Mark Witcher

Affiliations

Section of Neurosurgery, Carilion Clinic, Carilion Roanoke Memorial Hospital, 1906 Belleview Ave SE, Roanoke, VA 24014, USA.

Publications (21)

Single base-pair resolution analysis of DNA binding motif with MoMotif reveals an oncogenic function of CTCF zinc-finger 1 mutation.

Nucleic acids research

Avec: Benjamin Lebeau , Kaiqiong Zhao , Maika Jangal , Tiejun Zhao , Maria Guerra , Celia M T Greenwood , Michael Witcher

MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma

Cancer research

Avec: Qianyu Guo , Vivian Z Li , Jessica N Nichol , Fan Huang , William Yang , Samuel E J Preston , Zahra Talat , Hanne Lefrère , Henry Yu , Guihua Zhang , Mark Basik , Christophe Gonçalves , Yao Zhan , Dany Plourde , Jie Su , Jose Torres , Maud Marques , Sara Al Habyan , Krikor Bijian , Frédéric Amant , Michael Witcher , Fariba Behbod , Luke McCaffrey , Moulay Alaoui-Jamali , Nadia V Giannakopoulos , Muriel Brackstone , Lynne-Marie Postovit , Sonia V Del Rincón , Wilson H Miller

Oncogenic activity of poly (ADP-ribose) glycohydrolase.

Oncogene

Avec: Maud Marques , Maika Jangal , Li-Chun Wang , Anna Kazanets , Sabrina Daniela da Silva , Tiejun Zhao , Amanda Lovato , Henry Yu , Su Jie , Sonia Del Rincon , John Mackey , Sambasivarao Damaraju , Moulay Alaoui-Jamali , Michael Witcher

3D chromatin remodeling potentiates transcriptional programs driving cell invasion.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Benjamin Lebeau , Maïka Jangal , Tiejun Zhao , Cheng Kit Wong , Nolan Wong , Eduardo Cepeda Cañedo , Steven Hébert , Adriana Aguilar-Mahecha , Catherine Chabot , Marguerite Buchanan , Rachel Catterall , Luke McCaffrey , Geneviève Deblois , Claudia Kleinman , Morag Park , Mark Basik , Michael Witcher

Unsupervised Multitaper Spectral Method for Identifying REM Sleep in Intracranial EEG Recordings Lacking EOG/EMG Data.

Bioengineering (Basel, Switzerland)

Avec: Kyle Q Lepage , Sparsh Jain , Andrew Kvavilashvili , Mark Witcher , Sujith Vijayan

Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition.

Molecular cancer therapeutics

Avec: Tatiana Shorstova , Jie Su , Tiejun Zhao , Michael Dahabieh , Matthew Leibovitch , Mariana De Sa Tavares Russo , Daina Avizonis , Shivshankari Rajkumar , Ian R Watson , Sonia V Del Rincón , Wilson H Miller , William D Foulkes , Michael Witcher

Achieving clinical success with BET inhibitors as anti-cancer agents.

British journal of cancer

Avec: Tatiana Shorstova , William D Foulkes , Michael Witcher

A Comparison of PET Tracers in Recurrent High-Grade Gliomas: A Systematic Review.

International journal of molecular sciences

Avec: Sankar Muthukumar , Jordan Darden , James Crowley , Mark Witcher , Jackson Kiser

The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple Negative Breast Cancer by Attenuating TGFβ Signaling.

Cancer research

Avec: John Heath , Caitlynn Mirabelli , Matthew G Annis , Valerie Sabourin , Steven Hébert , Steven Findlay , HaEun Kim , Michael Witcher , Claudia L Kleinman , Peter M Siegel , Alexandre Orthwein , Josie Ursini-Siegel

Multitaper estimates of phase-amplitude coupling.

Journal of neural engineering

Avec: Kyle Q Lepage , Cavan N Fleming , Mark Witcher , Sujith Vijayan

Medical Students' Knowledge and Perception of Deep Brain Stimulation.

