questionsmedicales.fr
Phénomènes génétiques
Régulation de l'expression des gènes
Modification traductionnelle des protéines
Maturation post-traductionnelle des protéines
Réponse aux protéines mal repliées
Réponse aux protéines mal repliées : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Réponse aux protéines mal repliées
Stress cellulaire
Biopsie
Analyse protéomique
Imagerie médicale
Complications
Biomarqueurs
Protéines chaperonnes
Antécédents médicaux
Maladies métaboliques
Symptômes
5
Fatigue
Troubles métaboliques
Douleur musculaire
Douleur articulaire
Troubles cognitifs
Céphalée
Métabolisme
Résistance à l'insuline
Nausées
Troubles gastro-intestinaux
Prévention
5
Mode de vie sain
Gestion du stress
Bilan de santé
Prévention
Éducation à la santé
Sensibilisation
Soutien psychologique
Santé mentale
Traitements
5
Thérapies ciblées
Médicaments anti-inflammatoires
Exercice physique
Stress cellulaire
Inhibiteurs de protéase
Médicaments
Thérapie génique
Recherche
Complications
5
Maladies métaboliques
Cancers
Troubles cardiovasculaires
Inflammation
Facteurs de risque
5
Stress oxydatif
Prédispositions génétiques
Vieillissement
Dysfonctionnement
Mode de vie sédentaire
Alimentation
Maladies auto-immunes
Exacerbation
Tabagisme
Stress cellulaire
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"@type": "Question",
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"name": "L'alimentation influence-t-elle l'UPR ?",
"position": 17,
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}
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"@type": "Question",
"name": "Les exercices physiques sont-ils bénéfiques ?",
"position": 18,
"acceptedAnswer": {
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"text": "Oui, l'exercice modéré peut améliorer la réponse au stress cellulaire."
}
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"@type": "Question",
"name": "Des médicaments spécifiques sont-ils prescrits ?",
"position": 19,
"acceptedAnswer": {
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"text": "Des médicaments comme les inhibiteurs de la protéase peuvent être utilisés."
}
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{
"@type": "Question",
"name": "La thérapie génique est-elle une option ?",
"position": 20,
"acceptedAnswer": {
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"text": "La thérapie génique est en recherche pour corriger des défauts liés à l'UPR."
}
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"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des maladies métaboliques, des troubles neurologiques et des cancers peuvent survenir."
}
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"@type": "Question",
"name": "L'UPR peut-elle entraîner des maladies chroniques ?",
"position": 22,
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"text": "Oui, l'UPR est liée à des maladies chroniques comme le diabète et l'obésité."
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"@type": "Question",
"name": "Y a-t-il un risque accru de cancer ?",
"position": 23,
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}
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"@type": "Question",
"name": "Des troubles cardiovasculaires sont-ils possibles ?",
"position": 24,
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}
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"@type": "Question",
"name": "L'UPR affecte-t-elle la longévité ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études suggèrent que l'UPR peut influencer la longévité et la santé globale."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de l'UPR ?",
"position": 26,
"acceptedAnswer": {
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"text": "Les facteurs incluent le stress oxydatif, l'inflammation et des prédispositions génétiques."
}
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{
"@type": "Question",
"name": "L'âge est-il un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
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"text": "Oui, le vieillissement augmente le risque de dysfonctionnement de l'UPR."
}
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{
"@type": "Question",
"name": "Le mode de vie influence-t-il l'UPR ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque."
}
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{
"@type": "Question",
"name": "Les maladies auto-immunes sont-elles un risque ?",
"position": 29,
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"text": "Oui, les maladies auto-immunes peuvent exacerber la réponse aux protéines mal repliées."
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"@type": "Question",
"name": "Le tabagisme est-il un facteur de risque ?",
"position": 30,
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 08/04/2025
Contenu vérifié selon les dernières recommandations médicales
9 publications dans cette catégorie
Affiliations :
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, USA.
3 publications dans cette catégorie
Affiliations :
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
MSU-DOE Plant Research Lab and Plant Biology Department Michigan State University, East Lansing, MI, USA. fb@msu.edu.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Department of Neuroscience; Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Department of Orthopedics, University of Colorado Anschutz Medical Campus, 12800 E 19th Ave, Mailstop:8343, Aurora, CO, 80045, USA. Srividhya.Iyer@cuanschutz.edu.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile. chetz@med.uchile.cl.
FONDAP Center for Geroscience Brain Health and Metabolism (GERO), Santiago, Chile. chetz@med.uchile.cl.
Program of Cellular and Molecular Biology, Institute of Biomedical Science, University of Chile, Santiago, Chile. chetz@med.uchile.cl.
Buck Institute for Research on Aging, Novato, CA, USA. chetz@med.uchile.cl.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Apoptosis Research Centre, School of Natural Sciences, National University of Ireland, Galway, Ireland.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Apoptosis Research Centre, School of Natural Sciences, National University of Ireland, Galway, Ireland.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Apoptosis Research Centre, School of Natural Sciences, National University of Ireland, Galway, Ireland.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Medical Biochemistry and Molecular Biology, Medical Faculty, Saarland University, 66421 Homburg, Germany.
