A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness.
Adult
Animals
Cell Self Renewal
/ genetics
Cells, Cultured
Epigenesis, Genetic
/ immunology
Female
Fetal Blood
/ cytology
Flow Cytometry
Gene Knockdown Techniques
Hematopoiesis
Hematopoietic Stem Cell Transplantation
/ adverse effects
Hematopoietic Stem Cells
/ physiology
Humans
Immune Reconstitution
Immunomagnetic Separation
Infant, Newborn
Intracellular Signaling Peptides and Proteins
/ genetics
Male
Mice
Middle Aged
Multipotent Stem Cells
/ physiology
Nectins
/ metabolism
Primary Cell Culture
RNA-Seq
Single-Cell Analysis
Sirtuin 1
/ metabolism
Stress, Physiological
/ genetics
Transplantation, Heterologous
p21-Activated Kinases
/ genetics
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
05
10
2020
accepted:
25
03
2021
pubmed:
8
5
2021
medline:
22
7
2021
entrez:
7
5
2021
Statut:
ppublish
Résumé
Continuous supply of immune cells throughout life relies on the delicate balance in the hematopoietic stem cell (HSC) pool between long-term maintenance and meeting the demands of both normal blood production and unexpected stress conditions. Here we identified distinct subsets of human long-term (LT)-HSCs that responded differently to regeneration-mediated stress: an immune checkpoint ligand CD112
Identifiants
pubmed: 33958784
doi: 10.1038/s41590-021-00925-1
pii: 10.1038/s41590-021-00925-1
doi:
Substances chimiques
Inka1 protein, human
0
Intracellular Signaling Peptides and Proteins
0
Nectins
0
PAK4 protein, human
EC 2.7.1.11
p21-Activated Kinases
EC 2.7.11.1
SIRT1 protein, human
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
723-734Subventions
Organisme : CIHR
ID : 154293
Pays : Canada
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