Lipoplasty in the Overweight Patient.
The practice of large volume liposuction, when executed by board-certified plastic surgeons using a variety of energy-assisted liposuction devices, has been substantiated as a secure procedure, yieldi...
N-terminal acetyltransferases : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une déficience en N-terminal acetyltransferases ?
Des tests génétiques et des analyses protéomiques peuvent identifier des anomalies.
#2
Quels tests sont utilisés pour évaluer l'activité des N-terminal acetyltransferases ?
Des tests enzymatiques mesurant l'acétylation des substrats spécifiques sont utilisés.
#3
Les biopsies sont-elles nécessaires pour le diagnostic ?
Pas toujours, mais elles peuvent être utiles pour des analyses plus approfondies.
#4
Quels marqueurs biologiques indiquent une activité anormale ?
Des niveaux anormaux de protéines acétylées peuvent indiquer une dysfonction enzymatique.
#5
Peut-on utiliser l'imagerie pour le diagnostic ?
L'imagerie n'est pas couramment utilisée pour diagnostiquer des troubles enzymatiques.
Symptômes 5
#1
Quels symptômes sont associés à une déficience en N-terminal acetyltransferases ?
Les symptômes peuvent inclure des troubles neurologiques et des anomalies métaboliques.
#2
Les symptômes varient-ils selon le type d'enzyme affectée ?
Oui, chaque enzyme a des substrats spécifiques, entraînant des symptômes variés.
#3
Y a-t-il des symptômes cutanés associés ?
Certaines déficiences peuvent provoquer des éruptions cutanées ou des anomalies dermatologiques.
#4
Les troubles cognitifs sont-ils liés à ces enzymes ?
Oui, des troubles cognitifs peuvent survenir en raison de l'impact sur le métabolisme neuronal.
#5
Les symptômes apparaissent-ils dès la naissance ?
Pas toujours, certains symptômes peuvent se développer plus tard dans l'enfance ou l'adolescence.
Prévention 5
#1
Peut-on prévenir les déficiences en N-terminal acetyltransferases ?
La prévention est difficile, mais un diagnostic précoce peut aider à gérer les symptômes.
#2
Les conseils génétiques sont-ils recommandés ?
Oui, les conseils génétiques peuvent être utiles pour les familles à risque.
#3
L'alimentation peut-elle jouer un rôle préventif ?
Une alimentation équilibrée peut soutenir la santé métabolique, mais ne prévient pas directement.
#4
Des dépistages réguliers sont-ils conseillés ?
Des dépistages peuvent être recommandés pour les individus à risque ou avec des antécédents familiaux.
#5
Les vaccinations peuvent-elles aider ?
Les vaccinations ne préviennent pas les déficiences enzymatiques, mais protègent contre d'autres maladies.
Traitements 5
#1
Quels traitements sont disponibles pour les déficiences en N-terminal acetyltransferases ?
Les traitements peuvent inclure des thérapies enzymatiques et des approches diététiques.
#2
Les suppléments nutritionnels peuvent-ils aider ?
Oui, certains suppléments peuvent soutenir le métabolisme et compenser les déficiences.
#3
La thérapie génique est-elle une option ?
La thérapie génique est en recherche, mais elle pourrait offrir des solutions futures.
#4
Les médicaments peuvent-ils améliorer la fonction enzymatique ?
Certains médicaments expérimentaux visent à améliorer l'activité des enzymes déficientes.
#5
Y a-t-il des traitements symptomatiques disponibles ?
Oui, des traitements symptomatiques peuvent aider à gérer les manifestations cliniques.
Complications 5
#1
Quelles complications peuvent survenir avec ces déficiences ?
Des complications neurologiques, métaboliques et immunitaires peuvent se développer.
#2
Les complications sont-elles réversibles ?
Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes.
#3
Y a-t-il un risque accru de maladies associées ?
Oui, les déficiences peuvent augmenter le risque de maladies métaboliques et neurologiques.
