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"name": "Diagnostic",
"headline": "Diagnostic sur Cellules de Leydig",
"description": "Comment diagnostiquer une dysfonction des cellules de Leydig ?\nQuels tests sont utilisés pour évaluer les cellules de Leydig ?\nQuels signes indiquent une insuffisance des cellules de Leydig ?\nComment évaluer la fonction des cellules de Leydig ?\nQuel rôle joue l'échographie dans le diagnostic ?",
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"@type": "Question",
"name": "Comment diagnostiquer une dysfonction des cellules de Leydig ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un dosage hormonal et une échographie testiculaire peuvent aider au diagnostic."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les cellules de Leydig ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests sanguins pour mesurer les niveaux de testostérone et LH sont courants."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une insuffisance des cellules de Leydig ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une baisse de libido, fatigue et troubles de l'érection peuvent indiquer une insuffisance."
}
},
{
"@type": "Question",
"name": "Comment évaluer la fonction des cellules de Leydig ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'évaluation se fait par des tests hormonaux et l'examen clinique des symptômes."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'échographie dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'échographie permet de visualiser les testicules et détecter des anomalies structurelles."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont associés à une hyperplasie des cellules de Leydig ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une augmentation de la testostérone peut causer l'acné, l'hypertrichose et l'agressivité."
}
},
{
"@type": "Question",
"name": "Comment reconnaître une carence en testostérone ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, dépression, perte de masse musculaire et libido réduite."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques indiquent une tumeur des cellules de Leydig ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des douleurs testiculaires, une masse palpable et des changements hormonaux peuvent survenir."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un déséquilibre hormonal ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles de l'érection, des sautes d'humeur et une prise de poids peuvent être présents."
}
},
{
"@type": "Question",
"name": "Comment les symptômes varient-ils selon l'âge ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes de dysfonction peuvent s'aggraver avec l'âge, affectant la libido et l'énergie."
}
},
{
"@type": "Question",
"name": "Comment prévenir les troubles des cellules de Leydig ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain, incluant une alimentation équilibrée et de l'exercice, peut aider."
}
},
{
"@type": "Question",
"name": "Quels examens réguliers sont recommandés ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens médicaux réguliers et des bilans hormonaux peuvent aider à détecter des problèmes tôt."
}
},
{
"@type": "Question",
"name": "Comment éviter les facteurs de risque liés à l'environnement ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Réduire l'exposition aux toxines environnementales et aux perturbateurs endocriniens est crucial."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'alimentation dans la santé des cellules de Leydig ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en nutriments essentiels peut soutenir la fonction hormonale et cellulaire."
}
},
{
"@type": "Question",
"name": "Comment le stress affecte-t-il les cellules de Leydig ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut perturber l'équilibre hormonal et affecter la fonction des cellules de Leydig."
}
},
{
"@type": "Question",
"name": "Quels traitements existent pour l'insuffisance des cellules de Leydig ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie de remplacement de la testostérone est couramment utilisée pour traiter l'insuffisance."
}
},
{
"@type": "Question",
"name": "Comment traiter une hyperplasie des cellules de Leydig ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement peut inclure des médicaments anti-androgènes ou une intervention chirurgicale."
}
},
{
"@type": "Question",
"name": "Quels sont les effets secondaires de la thérapie de testostérone ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires peuvent inclure l'acné, la rétention d'eau et des troubles du sommeil."
}
},
{
"@type": "Question",
"name": "Quand envisager une intervention chirurgicale ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une chirurgie peut être envisagée en cas de tumeur des cellules de Leydig ou d'anomalies structurelles."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont utilisés pour traiter les troubles hormonaux ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme les inhibiteurs de l'aromatase peuvent être prescrits pour équilibrer les hormones."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une tumeur des cellules de Leydig ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent la propagation du cancer et des déséquilibres hormonaux graves."
}
},
{
"@type": "Question",
"name": "Quels risques sont associés à une thérapie de testostérone prolongée ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une thérapie prolongée peut augmenter le risque de maladies cardiovasculaires et de cancer de la prostate."
}
},
{
"@type": "Question",
"name": "Comment une insuffisance des cellules de Leydig affecte-t-elle la fertilité ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut entraîner une oligospermie ou une azoospermie, réduisant ainsi la fertilité masculine."
}
},
{
"@type": "Question",
"name": "Quelles sont les conséquences d'un déséquilibre hormonal ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les conséquences peuvent inclure des troubles de l'humeur, des problèmes de libido et des dysfonctionnements érectiles."
}
},
{
"@type": "Question",
"name": "Quels effets à long terme peut avoir une hyperplasie des cellules de Leydig ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "À long terme, cela peut entraîner des problèmes métaboliques et des troubles endocriniens."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de tumeurs des cellules de Leydig ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge, des antécédents familiaux et des anomalies testiculaires sont des facteurs de risque connus."
}
},
{
"@type": "Question",
"name": "Comment l'exposition à des produits chimiques affecte-t-elle les cellules de Leydig ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exposition à des perturbateurs endocriniens peut altérer la fonction des cellules de Leydig."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'obésité dans la santé des cellules de Leydig ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'obésité peut entraîner des déséquilibres hormonaux et affecter la production de testostérone."
