Tabletability and compactibility of
This study aimed to evaluate a material sparing method to predict tabletability and compactibility relationships. Seven...
N-terminal acetyltransferases : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une déficience en N-terminal acetyltransferases ?
Des tests génétiques et des analyses protéomiques peuvent identifier des anomalies.
#2
Quels tests sont utilisés pour évaluer l'activité des N-terminal acetyltransferases ?
Des tests enzymatiques mesurant l'acétylation des substrats spécifiques sont utilisés.
#3
Les biopsies sont-elles nécessaires pour le diagnostic ?
Pas toujours, mais elles peuvent être utiles pour des analyses plus approfondies.
#4
Quels marqueurs biologiques indiquent une activité anormale ?
Des niveaux anormaux de protéines acétylées peuvent indiquer une dysfonction enzymatique.
#5
Peut-on utiliser l'imagerie pour le diagnostic ?
L'imagerie n'est pas couramment utilisée pour diagnostiquer des troubles enzymatiques.
Symptômes 5
#1
Quels symptômes sont associés à une déficience en N-terminal acetyltransferases ?
Les symptômes peuvent inclure des troubles neurologiques et des anomalies métaboliques.
#2
Les symptômes varient-ils selon le type d'enzyme affectée ?
Oui, chaque enzyme a des substrats spécifiques, entraînant des symptômes variés.
#3
Y a-t-il des symptômes cutanés associés ?
Certaines déficiences peuvent provoquer des éruptions cutanées ou des anomalies dermatologiques.
#4
Les troubles cognitifs sont-ils liés à ces enzymes ?
Oui, des troubles cognitifs peuvent survenir en raison de l'impact sur le métabolisme neuronal.
#5
Les symptômes apparaissent-ils dès la naissance ?
Pas toujours, certains symptômes peuvent se développer plus tard dans l'enfance ou l'adolescence.
Prévention 5
#1
Peut-on prévenir les déficiences en N-terminal acetyltransferases ?
La prévention est difficile, mais un diagnostic précoce peut aider à gérer les symptômes.
#2
Les conseils génétiques sont-ils recommandés ?
Oui, les conseils génétiques peuvent être utiles pour les familles à risque.
#3
L'alimentation peut-elle jouer un rôle préventif ?
Une alimentation équilibrée peut soutenir la santé métabolique, mais ne prévient pas directement.
#4
Des dépistages réguliers sont-ils conseillés ?
Des dépistages peuvent être recommandés pour les individus à risque ou avec des antécédents familiaux.
#5
Les vaccinations peuvent-elles aider ?
Les vaccinations ne préviennent pas les déficiences enzymatiques, mais protègent contre d'autres maladies.
Traitements 5
#1
Quels traitements sont disponibles pour les déficiences en N-terminal acetyltransferases ?
Les traitements peuvent inclure des thérapies enzymatiques et des approches diététiques.
#2
Les suppléments nutritionnels peuvent-ils aider ?
Oui, certains suppléments peuvent soutenir le métabolisme et compenser les déficiences.
#3
La thérapie génique est-elle une option ?
La thérapie génique est en recherche, mais elle pourrait offrir des solutions futures.
#4
Les médicaments peuvent-ils améliorer la fonction enzymatique ?
Certains médicaments expérimentaux visent à améliorer l'activité des enzymes déficientes.
#5
Y a-t-il des traitements symptomatiques disponibles ?
Oui, des traitements symptomatiques peuvent aider à gérer les manifestations cliniques.
Complications 5
#1
Quelles complications peuvent survenir avec ces déficiences ?
Des complications neurologiques, métaboliques et immunitaires peuvent se développer.
#2
Les complications sont-elles réversibles ?
Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes.
#3
Y a-t-il un risque accru de maladies associées ?
Oui, les déficiences peuvent augmenter le risque de maladies métaboliques et neurologiques.
#4
Les complications affectent-elles la qualité de vie ?
Oui, les complications peuvent significativement impacter la qualité de vie des patients.
#5
Des soins palliatifs sont-ils nécessaires ?
Dans les cas graves, des soins palliatifs peuvent être nécessaires pour améliorer le confort.
Facteurs de risque 5
#1
Quels sont les facteurs de risque pour ces déficiences ?
