Comprehensive chemotaxonomic and genomic profiling of a biosynthetically talented Australian fungus, Aspergillus burnettii sp. nov.

Aspergillus / classification Biosynthetic Pathways / genetics Classification Genomics Multigene Family / genetics Peptide Synthases / genetics Phylogeny Polyketide Synthases / genetics Sequence Analysis, DNA
Aspergillus Biosynthetic gene cluster analysis Carbohydrate active enzymes Chemotaxonomy Molecular phylogeny Secondary metabolites

Journal

Fungal genetics and biology : FG & B
ISSN: 1096-0937
Titre abrégé: Fungal Genet Biol
Pays: United States
ID NLM: 9607601

Informations de publication

Date de publication:
10 2020
Historique:
received: 07 06 2020
revised: 14 07 2020
accepted: 15 07 2020
pubmed: 24 7 2020
medline: 17 8 2021
entrez: 24 7 2020
Statut: ppublish

Résumé

Aspergillus burnettii is a new species belonging to the A. alliaceus clade in Aspergillus subgenus Circumdati section Flavi isolated from peanut-growing properties in southern Queensland, Australia. A. burnettii is a fast-growing, floccose fungus with distinctive brown conidia and is a talented producer of biomass-degrading enzymes and secondary metabolites. Chemical profiling of A. burnettii revealed the metabolites ochratoxin A, kotanins, isokotanins, asperlicin E, anominine and paspalinine, which are common to subgenus Circumdati, together with burnettiene A, burnettramic acids, burnettides, and high levels of 14α-hydroxypaspalinine and hirsutide. The genome of A. burnettii was sequenced and an annotated draft genome is presented. A. burnettii is rich in secondary metabolite biosynthetic gene clusters, containing 51 polyketide synthases, 28 non-ribosomal peptide synthetases and 19 genes related to terpene biosynthesis. Functional annotation of digestive enzymes of A. burnettii and A. alliaceus revealed overlapping carbon utilisation profiles, consistent with a close phylogenetic relationship.

Identifiants

DOI: 10.1016/j.fgb.2020.103435 PMID: 32702474
pubmed: 32702474
pii: S1087-1845(20)30126-2
doi: 10.1016/j.fgb.2020.103435
pii:
doi:

Substances chimiques

Polyketide Synthases 79956-01-7
Peptide Synthases EC 6.3.2.-
non-ribosomal peptide synthase EC 6.3.2.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103435

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Cameron L M Gilchrist (CLM)

School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.

Heather J Lacey (HJ)

Microbial Screening Technologies, Smithfield, NSW 2164, Australia.

Daniel Vuong (D)

Microbial Screening Technologies, Smithfield, NSW 2164, Australia.

John I Pitt (JI)

Microbial Screening Technologies, Smithfield, NSW 2164, Australia.

Lene Lange (L)

Center for Bioprocess Engineering, Department of Chemical and Biochemical Engineering, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark; BioEconomy, Research & Advisory, Karensgade 5, 2500 Valby, Copenhagen, Denmark.

Ernest Lacey (E)

Microbial Screening Technologies, Smithfield, NSW 2164, Australia; Department of Molecular Sciences, Macquarie University, NSW 2109, Australia.

Bo Pilgaard (B)

Center for Bioprocess Engineering, Department of Chemical and Biochemical Engineering, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.

Yit-Heng Chooi (YH)

School of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia. Electronic address: yitheng.chooi@uwa.edu.au.

Andrew M Piggott (AM)

Department of Molecular Sciences, Macquarie University, NSW 2109, Australia. Electronic address: andrew.piggott@mq.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Aspergillus › Comprehensive chemotaxonomic and genomic...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Voies de biosynthèse › Comprehensive chemotaxonomic and genomic...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Classification › Comprehensive chemotaxonomic and genomic...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Comprehensive chemotaxonomic and genomic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Famille multigénique › Comprehensive chemotaxonomic and genomic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-nitrogen ligases › Amino-acid ligases › Comprehensive chemotaxonomic and genomic...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Comprehensive chemotaxonomic and genomic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Polyketide synthases › Comprehensive chemotaxonomic and genomic...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Comprehensive chemotaxonomic and genomic...