Genome Mining-Based Discovery of Fungal Macrolides Modified by glycosylphosphatidylinositol (GPI)-Ethanolamine Phosphate Transferase Homologues.

Aspergillus / chemistry Colletotrichum / chemistry Ethanolamines / chemistry Fungal Proteins / chemistry Glycosylphosphatidylinositols / biosynthesis Macrolides / chemistry Molecular Structure Multigene Family Protein Biosynthesis

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
07 08 2020
Historique:
pubmed: 15 7 2020
medline: 4 8 2021
entrez: 15 7 2020
Statut: ppublish

Résumé

Through genome mining for fungal macrolide natural products, we discovered a characteristic family of putative macrolide biosynthetic gene clusters that contain a glycosylphosphatidylinositol-ethanolamine phosphate transferase (GPI-EPT) homologue. Through the heterologous expression of two clusters from

Identifiants

DOI: 10.1021/acs.orglett.0c01975 PMID: 32663020
pubmed: 32663020
doi: 10.1021/acs.orglett.0c01975
doi:

Substances chimiques

Ethanolamines 0
Fungal Proteins 0
Glycosylphosphatidylinositols 0
Macrolides 0
phosphorylethanolamine 78A2BX7AEU

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5876-5879

Auteurs

Yohei Morishita (Y)

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

Yu Aoki (Y)

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.

Mei Ito (M)

Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan.

Daisuke Hagiwara (D)

Department of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
Microbiology Research Center for Sustainability (MiCS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.

Kensho Torimaru (K)

Department of Microbiology, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Daichi Morita (D)

Department of Microbiology, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Teruo Kuroda (T)

Department of Microbiology, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Hanako Fukano (H)

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aobacho, Higashimurayama-shi, Tokyo 189-0002, Japan.

Yoshihiko Hoshino (Y)

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aobacho, Higashimurayama-shi, Tokyo 189-0002, Japan.

Masato Suzuki (M)

Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, 4-2-1 Aobacho, Higashimurayama-shi, Tokyo 189-0002, Japan.

Tohru Taniguchi (T)

Frontier Research Center for Advanced Material and Life Science, Faculty of Advanced Life Science, Hokkaido University, Kita 21 Nishi 11, Sapporo 001-0021, Japan.
ORCID: 0000-0002-4965-7383

Keiji Mori (K)

Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan.
ORCID: 0000-0002-9878-993X

Teigo Asai (T)

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.
Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
ORCID: 0000-0002-8903-392X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Aspergillus › Genome Mining-Based Discovery of Fungal...
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Colletotrichum › Genome Mining-Based Discovery of Fungal...
questionsmedicales.fr › Composés chimiques organiques › Amines › Aminoalcools › Éthanolamines › Genome Mining-Based Discovery of Fungal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Genome Mining-Based Discovery of Fungal...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidyl inositols › Glycosylphosphatidylinositols › Genome Mining-Based Discovery of Fungal...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Macrolides › Genome Mining-Based Discovery of Fungal...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Genome Mining-Based Discovery of Fungal...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Famille multigénique › Genome Mining-Based Discovery of Fungal...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Biosynthèse des protéines › Genome Mining-Based Discovery of Fungal...