Comment diagnostiquer une dysfonction mitochondriale ?

Un diagnostic peut inclure des tests génétiques, des biopsies musculaires et des analyses biochimiques.

Quels tests sanguins sont utilisés pour évaluer les protéines mitochondriales ?

Des tests de lactate, pyruvate et des enzymes spécifiques peuvent être effectués.

Quels symptômes indiquent une maladie mitochondriale ?

Fatigue, faiblesse musculaire, troubles neurologiques et problèmes cardiaques peuvent indiquer une maladie.

Les tests génétiques sont-ils fiables pour les maladies mitochondriales ?

Oui, les tests génétiques peuvent identifier des mutations spécifiques liées aux maladies mitochondriales.

Quel rôle joue l'imagerie dans le diagnostic mitochondrial ?

L'imagerie par résonance magnétique (IRM) peut aider à visualiser des anomalies cérébrales.

Quels sont les symptômes courants des maladies mitochondriales ?

Les symptômes incluent fatigue, douleurs musculaires, troubles de la vision et épilepsie.

Les troubles cognitifs sont-ils liés aux protéines mitochondriales ?

Oui, des troubles cognitifs peuvent survenir en raison de dysfonctionnements mitochondriaux.

Comment la myopathie mitochondriale se manifeste-t-elle ?

Elle se manifeste par une faiblesse musculaire, des crampes et une intolérance à l'exercice.

Les troubles cardiaques sont-ils fréquents dans les maladies mitochondriales ?

Oui, des cardiomyopathies peuvent se développer en raison de dysfonctionnements mitochondriaux.

Les symptômes varient-ils selon l'âge d'apparition ?

Oui, les symptômes peuvent varier considérablement selon l'âge d'apparition de la maladie.

Peut-on prévenir les maladies mitochondriales ?

Certaines maladies génétiques ne peuvent pas être prévenues, mais un mode de vie sain aide.

L'exercice physique peut-il réduire les risques ?

Oui, l'exercice régulier peut améliorer la santé mitochondriale et réduire les risques.

Les antioxydants jouent-ils un rôle préventif ?

Oui, les antioxydants peuvent protéger les mitochondries des dommages oxydatifs.

Une alimentation équilibrée est-elle importante ?

Oui, une alimentation riche en nutriments soutient la santé mitochondriale.

Les dépistages précoces sont-ils recommandés ?

Oui, le dépistage précoce peut aider à identifier les risques et à intervenir rapidement.

Quels traitements sont disponibles pour les maladies mitochondriales ?

Les traitements incluent des suppléments, des thérapies symptomatiques et des approches nutritionnelles.

Les coenzymes Q10 sont-elles bénéfiques ?

Oui, le coenzyme Q10 peut améliorer la fonction mitochondriale et réduire les symptômes.

La thérapie génique est-elle une option pour ces maladies ?

La thérapie génique est en recherche, mais elle pourrait offrir des solutions futures.

Les régimes alimentaires peuvent-ils aider ?

Oui, des régimes spécifiques peuvent soutenir la fonction mitochondriale et améliorer les symptômes.

Les traitements varient-ils selon le type de maladie mitochondriale ?

Oui, les traitements doivent être adaptés au type spécifique de maladie mitochondriale.

Quelles complications peuvent survenir avec les maladies mitochondriales ?

Les complications incluent des troubles neurologiques, cardiaques et endocriniens.

Les maladies mitochondriales peuvent-elles affecter la fertilité ?

Oui, certaines maladies mitochondriales peuvent entraîner des problèmes de fertilité.

Les complications peuvent-elles être gérées ?

Certaines complications peuvent être gérées avec des traitements symptomatiques appropriés.

Les maladies mitochondriales augmentent-elles le risque de cancer ?

Certaines études suggèrent un lien entre dysfonction mitochondriale et risque accru de cancer.

Les complications cardiovasculaires sont-elles fréquentes ?

Oui, les maladies mitochondriales peuvent entraîner des cardiomyopathies et d'autres complications.

Quels sont les facteurs de risque pour les maladies mitochondriales ?

Les facteurs incluent des antécédents familiaux, des mutations génétiques et des expositions environnementales.

L'âge est-il un facteur de risque ?

Oui, certaines maladies mitochondriales se manifestent plus fréquemment avec l'âge.

Les facteurs environnementaux influencent-ils les maladies mitochondriales ?

Oui, l'exposition à des toxines peut augmenter le risque de dysfonction mitochondriale.

Le stress oxydatif est-il un facteur de risque ?

Oui, le stress oxydatif peut endommager les mitochondries et contribuer à des maladies.

Les habitudes alimentaires peuvent-elles influencer le risque ?

Oui, une alimentation pauvre en nutriments peut augmenter le risque de dysfonction mitochondriale.

Protéines mitochondriales - Informations médicales vérifiées

Accuracy of robotic-assisted pedicle screw placement comparing junior surgeons with expert surgeons: Can junior surgeons place pedicle screws as accurately as expert surgeons?