}
},
{
"@type": "Question",
"name": "Quels comportements augmentent le risque de dysfonction des cellules de Leydig ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme, l'alcoolisme et un mode de vie sédentaire sont des comportements à risque."
}
},
{
"@type": "Question",
"name": "Comment le stress chronique influence-t-il les cellules de Leydig ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut perturber l'axe hypothalamo-hypophyso-testiculaire, affectant la fonction."
}
}
]
}
]
}
Department of Anesthesiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: r_ge@yahoo.com.
Center of Reproductive Medicine, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325003, China.
Zhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Gynecology and Obstetrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Zhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Gynecology and Obstetrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Pharmacology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Laboratory for Chronobiology and Aging, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Dositeja Obradovica Sq 2, 21000, Novi Sad, Serbia.
Laboratory for Reproductive Endocrinology and Signaling, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Dositeja Obradovica Sq 2, 21000, Novi Sad, Serbia.
Laboratory for Chronobiology and Aging, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Dositeja Obradovica Sq 2, 21000, Novi Sad, Serbia. tatjana.kostic@dbe.uns.ac.rs.
Laboratory for Reproductive Endocrinology and Signaling, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Dositeja Obradovica Sq 2, 21000, Novi Sad, Serbia. tatjana.kostic@dbe.uns.ac.rs.
Zhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Zhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Anesthesiology, Perioperative Medicine, Zhejiang Province Key Lab of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Department of Gynecology and Obstetrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Department of Gynecology and Obstetrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Acromegaly is a systemic disease caused by excessive inappropriate secretion of GH and IGF-I levels, resulting in many systemic complications, including cardiovascular, respiratory, metabolic diseases...
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We used data from physical exams and blood analyses to determine the incidence of colorectal polyp. However, these features exhibit highly overlapping classes. The use of a kernel density estimator (K...
Along with an adequate polyp size threshold, the optimal machine learning (ML) models' performance provided 0.37 and 0.39 Matthews correlation coefficient (MCC) for the datasets of men and women, resp...
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Both the clinical manifestation and molecular characteristics of colorectal cancer (CRC) vary according to the anatomical site. We explored the risk factors for four groups of colorectal neoplasms (CR...
We extracted data from the database of Tianjin Colorectal Cancer Screening Program from 2010 to 2020. According to the CRN anatomical sites, patients were divided into four groups: the proximal colon ...
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We observed differences in advanced age, obesity, smoking, alcohol consumption, and family history of colorectal cancer at different anatomical sites of colorectal neoplasms. These factors vary by gen...
National consensus recommendations have recently been developed to standardize colorectal tumour localization and documentation during colonoscopy. In this qualitative semi-structured interview study,...
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The Asia-Pacific Colorectal Screening (APCS) scoring system was developed to stratify the risk of colorectal advanced neoplasm (AN). We aimed to evaluate the performance of the APCS score combined wit...
A total of 2842 subjects who visited outpatient clinics or cancer screening centers were enrolled. Age, sex, smoking status, and family history were recorded and APCS scores were calculated in 2439 pa...
Based on the APCS score, 38.8% (946 of 2439) of the subjects were categorized as high risk, and they had a 1.8-fold increase in risk for AN (95% CI, 1.4-2.3) compared with low and moderate risk. The A...
The APCS score combined with a stool DNA test significantly improved the detection of colorectal ANs, while limiting colonoscopy resource utilization (Chictr.org.cn, ChiCTR-DDD-17011169)....
Screening recommendations for colorectal cancer (CRC) are mainly based on family history rather than lifestyle risk factors. We aimed to assess and compare risk factors for colorectal neoplasm (CRN) a...
This study was based on 89,535 first-recorded colonoscopies in Tianjin CRC screening program, 2012-2020. Of these, 45,380 individuals with complete family history and lifestyle factors were included f...
The overall detection rate of nonadvanced adenomas, advanced adenomas and CRC was 39.3%, 5.9% and 1.5%, respectively. The PAFs of current smoking, alcohol consumption, physical activity, higher BMI an...
Modifiable lifestyle factors, including smoking, alcohol consumption, physical activity and BMI, have a larger contribution to CRN than family history of CRC. Our findings will provide references for ...
Colonoscopy is the gold standard for diagnosing colorectal neoplasms. However, colonoscopy is often repeated preoperatively due to non-standard documentation and inconsistent practices by index endosc...
We performed a retrospective review of patients who underwent elective surgery for colorectal neoplasms at a single institution in Winnipeg between 2007-2020. We compared endoscopy report quality to t...
One hundred ninety-four patients were included (97 rural, 97 urban). The mean overall compliance with the recommendations for urban endoscopies was marginally better compared to rural endoscopies (50%...
Endoscopists frequently omit recommended practices for optimal colorectal lesion localization. Rural reports miss more recommended information compared to urban reports. Future research is needed to f...
A positive resection margin after colorectal endoscopic submucosal dissection (ESD) is associated with an increased risk of recurrence. We aimed to identify the clinical significance of positive resec...