Journal of medical education and curricular development

Avec: Brian F Saway , Sanaz Monjazeb , Kerilyn Godbe , Tessa Anwyll , Anita Kablinger , Mark Witcher

MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors.

iScience

Avec: HaEun Kim , Benjamin Lebeau , David Papadopoli , Predrag Jovanovic , Mariana Russo , Daina Avizonis , Masahiro Morita , Farzaneh Afzali , Josie Ursini-Siegel , Lynne-Marie Postovit , Michael Witcher , Ivan Topisirovic

Antitumor activity of the dual BET and CBP/EP300 inhibitor NEO2734.

Blood advances

Avec: Filippo Spriano , Eugenio Gaudio , Luciano Cascione , Chiara Tarantelli , Federica Melle , Giovanna Motta , Valdemar Priebe , Andrea Rinaldi , Gaetanina Golino , Afua Adjeiwaa Mensah , Luca Aresu , Emanuele Zucca , Stefano Pileri , Michael Witcher , Bill Brown , Claes Wahlestedt , Francis Giles , Anastasios Stathis , Francesco Bertoni

Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.

Cell metabolism

Avec: Dominic G Roy , Jocelyn Chen , Victoria Mamane , Eric H Ma , Brejnev M Muhire , Ryan D Sheldon , Tatiana Shorstova , Rutger Koning , Radia M Johnson , Ekaterina Esaulova , Kelsey S Williams , Sebastian Hayes , Mya Steadman , Bozena Samborska , Amanda Swain , Audrey Daigneault , Victor Chubukov , Thomas P Roddy , William Foulkes , J Andrew Pospisilik , Marie-Claude Bourgeois-Daigneault , Maxim N Artyomov , Michael Witcher , Connie M Krawczyk , Catherine Larochelle , Russell G Jones

Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Marc Tischkowitz , Sidong Huang , Susana Banerjee , Jennifer Hague , William P D Hendricks , David G Huntsman , Jessica D Lang , Krystal A Orlando , Amit M Oza , Patricia Pautier , Isabelle Ray-Coquard , Jeffrey M Trent , Michael Witcher , Leora Witkowski , W Glenn McCluggage , Douglas A Levine , William D Foulkes , Bernard E Weissman

SWI/SNF-Compromised Cancers Are Susceptible to Bromodomain Inhibitors.

Cancer research

Avec: Tatiana Shorstova , Maud Marques , Jie Su , Jake Johnston , Claudia L Kleinman , Nancy Hamel , Sidong Huang , Moulay A Alaoui-Jamali , William D Foulkes , Michael Witcher

CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary.

Nature communications

Avec: Yibo Xue , Brian Meehan , Elizabeth Macdonald , Sriram Venneti , Xue Qing D Wang , Leora Witkowski , Petar Jelinic , Tim Kong , Daniel Martinez , Geneviève Morin , Michelle Firlit , Atefeh Abedini , Radia M Johnson , Regina Cencic , Jay Patibandla , Hongbo Chen , Andreas I Papadakis , Aurelie Auguste , Iris de Rink , Ron M Kerkhoven , Nicholas Bertos , Walter H Gotlieb , Blaise A Clarke , Alexandra Leary , Michael Witcher , Marie-Christine Guiot , Jerry Pelletier , Josée Dostie , Morag Park , Alexander R Judkins , Ralf Hass , Douglas A Levine , Janusz Rak , Barbara Vanderhyden , William D Foulkes , Sidong Huang

Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles.

Blood advances

Avec: Nadim Tawil , Rayhaan Bassawon , Brian Meehan , Ali Nehme , Laura Montermini , Tenzin Gayden , Nicolas De Jay , Cristiana Spinelli , Shilpa Chennakrishnaiah , Dongsic Choi , Lata Adnani , Michele Zeinieh , Nada Jabado , Claudia L Kleinman , Michael Witcher , Yasser Riazalhosseini , Nigel S Key , David Schiff , Steven P Grover , Nigel Mackman , Charles P Couturier , Kevin Petrecca , Mario L Suvà , Anoop Patel , Itay Tirosh , Hamed Najafabadi , Janusz Rak

POGZ promotes homology-directed DNA repair in an HP1-dependent manner.

