Construction of a Fusellovirus with a Minimal Set of Genes.

Frameshift Mutation Fuselloviridae / genetics Genes, Viral Open Reading Frames Sequence Deletion Synthetic Biology / methods Viral Genome Packaging Viral Structural Proteins / genetics Virulence / genetics
fusellovirus genetic manipulation minimum genome mutation packaging capacity

Journal

ACS synthetic biology
ISSN: 2161-5063
Titre abrégé: ACS Synth Biol
Pays: United States
ID NLM: 101575075

Informations de publication

Date de publication:
15 10 2021
Historique:
pubmed: 21 9 2021
medline: 3 3 2022
entrez: 20 9 2021
Statut: ppublish

Résumé

A large number of fuselloviruses have been found in acidic hot springs around the globe. They share a set of highly conserved genes (core genes) and possess a varying number of less-conserved genes (non-core genes). However, the functions of most of these genes are unknown. Recent studies show that as many as half of these genes tolerate mutation. In this study, we conducted a genetic analysis on

Identifiants

DOI: 10.1021/acssynbio.1c00232 PMID: 34543007
pubmed: 34543007
doi: 10.1021/acssynbio.1c00232
doi:

Substances chimiques

Viral Structural Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2617-2627

Auteurs

Junxia Zhang (J)

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
ORCID: 0000-0001-7904-0192

Li Huang (L)

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
ORCID: 0000-0003-2421-8162

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation avec décalage du cadre de lecture › Construction of a Fusellovirus with a Minimal...
questionsmedicales.fr › Virus › Virus à ADN › Fuselloviridae › Construction of a Fusellovirus with a Minimal...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome viral › Gènes viraux › Construction of a Fusellovirus with a Minimal...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Cadres ouverts de lecture › Construction of a Fusellovirus with a Minimal...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Construction of a Fusellovirus with a Minimal...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Biologie synthétique › Construction of a Fusellovirus with a Minimal...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Assemblage viral › Encapsidation du génome viral › Construction of a Fusellovirus with a Minimal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Construction of a Fusellovirus with a Minimal...
questionsmedicales.fr › Phénomènes microbiologiques › Virulence › Construction of a Fusellovirus with a Minimal...