#4
Les complications affectent-elles la qualité de vie ?
Oui, les complications peuvent significativement impacter la qualité de vie des patients.
#5
Des soins palliatifs sont-ils nécessaires ?
Dans les cas graves, des soins palliatifs peuvent être nécessaires pour améliorer le confort.
Facteurs de risque 5
#1
Quels sont les facteurs de risque pour ces déficiences ?
Les antécédents familiaux et certaines mutations génétiques sont des facteurs de risque clés.
#2
L'âge joue-t-il un rôle dans le risque ?
Oui, certains troubles se manifestent plus fréquemment chez les jeunes enfants.
#3
Les facteurs environnementaux influencent-ils le risque ?
Des facteurs environnementaux peuvent interagir avec des prédispositions génétiques.
#4
Les maladies auto-immunes sont-elles un facteur de risque ?
Certaines maladies auto-immunes peuvent augmenter le risque de dysfonction enzymatique.
#5
Le sexe a-t-il un impact sur le risque ?
Des études montrent que certains troubles peuvent affecter différemment les sexes.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 03/03/2025
Contenu vérifié selon les dernières recommandations médicales
Sous-catégories
6 au total
└─
N-terminal acetyltransferase A
N-Terminal Acetyltransferase AD063209 -
D08.811.913.050.134.423.100
└─
N-terminal acetyltransferase B
N-Terminal Acetyltransferase BD063210 -
D08.811.913.050.134.423.200
└─
N-terminal acetyltransferase C
N-Terminal Acetyltransferase CD063211 -
D08.811.913.050.134.423.300
└─
N-terminal acetyltransferase D
N-Terminal Acetyltransferase DD063212 -
D08.811.913.050.134.423.400
└─
N-terminal acetyltransferase E
N-Terminal Acetyltransferase ED063213 -
D08.811.913.050.134.423.500
└─
N-terminal acetyltransferase F
N-Terminal Acetyltransferase FD063214 -
D08.811.913.050.134.423.600
Auteurs principaux
Thomas Arnesen
11 publications dans cette catégorie
Affiliations :
- Department of Biological Sciences, University of Bergen, Bergen, Norway.
- Department of Biomedicine, University of Bergen, Bergen, Norway.
- Department of Surgery, Haukeland University Hospital, Bergen, Norway.
Publications dans "N-terminal acetyltransferases" :
-
Dynamics-function relationship in the catalytic domains of N-terminal acetyltransferases.
Computational and structural biotechnology journal 2020-03-03
-
Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80.
Frontiers in chemistry 2023-06-20
-
Using cell lysates to assess N-terminal acetyltransferase activity and impairment.
Methods in enzymology 2023-03-24
-
Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
The Journal of biological chemistry 2022-12-22
-
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.
Molecular cell 2019-03-13
Ronen Marmorstein
5 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Pennsylvania, Philadelphia, PA, United States; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Electronic address: marmor@upenn.edu.
Publications dans "N-terminal acetyltransferases" :
-
Biochemical and structural analysis of N-terminal acetyltransferases.
Methods in enzymology 2019-08-12
-
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.
Journal of medicinal chemistry 2021-06-10
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
bioRxiv : the preprint server for biology 2023-04-03
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
Sunbin Deng
4 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Publications dans "N-terminal acetyltransferases" :
-
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.
Journal of medicinal chemistry 2021-06-10
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
bioRxiv : the preprint server for biology 2023-04-03
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
Antonis Kirmizis
4 publications dans cette catégorie
Affiliations :
- Epigenetics and Gene Regulation Laboratory, Department of Biological Sciences, University of Cyprus, Nicosia 2109, Cyprus.
Publications dans "N-terminal acetyltransferases" :
-
Biochemical Characterisation of the Short Isoform of Histone N-Terminal Acetyltransferase NAA40.
Biomolecules 2024-09-02
-
N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours.
Cancers 2020-09-15
-
Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance.
Oncogene 2021-11-16
-
Yeast Nat4 regulates DNA damage checkpoint signaling through its N-terminal acetyltransferase activity on histone H4.
