Comment diagnostiquer un trouble gonadique ?

Le diagnostic repose sur des tests hormonaux, échographies et examens cliniques.

Quels tests sont utilisés pour évaluer la fonction gonadique ?

Les tests incluent les dosages de testostérone, d'œstrogènes et d'autres hormones.

Les imageries sont-elles nécessaires pour le diagnostic ?

Oui, des échographies ou IRM peuvent aider à visualiser les anomalies des gonades.

Quels signes cliniques indiquent un trouble gonadique ?

Des signes comme l'infertilité, des irrégularités menstruelles ou des changements de libido.

Les antécédents médicaux sont-ils importants ?

Oui, les antécédents familiaux et personnels peuvent orienter le diagnostic.

Quels sont les symptômes courants des troubles gonadiques ?

Les symptômes incluent fatigue, infertilité, dysfonction érectile et changements hormonaux.

Comment les troubles gonadiques affectent-ils la libido ?

Ils peuvent entraîner une diminution de la libido due à des déséquilibres hormonaux.

Les troubles menstruels sont-ils liés aux troubles gonadiques ?

Oui, des irrégularités menstruelles peuvent signaler un dysfonctionnement gonadique.

Peut-on observer des changements physiques ?

Oui, des changements comme l'acné, la pilosité excessive ou la gynécomastie peuvent survenir.

Les troubles de l'humeur sont-ils fréquents ?

Oui, des troubles de l'humeur comme l'anxiété et la dépression peuvent être présents.

Comment prévenir les troubles gonadiques ?

Maintenir un mode de vie sain, éviter les toxines et gérer le stress sont essentiels.

L'alimentation joue-t-elle un rôle ?

Oui, une alimentation équilibrée peut soutenir la santé hormonale et reproductive.

Le tabagisme influence-t-il la santé gonadique ?

Oui, le tabagisme peut nuire à la fonction gonadique et à la fertilité.

L'exercice physique est-il bénéfique ?

Oui, l'exercice régulier aide à réguler les hormones et à maintenir un poids santé.

Les examens médicaux réguliers sont-ils importants ?

Oui, des bilans réguliers peuvent aider à détecter précocement des troubles gonadiques.

Quels traitements sont disponibles pour les troubles gonadiques ?

Les traitements incluent des thérapies hormonales, des médicaments et parfois la chirurgie.

La thérapie hormonale est-elle efficace ?

Oui, elle peut restaurer les niveaux hormonaux et améliorer les symptômes associés.

Quand la chirurgie est-elle nécessaire ?

La chirurgie est envisagée en cas de tumeurs, malformations ou autres anomalies structurelles.

Les traitements sont-ils personnalisés ?

Oui, les traitements sont adaptés en fonction des besoins individuels et des causes sous-jacentes.

Y a-t-il des effets secondaires aux traitements ?

Oui, des effets secondaires peuvent inclure des changements d'humeur, des nausées ou des douleurs.

Quelles complications peuvent survenir ?

Les complications incluent l'infertilité, des troubles métaboliques et des maladies cardiovasculaires.

Les troubles gonadiques augmentent-ils le risque de cancer ?

Oui, certains troubles peuvent augmenter le risque de cancers hormonodépendants.

Comment les troubles gonadiques affectent-ils la santé mentale ?

Ils peuvent entraîner des troubles de l'humeur, de l'anxiété et des problèmes d'estime de soi.

Les complications sont-elles réversibles ?

Certaines complications peuvent être réversibles avec un traitement approprié et précoce.

Les troubles gonadiques peuvent-ils affecter la qualité de vie ?

Oui, ils peuvent réduire la qualité de vie en raison de symptômes physiques et émotionnels.

Quels sont les facteurs de risque des troubles gonadiques ?

Les facteurs incluent l'âge, les antécédents familiaux, l'obésité et les maladies chroniques.

Le stress peut-il influencer les troubles gonadiques ?

Oui, le stress chronique peut perturber l'équilibre hormonal et aggraver les troubles.

Les infections peuvent-elles être un facteur de risque ?

Oui, certaines infections sexuellement transmissibles peuvent affecter la fonction gonadique.

L'exposition à des toxines est-elle préoccupante ?

Oui, l'exposition à des produits chimiques et toxines peut nuire à la santé gonadique.

Les habitudes alimentaires influencent-elles le risque ?

Oui, une mauvaise alimentation peut contribuer à des déséquilibres hormonaux et à des troubles.

Troubles gonadiques - Informations médicales vérifiées

Classification of Local Recurrence After Nipple-Sparing Mastectomy Based on Location: The Features of Nipple-Areolar Recurrence Differ from Those of Other Local Recurrences.

