Sequence-dependent nucleosome formation in trinucleotide repeats evaluated by in vivo chemical mapping.

Base Sequence / genetics Chromosomes, Fungal / chemistry DNA / chemistry Histones / metabolism Nucleosomes / chemistry Saccharomyces cerevisiae / genetics Trinucleotide Repeats / genetics
Chromatin Nucleosome formation Site-directed chemical mapping Trinucleotide repeat sequences Yeast

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
04 06 2021
Historique:
received: 21 03 2021
accepted: 28 03 2021
pubmed: 12 4 2021
medline: 21 7 2021
entrez: 11 4 2021
Statut: ppublish

Résumé

Trinucleotide repeat sequences (TRSs), consisting of 10 unique classes of repeats in DNA, are members of microsatellites and abundantly and non-randomly distributed in many eukaryotic genomes. The lengths of TRSs are mutable, and the expansions of several TRSs are implicated in hereditary neurological diseases. However, the underlying causes of the biased distribution and the dynamic properties of TRSs in the genome remain elusive. Here, we examined the effects of TRSs on nucleosome formation in vivo by histone H4-S47C site-directed chemical cleavages, using well-defined yeast minichromosomes in which each of the ten TRS classes resided in the central region of a positioned nucleosome. We showed that (AAT)

Identifiants

DOI: 10.1016/j.bbrc.2021.03.155 PMID: 33839413
pubmed: 33839413
pii: S0006-291X(21)00568-4
doi: 10.1016/j.bbrc.2021.03.155
pii:
doi:

Substances chimiques

Histones 0
Nucleosomes 0
DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

179-184

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Koji Katsumata (K)

Department of Chemistry, Graduate School of Science and Engineering, Meisei University, 2-1-1 Hodokubo, Hino, Tokyo, 191-8506, Japan.

Yuichi Ichikawa (Y)

Division of Cancer Biology, The Cancer Institute of JFCR, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Tomohiro Fuse (T)

Department of Chemistry, Graduate School of Science and Engineering, Meisei University, 2-1-1 Hodokubo, Hino, Tokyo, 191-8506, Japan.

Hitoshi Kurumizaka (H)

Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.

Akio Yanagida (A)

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.

Takeshi Urano (T)

Department of Biochemistry, Shimane University School of Medicine, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.

Hiroaki Kato (H)

Department of Biochemistry, Shimane University School of Medicine, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.

Mitsuhiro Shimizu (M)

Department of Chemistry, Graduate School of Science and Engineering, Meisei University, 2-1-1 Hodokubo, Hino, Tokyo, 191-8506, Japan. Electronic address: shimizum@chem.meisei-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence nucléotidique › Sequence-dependent nucleosome formation in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes de champignon › Sequence-dependent nucleosome formation in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Sequence-dependent nucleosome formation in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Sequence-dependent nucleosome formation in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Nucléosomes › Sequence-dependent nucleosome formation in...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Sequence-dependent nucleosome formation in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées en tandem › Répétitions microsatellites › Répétitions de trinucléotides › Sequence-dependent nucleosome formation in...