients underwent CLA. The groups were similar in terms of demographic features. Pathological diagnoses were divided into the following categories: catarrhalis... NA might be an effective surgical technique when performing a laparoscopic appendectomy in young patients with appendicitis....

Humans Retrospective Studies Appendectomy Laparoscopy Appendicitis +3 autres

Varying negative appendectomy rates after laparoscopic appendectomy: a systematic review and meta-analysis.

23 May 2023

DOI: 10.1007/s00423-023-02935-z PMID: 37219616

Appendicitis is a common cause of acute abdominal pain, and treatment with laparoscopy has become increasingly common during the past two decades. Guidelines recommend that normal appendices are remov... This study was reported following the PRISMA 2020 statement. A systematic search was conducted in PubMed and Embase for retrospective or prospective cohort studies (with n ≥ 100) including patients wi... In total, 74 studies were identified, summing up to 76,688 patients. The negative appendectomy rate varied from 0% to 46% in the included studies (interquartile range 4-20%). The meta-analysis estimat... The overall estimated negative appendectomy rate after laparoscopic surgery was 13% with moderate certainty of evidence. The negative appendectomy rate varied greatly between studies....

Humans Appendectomy Appendicitis Prospective Studies Retrospective Studies +1 autres

Single-center comparison of outcomes between laparoscopic appendectomy and transumbilical laparoscopic assisted appendectomy.

May 2023

DOI: 10.1016/j.jpedsurg.2023.01.033 PMID: 36805141

Appendectomy is the most common pediatric emergency surgery performed to date. This study compared outcomes between laparoscopic appendectomy (LA) and transumbilical laparoscopic assisted appendectomy... Demographic and clinical data was collected for 1154 eligible patients treated for uncomplicated appendicitis between August 2014-October 2019, with 830 patients in the LA group, and 324 in the TULAA ... Of 1154 patients, 62.7% were male, and mean (SD) age was 10.9 (3.6) years. Median [IQR] LOS was 28.0 h [22.0, 36.0], mean (SD) OR time was 29.0 (10.0) minutes, and median [IQR] pain at maximum level w... Retrospective analysis of 1154 pediatric appendectomies, found no difference in complications between single- and three-incision laparoscopic procedures (TULAA vs. LA). Findings suggest TULAA is a saf... IV....

Humans Child Male Female Appendectomy +7 autres

Construction of a laparoscopic appendectomy model.

2024

DOI: 10.1590/0100-6991e-20243770-en PMID: 39166610

Appendectomy is the standard treatment for appendicitis, with the laparoscopic technique offering benefits like lower infection rates and quicker recovery. However, residents often have their first pr... Cold ceramic structures were used to manually shape the anatomical model of the appendix, ensuring its rigidity. On this model, we poured materials to create a flexible mold using acetic silicone. Onc... This process resulted in the manufacture of a piece that simulates the appendix, being tear-resistant and suturable, faithfully replicating the structure and characteristics of a human organ. The low ... This work not only contributes to the advancement of medical simulation but also highlights the importance of innovative and collaborative solutions in improving medical education and promoting patien...

Appendectomy Laparoscopy Humans Models, Anatomic

Transumbilical laparoscopic-assisted appendectomy <em>versus</em> laparoscopic appendectomy in children: a single center experience.

27 Apr 2023

DOI: 10.4081/pmc.2023.306 PMID: 37114377

Laparoscopic Appendectomy (LPSA) is the first choice for appendectomy in pediatric surgery. Trans-Umbilical Laparoscopic Assisted Appendicectomy (TULAA) is another used technique. We compared both the...

Humans Child Appendectomy Treatment Outcome Retrospective Studies +3 autres

Incidence of appendiceal neoplasms in appendectomy patients.

21 Sep 2023

DOI: 10.1186/s12893-023-02183-4 PMID: 37735406

Non-operative management has been suggested as a therapy for uncomplicated appendicitis. Notwithstanding, the risk of missing an appendiceal tumor must be considered, being the surgical piece crucial ... Retrospective study in which we described patients who underwent emergent appendectomy with histopathological findings of appendiceal neoplasms from January 2012 to September 2018. Descriptive analysi... 2993 patients diagnosed with acute appendicitis who underwent an emergency appendectomy. 64 neoplasms of the appendix were found with an incidence of 2,14%. 67.2% were women, the mean age was 46,4 yea... Appendiceal tumors are rare and must be ruled out in patients with suspected acute appendicitis. The incidence of incidental neoplasms is higher in this study than in the previously reported series. T...

Humans Female Male Appendiceal Neoplasms Appendectomy +4 autres

Laparoscopic appendectomy in children Evaluation of the learning curve

19 Jun 2022

DOI: 10.1556/650.2022.32485 PMID: 35895553

Introduction: The advantages of laparoscopic against open appendectomy were observed both in adults and children. Objective: The aim of the authors was to study the learning period when they switched ...

Adult Appendectomy Appendicitis Child Humans +5 autres

Pathological Assessment of the Appendix in Appendectomies Performed in Children.

01 May 2024

DOI: 10.34172/aim.2024.38 PMID: 38690793

Acute appendicitis is known as the most common diagnosis of acute abdomen leading to surgery. Therefore, timely diagnosis is of special importance. This study was conducted with the aim of pathologica... This is a cross-sectional descriptive study. All children who underwent appendectomy at Shahid Motahari Hospital in Urmia from March 2021 to March 2022 were examined. The required data including demog... Among 234 pathology samples of the appendix, 22 cases were related to accidental appendectomy. In addition, 11.3% of cases were negative appendectomy and 88.7% were positive appendectomy. The age rang... A relatively significant number of accidental and negative appendectomies are performed. More careful investigation and the use of expectant and medical treatment instead of surgery, especially in fem...

Humans Appendectomy Child Female Appendicitis +8 autres

Protéines mitochondriales : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Aldehyde dehydrogenase, mitochondrial

Mitochondrial creatine kinase

DNA Polymerase gamma

Ferrochelatase

Protéines de transport de la membrane mitochondriale

Protéine trifonctionnelle mitochondriale

Nucleoside diphosphate kinase D

Peroxiredoxin III

Prohibitines

Sirtuine-3

Mitochondrial ADP, ATP Translocases

Pore de transition de perméabilité mitochondriale

Protéines du complexe d'import des protéines précurseurs mitochondriales

Mitochondrial Proton-Translocating ATPases

Protéines de découplage mitochondrial

Canal anionique-1 voltage-dépendant

Canal anionique-2 voltage-dépendant

Sous-unité alpha de la protéine trifonctionnelle mitochondriale

Sous-unité bêta de la protéine trifonctionnelle mitochondriale

Translocateur-1 de nucléotides adényliques

Translocateur-2 de nucléotides adényliques

Translocateur-3 de nucléotides adényliques

Protéine-1 de découplage

Protéine-2 de découplage

Protéine-3 de découplage

Auteurs principaux

Sources (543 au total)