EMBO reports

Avec: John Heath , Estelle Simo Cheyou , Steven Findlay , Vincent M Luo , Edgar Pinedo Carpio , Jeesan Lee , Billel Djerir , Xiaoru Chen , Théo Morin , Benjamin Lebeau , Martin Karam , Halil Bagci , Damien Grapton , Josie Ursini-Siegel , Jean-Francois Côté , Michael Witcher , Stéphane Richard , Alexandre Maréchal , Alexandre Orthwein

p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors.

JCI insight

Avec: Eduardo Cepeda Cañedo , Stephanie Totten , Ryuhjin Ahn , Paul Savage , Deanna MacNeil , Jesse Hudson , Chantal Autexier , Genevieve Deblois , Morag Park , Michael Witcher , Josie Ursini-Siegel

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer.

Nature communications

Avec: Stephanie P Totten , Young Kyuen Im , Eduardo Cepeda Cañedo , Ouafa Najyb , Alice Nguyen , Steven Hébert , Ryuhjin Ahn , Kyle Lewis , Benjamin Lebeau , Rachel La Selva , Valérie Sabourin , Constanza Martínez , Paul Savage , Hellen Kuasne , Daina Avizonis , Nancy Santos Martínez , Catherine Chabot , Adriana Aguilar-Mahecha , Marie-Line Goulet , Matthew Dankner , Michael Witcher , Kevin Petrecca , Mark Basik , Michael Pollak , Ivan Topisirovic , Rongtuan Lin , Peter M Siegel , Claudia L Kleinman , Morag Park , Julie St-Pierre , Josie Ursini-Siegel