PLoS genetics 2024-10-02
Henriette Aksnes
4 publications dans cette catégorie
Affiliations :
- Department of Biomedicine, University of Bergen, Bergen, Norway. Electronic address: henriette.aksnes@uib.no.
Publications dans "N-terminal acetyltransferases" :
-
Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
The Journal of biological chemistry 2022-12-22
-
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.
Molecular cell 2019-03-13
-
Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae.
Nature communications 2023-07-27
-
Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly.
Genetics in medicine : official journal of the American College of Medical Genetics 2021-07-06
Owen A Collars
3 publications dans cette catégorie
Affiliations :
- Department of Biological Sciences, University of Notre Dame , Notre Dame, Indiana, USA.
- Eck Institute for Global Health, University of Note Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferases" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Daniel D Hu
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferases" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Simon D Weaver
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferases" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Matthew M Champion
3 publications dans cette catégorie
Affiliations :
- Eck Institute for Global Health, University of Note Dame , Notre Dame, Indiana, USA.
- Department of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferases" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Patricia A Champion
3 publications dans cette catégorie
Affiliations :
- Department of Biological Sciences, University of Notre Dame , Notre Dame, Indiana, USA.
- Eck Institute for Global Health, University of Note Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferases" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Jonas Weidenhausen
3 publications dans cette catégorie
Affiliations :
- Heidelberg University Biochemistry Center, 69120 Heidelberg, Germany.
Publications dans "N-terminal acetyltransferases" :
-
Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Structure (London, England : 1993) 2021-01-04
-
Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.
International journal of molecular sciences 2022-09-16
-
HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana.
Cell reports 2024-02-15
Markus Wirtz
3 publications dans cette catégorie
Affiliations :
- Centre for Organismal Studies, Heidelberg University, 69120 Heidelberg, Germany.
Publications dans "N-terminal acetyltransferases" :
-
Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Structure (London, England : 1993) 2021-01-04
-
Dual lysine and N-terminal acetyltransferases reveal the complexity underpinning protein acetylation.
Molecular systems biology
-
HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana.
Cell reports 2024-02-15
Irmgard Sinning
3 publications dans cette catégorie
Affiliations :
- Heidelberg University Biochemistry Center, 69120 Heidelberg, Germany. Electronic address: irmi.sinning@bzh.uni-heidelberg.de.
Publications dans "N-terminal acetyltransferases" :
-
Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Structure (London, England : 1993) 2021-01-04
-
Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.
International journal of molecular sciences 2022-09-16
-
HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana.
Cell reports 2024-02-15
Sarah M Gardner
3 publications dans cette catégorie
Affiliations :
- Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Publications dans "N-terminal acetyltransferases" :
-
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.
Journal of medicinal chemistry 2021-06-10
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
Costas Koufaris
3 publications dans cette catégorie
Affiliations :
- Epigenetics and Gene Regulation Laboratory, Department of Biological Sciences, University of Cyprus, Nicosia 2109, Cyprus.
- Cyprus Cancer Research Institute, Nicosia 2109, Cyprus.
Publications dans "N-terminal acetyltransferases" :
-
Biochemical Characterisation of the Short Isoform of Histone N-Terminal Acetyltransferase NAA40.
Biomolecules 2024-09-02
-
N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours.
Cancers 2020-09-15
-
Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance.
Oncogene 2021-11-16
Kris Gevaert
3 publications dans cette catégorie
Affiliations :
- VIB-UGent Center for Medical Biotechnology, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Publications dans "N-terminal acetyltransferases" :
-
Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
The Journal of biological chemistry 2022-12-22
-
N-Terminal Proteoforms in Human Disease.
Trends in biochemical sciences 2020-01-27
-
The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.
Journal of molecular biology 2021-12-09
Yan Li
3 publications dans cette catégorie
Affiliations :
- College of Life Sciences, Capital Normal University, Beijing, 100048, China.
