Analysis of a plasmid encoding botulinum neurotoxin type G gene in Clostridium argentinense.
Anaerobe
Botulinum neurotoxin type G
Botulism
Clostridium argentinense
Plasmid
Journal
Anaerobe
ISSN: 1095-8274
Titre abrégé: Anaerobe
Pays: England
ID NLM: 9505216
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
06
08
2020
revised:
17
09
2020
accepted:
01
10
2020
pubmed:
16
10
2020
medline:
14
8
2021
entrez:
15
10
2020
Statut:
ppublish
Résumé
Clostridium argentinense produces botulinum neurotoxin type G (BoNT/G). We sequenced and analyzed the plasmid harboring the bont/G gene, designated pCAG, in C. argentinense strain 2740. The pCAG consisted of 140,070 bp containing the bont/G gene cluster. Although this gene cluster showed high similarities in its DNA sequence and ORF arrangement to those of other bont gene clusters, the other regions of the plasmid did not. A phylogenetic study suggested that pCAG had a unique evolutionary history compared with other clostridial bont-harboring plasmids. This suggests that pCAG is possibly a novel type of plasmid expressing the bont/G gene in C. argentinense.
Identifiants
pubmed: 33059044
pii: S1075-9964(20)30137-2
doi: 10.1016/j.anaerobe.2020.102281
pii:
doi:
Substances chimiques
DNA, Bacterial
0
RNA, Ribosomal, 16S
0
botulinum toxin type G
2C3DD06QGJ
Botulinum Toxins
EC 3.4.24.69
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102281Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no conflicts of interest relevant to this article.