Titre : Nucléosomes

Nucléosomes : Questions médicales fréquentes

Termes MeSH sélectionnés :

Tissue Array Analysis

Questions fréquentes et termes MeSH associés

Diagnostic 2

#1

Comment identifier les nucléosomes dans une cellule ?

Les nucléosomes peuvent être identifiés par des techniques comme l'électrophorèse sur gel.
Nucléosomes Électrophorèse ADN
#2

Quels tests détectent les niveaux de nucléosomes ?

Des tests sanguins mesurant les niveaux de nucléosomes libres sont utilisés en clinique.
Nucléosomes Tests sanguins Biomarqueurs

Symptômes 2

#1

Les nucléosomes sont-ils associés à des symptômes ?

Les nucléosomes eux-mêmes ne causent pas de symptômes, mais leur dysfonction peut être liée à des maladies.
Nucléosomes Maladies Dysfonction
#2

Quels troubles sont liés aux anomalies des nucléosomes ?

Des anomalies des nucléosomes sont associées à des cancers et des maladies auto-immunes.
Nucléosomes Cancers Maladies auto-immunes

Prévention 2

#1

Peut-on prévenir les anomalies des nucléosomes ?

Une alimentation saine et un mode de vie actif peuvent réduire le risque de maladies associées.
Nucléosomes Prévention Mode de vie
#2

Y a-t-il des dépistages pour les problèmes de nucléosomes ?

Actuellement, il n'existe pas de dépistage spécifique pour les anomalies des nucléosomes.
Nucléosomes Dépistage Anomalies

Traitements 2

#1

Comment traiter les maladies liées aux nucléosomes ?

Le traitement dépend de la maladie sous-jacente, incluant chimiothérapie ou immunothérapie.
Nucléosomes Chimiothérapie Immunothérapie
#2

Les médicaments ciblent-ils les nucléosomes ?

Certains médicaments visent les voies de signalisation affectées par les nucléosomes.
Nucléosomes Médicaments Voies de signalisation

Complications 2

#1

Quelles complications peuvent survenir avec des nucléosomes anormaux ?

Des nucléosomes anormaux peuvent entraîner des cancers et des troubles immunitaires.
Nucléosomes Complications Cancers
#2

Les nucléosomes affectent-ils la réparation de l'ADN ?

Oui, des anomalies dans les nucléosomes peuvent perturber les mécanismes de réparation de l'ADN.
Nucléosomes Réparation de l'ADN Anomalies

Facteurs de risque 2

#1

Quels facteurs augmentent le risque d'anomalies des nucléosomes ?

Des facteurs comme l'exposition à des toxines et des prédispositions génétiques augmentent le risque.
Nucléosomes Facteurs de risque Toxines
#2

L'âge influence-t-il les nucléosomes ?

Oui, le vieillissement peut affecter la structure et la fonction des nucléosomes.
Nucléosomes Âge Vieillissement
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Dr Olivier Menir

Contenu validé par Dr Olivier Menir

Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale


Validation scientifique effectuée le 02/06/2026

Contenu vérifié selon les dernières recommandations médicales

Auteurs principaux

Hitoshi Kurumizaka

6 publications dans cette catégorie

Affiliations :
  • Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address: kurumizaka@iam.u-tokyo.ac.jp.

Karolin Luger

4 publications dans cette catégorie

Publications dans "Nucléosomes" :

Vladimir B Teif

4 publications dans cette catégorie

Affiliations :
  • School of Life Sciences, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK. vteif@essex.ac.uk.

Felix Mueller-Planitz

3 publications dans cette catégorie

Affiliations :
  • Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. felix.mueller-planitz@tu-dresden.de.
Publications dans "Nucléosomes" :

Tomoya Kujirai

3 publications dans cette catégorie

Affiliations :
  • Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Publications dans "Nucléosomes" :

Andrea Schmid

3 publications dans cette catégorie

Affiliations :
  • Biomedical Center (BMC), Molecular Biology, Faculty of Medicine, LMU Munich, Planegg-Martinsried, 82152 Munich, Germany.
Publications dans "Nucléosomes" :

Philipp Korber

3 publications dans cette catégorie

Affiliations :
  • Biomedical Center (BMC), Molecular Biology, Faculty of Medicine, LMU Munich, Planegg-Martinsried, 82152 Munich, Germany.
Publications dans "Nucléosomes" :

Ayako Furukawa

3 publications dans cette catégorie

Affiliations :
  • Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

Yasuhiro Arimura

3 publications dans cette catégorie

Affiliations :
  • Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Yasuo Tsunaka

3 publications dans cette catégorie

Affiliations :
  • Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

Yoshifumi Nishimura

3 publications dans cette catégorie

Affiliations :
  • Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Graduate School of Integrated Sciences for Life, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8258, Japan.