Mar 2023

DOI: 10.1245/s10434-022-12760-1 PMID: 36371582

Little information is available about the clinical and pathologic characteristics of local recurrence (LR) after nipple-sparing mastectomy according to the locations of LR.... This study classified 99 patients into the following two groups according to the location of LR after nipple-sparing mastectomy: nipple-areolar recurrence (NAR) group and other locations of LR (oLR) g... For about half of the patients (44.4 %) with NAR, the primary cancer was estrogen receptor (ER)-negative and human epidermal growth factor receptor 2 (HER2)-positive. Conversely, in most of the patien... This multi-institutional retrospective study demonstrated that the features of NAR, such as the characteristics of the primary and recurrent tumors and the prognostic factors after LR resection, were ...

Humans Female Breast Neoplasms Mastectomy Nipples +4 autres

Feasibility of local therapy for recurrent pancreatic cancer.

Sep 2022

DOI: 10.1016/j.pan.2022.05.004 PMID: 35641368

Despite advances in perioperative management, recurrence after curative pancreatectomy is a critical issue in the treatment of pancreatic ductal adenocarcinoma (PDAC). The significance of local therap... We reviewed the medical records of patients with PDAC who underwent curative resection at our institution between January 2009 and December 2019. We examined the patterns of relapse and assessed the c... A total of 246 patients with PDAC who underwent R0 or R1 resection were included in this study. The 3-year overall survival (OS) rate was 39.8%, and the 1-year recurrence-free survival rate was 51.2% ... Our results suggest that a multimodal approach may improve the clinical outcomes of patients with recurrent PDAC....

Adenocarcinoma Carcinoma, Pancreatic Ductal Feasibility Studies Humans Neoplasm Recurrence, Local +6 autres

Ultrasound Assessment of Skin Tumors Local Recurrence.

Oct 2023

DOI: 10.1002/jum.16255 PMID: 37195073

Skin cancer may recur at or around the surgical site despite wide excisions. Prompt clinical and sonographic detection of local recurrence is important since subjects with relapsing melanomas or nonme...

Humans Skin Neoplasms Skin Melanoma Ultrasonography +1 autres

Pathological determinants of outcome following resection of locally advanced or locally recurrent rectal cancer.

Nov 2023

DOI: 10.1016/j.ejso.2023.06.023 PMID: 37442715

Pathological factors that influence and predict survival following pelvic exenteration (PE) for locally advanced (LARC) or locally recurrent rectal cancer (LRRC), especially LRRC, remain poorly unders... A retrospective cohort study was performed for all patients undergoing a curative PE for LARC or LRRC between 2008 and 2021 at a tertiary referral UK specialist colorectal hospital. Cox regression ana... 388 patients were included in the analysis with 256 resections for LARC and 132 for LRRC. 62.4% of patients were male with a median age of 59 years (IQR 49-67). 247 (64%) partial pelvic exenterations ... A positive resection margin and poorly differentiated tumours are significant negative prognostic markers for survival and recurrence in LARC. The results of this study support the need to look for al...

Humans Male Middle Aged Aged Female +7 autres

Intraparenchymal metastases as a cause for local recurrence of pancreatic cancer.

Feb 2023

DOI: 10.1111/his.14839 PMID: 36371607

Using CODA, a technique for three-dimensional reconstruction of large tissues, Kiemen et al. report observation of a microscopic focus of pancreatic cancer found in the vasculature of grossly normal h...

Humans Pancreatic Neoplasms Pancreas Neoplasm Recurrence, Local Pancreatic Neoplasms

Does the Addition of Mutations of CTNNB1 S45F to Clinical Factors Allow Prediction of Local Recurrence in Patients With a Desmoid Tumor? A Local Recurrence Risk Model.

01 10 2023

DOI: 10.1097/CORR.0000000000002627 PMID: 37104792

The initial approach to the treatment of desmoid tumors has changed from surgical resection to watchful waiting. However, surgery is still sometimes considered for some patients, and it is likely that... We sought to explore whether a combined molecular and clinical prognostic model for relapse in patients with desmoid tumors treated with surgery would allow us to identify patients who might do well w... This was a retrospective, single-center study of 107 patients with desmoid tumors who were surgically treated between January 1980 and December 2015, with a median follow-up of 106 months (range 7 to ... The multivariable analysis showed that S45F mutations (hazard ratio 5.25 [95% confidence interval 2.27 to 12.15]; p < 0.001) and tumor in the extremities (HR 3.15 [95% CI 1.35 to 7.33]; p = 0.008) wer... CTNNB1 S45F mutations combined with other clinical variables are a potential prognostic biomarker associated with the risk of relapse in patients with desmoid tumors. The developed nomogram is simple ... Level III, therapeutic study....

Humans Fibromatosis, Aggressive Retrospective Studies Neoplasm Recurrence, Local Mutation +2 autres

Risk Factors of Second Local Recurrence in Surgically Treated Recurrent Brain Metastases: An Exploratory Analysis.