Réseau de co-auteurs

Michael Witcher 17 collaborations

Benjamin Lebeau 5 collaborations

William D Foulkes 5 collaborations

Josie Ursini-Siegel 5 collaborations

Tiejun Zhao 4 collaborations

Morag Park 4 collaborations

Tatiana Shorstova 4 collaborations

Claudia L Kleinman 4 collaborations

Mark Basik 3 collaborations

Jie Su 3 collaborations

Maud Marques 3 collaborations

Eduardo Cepeda Cañedo 3 collaborations

Steven Hébert 3 collaborations

Daina Avizonis 3 collaborations

Sidong Huang 3 collaborations

Maika Jangal 2 collaborations

Henry Yu 2 collaborations

Luke McCaffrey 2 collaborations

Moulay Alaoui-Jamali 2 collaborations

Lynne-Marie Postovit 2 collaborations

Sonia V Del Rincón 2 collaborations

Wilson H Miller 2 collaborations

Adriana Aguilar-Mahecha 2 collaborations

Catherine Chabot 2 collaborations

Kyle Q Lepage 2 collaborations

Sujith Vijayan 2 collaborations

John Heath 2 collaborations

Steven Findlay 2 collaborations

HaEun Kim 2 collaborations

Peter M Siegel 2 collaborations

Alexandre Orthwein 2 collaborations

Ivan Topisirovic 2 collaborations

Radia M Johnson 2 collaborations

Leora Witkowski 2 collaborations

Douglas A Levine 2 collaborations

Brian Meehan 2 collaborations

Janusz Rak 2 collaborations

Kevin Petrecca 2 collaborations

Ryuhjin Ahn 2 collaborations

Paul Savage 2 collaborations

Kaiqiong Zhao 1 collaboration

Maria Guerra 1 collaboration

Celia M T Greenwood 1 collaboration

Qianyu Guo 1 collaboration

Vivian Z Li 1 collaboration

Jessica N Nichol 1 collaboration

Fan Huang 1 collaboration

William Yang 1 collaboration

Samuel E J Preston 1 collaboration

Zahra Talat 1 collaboration

Hanne Lefrère 1 collaboration

Guihua Zhang 1 collaboration

Christophe Gonçalves 1 collaboration

Yao Zhan 1 collaboration

Dany Plourde 1 collaboration

Jose Torres 1 collaboration

Sara Al Habyan 1 collaboration

Krikor Bijian 1 collaboration

Frédéric Amant 1 collaboration

Fariba Behbod 1 collaboration

Nadia V Giannakopoulos 1 collaboration

Muriel Brackstone 1 collaboration

Li-Chun Wang 1 collaboration

Anna Kazanets 1 collaboration

Sabrina Daniela da Silva 1 collaboration

Amanda Lovato 1 collaboration

Su Jie 1 collaboration

Sonia Del Rincon 1 collaboration

John Mackey 1 collaboration

Sambasivarao Damaraju 1 collaboration

Maïka Jangal 1 collaboration

Cheng Kit Wong 1 collaboration

Nolan Wong 1 collaboration

Marguerite Buchanan 1 collaboration

Rachel Catterall 1 collaboration

Geneviève Deblois 1 collaboration

Claudia Kleinman 1 collaboration

Sparsh Jain 1 collaboration

Andrew Kvavilashvili 1 collaboration

Michael Dahabieh 1 collaboration

Matthew Leibovitch 1 collaboration

Mariana De Sa Tavares Russo 1 collaboration

Shivshankari Rajkumar 1 collaboration

Ian R Watson 1 collaboration

Sankar Muthukumar 1 collaboration

Jordan Darden 1 collaboration

James Crowley 1 collaboration

Jackson Kiser 1 collaboration

Caitlynn Mirabelli 1 collaboration

Matthew G Annis 1 collaboration

Valerie Sabourin 1 collaboration

Cavan N Fleming 1 collaboration

Brian F Saway 1 collaboration

Sanaz Monjazeb 1 collaboration

Kerilyn Godbe 1 collaboration

Tessa Anwyll 1 collaboration

Anita Kablinger 1 collaboration

David Papadopoli 1 collaboration

Predrag Jovanovic 1 collaboration

Mariana Russo 1 collaboration

Masahiro Morita 1 collaboration

Farzaneh Afzali 1 collaboration

Filippo Spriano 1 collaboration

Eugenio Gaudio 1 collaboration

Luciano Cascione 1 collaboration

Chiara Tarantelli 1 collaboration

Federica Melle 1 collaboration

Giovanna Motta 1 collaboration

Valdemar Priebe 1 collaboration

Andrea Rinaldi 1 collaboration

Gaetanina Golino 1 collaboration

Afua Adjeiwaa Mensah 1 collaboration

Luca Aresu 1 collaboration

Emanuele Zucca 1 collaboration

Stefano Pileri 1 collaboration

Bill Brown 1 collaboration

Claes Wahlestedt 1 collaboration

Francis Giles 1 collaboration

Anastasios Stathis 1 collaboration

Francesco Bertoni 1 collaboration

