questionsmedicales.fr
Facteurs biologiques
Toxines biologiques
Toxines bactériennes
Endotoxines
Endotoxines : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Tests de laboratoire
Endotoxines
Culture bactérienne
Endotoxines
Symptômes
5
Système immunitaire
Choc septique
Choc septique
Hypotension
Prévention
5
Sécurité en laboratoire
Équipements de protection
Infections nosocomiales
Hygiène hospitalière
Traitements
5
Antibiotiques
Soins de soutien
Corticostéroïdes
Inflammation
Choc septique
Vasopresseurs
Antidotes
Traitement symptomatique
Prise en charge précoce
Complications
Complications
5
Choc septique
Insuffisance organique
Défaillance organique
Inflammation
Syndrome de détresse respiratoire
Inflammation pulmonaire
Dommages neurologiques
Inflammation systémique
Facteurs de risque
5
Facteurs de risque
Immunodépression
Infections bactériennes
Gram-négatif
Interventions chirurgicales
Infections
Diabète
Système immunitaire
Conditions de vie
Bactéries
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"text": "Le diagnostic repose sur des tests sanguins, cultures et évaluation clinique."
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{
"@type": "Question",
"name": "Quels tests sont utilisés pour détecter les endotoxines ?",
"position": 2,
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"@type": "Question",
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"position": 3,
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"@type": "Question",
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"@type": "Question",
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"position": 7,
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}
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"@type": "Question",
"name": "Les endotoxines causent-elles des douleurs ?",
"position": 8,
"acceptedAnswer": {
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"text": "Oui, elles peuvent provoquer des douleurs abdominales et musculaires."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent un choc septique dû aux endotoxines ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Hypotension, tachycardie, confusion et peau froide sont des signes clés."
}
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{
"@type": "Question",
"name": "Les symptômes varient-ils selon l'exposition ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'intensité des symptômes dépend de la dose et de la durée d'exposition."
}
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{
"@type": "Question",
"name": "Comment prévenir l'exposition aux endotoxines ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les environnements contaminés et respecter les protocoles d'hygiène."
}
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{
"@type": "Question",
"name": "Les vaccins peuvent-ils prévenir les infections à endotoxines ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de vaccin spécifique contre les endotoxines, mais contre certaines bactéries."
}
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{
"@type": "Question",
"name": "Quelles mesures de sécurité en laboratoire sont nécessaires ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Utiliser des équipements de protection individuelle et des procédures de désinfection."
}
},
{
"@type": "Question",
"name": "Les antibiotiques préventifs sont-ils efficaces ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent être utilisés dans certains cas à risque, mais pas systématiquement."
}
},
{
"@type": "Question",
"name": "Comment réduire le risque d'infections nosocomiales ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Améliorer l'hygiène hospitalière et le contrôle des infections est essentiel."
}
},
{
"@type": "Question",
"name": "Quel est le traitement principal pour une intoxication par endotoxines ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement inclut des antibiotiques et des soins de soutien pour stabiliser le patient."
}
},
{
"@type": "Question",
"name": "Les corticostéroïdes sont-ils efficaces contre les endotoxines ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent réduire l'inflammation, mais leur utilisation est controversée."
}
},
{
"@type": "Question",
"name": "Comment traiter le choc septique causé par des endotoxines ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement nécessite des fluides intraveineux et des vasopresseurs."
}
},
{
"@type": "Question",
"name": "Les antidotes existent-ils pour les endotoxines ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas d'antidote spécifique, le traitement est symptomatique."
}
},
{
"@type": "Question",
"name": "Quelle est l'importance de la prise en charge précoce ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une prise en charge rapide améliore les chances de survie et réduit les complications."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles d'une intoxication par endotoxines ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent le choc septique, l'insuffisance organique et la mort."
}
},
{
"@type": "Question",
"name": "Comment les endotoxines affectent-elles les organes ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent provoquer une défaillance multi-organique en raison de l'inflammation."
}
},
{
"@type": "Question",
"name": "Le syndrome de détresse respiratoire est-il lié aux endotoxines ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'inflammation pulmonaire peut entraîner un syndrome de détresse respiratoire."
}
},
{
"@type": "Question",
"name": "Les endotoxines peuvent-elles causer des dommages neurologiques ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent provoquer des troubles neurologiques en raison de l'inflammation systémique."
}
},
{
"@type": "Question",
"name": "Quel est le pronostic après une exposition aux endotoxines ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le pronostic dépend de la rapidité du traitement et de la gravité de l'exposition."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque d'intoxication par endotoxines ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les patients immunodéprimés, les personnes âgées et les hospitalisés sont à risque."