Nov 2022

DOI: 10.1016/j.wneu.2022.08.066 PMID: 36028114

A first local recurrence is common after resection or radiotherapy for brain metastasis (BM). However, patients with BMs can develop multiple local recurrences over time. Published data on second loca... Patients were identified from a database at Brigham and Women's Hospital in Boston. Hazard ratios and 95% confidence intervals for predictors of a second local recurrence were computed using a Cox pro... Of 170 identified surgically treated first locally recurrent lesions, 74 (43.5%) progressed to second locally recurrent lesions at a median of 7 months after craniotomy. Subtotal resection of the firs... A second local recurrence occurred after 43.5% of craniotomies for first recurrent lesions. Subtotal resection and infratentorial location were the strongest risk factors for worse second local recurr...

Humans Female Neoplasm Recurrence, Local Prognosis Risk Factors +3 autres

Applying a neoscore in locally advanced rectal cancer is beneficial in predicting local recurrences after surgery.

2023

DOI: 10.1371/journal.pone.0285709 PMID: 37172066

The current study was undertaken to provide more detailed prognostic models for early prediction of local recurrences and local recurrence free survival (RFS) using different radiologic and pathologic... One hundred patients with locally advanced rectal carcinomas decided to receive neoadjuvant CRT were retrospectively recruited, Hazard ratios (HR) were determined in the two cox regression models and ... HR of 1st group of models: T+N, T+N+G, T+N+G+S, T+N+G+S+PNI, and T+N+G+S+PNI+R were summated and categorized into scores, these scores were significantly correlated with the risk of recurrence (Somer'... We propose that the addition of biologic factors to staging of rectal cancer provide precise stratification and association with local recurrences in patients received preoperative CRT....

Humans Retrospective Studies Prognosis Rectum Rectal Neoplasms +6 autres

Surgery of resectable local recurrence following colorectal cancer: Compartmental surgery improves local control.

Nov 2022

DOI: 10.1002/jso.26990 PMID: 35779039

This study aims to identify prognostic factors and define the best extent of surgery for optimizing treatment of local recurrence (LR) following colorectal cancer (CRC).... An institutional database of consecutive patients who underwent radical resection (R0/R1) of LR following CRC was analyzed prospectively from 2010 to 2021 at one tertiary cancer center.... In this study, 75 patients were included with LR following CRC and analyzed. Patients were categorized as compartmental resections (CompRe) (n = 47) if all adjacent organs were systematically removed,... Complete compartmental surgery is safe and improves local control. Optimal LR resection needs to remove all contiguous organs, with or without tumor involvement....

Colorectal Neoplasms Digestive System Surgical Procedures Humans Neoplasm Recurrence, Local Prognosis +3 autres

Recurrent RET fusions in fibrosarcoma-like neoplasms in adult viscera: expanding the clinicopathological and genetic spectrum.

Mar 2023

DOI: 10.1111/his.14847 PMID: 36443894

RET-fused mesenchymal neoplasms mostly affect the soft tissue of paediatric patients. Given their responsiveness to selective RET inhibitors, it remains critical to identify those extraordinary cases ... Clinicopathological features were assessed and partner agnostic targeted next-generation sequencing on clinically validated platforms were performed. The patients were 18, 53, and 55 years old and inc... Our study expands the clinicopathological and genetic spectrum of mesenchymal neoplasms associated with RET fusions....

Female Humans Male Adult Child +7 autres

Troubles gonadiques : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Troubles du développement sexuel

Hypogonadisme

Maladies ovariennes

Retard pubertaire

Puberté précoce

Maladies testiculaires

Troubles du développement sexuel de sujets 46, XX

Syndrome génitosurrénal

Troubles du développement sexuel de sujets 46, XY

Dysgénésie gonadique

Troubles ovotesticulaires du développement sexuel

Troubles du développement sexuel avec anomalie des gonosomes

Eunuchisme

Syndrome de Kallmann

Syndrome de Klinefelter

Infantilisme sexuel

Ovarite

Kystes de l'ovaire

Syndrome d'hyperstimulation ovarienne

Tumeurs de l'ovaire

Insuffisance ovarienne primitive

Cryptorchidie

Orchite

Tumeurs du testicule

Syndrome du mâle XX

Hyperplasie congénitale des surrénales

Hyperandrogénie

Syndrome d'insensibilité aux androgènes

Syndrome de Denys-Drash

Syndrome WAGR

Dysgénésie gonadique 46, XX

Dysgénésie gonadique 46, XY

Dysgénésie gonadique mixte

Syndrome de Turner

Syndrome des ovaires polykystiques

Tumeur de Brenner

Carcinome endométrioïde

Carcinome épithélial de l'ovaire

Tumeur de la granulosa

Syndrome héréditaire de cancer du sein et de l'ovaire

Lutéome

Syndrome de Meigs

Thécome

Tumeur à cellules de Sertoli et de Leydig

Gonadoblastome

Tumeur à cellules de Leydig

Tumeur à cellules de Sertoli

Auteurs principaux

Sources (10000 au total)