Dominic G Roy 1 collaboration

Jocelyn Chen 1 collaboration

Victoria Mamane 1 collaboration

Eric H Ma 1 collaboration

Brejnev M Muhire 1 collaboration

Ryan D Sheldon 1 collaboration

Rutger Koning 1 collaboration

Ekaterina Esaulova 1 collaboration

Kelsey S Williams 1 collaboration

Sebastian Hayes 1 collaboration

Mya Steadman 1 collaboration

Bozena Samborska 1 collaboration

Amanda Swain 1 collaboration

Audrey Daigneault 1 collaboration

Victor Chubukov 1 collaboration

Thomas P Roddy 1 collaboration

William Foulkes 1 collaboration

J Andrew Pospisilik 1 collaboration

Marie-Claude Bourgeois-Daigneault 1 collaboration

Maxim N Artyomov 1 collaboration

Connie M Krawczyk 1 collaboration

Catherine Larochelle 1 collaboration

Russell G Jones 1 collaboration

Marc Tischkowitz 1 collaboration

Susana Banerjee 1 collaboration

Jennifer Hague 1 collaboration

William P D Hendricks 1 collaboration

David G Huntsman 1 collaboration

Jessica D Lang 1 collaboration

Krystal A Orlando 1 collaboration

Amit M Oza 1 collaboration

Patricia Pautier 1 collaboration

Isabelle Ray-Coquard 1 collaboration

Jeffrey M Trent 1 collaboration

W Glenn McCluggage 1 collaboration

Bernard E Weissman 1 collaboration

Jake Johnston 1 collaboration

Nancy Hamel 1 collaboration

Moulay A Alaoui-Jamali 1 collaboration

Yibo Xue 1 collaboration

Elizabeth Macdonald 1 collaboration

Sriram Venneti 1 collaboration

Xue Qing D Wang 1 collaboration

Petar Jelinic 1 collaboration

Tim Kong 1 collaboration

Daniel Martinez 1 collaboration

Geneviève Morin 1 collaboration

Michelle Firlit 1 collaboration

Atefeh Abedini 1 collaboration

Regina Cencic 1 collaboration

Jay Patibandla 1 collaboration

Hongbo Chen 1 collaboration

Andreas I Papadakis 1 collaboration

Aurelie Auguste 1 collaboration

Iris de Rink 1 collaboration

Ron M Kerkhoven 1 collaboration

Nicholas Bertos 1 collaboration

Walter H Gotlieb 1 collaboration

Blaise A Clarke 1 collaboration

Alexandra Leary 1 collaboration

Marie-Christine Guiot 1 collaboration

Jerry Pelletier 1 collaboration

Josée Dostie 1 collaboration

Alexander R Judkins 1 collaboration

Ralf Hass 1 collaboration

Barbara Vanderhyden 1 collaboration

Nadim Tawil 1 collaboration

Rayhaan Bassawon 1 collaboration

Ali Nehme 1 collaboration

Laura Montermini 1 collaboration

Tenzin Gayden 1 collaboration

Nicolas De Jay 1 collaboration

Cristiana Spinelli 1 collaboration

Shilpa Chennakrishnaiah 1 collaboration

Dongsic Choi 1 collaboration

Lata Adnani 1 collaboration

Michele Zeinieh 1 collaboration

Nada Jabado 1 collaboration

Yasser Riazalhosseini 1 collaboration

Nigel S Key 1 collaboration

David Schiff 1 collaboration

Steven P Grover 1 collaboration

Nigel Mackman 1 collaboration

Charles P Couturier 1 collaboration

Mario L Suvà 1 collaboration

Anoop Patel 1 collaboration

Itay Tirosh 1 collaboration

Hamed Najafabadi 1 collaboration

Estelle Simo Cheyou 1 collaboration

Vincent M Luo 1 collaboration

Edgar Pinedo Carpio 1 collaboration

Jeesan Lee 1 collaboration

Billel Djerir 1 collaboration

Xiaoru Chen 1 collaboration

Théo Morin 1 collaboration

Martin Karam 1 collaboration

Halil Bagci 1 collaboration

Damien Grapton 1 collaboration

Jean-Francois Côté 1 collaboration

Stéphane Richard 1 collaboration

Alexandre Maréchal 1 collaboration

Stephanie Totten 1 collaboration

Deanna MacNeil 1 collaboration

Jesse Hudson 1 collaboration

Chantal Autexier 1 collaboration

Genevieve Deblois 1 collaboration

Stephanie P Totten 1 collaboration

Young Kyuen Im 1 collaboration

Ouafa Najyb 1 collaboration

Alice Nguyen 1 collaboration

Kyle Lewis 1 collaboration

Rachel La Selva 1 collaboration

Valérie Sabourin 1 collaboration

Constanza Martínez 1 collaboration

Hellen Kuasne 1 collaboration

Nancy Santos Martínez 1 collaboration

Marie-Line Goulet 1 collaboration

Matthew Dankner 1 collaboration

Michael Pollak 1 collaboration

Rongtuan Lin 1 collaboration

Julie St-Pierre 1 collaboration