}
},
{
"@type": "Question",
"name": "Les infections bactériennes augmentent-elles le risque d'endotoxines ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les infections par des bactéries Gram-négatives sont un facteur de risque majeur."
}
},
{
"@type": "Question",
"name": "Les interventions chirurgicales augmentent-elles le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les interventions chirurgicales peuvent exposer à des endotoxines, surtout en cas d'infection."
}
},
{
"@type": "Question",
"name": "Le diabète est-il un facteur de risque pour les endotoxines ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le diabète peut affaiblir le système immunitaire et augmenter le risque d'infections."
}
},
{
"@type": "Question",
"name": "Les conditions de vie insalubres augmentent-elles le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles favorisent la prolifération bactérienne et l'exposition aux endotoxines."
}
}
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}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 06/02/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Microcoat Biotechnologie GmbH, Am Neuland 3, 82347 Bernried am Stanberger See, Germany. j.reich@microcoat.de.
Publications dans "Endotoxines" :
3 publications dans cette catégorie
Affiliations :
Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK. gcb3@cam.ac.uk.
Publications dans "Endotoxines" :
3 publications dans cette catégorie
Affiliations :
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Spectral Medical Inc., Toronto, Ontario, Canada.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Nanomedicine and Molecular Imaging Group, Department of Clinical Medicine, Trinity Translational Medicine Institute, Dublin, Ireland.
Laboratory of Biological Characterization of Advanced Materials (LBCAM), Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Nanomedicine and Molecular Imaging Group, Department of Clinical Medicine, Trinity Translational Medicine Institute, Dublin, Ireland.
Laboratory of Biological Characterization of Advanced Materials (LBCAM), Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Advanced Materials and Bioengineering Research (AMBER) Centre, CRANN institute, Trinity College Dublin, Dublin, Ireland.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Biophotonics and Advanced Microscopy, Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Biophotonics and Advanced Microscopy, Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Innate Immunity, Inflammation and Immuno-nanosafety, IBBC-CNR, Napoli, Italy.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Innate Immunity, Inflammation and Immuno-nanosafety, IBBC-CNR, Napoli, Italy.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Biophotonics and Advanced Microscopy, Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Toray Medical Co., Ltd., Tokyo, Japan.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Microbial Solutions, Charles River Laboratories, 1023 Wappoo Road, Suite 43-B, Charleston, SC 29407, United States.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States.
Publications dans "Endotoxines" :
2 publications dans cette catégorie
Affiliations :
Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States.
Publications dans "Endotoxines" :
1 publication dans cette catégorie
Affiliations :
Microcoat Biotechnologie GmbH, Am Neuland 3, 82347 Bernried am Stanberger See, Germany. f.weyer@microcoat.de.
Publications dans "Endotoxines" :
1 publication dans cette catégorie
Affiliations :
LPS (Laboratory Program Support) Consulting Office, Tokyo 160-0023, Japan. htamura@lpsct.com.
Department of Host Defense and Biochemical Research, Juntendo University Graduate School of Medicine, Tokyo 113-8431, Japan. htamura@lpsct.com.
Publications dans "Endotoxines" :
1 publication dans cette catégorie
Affiliations :
Department of Host Defense and Biochemical Research, Juntendo University Graduate School of Medicine, Tokyo 113-8431, Japan. nagaokai@juntendo.ac.jp.
Publications dans "Endotoxines" :
1 publication dans cette catégorie
Affiliations :
Institute of Physical and Theoretical Chemistry, University of Regensburg, 93040 Regensburg, Germany. Hubert.Motschmann@chemie.uni-regensburg.de.
Publications dans "Endotoxines" :
Benign prostatic hyperplasia (BPH) is the most common cause of bladder outlet obstruction in men over the age of 50 years. An association between the prostate specific antigen (PSA), International Pro...
To determine the correlation between the PSA, IPSS and PV in men of African descent....
This was a cross sectional analysis involving 92 patients diagnosed as having symptomatic BPH at the Ho Teaching Hospital....
The data were collected using standardised questionnaires. The IPSS determined urinary symptom severity. The PV was determined using a transabdominal ultrasound machine. Serum PSA was retrieved from t...
The mean PV was 61.04 cm3 ± 21.95 cm3, the mean PSA was 4.21 ng/mL ± 3.85 ng/mL, and mean IPSS of 21.59 ± 3.78. The Pearson's correlation between PV and PSA was 0.283 (p = 0.01), between PV and IPSS w...
This study showed that serum PSA has a positive correlation with PV. However, IPSS had no significant association with PSA or PV in patients with BPH.Contribution: This study provides insights into th...
