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Enzymes et coenzymes
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Granzymes : Questions médicales fréquentes
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5
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5
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5
Granzymes
Facteurs de risque
Granzymes
Maladies auto-immunes
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"position": 8,
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"@type": "Question",
"name": "Les granzymes sont-ils impliqués dans des maladies auto-immunes ?",
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"@type": "Question",
"name": "Y a-t-il des vaccins contre les granzymes ?",
"position": 12,
"acceptedAnswer": {
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"@type": "Question",
"name": "Comment réduire le risque de maladies liées aux granzymes ?",
"position": 13,
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{
"@type": "Question",
"name": "Les infections peuvent-elles influencer les granzymes ?",
"position": 14,
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"position": 15,
"acceptedAnswer": {
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}
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"position": 16,
"acceptedAnswer": {
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"position": 17,
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}
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"@type": "Question",
"name": "Comment inhiber l'activité des granzymes ?",
"position": 18,
"acceptedAnswer": {
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"@type": "Question",
"name": "Les traitements à base de granzymes sont-ils sûrs ?",
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{
"@type": "Question",
"name": "Les granzymes sont-ils impliqués dans des essais cliniques ?",
"position": 20,
"acceptedAnswer": {
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"text": "Oui, des essais cliniques explorent leur rôle dans le traitement du cancer."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des granzymes élevés ?",
"position": 21,
"acceptedAnswer": {
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}
},
{
"@type": "Question",
"name": "Les granzymes sont-ils liés à des complications cancéreuses ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une activité excessive peut contribuer à la progression tumorale et à la résistance."
}
},
{
"@type": "Question",
"name": "Comment les granzymes affectent-ils la santé des tissus ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent causer des dommages aux tissus sains en induisant une apoptose non régulée."
}
},
{
"@type": "Question",
"name": "Les granzymes peuvent-ils causer des effets indésirables ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des effets indésirables peuvent survenir lors de traitements ciblant les granzymes."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques associés aux thérapies ciblant les granzymes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des risques d'inflammation et de réactions immunitaires peuvent exister."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent l'activité des granzymes ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les infections chroniques et certains cancers peuvent augmenter leur activité."
}
},
{
"@type": "Question",
"name": "Le stress influence-t-il les granzymes ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut moduler l'activité des granzymes et affecter l'immunité."
}
},
{
"@type": "Question",
"name": "L'âge affecte-t-il les niveaux de granzymes ?",
"position": 28,
"acceptedAnswer": {
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"text": "Oui, l'âge peut influencer la production et l'activité des granzymes dans l'organisme."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes augmentent-elles les granzymes ?",
"position": 29,
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}
},
{
"@type": "Question",
"name": "Une alimentation déséquilibrée influence-t-elle les granzymes ?",
"position": 30,
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"text": "Oui, une mauvaise alimentation peut affecter la réponse immunitaire et l'activité des granzymes."
}
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}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 17/04/2025
Contenu vérifié selon les dernières recommandations médicales
16 publications dans cette catégorie
Affiliations :
International Collaboration on Repair Discoveries (ICORD), Vancouver Coastal Health Research Institute, University of British Columbia (UBC), Vancouver, British Columbia (BC), Canada; Department of Pathology and Laboratory Medicine, UBC, Vancouver, BC, Canada; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, UBC, Vancouver, BC, Canada. Electronic address: david.granville@hli.ubc.ca.
6 publications dans cette catégorie
Affiliations :
International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute, University of British Columbia, 818 West 10th Ave., Vancouver V5Z 1M9, BC, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 2B5, BC, Canada.
6 publications dans cette catégorie
Affiliations :
International Collaboration on Repair Discoveries (ICORD), British Columbia Professional Firefighters' Wound Healing Laboratory, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
5 publications dans cette catégorie
Affiliations :
Department of Dermatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Publications dans "Granzymes" :
4 publications dans cette catégorie
Affiliations :
International Collaboration on Repair Discoveries (ICORD), Vancouver Coastal Health Research Institute, University of British Columbia (UBC), Vancouver, British Columbia (BC), Canada; Department of Pathology and Laboratory Medicine, UBC, Vancouver, BC, Canada; UBC Centre for Heart Lung Innovation, St. Paul's Hospital, UBC, Vancouver, BC, Canada. Electronic address: mzeglins@icord.org.