Sep 2023

DOI: 10.1016/j.jos.2022.06.012 PMID: 35864030

The purpose of this study was to verify whether a spine robotic system was useful for junior surgeons.... Twenty-seven patients underwent posterior spinal fusion with open surgery using a spine robotic system (Mazor X Stealth Edition, Medtronic Inc., Dublin, Ireland) from April to August 2021. Pedicle scr... In the expert surgeon group, the GR grades were Grade A for 79 screws (90.8%), Grade B for 6 (6.9%), Grade C for 2 (2.3%), and 0 (0%) for Grades D and E. I In the junior surgeon group, the GR grades w... There were no significant differences in the deviation rate and the insertion time of robotic-assisted pedicle screw placement between expert surgeons and junior surgeons who were training to acquire ...

Humans Pedicle Screws Robotic Surgical Procedures Spine Surgery, Computer-Assisted +2 autres

Survey of New Zealand Arthroplasty Surgeons on Surgeon-Level Outcome Reporting.

11 2023

DOI: 10.1016/j.arth.2023.05.069 PMID: 37279844

Surgeon-specific outcome monitoring has become increasingly prevalent over the last 3 decades. The New Zealand Orthopaedic Association monitors individual surgeon performance through 2 mechanisms: art... The survey consisted of 9 questions on surgeon-specific outcome reporting, using a five-point Likert scale, and 5 demographic questions. It was distributed to all current hip and knee arthroplasty sur... Respondents agreed that monitoring arthroplasty outcomes is important and that revision rates are an acceptable measure of performance. Reporting risk-adjusted revision rates and more recent timeframe... The findings of this survey support the use of revision rates to confidentially monitor surgeon-level arthroplasty outcomes and suggest that concurrent use of patient-reported outcome measures would b...

Humans Arthroplasty, Replacement, Hip New Zealand Surgeons Arthroplasty, Replacement, Knee +2 autres

Does surgeon specialization add value to surgeon volume in gastric cancer surgery?

Nov 2023

DOI: 10.1016/j.ejso.2023.107091 PMID: 37757682

This study aimed to assess the combined impact of surgeon specialization and surgeon volume on both short- and long-term outcomes in patients underwent curative gastrectomy for gastric cancer.... Patients with cStage1-3 gastric adenocarcinoma who underwent curative-intent surgery between January 2010 and December 2020 were evaluated. The impact of surgeon specialization and surgeon volume on c... Total of 537 patients operated by twelve surgeons were included in the analysis. For all cohort, the 30d-, in-hospital and 90d-mortality were 3.5%, 3%, and 6.3%, respectively. High surgeon volume alon... The primary factor influencing short-term outcomes for patients who underwent gastric cancer surgery was found to be surgeon volume, while specialization provided a limited additional value. However, ...

Humans Stomach Neoplasms Proportional Hazards Models Gastrectomy Surgeons +3 autres

Can the surgeon prolong the remaining life of the patient in pancreaticoduodenectomy surgery? or Is the surgeon helpless?

23 05 2022

DOI: 10.24875/CIRU.21000683 PMID: 35259757

We aimed to evaluate the effects of R0 and R1 resections after pancreatic surgery.... Data of 130 patients were evaluated. Re-resection was performed in patients who were found to have R1 resection after frozen section (FS). Overall survival (OS), disease free survival (DFS) among pati... Tumor diameter, differentiation, age and complications were found to negatively affect OS. It was observed that DFS increased (p:0.02) and local recurrence rates decreased (p:0.037) in group 2 compare... R0 resection obtained by surgical margin resection of the neck in pancreatic head adenocarcinomas decreases local recurrence and increases the duration of DFS. However, it has no effect on preventing ...

Humans Margins of Excision Neoplasm Recurrence, Local Pancreatectomy Pancreatic Neoplasms +5 autres

Ethnic and Racial Diversity Among Surgeon and Non-Surgeon Deans of Allopathic Medical Schools.

Nov 2023

DOI: 10.1177/00031348221117036 PMID: 36113434

Previous publications have assessed the diversity among medical students, residents, faculty, and department leaders in surgery and medicine overall. We aim to evaluate the diversity among medical sch... 151 allopathic medical schools were included. Data regarding demographics, education, training, and previous leadership position were collected from institutional websites, online resources, and July ... 21.9% (n = 33) of all medical school deans were surgeons. 21.2% (n = 7) were women, which was not significantly different from non-surgeons (22%,... The demographic diversity of surgeon and non-surgeon US medical school deans is not significantly different. The deficiencies in leadership diversity in medicine persists among medical school deans. T...

Humans United States Female Male Schools, Medical +4 autres

Appendectomy by Pediatric Surgeons in North Carolina is Associated With Higher Charge Than General Surgeons.

01 2023

DOI: 10.1016/j.jss.2022.08.022 PMID: 36228340

The delivery of pediatric surgical care for acute appendicitis involves general surgeons (GS) and pediatric surgeons (PS), but the differences in clinical practice are primarily undescribed. We examin... We performed a retrospective review of the North Carolina hospital discharge database (2013-2017) in pediatric patients (≤18 y) who had surgery for appendiceal pathology (acute or chronic appendicitis... Over the study period, 21,049 patients had appendicitis or other diseases of the appendix, and 15,230 (72.4%) underwent appendectomy. Patients who were operated on by PS were younger (10 y, interquart... The total charge for operations for appendiceal disease is significantly higher for PS compared to GS. Pediatric surgeons had increased surgical charges compared to GS but decreased radiology charges....

