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"description": "Comment diagnostiquer une dysfonction des cellules de Leydig ?\nQuels tests sont utilisés pour évaluer les cellules de Leydig ?\nQuels signes indiquent une insuffisance des cellules de Leydig ?\nComment évaluer la fonction des cellules de Leydig ?\nQuel rôle joue l'échographie dans le diagnostic ?",
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"@type": "Question",
"name": "Comment diagnostiquer une dysfonction des cellules de Leydig ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un dosage hormonal et une échographie testiculaire peuvent aider au diagnostic."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les cellules de Leydig ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests sanguins pour mesurer les niveaux de testostérone et LH sont courants."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une insuffisance des cellules de Leydig ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une baisse de libido, fatigue et troubles de l'érection peuvent indiquer une insuffisance."
}
},
{
"@type": "Question",
"name": "Comment évaluer la fonction des cellules de Leydig ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'évaluation se fait par des tests hormonaux et l'examen clinique des symptômes."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'échographie dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'échographie permet de visualiser les testicules et détecter des anomalies structurelles."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont associés à une hyperplasie des cellules de Leydig ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une augmentation de la testostérone peut causer l'acné, l'hypertrichose et l'agressivité."
}
},
{
"@type": "Question",
"name": "Comment reconnaître une carence en testostérone ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, dépression, perte de masse musculaire et libido réduite."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques indiquent une tumeur des cellules de Leydig ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des douleurs testiculaires, une masse palpable et des changements hormonaux peuvent survenir."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un déséquilibre hormonal ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles de l'érection, des sautes d'humeur et une prise de poids peuvent être présents."
}
},
{
"@type": "Question",
"name": "Comment les symptômes varient-ils selon l'âge ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes de dysfonction peuvent s'aggraver avec l'âge, affectant la libido et l'énergie."
}
},
{
"@type": "Question",
"name": "Comment prévenir les troubles des cellules de Leydig ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain, incluant une alimentation équilibrée et de l'exercice, peut aider."
}
},
{
"@type": "Question",
"name": "Quels examens réguliers sont recommandés ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens médicaux réguliers et des bilans hormonaux peuvent aider à détecter des problèmes tôt."
}
},
{
"@type": "Question",
"name": "Comment éviter les facteurs de risque liés à l'environnement ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Réduire l'exposition aux toxines environnementales et aux perturbateurs endocriniens est crucial."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'alimentation dans la santé des cellules de Leydig ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en nutriments essentiels peut soutenir la fonction hormonale et cellulaire."
}
},
{
"@type": "Question",
"name": "Comment le stress affecte-t-il les cellules de Leydig ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut perturber l'équilibre hormonal et affecter la fonction des cellules de Leydig."
}
},
{
"@type": "Question",
"name": "Quels traitements existent pour l'insuffisance des cellules de Leydig ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie de remplacement de la testostérone est couramment utilisée pour traiter l'insuffisance."
}
},
{
"@type": "Question",
"name": "Comment traiter une hyperplasie des cellules de Leydig ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement peut inclure des médicaments anti-androgènes ou une intervention chirurgicale."
}
},
{
"@type": "Question",
"name": "Quels sont les effets secondaires de la thérapie de testostérone ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires peuvent inclure l'acné, la rétention d'eau et des troubles du sommeil."
}
},
{
"@type": "Question",
"name": "Quand envisager une intervention chirurgicale ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une chirurgie peut être envisagée en cas de tumeur des cellules de Leydig ou d'anomalies structurelles."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont utilisés pour traiter les troubles hormonaux ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme les inhibiteurs de l'aromatase peuvent être prescrits pour équilibrer les hormones."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une tumeur des cellules de Leydig ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent la propagation du cancer et des déséquilibres hormonaux graves."
}
},
{
"@type": "Question",
"name": "Quels risques sont associés à une thérapie de testostérone prolongée ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une thérapie prolongée peut augmenter le risque de maladies cardiovasculaires et de cancer de la prostate."
