Comment diagnostiquer une dysfonction mitochondriale ?

Un diagnostic peut inclure des tests génétiques, des biopsies musculaires et des analyses biochimiques.

Quels tests sanguins sont utilisés pour évaluer les protéines mitochondriales ?

Des tests de lactate, pyruvate et des enzymes spécifiques peuvent être effectués.

Quels symptômes indiquent une maladie mitochondriale ?

Fatigue, faiblesse musculaire, troubles neurologiques et problèmes cardiaques peuvent indiquer une maladie.

Les tests génétiques sont-ils fiables pour les maladies mitochondriales ?

Oui, les tests génétiques peuvent identifier des mutations spécifiques liées aux maladies mitochondriales.

Quel rôle joue l'imagerie dans le diagnostic mitochondrial ?

L'imagerie par résonance magnétique (IRM) peut aider à visualiser des anomalies cérébrales.

Quels sont les symptômes courants des maladies mitochondriales ?

Les symptômes incluent fatigue, douleurs musculaires, troubles de la vision et épilepsie.

Les troubles cognitifs sont-ils liés aux protéines mitochondriales ?

Oui, des troubles cognitifs peuvent survenir en raison de dysfonctionnements mitochondriaux.

Comment la myopathie mitochondriale se manifeste-t-elle ?

Elle se manifeste par une faiblesse musculaire, des crampes et une intolérance à l'exercice.

Les troubles cardiaques sont-ils fréquents dans les maladies mitochondriales ?

Oui, des cardiomyopathies peuvent se développer en raison de dysfonctionnements mitochondriaux.

Les symptômes varient-ils selon l'âge d'apparition ?

Oui, les symptômes peuvent varier considérablement selon l'âge d'apparition de la maladie.

Peut-on prévenir les maladies mitochondriales ?

Certaines maladies génétiques ne peuvent pas être prévenues, mais un mode de vie sain aide.

L'exercice physique peut-il réduire les risques ?

Oui, l'exercice régulier peut améliorer la santé mitochondriale et réduire les risques.

Les antioxydants jouent-ils un rôle préventif ?

Oui, les antioxydants peuvent protéger les mitochondries des dommages oxydatifs.

Une alimentation équilibrée est-elle importante ?

Oui, une alimentation riche en nutriments soutient la santé mitochondriale.

Les dépistages précoces sont-ils recommandés ?

Oui, le dépistage précoce peut aider à identifier les risques et à intervenir rapidement.

Quels traitements sont disponibles pour les maladies mitochondriales ?

Les traitements incluent des suppléments, des thérapies symptomatiques et des approches nutritionnelles.

Les coenzymes Q10 sont-elles bénéfiques ?

Oui, le coenzyme Q10 peut améliorer la fonction mitochondriale et réduire les symptômes.

La thérapie génique est-elle une option pour ces maladies ?

La thérapie génique est en recherche, mais elle pourrait offrir des solutions futures.

Les régimes alimentaires peuvent-ils aider ?

Oui, des régimes spécifiques peuvent soutenir la fonction mitochondriale et améliorer les symptômes.

Les traitements varient-ils selon le type de maladie mitochondriale ?

Oui, les traitements doivent être adaptés au type spécifique de maladie mitochondriale.

Quelles complications peuvent survenir avec les maladies mitochondriales ?

Les complications incluent des troubles neurologiques, cardiaques et endocriniens.

Les maladies mitochondriales peuvent-elles affecter la fertilité ?

Oui, certaines maladies mitochondriales peuvent entraîner des problèmes de fertilité.

Les complications peuvent-elles être gérées ?

Certaines complications peuvent être gérées avec des traitements symptomatiques appropriés.

Les maladies mitochondriales augmentent-elles le risque de cancer ?

Certaines études suggèrent un lien entre dysfonction mitochondriale et risque accru de cancer.

Les complications cardiovasculaires sont-elles fréquentes ?

Oui, les maladies mitochondriales peuvent entraîner des cardiomyopathies et d'autres complications.

Quels sont les facteurs de risque pour les maladies mitochondriales ?

Les facteurs incluent des antécédents familiaux, des mutations génétiques et des expositions environnementales.

L'âge est-il un facteur de risque ?

Oui, certaines maladies mitochondriales se manifestent plus fréquemment avec l'âge.

Les facteurs environnementaux influencent-ils les maladies mitochondriales ?

Oui, l'exposition à des toxines peut augmenter le risque de dysfonction mitochondriale.

Le stress oxydatif est-il un facteur de risque ?

Oui, le stress oxydatif peut endommager les mitochondries et contribuer à des maladies.

Les habitudes alimentaires peuvent-elles influencer le risque ?

Oui, une alimentation pauvre en nutriments peut augmenter le risque de dysfonction mitochondriale.