Publications dans "N-terminal acetyltransferases" :
-
The N-terminal acetyltransferase Naa50 regulates tapetum degradation and pollen development in Arabidopsis.
Plant science : an international journal of experimental plant biology 2022-01-11
-
The N-Terminal Acetyltransferase Naa50 Regulates Arabidopsis Growth and Osmotic Stress Response.
Plant & cell physiology
-
N-Terminalized Ti
Small (Weinheim an der Bergstrasse, Germany) 2023-10-12
Rasmus Ree
3 publications dans cette catégorie
Affiliations :
- Department of Biomedicine, University of Bergen, 5020 Bergen, Norway.
Publications dans "N-terminal acetyltransferases" :
-
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.
Molecular cell 2019-03-13
-
Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae.
Nature communications 2023-07-27
-
Mechanism of actin N-terminal acetylation.
Science advances 2020-04-08
Buyan Pan
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Pennsylvania, 231 South 34(th) Street, Philadelphia, PA 19104, USA.
Publications dans "N-terminal acetyltransferases" :
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
bioRxiv : the preprint server for biology 2023-04-03
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
E James Petersson
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Pennsylvania, 231 South 34(th) Street, Philadelphia, PA 19104, USA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Publications dans "N-terminal acetyltransferases" :
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
bioRxiv : the preprint server for biology 2023-04-03
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
Sources (4557 au total)
Boys with overweight status lagged behind girls with overweight status in reading: evidence from mendelian randomization.
We investigated the relationship between childhood weight status and academic achievement across sexes and different school subjects in Norway.... We used data from the Norwegian Mother, Father and Child Cohort Study (MoBa), which includes genetic data (N = 13,648, 8-year-old children). We employed within-family mendelian randomization, using a ... Contrary to most previous findings, we observed that overweight status (including obesity) has more detrimental effects on reading achievement in boys than in girls; the test scores of boys with overw... Previous obesity prevention studies have mainly targeted girls, based on the assumption that the obesity penalty is greater for girls. Our findings highlight that particular attention to boys with ove...
Overweight grandsons and grandfathers' starvation exposure.
Much of the increase in the prevalence of overweight and obesity has been in developing countries with a history of famines and malnutrition. This paper is the first to examine overweight among adult ...
Homocysteine concentrations in overweight children and adolescents.
The aim of this study was to describe homocysteine concentrations in overweight and obese children and adolescents and relate them to blood pressure levels, renal function, and insulin resistance.... This is a cross-sectional and observational study with 64 overweight children and adolescents (mean age: 11.6±3.5 years) in outpatient follow-up. The following parameters were evaluated: body mass ind... The mean body mass index z-score was 2.9±1.1. The mean homocysteine concentrations were 8.6±2.2 μmol/L (10th and 90th percentiles: 6.6 and 11.2 μmol/L, respectively), with no difference when compared ... Homocysteine concentrations in overweight children and adolescents (mean 8.6±2.2 μmol/L) were not associated with body mass index z-score, blood pressure, renal function, and insulin resistance....
Cancers attributable to overweight and obesity in Italy.
Overweight and obesity are associated with multiple cancers. We quantified the burden of cancer attributable to overweight and obesity in Italy.... We estimated sex- and cancer site-specific population attributable fractions (PAFs) combining relative risks (from recent meta-analyses) with national obesity prevalence data (from a large sample surv... 3.6% of cancers in men and 4.0% in women in Italy were attributable to overweight and obesity, corresponding, respectively, to over 6900 and 7200 diagnoses in 2020. Attributable deaths were over 3600 ... The cancer burden associated with overweight and obesity in Italy is considerable, but smaller compared to other high income countries, likely because of the lower prevalence of overweight and obesity...
Impact of overweight and obesity in postmenopausal women.
