Regenerative potential of prostate luminal cells revealed by single-cell analysis.
Androgen Antagonists
/ therapeutic use
Androgen-Binding Protein
/ genetics
Androgens
/ metabolism
Animals
Antigens, Neoplasm
/ genetics
Ataxin-1
/ genetics
Cell Differentiation
/ genetics
GPI-Linked Proteins
/ genetics
Gene Expression
Homeodomain Proteins
/ genetics
Humans
Male
Mesenchymal Stem Cells
/ physiology
Mice
Neoplasm Proteins
/ genetics
Nerve Growth Factors
/ genetics
Organ Size
Organoids
/ metabolism
Prostate
/ metabolism
Prostatic Neoplasms
/ drug therapy
Regeneration
/ genetics
Sequence Analysis, RNA
Single-Cell Analysis
Thrombospondins
/ genetics
Transcription Factors
/ genetics
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
01 05 2020
01 05 2020
Historique:
received:
15
05
2019
accepted:
14
03
2020
entrez:
2
5
2020
pubmed:
2
5
2020
medline:
19
5
2020
Statut:
ppublish
Résumé
Androgen deprivation is the cornerstone of prostate cancer treatment. It results in involution of the normal gland to ~90% of its original size because of the loss of luminal cells. The prostate regenerates when androgen is restored, a process postulated to involve stem cells. Using single-cell RNA sequencing, we identified a rare luminal population in the mouse prostate that expresses stemlike genes (
Identifiants
pubmed: 32355025
pii: 368/6490/497
doi: 10.1126/science.aay0267
pmc: PMC7313621
mid: NIHMS1597849
doi:
Substances chimiques
Androgen Antagonists
0
Androgen-Binding Protein
0
Androgens
0
Antigens, Neoplasm
0
Ataxin-1
0
Atxn1 protein, mouse
0
GPI-Linked Proteins
0
Homeodomain Proteins
0
Neoplasm Proteins
0
Nerve Growth Factors
0
Nkx3-1 protein, mouse
0
Nrg2 protein, mouse
0
Psca protein, mouse
0
R-spondin3 protein, mouse
0
Thrombospondins
0
Transcription Factors
0
probasin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
497-505Subventions
Organisme : NCI NIH HHS
ID : U24 CA180922
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA193837
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA155169
Pays : United States
Organisme : NCI NIH HHS
ID : R33 CA202820
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA224079
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA182503
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014051
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA092629
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Références
Am J Surg Pathol. 1988 Aug;12(8):619-33
pubmed: 2456702
Cancer Cell. 2010 Jul 13;18(1):11-22
pubmed: 20579941
Cell. 2010 Oct 1;143(1):134-44
pubmed: 20887898
PLoS One. 2009;4(2):e4471
pubmed: 19214237
Nat Commun. 2017 Jan 23;8:14284
pubmed: 28112153
Nat Biotechnol. 2019 Dec;37(12):1482-1492
pubmed: 31796933
Nature. 2011 Oct 09;479(7372):189-93
pubmed: 21983963
Nature. 2018 Aug;560(7718):377-381
pubmed: 30069046
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20882-7
pubmed: 19088204
Stem Cells. 2016 Jan;34(1):191-202
pubmed: 26418304
Prostate. 1987;11(4):339-51
pubmed: 3684785
iScience. 2019 Mar 29;13:328-338
pubmed: 30878879
Cancer Cell. 2012 Feb 14;21(2):253-65
pubmed: 22340597
Nat Commun. 2015 Jul 22;6:7866
pubmed: 26198319
Cell Stem Cell. 2009 Jun 5;4(6):525-34
pubmed: 19497281
Stem Cells. 2013 Nov;31(11):2492-505
pubmed: 23897697
Nature. 2009 Sep 24;461(7263):495-500
pubmed: 19741607
Annu Rev Biochem. 2018 Jun 20;87:1015-1027
pubmed: 29494240
Mol Endocrinol. 2011 Nov;25(11):1849-57
pubmed: 21940754
Nat Cell Biol. 2012 Nov;14(11):1131-8
pubmed: 23064263
Cell. 2016 Aug 25;166(5):1132-1146.e7
pubmed: 27565343
Prostate. 1987;11(3):229-42
pubmed: 3684783
J Exp Zool. 1978 Aug;205(2):181-93
pubmed: 681909
Cell Rep. 2014 Aug 21;8(4):933-9
pubmed: 25131204
Cell Rep. 2018 Dec 18;25(12):3530-3542.e5
pubmed: 30566875
Dev Biol. 2003 Sep 1;261(1):39-54
pubmed: 12941620
Dev Biol. 2003 Jan 15;253(2):165-74
pubmed: 12645922
Am J Pathol. 2001 Mar;158(3):809-16
pubmed: 11238029
Science. 2016 Apr 8;352(6282):189-96
pubmed: 27124452
EMBO J. 2006 Sep 6;25(17):4131-41
pubmed: 16932748
Am J Respir Cell Mol Biol. 2001 Jun;24(6):671-81
pubmed: 11415931
Prostate. 1989;15(3):233-50
pubmed: 2555799
Dev Dyn. 2011 Nov;240(11):2548-60
pubmed: 21936019
Nature. 2018 Aug;560(7718):319-324
pubmed: 30069044
Nat Cell Biol. 2013 Mar;15(3):274-83
pubmed: 23434823