}
},
{
"@type": "Question",
"name": "Comment une insuffisance des cellules de Leydig affecte-t-elle la fertilité ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut entraîner une oligospermie ou une azoospermie, réduisant ainsi la fertilité masculine."
}
},
{
"@type": "Question",
"name": "Quelles sont les conséquences d'un déséquilibre hormonal ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les conséquences peuvent inclure des troubles de l'humeur, des problèmes de libido et des dysfonctionnements érectiles."
}
},
{
"@type": "Question",
"name": "Quels effets à long terme peut avoir une hyperplasie des cellules de Leydig ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "À long terme, cela peut entraîner des problèmes métaboliques et des troubles endocriniens."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de tumeurs des cellules de Leydig ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge, des antécédents familiaux et des anomalies testiculaires sont des facteurs de risque connus."
}
},
{
"@type": "Question",
"name": "Comment l'exposition à des produits chimiques affecte-t-elle les cellules de Leydig ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exposition à des perturbateurs endocriniens peut altérer la fonction des cellules de Leydig."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'obésité dans la santé des cellules de Leydig ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'obésité peut entraîner des déséquilibres hormonaux et affecter la production de testostérone."
}
},
{
"@type": "Question",
"name": "Quels comportements augmentent le risque de dysfonction des cellules de Leydig ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme, l'alcoolisme et un mode de vie sédentaire sont des comportements à risque."
}
},
{
"@type": "Question",
"name": "Comment le stress chronique influence-t-il les cellules de Leydig ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut perturber l'axe hypothalamo-hypophyso-testiculaire, affectant la fonction."
}
}
]
}
]
}
Department of Anesthesiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: r_ge@yahoo.com.
Center of Reproductive Medicine, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325003, China.
Zhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Gynecology and Obstetrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Zhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Gynecology and Obstetrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Pharmacology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Laboratory for Chronobiology and Aging, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Dositeja Obradovica Sq 2, 21000, Novi Sad, Serbia.
Laboratory for Reproductive Endocrinology and Signaling, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Dositeja Obradovica Sq 2, 21000, Novi Sad, Serbia.
Laboratory for Chronobiology and Aging, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Dositeja Obradovica Sq 2, 21000, Novi Sad, Serbia. tatjana.kostic@dbe.uns.ac.rs.
Laboratory for Reproductive Endocrinology and Signaling, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Dositeja Obradovica Sq 2, 21000, Novi Sad, Serbia. tatjana.kostic@dbe.uns.ac.rs.
Zhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Zhejiang Provincial Key Laboratory of Anesthesiology, Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Anesthesiology, Perioperative Medicine, Zhejiang Province Key Lab of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Department of Gynecology and Obstetrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Department of Gynecology and Obstetrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
to analyze the completeness of variables from Hospital-Based Cancer Registries of cases of prostate neoplasm in the Oncology Care Network of a Brazilian state between 2000 and 2020....
an ecological time series study, based on secondary data on prostate cancer Hospital-Based Cancer Registries prostate. Data incompleteness was classified as excellent (<5%), good (between 5%-10%), fai...
there were 13,519 cases of prostate cancer in the Hospital-Based Cancer Registries analyzed. The variables "family history of cancer" (p<0.001), "alcoholism" (p<0.001), "smoking" (p<0.001), "TNM stagi...
most Hospital-Based Cancer Registries variables showed excellent completeness, but important variables had high percentages of incompleteness, such as TNM and clinical staging, in addition to alcoholi...
We report the case of a 63-year-old male who came to the urology clinic with an increasing value of the prostate specific antigen and an asymmetrical enlargement at the digital rectal examination. The...
The optimal treatment of metastatic castration-resistant prostate cancer (mCRPC) continues to be challenging, given the multitude of life prolonging treatment options. Radionuclide therapy delivers co...
In recent observational studies, a potential link between prostatitis and prostate cancer (PCa) has been hinted at, yet the causality remains ambiguous. In our endeavor to scrutinize the conceivable c...
Prostate-specific membrane antigen (PSMA) hybrid imaging is a promising new technique gaining importance in the field of prostate cancer (PCa) diagnosis and treatment planning. By combining PSMA radio...