This study aimed to investigate the association between overweight and obesity in postmenopausal women and different aspects related to health such as quality of life, physical activity, sleep quality... An observational cross-sectional study was carried out during 2021-2022 in Spain in postmenopausal women. Health-related quality of life was assessed using the 12-item short-form survey (SF-12). The P... A total of 395 postmenopausal women participated: 64.6% (... Obesity in postmenopausal women negatively affects perceived quality of life, sleep quality, physical activity, the development of cardiovascular problems and pelvic floor-related problems....
Gene-Environment Interplay in the Development of Overweight.
Overweight in youth is influenced by genes and environment. Gene-environment interaction (G×E) has been demonstrated in twin studies and recent developments in genetics allow for studying G×E using in... Latent class growth models of overweight were fitted using data from the TRacking Adolescents' Individual Lives Survey (n = 2720). A polygenic score for body mass index (BMI) was derived using summary... A three-class model of developmental pathways of overweight fitted the data best ("non-overweight", "adolescent-onset overweight", and "persistent overweight"). The polygenic score for BMI and socioec... Higher genetic predisposition increased the risk of developing overweight during adolescence and young adulthood and was associated with an earlier age at onset. We did not find that genetic predispos...
Calcium supplementation for people with overweight or obesity.
Obesity is a major health problem worldwide as it can lead to high blood pressure, heart disease, stroke, diabetes, and insulin resistance. The prevalence of overweight and obesity is increasing world... To assess the effects of calcium supplementation on weight loss in individuals living with overweight or obesity.... We searched CENTRAL, MEDLINE, Embase, LILACS (Latin American and Caribbean Health Science Information database), and two clinical trials registries. The date of the last search of all databases (excep... We included randomised controlled trials evaluating the effect of calcium in participants with overweight or obesity of any age or gender. We excluded studies in participants with absorption problems.... We used standard methodological procedures expected by Cochrane. Our primary outcomes were body weight, health-related quality of life, and adverse events. Our secondary outcomes were anthropometric m... We found 18 studies that evaluated the effect of calcium compared to placebo or control, with a total of 1873 randomised participants (950 participants in the calcium supplementation groups and 923 in... Calcium supplementation for eight weeks to 24 months may result in little to no difference in body weight in people with overweight or obesity. The current evidence is of low certainty, due to concern...
Fish Oil And/Or Probiotics Intervention in Overweight/Obese Pregnant Women and Overweight Risk in 24-Month-Old Children.
To evaluate whether a fish oil and/or probiotics intervention in pregnant women with overweight or obesity would influence the tendency of their 24-month-old children to become overweight and alter th... Women (n = 439) were double-blindly randomized into 4 intervention groups: fish oil+placebo, probiotics+placebo, probiotics+fish oil, and placebo+placebo (fish oil: 1.9 g docosahexaenoic acid and 0.22... Probiotics+placebo [weight-for-height% adj. Odds ratio (OR) = 0.36, 95% confidence interval (CI) = 0.14-0.95] and probiotics+fish oil [weight-for-age standard deviation score (SD-score) adj. OR = 0.22... The administration of probiotics solely and in combination with fish oil during pregnancy to women with overweight or obesity lowered the overweight odds of their 24-month-old children....
Inflammatory profile associated with insulin resistance in non-overweight versus overweight people living with HIV in Pune, Western India.
People living with HIV have greater diabetes (T2DM) than the general population despite lower prevalence of overweight/obesity. Both insulin resistance (IR), a T2DM precursor, and HIV are independentl... To study the association between inflammation and IR in non-overweight and overweight people living with HIV.... In a cohort of adult people living with HIV with undetectable viral load in Pune, India, we measured fasting insulin, glucose, and 9 inflammatory markers. IR was defined as HOMA-IR ≥2, and non-overwei... Of 288 participants, 66% (n = 189) were non-overweight. Among non-overweight, prevalence of IR was 34% (n = 65). Each doubling of MCP-1 and leptin was associated with IR on univariate analysis (preval... One in 3 non-overweight people living with HIV in India with controlled viremia have IR. Leptin was associated with IR among non-overweight people living with HIV and may provide insight into the path...