Protéines mitochondriales - Informations médicales vérifiées

Effectiveness of Single Chest Tube vs Double Chest Tube Application Postdecortication: Prospective Randomized Controlled Study.

01 06 2023

DOI: 10.1097/XCS.0000000000000661 PMID: 36808127

Draining the chest cavity with 2 tubes is a common practice among thoracic surgeons. This research was conducted in Addis Ababa from March 2021 to May 2022. A total of 62 patients were included.... This study was conducted to investigate the superiority of either single or double tube insertion after decortication. Patients were randomized in a ratio of 1:1. In group A, 2 tubes were inserted; in... The age range of patients was 18 to 70 years, with a mean of 44 ± 14.4434 years; the male to female ratio was 2.9:1. The dominant underlying pathologies were tuberculosis and trauma (45.2% vs 35.5%); ... The placement of a single tube after decortication is effective in reducing drain output, time of drain, and hospital stay. There was no association with pain, and there was no effect on other endpoin...

Humans Male Female Adolescent Young Adult +8 autres

Development of nurses' knowledge questionnaire of chest tube maintenance and management.

Dec 2022

DOI: 10.1111/jocs.17211 PMID: 36378854

The lack of chest tube maintenance and management knowledge in nurses can lead to serious adverse consequences. The purpose of this study was to develop a chest tube maintenance and management knowled... Based on literature review and expert consultation, a questionnaire on chest tube maintenance and management knowledge of clinical nurses was designed, and the reliability and validity of the question... The initial questionnaire of chest tube maintenance and management knowledge for clinical nurses included 20 items, and three dimensions were finally determined by expert consultation method, includin... The clinical nurses' knowledge questionnaire developed in this study has good reliability and validity, which can effectively and objectively evaluate clinical nurses' mastery of chest tube maintenanc...

Humans Reproducibility of Results Clinical Competence Chest Tubes Surveys and Questionnaires

Necessity of Routine Chest Radiograph Following Chest Tube Removal in Pediatric Patients After Cardiovascular Surgery.

01 Jan 2023

DOI: 10.1097/RTI.0000000000000660 PMID: 35797657

Chest tube placement and subsequent removal is a routine step in patient management after cardiovascular surgery. The purpose of this retrospective study is to determine the necessity of routine chest... We retrospectively reviewed the hospital records of all consecutive children up to 5 years of age who had cardiovascular surgery at our hospital between January 2015 and December 2020. Two radiologist... We identified 147 children (73 [49.7%] male and 74 [50.3%] female; mean age=13.8 mo old; range 0 to 60 mo) who met the inclusion criteria. Complications were detected on routine chest radiograph after... Our study shows that routine chest radiograph performed shortly after chest tube removal may not be necessary for the safe management of asymptomatic children after cardiovascular surgery because comp...

Humans Child Male Female Adolescent +5 autres

Evaluating the safety of intraprocedural chest tube removal during medical thoracoscopy.

Apr 2024

DOI: 10.1016/j.rmed.2024.107560 PMID: 38331227

Medical Thoracoscopy (MT) is a diagnostic procedure during which after accessing the pleural space the patient's negative-pressure inspiratory efforts draw atmospheric air into the pleural cavity, whi... A retrospective review was conducted of all the MT with intraprocedural chest tube removal done between 2019 to 2023 in adult patients in a single center in New York, NY by interventional pulmonology.... A total of 100 MT cases were identified in which the chest tube was removed intra-operatively. Seventy-seven percent of cases were performed as outpatient and all these patients were discharged on the... Intraprocedural CT removal for MT is safe and may decrease utilization of additional analgesia post procedure. Further prospective studies are necessary to validate these conclusions....

Adult Humans Pleural Effusion Chest Tubes Prospective Studies +3 autres

Spontaneous large volume hemothorax managed with a small-bore chest tube.

02 Feb 2023

DOI: 10.4081/monaldi.2023.2496 PMID: 36786166

A 67-year-old male with metastatic lung cancer presented with acute shortness of breath and increasing oxygen requirements. He had a decreasing hemoglobin for which he required red blood cell transfus...

Male Humans Aged Hemothorax Chest Tubes +3 autres

Misconnected chest tube: An extremely unusual fatal complication of secondary pneumothorax.

Jul 2023

DOI: 10.1177/00258024231165960 PMID: 36949674

A rare and fatal complication of suction drainage of secondary spontaneous pneumothorax is reported. The patient, likely by a mistake, arbitrarily connected the oxygen supply tube to the thoracic drai...

Humans Pneumothorax Chest Tubes Drainage Lung Injury

Assessing competence in Chest Tube Insertion with the ACTION-tool: A Delphi study.