Humans Child Appendectomy Appendicitis North Carolina +5 autres

The job market for HPB surgeons: leadership perspectives on surgeon skillsets, training pathways, and hiring.

12 2022

DOI: 10.1016/j.hpb.2022.09.017 PMID: 36307255

Three tracks prepare Hepato-Pancreato-Biliary (HPB) surgeons: HPB, surgical oncology, and transplant fellowships. This study explored how surgical leaders thought about HPB surgery and evaluated poten... This descriptive qualitative study utilized interviews of healthcare leaders whose responsibilities included hiring HPB surgeons. We coded inductively then used thematic network analysis to organize t... Primary themes were: (1) What defines an HPB surgical practice?, (2) How do they assess candidates for HPB positions?, and (3) How will HPB practices continue to evolve? Leaders assessed applicants' t... Surgical societies should focus on facilitating networking, promoting transparency, sharing quality data, providing evidence of technical skills and teamwork, mentorship, and providing guidance to gen...

Humans Education, Medical, Graduate Digestive System Surgical Procedures Surgeons Fellowships and Scholarships +1 autres

[What female surgeons wish for!]

Nov 2023

DOI: 10.1007/s00113-023-01354-5 PMID: 37450023

Surgical specialties have a recruitment problem. A magnification of the problem is often seen in the "feminization" of medicine but the causes are multifactorial. Female physicians of the association ... An anonymized online survey was conducted internally within the association ("Die Chirurginnen e. V.") in October 2022. The survey contained a total of 57 questions and was divided into 7 sections (de... A total of 358 female surgeons participated in the survey. This represented a response rate of 25.5% of association members (as of October 2022: n = 1406). The mean age was 39.25 years (±8.06 years; r... Motivated and dedicated surgeons are needed to counteract the already existing and increasingly severe shortage of manpower. In recent decades, the proportion of female students and physicians has bee...

Humans Female Male Adult Surgeons +4 autres

Becoming a Sustainable Academic Surgeon.

Mar 2023

DOI: 10.1016/j.jss.2022.10.091 PMID: 36442260

Health care facilities represent a significant source of pollution, contributing to the growing problems associated with global warming. The resulting climate change impacts our health through worseni... We outline here the not only the role of the surgeon in contributing to climate change, but also ways in which to minimize one's carbon footprint.... Surgeons are leaders within healthcare systems. Adopting environmentally conscious practices can reduce solid waste, energy usage, and carbon emissions. Practices outside of the clinical setting can a... Academic surgery combines clinical practice with an element of leadership, at all levels. Our recognition and action to reduce wasteful practices can help leave a better earth for generations to come....

Humans Carbon Footprint Delivery of Health Care Climate Change Surgeons

Surgeon Volume and Laryngectomy Outcomes.

04 2023

DOI: 10.1002/lary.30229 PMID: 35634691

To examine the relationship between surgeon volume and operative morbidity and mortality for laryngectomy.... The Nationwide Inpatient Sample was used to identify 45,156 patients who underwent laryngectomy procedures for laryngeal or hypopharyngeal cancer between 2001 and 2011. Hospital and surgeon laryngecto... Relationships between hospital and surgeon volume and mortality, surgical complications, and acute medical complications were examined using multivariable regression.... Higher-volume surgeons were more likely to operate at large, teaching, nonprofit hospitals and were more likely to treat patients who were white, had private insurance, hypopharyngeal cancer, low como... There is a strong volume-outcome relationship for laryngectomy, with reduced mortality and morbidity associated with higher surgeon and higher hospital volumes. Observed associations between hospital ...

Humans Laryngectomy Hypopharyngeal Neoplasms Treatment Outcome Hospitals, High-Volume +2 autres

Protéines mitochondriales : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Aldehyde dehydrogenase, mitochondrial

Mitochondrial creatine kinase

DNA Polymerase gamma

Ferrochelatase

Protéines de transport de la membrane mitochondriale

Protéine trifonctionnelle mitochondriale

Nucleoside diphosphate kinase D

Peroxiredoxin III

Prohibitines

Sirtuine-3

Mitochondrial ADP, ATP Translocases

Pore de transition de perméabilité mitochondriale

Protéines du complexe d'import des protéines précurseurs mitochondriales

Mitochondrial Proton-Translocating ATPases

Protéines de découplage mitochondrial

Canal anionique-1 voltage-dépendant

Canal anionique-2 voltage-dépendant

Sous-unité alpha de la protéine trifonctionnelle mitochondriale

Sous-unité bêta de la protéine trifonctionnelle mitochondriale

Translocateur-1 de nucléotides adényliques

Translocateur-2 de nucléotides adényliques

Translocateur-3 de nucléotides adényliques

Protéine-1 de découplage

Protéine-2 de découplage

Protéine-3 de découplage

Auteurs principaux

Sources (3595 au total)