Les antécédents familiaux et certaines mutations génétiques sont des facteurs de risque clés.
#2
L'âge joue-t-il un rôle dans le risque ?
Oui, certains troubles se manifestent plus fréquemment chez les jeunes enfants.
#3
Les facteurs environnementaux influencent-ils le risque ?
Des facteurs environnementaux peuvent interagir avec des prédispositions génétiques.
#4
Les maladies auto-immunes sont-elles un facteur de risque ?
Certaines maladies auto-immunes peuvent augmenter le risque de dysfonction enzymatique.
#5
Le sexe a-t-il un impact sur le risque ?
Des études montrent que certains troubles peuvent affecter différemment les sexes.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 03/03/2025
Contenu vérifié selon les dernières recommandations médicales
Sous-catégories
6 au total
└─
N-terminal acetyltransferase A
N-Terminal Acetyltransferase AD063209 -
D08.811.913.050.134.423.100
└─
N-terminal acetyltransferase B
N-Terminal Acetyltransferase BD063210 -
D08.811.913.050.134.423.200
└─
N-terminal acetyltransferase C
N-Terminal Acetyltransferase CD063211 -
D08.811.913.050.134.423.300
└─
N-terminal acetyltransferase D
N-Terminal Acetyltransferase DD063212 -
D08.811.913.050.134.423.400
└─
N-terminal acetyltransferase E
N-Terminal Acetyltransferase ED063213 -
D08.811.913.050.134.423.500
└─
N-terminal acetyltransferase F
N-Terminal Acetyltransferase FD063214 -
D08.811.913.050.134.423.600
Auteurs principaux
Thomas Arnesen
11 publications dans cette catégorie
Affiliations :
- Department of Biological Sciences, University of Bergen, Bergen, Norway.
- Department of Biomedicine, University of Bergen, Bergen, Norway.
- Department of Surgery, Haukeland University Hospital, Bergen, Norway.
Publications dans "N-terminal acetyltransferases" :
-
Dynamics-function relationship in the catalytic domains of N-terminal acetyltransferases.
Computational and structural biotechnology journal 2020-03-03
-
Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80.
Frontiers in chemistry 2023-06-20
-
Using cell lysates to assess N-terminal acetyltransferase activity and impairment.
Methods in enzymology 2023-03-24
-
Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
The Journal of biological chemistry 2022-12-22
-
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.
Molecular cell 2019-03-13
Ronen Marmorstein
5 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Pennsylvania, Philadelphia, PA, United States; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Electronic address: marmor@upenn.edu.
Publications dans "N-terminal acetyltransferases" :
-
Biochemical and structural analysis of N-terminal acetyltransferases.
Methods in enzymology 2019-08-12
-
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.
Journal of medicinal chemistry 2021-06-10
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
bioRxiv : the preprint server for biology 2023-04-03
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
Sunbin Deng
4 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Publications dans "N-terminal acetyltransferases" :
-
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.
Journal of medicinal chemistry 2021-06-10
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
bioRxiv : the preprint server for biology 2023-04-03
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
Antonis Kirmizis
4 publications dans cette catégorie
Affiliations :
- Epigenetics and Gene Regulation Laboratory, Department of Biological Sciences, University of Cyprus, Nicosia 2109, Cyprus.
Publications dans "N-terminal acetyltransferases" :
-
Biochemical Characterisation of the Short Isoform of Histone N-Terminal Acetyltransferase NAA40.
Biomolecules 2024-09-02
-
N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours.
Cancers 2020-09-15
-
Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance.
Oncogene 2021-11-16
-
Yeast Nat4 regulates DNA damage checkpoint signaling through its N-terminal acetyltransferase activity on histone H4.
PLoS genetics 2024-10-02
Henriette Aksnes
4 publications dans cette catégorie
Affiliations :
- Department of Biomedicine, University of Bergen, Bergen, Norway. Electronic address: henriette.aksnes@uib.no.
Publications dans "N-terminal acetyltransferases" :
-
Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
The Journal of biological chemistry 2022-12-22
-
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.
Molecular cell 2019-03-13
-
Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae.
Nature communications 2023-07-27
-
Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly.
Genetics in medicine : official journal of the American College of Medical Genetics 2021-07-06
Owen A Collars
3 publications dans cette catégorie
Affiliations :
- Department of Biological Sciences, University of Notre Dame , Notre Dame, Indiana, USA.