We report the case of a 63-year-old male who came to the urology clinic with an increasing value of the prostate specific antigen and an asymmetrical enlargement at the digital rectal examination. The...
To compare the cost effectiveness of prostatic artery embolization (PAE) with that of transurethral resection of the prostate (TURP) for the treatment of medically refractory benign prostatic hyperpla...
A cost-effectiveness analysis with Markov modeling was performed, comparing the clinical course after PAE with that after TURP for 3 years. Probabilities were obtained from the available literature, a...
Base case calculation showed comparable outcomes (PAE, 2.845 QALY; TURP, 2.854 QALY), with a cost difference of $3,104 (PAE, $2,934; TURP, $6,038). The incremental cost-effectiveness ratio was $360,24...
PAE is a cost-effective strategy to treat medically refractory BPH, resulting in comparable health benefits at a lower cost than that of TURP even when accounting for extreme alterations in adverse ev...
Prostate organogenesis begins during embryonic development and continues through puberty when the prostate becomes an important exocrine gland of the male reproductive system. The specification and gr...
Benign prostatic hyperplasia is associated with structural and morphological changes including elongation of prostatic urethral length. The aim of our study was to assess whether prostatic urethral le...
This prospective observational study was conducted over a 12-months duration. All the patients who presented with lower urinary tract symptoms secondary to benign prostatic hyperplasia were evaluated ...
A total of 153 patients were included in the study. Eighty-three (54.2%) patients underwent surgery during the study period. Prostate volume, intravesical prostatic protrusion, post-void residual volu...
BPH patients with longer PUL may require surgical management. PUL measured by TRUS may be a predicting factor for the need of surgery in BPH Keywords: Benign prostatic hyperplasia; lower urinary tract...
Biomarkers of DNA damage repair deficiency provide opportunities for personalized treatment with immunotherapy. However, there is limited research on the immune microenvironment of adeno-neuroendocrin...
A retrospective medical record review of 66 patients with prostate cancer (PCa) was performed. PCa samples from the 66 patients were analyzed using immunohistochemical staining for the detection of ch...
Twenty patients presented with adeno-NEPC, whereas 46 presented with adeno-PCa. The median age of patients at PCa diagnosis was 67.86 ± 7.05 years (68.65 ± 7.23 years, adeno-NEPC; 67.52 ± 7.02 years, ...
Our study revealed clinicopathological manifestations of adeno-NEPC and some possible predictive factors significantly associated with better outcomes in patients with adeno-NEPC. These findings might...
The purpose of the study was to evaluate the diagnostic significance of two new and a few clinical markers for prostate cancer (PCa) at various prostate volumes (PV)....
The study subjects were divided into two groups. Among them, there were 70 cases in the PV ≤30 ml group (benign prostatic hyperplasia [BPH]: 32 cases, PCa: 38 cases) and 372 cases in the PV > 30 ml gr...
In the PV ≤30 ml group, the diagnostic parameters based on prostate-specific antigen (PSA) had a decreased diagnostic significance for PCa. In the PV > 30 ml group, PSAD (AUC = 0.709), AVR (AVR = Age/...
Choosing appropriate indicators for different PVs could contribute to the early screening and diagnosis of PCa. The difference in the diagnostic value of two new indicators (A-PSAD and AVR), and PSAD ...
Holmium laser enucleation of the prostate (HoLEP) is a size-independent surgical option for treating benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) with excellent, durable ...
This study aims to compare the ability of the PHI versus tPSA test to predict the presence of PCa in our population....
A prospective observational study was performed. We included patients with tPSA ≥ 2.5 ng/ml, biopsy naïve or previous negative biopsy, undergoing a blood test, which includes tPSA, fPSA, and p2PSA, an...
140 men were included. Fifty-seven (40.7%) had a positive prostate biopsy result (Group A), and 83 (59.3%) had a negative biopsy result (Group B). The mean age was similar in both groups (mean ± stand...
The PHI test improves PCa detection compared to tPSA in our population....
We compare Prostate Health Index, Prostate Health Index density, and PSA density in predicting clinically significant prostate cancer in MRI-guided prostate biopsy....
This is a multicenter evaluation of prospectively maintained prostate biopsy databases at 10 urology centers. Men with Prostate Health Index and MRI-guided targeted and systematic prostate biopsy perf...
A total of 1,215 men were analyzed. Prostate cancer and clinically significant prostate cancer were diagnosed in 51% (617/1,215) and 35% (422/1,215) of men, respectively. Clinically significant prosta...
Prostate Health Index density outperformed Prostate Health Index or PSA density in clinically significant prostate cancer detection in men with multiparametric MRI performed, and further reduced unnec...