Tae-Hee Lee

3 publications dans cette catégorie

Publications dans "Nucléosomes" :

Petra Vizjak

2 publications dans cette catégorie

Affiliations :
  • Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Department of Molecular Biology, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
  • Early Stage Bioprocess Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.
Publications dans "Nucléosomes" :

Dieter Kamp

2 publications dans cette catégorie

Affiliations :
  • Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Publications dans "Nucléosomes" :

Nicola Hepp

2 publications dans cette catégorie

Affiliations :
  • Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Department of Molecular Biology, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
  • Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Publications dans "Nucléosomes" :

Alessandro Scacchetti

2 publications dans cette catégorie

Affiliations :
  • Department of Molecular Biology, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
  • Epigenetics Institute and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Publications dans "Nucléosomes" :

Mariano Gonzalez Pisfil

2 publications dans cette catégorie

Affiliations :
  • Core Facility Bioimaging and Walter-Brendel-Centre of Experimental Medicine, Biomedical Center, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
Publications dans "Nucléosomes" :

Joseph Bartho

2 publications dans cette catégorie

Affiliations :
  • Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
  • European Molecular Biology Laboratory, Heidelberg, Germany.
Publications dans "Nucléosomes" :

Mario Halic

2 publications dans cette catégorie

Affiliations :
  • Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Publications dans "Nucléosomes" :

Sources (10000 au total)

CYP7B1 as a Biomarker for Prostate Cancer Risk and Progression: Metabolic and Oncogenic Signatures (Diagnostic Immunohistochemistry Analysis by Tissue Microarray in Prostate Cancer Patients-Diamond Study).

We aimed to analyze the association between CYP7B1 and prostate cancer, along with its association with proteins involved in cancer and metabolic processes. A retrospective analysis was performed on 3...

KLK7 expression in human tumors: a tissue microarray study on 13,447 tumors.

Kallikrein-related peptidase 7 (KLK7) is a chymotrypsin-like serine protease which is essential for the desquamation of corneocytes and thus plays a pivotal role in maintaining skin homeostasis. In ca... To comprehensively determine KLK7 protein expression in normal and neoplastic tissues, a tissue microarray containing 13,447 samples from 147 different tumor types and subtypes as well as 608 samples ... KLK7 positivity was found in 64 of 147 tumor categories, including 17 tumor categories with at least one strongly positive case. The highest rate of KLK7 positivity was found in squamous cell carcinom... These data provide a comprehensive overview on KLK7 expression in normal and neoplastic human tissues. The prognostic relevance of KLK7 expression and the possible role of KLK7 as a drug target need t...

Tissue Microarray Immunohistochemical Staining for Androgen Receptor in Breast Cancer in a Ghanaian Cohort.

Despite the advancement in therapy, breast cancer still remains the most common malignancy in women globally due in part to its heterogeneity. Triple-negative breast cancer (TNBC) represents up to 20%... Immunohistochemical staining for AR was performed on tissue microarray (TMA) blocks, of which estrogen receptor, progesterone receptor, and Her-2/neu had already been done. 197 cases were suitable for... 197 TMA cases were used. TNBCs constitute 61.9% of the cancers. The majority of these tumors were grade III, ductal carcinoma NST. The mean age was 49.86 ± 14.09, and the modal age group was 40-49 yea... There is an appreciable level of AR expression in our cases; however, most are quadruple negative. However, AR is more frequently expressed in low-grade tumors than high-grade ones....

Tissue microarray analyses of the essential DNA repair factors ATM, DNA-PKcs and Ku80 in head and neck squamous cell carcinoma.

Head and neck squamous cell carcinoma (HNSCC) negative for Human Papillomavirus (HPV) has remained a difficult to treat entity, whereas tumors positive for HPV are characterized by radiosensitivity an... A tissue microarray of a single center HNSCC cohort was stained for ATM, DNA-PKcs and Ku80 and the expression scored based on staining intensity and the percentages of tumor cells stained. Scores were... Samples from 427 HNSCC patients yielded interpretable stainings and were scored following an established algorithm. The majority of tumors showed strong expression of both NHEJ factors, whereas the ex... Our data suggest that HPV-negative HNSCC with particularly low Ku80 expression represent a highly radiosensitive subpopulation. Confirmation in independent cohorts is required....

EBV-Associated Gastric Cancer; An In Situ Hybridization Assay on Tissue Microarray: A Multi-Region Study from Four Major Provinces of Iran.

Gastric cancer is the fourth leading cause of cancer-related deaths in the world. The identification of gastric cancer subtypes related to recognizable microbial agents may play a pivotal role in the ... Paraffin blocks of 682 cases of various types of gastric cancer from Tehran, South and North areas of Iran were collected. Twelve tissue microarray (TMA) blocks were constructed from these blocks. Loc... Fourteen out of 682 cases (2.1%) of gastric adenocarcinoma were EBER-positive. EBER was positive in 8 out of 22 (36.4%) of medullary carcinomas and 6 out of 660 (0.9%) of non-medullary type, which was... EBV-associated gastric adenocarcinoma has a low prevalence in Iran. This finding can be due to epidemiologic differences in risk factors and exposures, and the low number of gastric medullary carcinom...

Topographic analysis of pancreatic cancer by TMA and digital spatial profiling reveals biological complexity with potential therapeutic implications.

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human malignancies. Tissue microarrays (TMA) are an established method of high throughput biomarker interrogation in tissues but ...