Structure-Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT

Serotonin Receptor, Serotonin, 5-HT2A Molecular Docking Simulation Hallucinogens / pharmacology Phenethylamines / pharmacology Serotonin 5-HT2 Receptor Agonists / pharmacology
5-HT2A biased agonism in vitro pharmacology miniGαq psychedelics β-arrestin

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
02 08 2023
Historique:
medline: 3 8 2023
pubmed: 21 7 2023
entrez: 20 7 2023
Statut: ppublish

Résumé

Serotonergic psychedelics are described to have activation of the serotonin 2A receptor (5-HT

Identifiants

DOI: 10.1021/acschemneuro.3c00267 PMID: 37474114 PMC: PMC10401645
pubmed: 37474114
doi: 10.1021/acschemneuro.3c00267
pmc: PMC10401645
doi:

Substances chimiques

Serotonin 333DO1RDJY
Receptor, Serotonin, 5-HT2A 0
Hallucinogens 0
Phenethylamines 0
Serotonin 5-HT2 Receptor Agonists 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2727-2742

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Auteurs

Eline Pottie (E)

Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

Christian B M Poulie (CBM)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
ORCID: 0000-0003-2662-9803

Icaro A Simon (IA)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
ORCID: 0000-0003-4550-4248

Kasper Harpsøe (K)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
ORCID: 0000-0002-9326-9644

Laura D'Andrea (L)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

Igor V Komarov (IV)

Enamine Ltd., Kyiv 02094, Ukraine.
ORCID: 0000-0002-7908-9145

David E Gloriam (DE)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
ORCID: 0000-0002-4299-7561

Anders A Jensen (AA)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

Jesper L Kristensen (JL)

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
ORCID: 0000-0002-5613-1267

Christophe P Stove (CP)

Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
ORCID: 0000-0001-7126-348X

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › Structure-Activity Assessment and In-Depth...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs sérotoninergiques › Récepteurs de la sérotonine de type 5-HT2 › Récepteur de la sérotonine de type 5-HT2A › Structure-Activity Assessment and In-Depth...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Structure-Activity Assessment and In-Depth...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Hallucinogènes › Structure-Activity Assessment and In-Depth...
questionsmedicales.fr › Composés chimiques organiques › Amines › Éthylamines › Phénéthylamines › Structure-Activity Assessment and In-Depth...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents sérotoninergiques › Agonistes des récepteurs de la sérotonine › Agonistes des récepteurs 5-HT2 de la sérotonine › Structure-Activity Assessment and In-Depth...