- Eck Institute for Global Health, University of Note Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferases" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Daniel D Hu
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferases" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Simon D Weaver
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferases" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Matthew M Champion
3 publications dans cette catégorie
Affiliations :
- Eck Institute for Global Health, University of Note Dame , Notre Dame, Indiana, USA.
- Department of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferases" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Patricia A Champion
3 publications dans cette catégorie
Affiliations :
- Department of Biological Sciences, University of Notre Dame , Notre Dame, Indiana, USA.
- Eck Institute for Global Health, University of Note Dame , Notre Dame, Indiana, USA.
Publications dans "N-terminal acetyltransferases" :
-
An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in
mBio 2023-09-29
-
An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum.
bioRxiv : the preprint server for biology 2023-03-14
-
N-terminal proteomics of
Microbiology resource announcements 2024-03-13
Jonas Weidenhausen
3 publications dans cette catégorie
Affiliations :
- Heidelberg University Biochemistry Center, 69120 Heidelberg, Germany.
Publications dans "N-terminal acetyltransferases" :
-
Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Structure (London, England : 1993) 2021-01-04
-
Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.
International journal of molecular sciences 2022-09-16
-
HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana.
Cell reports 2024-02-15
Markus Wirtz
3 publications dans cette catégorie
Affiliations :
- Centre for Organismal Studies, Heidelberg University, 69120 Heidelberg, Germany.
Publications dans "N-terminal acetyltransferases" :
-
Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Structure (London, England : 1993) 2021-01-04
-
Dual lysine and N-terminal acetyltransferases reveal the complexity underpinning protein acetylation.
Molecular systems biology
-
HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana.
Cell reports 2024-02-15
Irmgard Sinning
3 publications dans cette catégorie
Affiliations :
- Heidelberg University Biochemistry Center, 69120 Heidelberg, Germany. Electronic address: irmi.sinning@bzh.uni-heidelberg.de.
Publications dans "N-terminal acetyltransferases" :
-
Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Structure (London, England : 1993) 2021-01-04
-
Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.
International journal of molecular sciences 2022-09-16
-
HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana.
Cell reports 2024-02-15
Sarah M Gardner
3 publications dans cette catégorie
Affiliations :
- Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Publications dans "N-terminal acetyltransferases" :
-
Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.
Journal of medicinal chemistry 2021-06-10
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
Costas Koufaris
3 publications dans cette catégorie
Affiliations :
- Epigenetics and Gene Regulation Laboratory, Department of Biological Sciences, University of Cyprus, Nicosia 2109, Cyprus.
- Cyprus Cancer Research Institute, Nicosia 2109, Cyprus.
Publications dans "N-terminal acetyltransferases" :
-
Biochemical Characterisation of the Short Isoform of Histone N-Terminal Acetyltransferase NAA40.
Biomolecules 2024-09-02
-
N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours.
Cancers 2020-09-15
-
Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance.
Oncogene 2021-11-16
Kris Gevaert
3 publications dans cette catégorie
Affiliations :
- VIB-UGent Center for Medical Biotechnology, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Publications dans "N-terminal acetyltransferases" :
-
Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC.
The Journal of biological chemistry 2022-12-22
-
N-Terminal Proteoforms in Human Disease.
Trends in biochemical sciences 2020-01-27
-
The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.
Journal of molecular biology 2021-12-09
Yan Li
3 publications dans cette catégorie
Affiliations :
- College of Life Sciences, Capital Normal University, Beijing, 100048, China.
Publications dans "N-terminal acetyltransferases" :
-
The N-terminal acetyltransferase Naa50 regulates tapetum degradation and pollen development in Arabidopsis.
Plant science : an international journal of experimental plant biology 2022-01-11
-
The N-Terminal Acetyltransferase Naa50 Regulates Arabidopsis Growth and Osmotic Stress Response.
Plant & cell physiology
-
N-Terminalized Ti
Small (Weinheim an der Bergstrasse, Germany) 2023-10-12
Rasmus Ree
3 publications dans cette catégorie
Affiliations :
- Department of Biomedicine, University of Bergen, 5020 Bergen, Norway.
Publications dans "N-terminal acetyltransferases" :
-
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.