Aug 2022

DOI: 10.1016/j.ijsu.2022.106791 PMID: 35922003

Chest Tube Insertion (CTI) should be trained in simulated settings prior to patient contact. Feedback and certification is based on valid assessments, especially in simulation-based training. This stu... A diverse European expert panel was invited to participate. In round 1, the experts provided at least five procedural steps and three errors involved in CTI. Round 2 evaluated the level of agreement w... Thirty-six of 105 (34%) invited surgeons (26/75, 35%), pulmonologists (8/23, 35%) and emergency physicians (2/7, 29%) participated. The overall response rate was 81% (29/36): 100% (36/36) in round 1, ... A multidisciplinary expert panel achieved consensus in the development of the ACTION (Assessment of Competence in Chest Tube Insertion) tool. This procedure-specific rating scale of 17 steps, suppleme...

Checklist Chest Tubes Clinical Competence Consensus Delphi Technique +2 autres

Patients' Perceptions of Experiences of Postoperative Chest Drain Tube Insertion: A Pilot Survey.

21 02 2023

DOI: 10.3390/ijerph20053773 PMID: 36900784

Pleural drainage is a routine procedure conducted after thoracotomy and thoracoscopy. It is used to remove air or excess fluid from a pleural cavity and enables proper lung expansion. Essential elemen... This study aimed to explore patients' experiences with pleural drainage after thoracic surgery and their correlation with socio-demographic data.... A pilot survey with an exploratory design was conducted at a large teaching hospital in Poland, in the Department of Thoracic Surgery at the University Clinical Centre in Gdansk. The study involved th... Individuals fitted with a traditional water-seal drainage system felt safer than those from the digital drainage group (... Demographic and social characteristics did not significantly affect patients' sense of safety with chest drainage types. Patients with traditional drainage felt significantly safer than patients with ...

Humans Chest Tubes Thoracotomy Lung Hospitalization +1 autres

Chest Tube Management following Lung Resection in Pediatric Patients: A Retrospective Analysis.

Jul 2023

DOI: 10.1016/j.jpedsurg.2023.02.051 PMID: 37003926

Pleural drainage following lung resection is almost universally practiced in pediatric surgery, but its necessity has been questioned in adult literature. We performed a cross-sectional study of pedia... Retrospective chart review of patients <21 years of age undergoing pulmonary lobectomy or wedge resection at an academic children's hospital from 2013 to 2022. Variables regarding demographics and pos... 130 procedures meet inclusion criteria: 59 lobectomies (group 1), 19 diagnostic wedges (group 2), and 52 excisional wedges (group 3). 74.6% of group 1 patients had no air leak, and median CT duration ... CT duration following lung resection in pediatric patients is typically brief, with most patients having no air leak and CT removal within 2 days of surgery. Obligatory CT drainage may not be necessar... Level IV.... Retrospective Study....

Adult Humans Child Chest Tubes Retrospective Studies +4 autres

Early Water Seal of Chest Tubes Following Video-Assisted Thoracic Surgery Pleurodesis.

03 2023

DOI: 10.1016/j.jss.2022.11.052 PMID: 36914993

Early water seal following minimally invasive pulmonary lobectomy has been shown to reduce chest tube duration and postoperative length of stay (LOS). We evaluated chest tube duration and postoperativ... We identified adult patients undergoing VATS pleurodesis from August 2013 to December 2021. The chest tube protocol was changed in January 2017 such that patients were placed to water seal on the morn... A total of 488 patients underwent VATS pleurodesis during the study period (Group 1: 329 patients; Group 2: 159 patients). The median age was 61 y (interquartile range [IQR] 49-68), 51% were females, ... Development of a standardized protocol to water seal chest tubes on postoperative day 1 following VATS pleurodesis is associated with reduced chest tube duration and LOS without an increase in postope...

Adult Female Humans Middle Aged Male +8 autres

Protéines mitochondriales : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Aldehyde dehydrogenase, mitochondrial

Mitochondrial creatine kinase

DNA Polymerase gamma

Ferrochelatase

Protéines de transport de la membrane mitochondriale

Protéine trifonctionnelle mitochondriale

Nucleoside diphosphate kinase D

Peroxiredoxin III

Prohibitines

Sirtuine-3

Mitochondrial ADP, ATP Translocases

Pore de transition de perméabilité mitochondriale

Protéines du complexe d'import des protéines précurseurs mitochondriales

Mitochondrial Proton-Translocating ATPases

Protéines de découplage mitochondrial

Canal anionique-1 voltage-dépendant

Canal anionique-2 voltage-dépendant

Sous-unité alpha de la protéine trifonctionnelle mitochondriale

Sous-unité bêta de la protéine trifonctionnelle mitochondriale

Translocateur-1 de nucléotides adényliques

Translocateur-2 de nucléotides adényliques

Translocateur-3 de nucléotides adényliques

Protéine-1 de découplage

Protéine-2 de découplage

Protéine-3 de découplage

Auteurs principaux

Sources (6387 au total)