Advances in the microbial synthesis of the neurotransmitter serotonin.
5-hydroxytryptophan
Aromatic-L-amino-acid decarboxylase
Cofactor
L-tryptophan hydroxylase
Microbial biosynthesis
Serotonin
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
12
03
2023
accepted:
10
05
2023
revised:
05
05
2023
medline:
17
7
2023
pubmed:
16
6
2023
entrez:
16
6
2023
Statut:
ppublish
Résumé
Serotonin, as a monoamine neurotransmitter, modulates the activity of the nervous system. Due to its importance in the coordination of movement and regulation of mood, impairments in the synthesis and homeostasis of serotonin are involved in numerous disorders, including depression, Parkinson's disease, and anxiety. Currently, serotonin is primarily obtained via natural extraction. But this method is time-consuming and low yield, as well as unstable supply of raw materials. With the development of synthetic biology, researchers have established the method of microbial synthesis of serotonin. Compared with natural extraction, microbial synthesis has the advantages of short production cycle, continuous production, not limited by season and source, and environment-friendly; hence, it has garnered considerable research attention. However, the yield of serotonin is still too low to industrialization. Therefore, this review provides the latest progress and examples that illustrate the synthesis pathways of serotonin as well as proposes strategies for increasing the production of serotonin. KEY POINTS: • Two biosynthesis pathways of serotonin are introduced. • L-tryptophan hydroxylation is the rate-limiting step in serotonin biosynthesis. • Effective strategies are proposed to improve serotonin production.
Identifiants
pubmed: 37326681
doi: 10.1007/s00253-023-12584-3
pii: 10.1007/s00253-023-12584-3
doi:
Substances chimiques
Serotonin
333DO1RDJY
Tryptophan Hydroxylase
EC 1.14.16.4
Tryptophan
8DUH1N11BX
Neurotransmitter Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4717-4725Subventions
Organisme : the National Key Research and Development Program
ID : 2021YFA0911400
Organisme : the National Nature Science Foundation for Young Scientists of China
ID : 21908101
Organisme : the China Postdoctoral Science Foundation
ID : 2022M710069
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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