Molecular cell 2019-03-13
-
Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae.
Nature communications 2023-07-27
-
Mechanism of actin N-terminal acetylation.
Science advances 2020-04-08
Buyan Pan
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Pennsylvania, 231 South 34(th) Street, Philadelphia, PA 19104, USA.
Publications dans "N-terminal acetyltransferases" :
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
bioRxiv : the preprint server for biology 2023-04-03
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
E James Petersson
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Pennsylvania, 231 South 34(th) Street, Philadelphia, PA 19104, USA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Publications dans "N-terminal acetyltransferases" :
-
Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure (London, England : 1993) 2023-01-12
-
Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.
bioRxiv : the preprint server for biology 2023-04-03
-
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.
Journal of the American Chemical Society 2023-06-15
Sources (1851 au total)
Effect of tableting temperature on tablet properties and dissolution behavior of heat sensitive formulations.
The tableting process involves the conversion of mechanical to thermal energy. This study evaluated the influence of temperature on the tableting behavior of formulations with different compositions. ...
Single-tablet-scale direct-compression: An on-demand manufacturing route for personalized tablets.
Today's pharmaceutical industry is facing various challenges. Two of them are issues with supply chain security and the increasing demand for personalized medicine. Both can be addressed by increasing...
Enhancing tabletability of high-dose tablets by tailoring properties of spray-dried insulin particles.
The oral delivery of proteins and peptides provides an attractive dosing option due to its high patient compliance. However, as oral formulations of such macromolecules require the addition of typical...
Pharmacokinetics and Bioequivalence of Mirogabalin Orally Disintegrating Tablets and Conventional Tablets in Healthy Japanese Participants.
This single-center, randomized, open-label, single-dose, 2-group, 2-stage crossover trial evaluated the bioequivalence of 15 mg of mirogabalin as orally disintegrating tablets (ODTs) with conventional...
Finite Element Modeling of Powder Compaction: Mini-Tablets in Comparison with Conventionally Sized Tablets.
Mini-tablets are considered a promising solid dosage form in the pharmaceutical industry due to advantages such as dosing accuracy, efficiency as a drug delivery system, and alleged improvement in mec... In this paper, the influence of powder properties and process parameters, such as punch shape and size, on the evolution of mechanical properties during the tableting process and the potential occurre... The numerical simulation cases consist of four different die sizes, mini-tablets of 2 mm, and 3 mm, and conventionally sized tablets of 8 mm and 11.28 mm. Each tablet size is simulated using four dist... The model predictions in terms of stress and density distribution at different stages of the compaction process indicate similar behavior in terms of density and stress distribution profiles between t... Based on tablet size, small localized differences are noted (e.g., low-density regions, high shear bands, and heterogeneous density profiles), suggesting a possible risk of tableting defects for conve...
On the complexity of predicting tablet capping.
Predicting tablet defects, such as capping, that might occur during manufacturing, is a challenge in the pharmaceutical industry. In the literature, different parameters were presented to predict capp...
The ubiquity of the tabletability flip phenomenon.
The plasticity of materials plays a critical role in adequate powder tabletability, which is required in developing a successful tablet product. Generally, a more plastic material can develop larger b...
EVG/COBI/FTC/TAF Bioequivalence Comparing Whole Tablets with Tablets Dissolved in Tap Water.
Medication adherence can be challenging for persons with difficulty swallowing tablets. We investigated the bioequivalence of a dissolved tablet when compared with that of a whole tablet of the fixed-...
Evaluation of the effect of granule size of raw tableting materials on critical quality attributes of tablets during the continuous tablet manufacturing process using near-infrared spectroscopy.
The effects of granule size of raw materials on tablet hardness (TH) and weight (TW) in the continuous tablet manufacturing process (CTMP) were investigated using near-infrared spectroscopy (NIRS).... Granule materials of different sizes were prepared by extrusion granulation from a standard granule formula powder containing lactose/starch and 4.5% acetaminophen. Large-, small-, and medium-sized gr... The best fitted calibration models for predicting TH and TW were obtained, with sufficient accuracy, based on NIRS using the partial least squares regression, and comprised both physical and chemical ... The changes in the predicted value profiles of TH and TW using NIRS reflected the changes in the measured values depending on the raw granule size during CTMP....