Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
16 02 2021
16 02 2021
Historique:
received:
30
06
2020
accepted:
26
10
2020
revised:
13
10
2020
entrez:
16
2
2021
pubmed:
17
2
2021
medline:
29
6
2021
Statut:
epublish
Résumé
Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism. Pancreatic catecholamine signaling has also been increasingly implicated as a mechanism responsible for the metabolic disturbances produced by antipsychotic drugs (APDs). Critically, however, the mechanisms by which catecholamines modulate pancreatic hormone release are not completely understood. We show that human and mouse pancreatic α- and β-cells express the catecholamine biosynthetic and signaling machinery, and that α-cells synthesize DA de novo. This locally-produced pancreatic DA signals via both α- and β-cell adrenergic and dopaminergic receptors with different affinities to regulate glucagon and insulin release. Significantly, we show DA functions as a biased agonist at α
Identifiants
pubmed: 33589583
doi: 10.1038/s41398-020-01171-z
pii: 10.1038/s41398-020-01171-z
pmc: PMC7884786
doi:
Substances chimiques
Adrenergic Agents
0
Insulin
0
Glucagon
9007-92-5
Dopamine
VTD58H1Z2X
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
59Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK097160
Pays : United States
Organisme : U.S. Department of Defense (United States Department of Defense)
ID : PR141292
Organisme : NIA NIH HHS
ID : R21 AG068607
Pays : United States
Organisme : NIDA NIH HHS
ID : K08 DA031241
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : R01DK097160
Organisme : U.S. Department of Veterans Affairs (Department of Veterans Affairs)
ID : I01BX002678
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