Cribriform (CBFM) pattern on prostate biopsy has been implicated as a predictor for high-risk features, potentially leading to adverse outcomes after definitive treatment. This study aims to investiga...
Patients who underwent multiparametric magnetic resonance imaging (mpMRI), combined 12-core transrectal ultrasound (TRUS) guided systematic (SB) and MRI/US fusion-guided biopsy were retrospectively qu...
Between 2015 and 2022, a total of 131 consecutive patients with CBFM pattern on prostate biopsy and pre-biopsy mpMRI were included. Clinical feature analysis included 1572 systematic biopsy cores (114...
The extent of disease for CBFM-containing tumors is difficult to capture on mpMRI. When comparing MRI lesions of similar dimensions and PIRADS scores, CBFM-containing tumors appear to have larger canc...
There is a clinical need to identify patients with an elevated PSA who would benefit from prostate biopsy due to the presence of clinically significant prostate cancer (CSCaP). We have previously repo...
To further develop and adapt the MiCheck® Prostate test so it can be performed using a standard clinical chemistry analyzer and characterize its performance using the MiCheck-01 clinical trial sample ...
About 358 patient samples from the MiCheck-01 US clinical trial were used for the development of the MiCheck® Prostate test. These consisted of 46 controls, 137 non-CaP, 62 non-CSCaP, and 113 CSCaP....
Serum analyte concentrations for cellular growth factors were determined using custom-made Luminex-based R&D Systems multi-analyte kits. Analytes that can also be measured using standard chemistry ana...
Logistic regression modeling with Monte Carlo cross-validation was used to identify Human Epidydimal Protein 4 (HE4) as an analyte able to significantly improve the algorithm specificity at 95% sensit...
The MiCheck® logistic regression model was developed and consisted of PSA, %free PSA, DRE, and HE4. The model differentiated clinically significant cancer from no cancer or not-clinically significant ...
The MiCheck® Prostate test identifies clinically significant prostate cancer with high sensitivity and negative predictive value (NPV). It can be performed in a clinical laboratory using a Roche Cobas...
We sought to determine whether two soluble forms with different size of mtDNA are linked to prostatic inflammation, and whether they discriminate prostate cancer (PCa) from inflammatory prostatic cond...
Histopathologically diagnosed prostatitis, PCa and benign prostatic hyperplasia patients (n = 93) were enrolled in this study and they were categorized as with and without prostate inflammation. Quant...
The urine mtDNA-79 and mtDNA-230 were significantly increased in patients with prostate inflammation compared with those in without inflammation. Here, 79-bp fragment of apoptotic origin was significa...
Our results demonstrate that shorter cf-mtDNA fragment size in particular, increase in the presence of prostate inflammation in post-prostatic massage urine but both fragments could never improve seru...
Although it is thought that prostatitis or benign prostatic hyperplasia (BPH) is related to prostate cancer (PCa), the underlying causal effects of these diseases are unclear....
We assessed the causal relationship between prostatitis or BPH and PCa using a two-sample Mendelian randomization (MR) approach. The data utilized in this study were sourced from genome-wide associati...
MR analysis showed that BPH had a significant causal effect on PCa (Odds Ratio = 1.209, 95% Confidence Interval: 0.098-0.281, P = 5.079 × 10...
This MR study supports that BPH has a positive causal effect on PCa, while genetically predicted prostatitis has no causal effect on PCa. Nonetheless, further studies should explore the underlying bio...
In recent decades, there has been an increasing role for magnetic resonance imaging (MRI) in the detection of clinically significant prostate cancer (csPC). The purpose of this review is to provide an...
In diagnosing clinically significant prostate cancer pre-biopsy, advances include our understanding of MRI-targeted biopsy, the role of biparametric MRI (non-contrast) and changing indications, for ex...
The utility of MRI in detecting csPC has been demonstrated in many clinical scenarios, initially from simply diagnosing csPC pre-biopsy, now to screening, active surveillance, clinical staging, and de...