Publications dans "Granzymes" :
4 publications dans cette catégorie
Affiliations :
International Collaboration on Repair Discoveries (ICORD), British Columbia Professional Firefighters' Wound Healing Laboratory, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Publications dans "Granzymes" :
4 publications dans cette catégorie
Affiliations :
International Collaboration on Repair Discoveries (ICORD) Centre; British Columbia Professional Firefighters' Burn and Wound Healing Group, Vancouver Coastal Health Research Institute; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Publications dans "Granzymes" :
4 publications dans cette catégorie
Affiliations :
International Collaboration on Repair Discoveries (ICORD), Vancouver Coastal Health Research Institute (VCHRI), University of British Columbia (UBC), Vancouver, British Columbia, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
British Columbia Professional Firefighters' Wound Healing Laboratory, VCHRI, Vancouver, British Columbia, Canada.
Publications dans "Granzymes" :
4 publications dans cette catégorie
Affiliations :
International Collaboration on Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Publications dans "Granzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.
Center for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
Publications dans "Granzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
Publications dans "Granzymes" :
3 publications dans cette catégorie
Affiliations :
Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragon (CIBA), Zaragoza, Spain.
Department of Microbiology, Radiology, Pediatrics and Public Health, University of Zaragoza, Zaragoza, Spain.
CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Zaragoza, Spain.
Publications dans "Granzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Biomedical Sciences, Venetian Institute of Molecular Medicine, Padova, Italy.
Department of Biomedical Sciences, University of Padua, Padova, Italy.
Publications dans "Granzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Oncology, Microbiology and Immunology, Anatomy Unit, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Publications dans "Granzymes" :
3 publications dans cette catégorie
Affiliations :
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
Publications dans "Granzymes" :
3 publications dans cette catégorie
Affiliations :
Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragón (CIBA), Zaragoza, Spain.
Publications dans "Granzymes" :
2 publications dans cette catégorie
Affiliations :
Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Publications dans "Granzymes" :
2 publications dans cette catégorie
Affiliations :
Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Division of Rheumatology and Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Publications dans "Granzymes" :
2 publications dans cette catégorie
Affiliations :
Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Publications dans "Granzymes" :
2 publications dans cette catégorie
Publications dans "Granzymes" :
T cell-derived pro-inflammatory cytokines are a major driver of rheumatoid arthritis (RA) pathogenesis. Although these cytokines have traditionally been attributed to CD4 T cells, we have found that C...
Colorectal cancer (CRC) is among the most common malignancies worldwide. CRC is considered a heterogeneous disease due to various clinical symptoms, biological behaviours, and a variety of mutations. ...
CD11c...
Twenty-six patients with hepatitis B virus (HBV)-related HCC and 25 healthy controls (HC) were enrolled. The frequency and phenotype of CD11c...
Both the HCC group and HC group had similar frequency and phenotype characteristics of CD11c...
These findings indicate that CD11c...
Autoimmune diseases often present with cutaneous symptoms that contribute to dysfunction, disfigurement, and in many cases, reduced quality-of-life. Unfortunately, treatment options for many autoimmun...
Granzymes are serine proteases previously believed to play exclusive and somewhat redundant roles in lymphocyte-mediated target cell death. However, recent studies have challenged this paradigm. Disti...
Pterygium is often associated with chronic ultraviolet (UV) radiation exposure and characterized by the overgrowth of conjunctiva and extracellular matrix (ECM) remodeling. Notably, several studies in...
Granzyme B is a serine protease extensively studied for its implication in cytotoxic lymphocyte-mediated apoptosis. In recent years, the paradigm that the role of granzyme B is restricted to immune ce...
After an overview of the current knowledge on granzyme B, a description of newly identified functions will be presented, focussing on granzyme B ability to promote cell-cell and dermal-epidermal junct...
The absence of endogenous extracellular inhibitors renders extracellular granzyme B accumulation deleterious for the proper healing of chronic wounds due to sustained proteolytic activity. Consequentl...
Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by chronic inflammation that affects synovial tissues of multiple joints. Granzymes (Gzms) are serine proteases that are release...
Granzyme B (GZMB) is a key enzyme released by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells to induce apoptosis in target cells. We designed a novel fluorogenic biosensor which is able t...
Granzymes are a family of small (∼32 kDa) serine proteases with a range of substrate specificities that are stored in, and released from, the cytoplasmic secretory vesicles ('granules') of cytotoxic T...