Preclinical Center for Molecular Signaling (PZMS), Medical Faculty, Saarland University, 66421 Homburg, Germany.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche, Milano 20133, Italy.
Publications dans "Réponse aux protéines mal repliées" :
2 publications dans cette catégorie
Affiliations :
Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche, Milano 20133, Italy.
Publications dans "Réponse aux protéines mal repliées" :
1 publication dans cette catégorie
Affiliations :
Department of Biosciences, Durham University, South Road, Durham DH1 3LE, UK.
Biophysical Sciences Institute, Durham University, South Road, Durham DH1 3LE, UK.
Publications dans "Réponse aux protéines mal repliées" :
1 publication dans cette catégorie
Affiliations :
Department of Biosciences, Durham University, South Road, Durham DH1 3LE, UK.
Biophysical Sciences Institute, Durham University, South Road, Durham DH1 3LE, UK.
Publications dans "Réponse aux protéines mal repliées" :
Interstitial lung diseases are associated with high morbitity and mortality. Rapid diagnosis in a qualified center is necessary in order to provide the best possible treatment. However, geographic dis...
We conducted a realist review of state-authorized dyslexia pilot projects to understand how they have been implemented and evaluated, and the extent to which they adhere to best practice recommendatio...
Increased noxious noise leads to adverse short-term and long-term effects on the growing neonate. The American Academy of Pediatrics recommends maintaining a noise level of less than 45 decibels (dBA)...
The purpose of this pilot project was to reduce the average noise levels by 39% at the end of an 11-week period....
The location of the project was in a large, high-acuity level IV open-pod layout NICU that consisted of 4 pods, one of which was cardiac-focused. The average baseline noise level in the cardiac pod wa...
At the end of the project, noise levels decreased from 62.6 dBA to 54 dBA, a 13.7% reduction....
At the end of this pilot project it was noted that: Online modules were the best way to educate staff. Parents should be included in the implementation of quality improvement. Healthcare providers nee...
Hospitalized patients after suicide attempts gave informed consent to a postvention project after discharge. A continuous caregiver contacted the subjects monthly by phone for a period of 1 year. In c...
Measuring the hypovolemic resuscitation end point remains a critical care challenge. Our project compared clinical hypovolemia (CH) with three diagnostic adjuncts: 1) noninvasive cardiac output monito...
Adult trauma/surgical intensive care unit patients were prospectively screened for suspected hypovolemia after acute resuscitation, excluding patients with burns, known heart failure, or severe liver/...
44 patients (62% male, median age 60) yielded 65 measures. Positive agreement with CH was 47% for NICOM, 37% for US-IVC and 10% for US-C. None of the three adjuncts correlated with CH (κ -0.045 to 0.0...
None of the adjunct measurements correlated with CH or each other, highlighting that fluid status assessment remains challenging in critical care. US should assess for right ventricular dysfunction pr...
People living with chronic disease should ideally engage with community-based exercise services following hospital-based rehabilitation. However, transition from hospital to community exercise setting...
The aims of this study were to develop and explore the feasibility of a pilot exercise referral pathway between an acute hospital and community gyms for patients with chronic health conditions and to ...
A stakeholder-informed exercise referral pathway was developed and offered to patients following completion of a hospital-based exercise programme for a chronic health condition. The pathway was evalu...
Forty-nine people living with chronic conditions (mean age 72 ± 7.8 years) participated (recruitment rate 59%). The average number of community gym visits over 4 months was 17.4 (range 0-51). Twenty-n...
A structured exercise referral pathway to support exercise transition between hospital and community settings in populations with chronic health conditions appears feasible. Participants reported high...
This manuscript offers findings from a pilot project which prepares nursing students for embodied professional practice through the lens of ethics. Four undergraduate nursing students were mentored by...
Chlamydia disproportionately affects individuals aged 15-24 years. A lack of chlamydia knowledge in this high-risk group likely contributes to decreased testing, but interventions to increase chlamydi...
A pre- and post-test design was used to evaluate participant knowledge of chlamydia before and after completing a nurse-developed web-based education intervention designed for university students....
Forty-seven undergraduate students at one U.S. university participated. A focus group and scientific evidence informed the development of the web-based education....
Participants had a significant increase in chlamydia knowledge after completing the online educational intervention (M = 8.0, SD = 0.000) compared to baseline (M = 6.5, SD = 1.5), t(33) = -5.821, p < ...
In the twenty-first century, health systems have to cope with the challenges posed by their rapidly changing environment. Among these changes, the emergence of digital health solutions is an opportuni...
This study is based on a survey of the dental care provided by three units (Oral Medicine, Periodontology, Orthodontics) of the Department of Community Dentistry, Semmelweis University, Budapest. Duri...
According to our findings, teledentistry has the potential to shorten the visit with an average of 5-10 min per patient, which adds up to 58-116 work hours in a year. If the pilot was rolled out to al...
The rapid development of digital health technologies coupled with the evolving task distribution between health professionals have a great potential to improve health system performance in pursuit of ...
Obesity is a chronic, multifactorial disease which is linked to a number of adverse endocrinological and metabolic conditions. Currently, bariatric surgery is one of the most effective treatments for ...