D Axford

Affiliations

Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, UK.

Publications (29)

Serial Femtosecond Zero Dose Crystallography Captures a Water-Free Distal Heme Site in a Dye-Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in Fe

Angewandte Chemie (International ed. in English)

Avec: Marina Lučić , Dimitri A Svistunenko , Michael T Wilson , Amanda K Chaplin , Bradley Davy , Ali Ebrahim , Danny Axford , Takehiko Tosha , Hiroshi Sugimoto , Shigeki Owada , Florian S N Dworkowski , Ivo Tews , Robin L Owen , Michael A Hough , Jonathan A R Worrall

An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography.

Nature communications

Avec: Agata Butryn , Philipp S Simon , Pierre Aller , Philip Hinchliffe , Ramzi N Massad , Gabriel Leen , Catherine L Tooke , Isabel Bogacz , In-Sik Kim , Asmit Bhowmick , Aaron S Brewster , Nicholas E Devenish , Jürgen Brem , Jos J A G Kamps , Pauline A Lang , Patrick Rabe , Danny Axford , John H Beale , Bradley Davy , Ali Ebrahim , Julien Orlans , Selina L S Storm , Tiankun Zhou , Shigeki Owada , Rie Tanaka , Kensuke Tono , Gwyndaf Evans , Robin L Owen , Frances A Houle , Nicholas K Sauter , Christopher J Schofield , James Spencer , Vittal K Yachandra , Junko Yano , Jan F Kern , Allen M Orville

xia2.multiplex: a multi-crystal data-analysis pipeline.

Acta crystallographica. Section D, Structural biology

Avec: Richard J Gildea , James Beilsten-Edmands , Danny Axford , Sam Horrell , Pierre Aller , James Sandy , Juan Sanchez-Weatherby , C David Owen , Petra Lukacik , Claire Strain-Damerell , Robin L Owen , Martin A Walsh , Graeme Winter

Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature.

IUCrJ

Avec: Tadeo Moreno-Chicano , Leiah M Carey , Danny Axford , John H Beale , R Bruce Doak , Helen M E Duyvesteyn , Ali Ebrahim , Robert W Henning , Diana C F Monteiro , Dean A Myles , Shigeki Owada , Darren A Sherrell , Megan L Straw , Vukica Šrajer , Hiroshi Sugimoto , Kensuke Tono , Takehiko Tosha , Ivo Tews , Martin Trebbin , Richard W Strange , Kevin L Weiss , Jonathan A R Worrall , Flora Meilleur , Robin L Owen , Reza A Ghiladi , Michael A Hough

An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin.

Communications chemistry

Avec: Jake A Hill , Yvonne Nyathi , Sam Horrell , David von Stetten , Danny Axford , Robin L Owen , Godfrey S Beddard , Arwen R Pearson , Helen M Ginn , Briony A Yorke

Experimental evidence for the benefits of higher X-ray energies for macromolecular crystallography.

IUCrJ

Avec: Selina L S Storm , Danny Axford , Robin L Owen

Serial Femtosecond Crystallography Reveals the Role of Water in the One- or Two-Electron Redox Chemistry of Compound I in the Catalytic Cycle of the B-Type Dye-Decolorizing Peroxidase DtpB.

ACS catalysis

Avec: Marina Lučić , Michael T Wilson , Takehiko Tosha , Hiroshi Sugimoto , Anastasya Shilova , Danny Axford , Robin L Owen , Michael A Hough , Jonathan A R Worrall

Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B.

eLife

Avec: Tamar Skaist Mehlman , Justin T Biel , Syeda Maryam Azeem , Elliot R Nelson , Sakib Hossain , Louise Dunnett , Neil G Paterson , Alice Douangamath , Romain Talon , Danny Axford , Helen Orins , Frank von Delft , Daniel A Keedy

A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from

Proceedings of the National Academy of Sciences of the United States of America

Avec: Rachel Bolton , Moritz M Machelett , Jack Stubbs , Danny Axford , Nicolas Caramello , Lucrezia Catapano , Martin Malý , Matthew J Rodrigues , Charlotte Cordery , Graham J Tizzard , Fraser MacMillan , Sylvain Engilberge , David von Stetten , Takehiko Tosha , Hiroshi Sugimoto , Jonathan A R Worrall , Jeremy S Webb , Mike Zubkov , Simon Coles , Eric Mathieu , Roberto A Steiner , Garib Murshudov , Tobias E Schrader , Allen M Orville , Antoine Royant , Gwyndaf Evans , Michael A Hough , Robin L Owen , Ivo Tews

Development and internal validation of machine learning-based models and external validation of existing risk scores for outcome prediction in patients with ischaemic stroke.

European heart journal. Digital health

Avec: Daniel Axford , Ferdous Sohel , Vida Abedi , Ye Zhu , Ramin Zand , Ebrahim Barkoudah , Troy Krupica , Kingsley Iheasirim , Umesh M Sharma , Sagar B Dugani , Paul Y Takahashi , Sumit Bhagra , Mohammad H Murad , Gustavo Saposnik , Mohammed Yousufuddin

Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins.

IUCrJ

Avec: Ali Ebrahim , Tadeo Moreno-Chicano , Martin V Appleby , Amanda K Chaplin , John H Beale , Darren A Sherrell , Helen M E Duyvesteyn , Shigeki Owada , Kensuke Tono , Hiroshi Sugimoto , Richard W Strange , Jonathan A R Worrall , Danny Axford , Robin L Owen , Michael A Hough

How best to use photons.

Acta crystallographica. Section D, Structural biology

Avec: Graeme Winter , Richard J Gildea , Neil G Paterson , John Beale , Markus Gerstel , Danny Axford , Melanie Vollmar , Katherine E McAuley , Robin L Owen , Ralf Flaig , Alun W Ashton , David R Hall

Reducing sample consumption for serial crystallography using acoustic drop ejection.

Journal of synchrotron radiation

Avec: Bradley Davy , Danny Axford , John H Beale , Agata Butryn , Peter Docker , Ali Ebrahim , Gabriel Leen , Allen M Orville , Robin L Owen , Pierre Aller

Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison.

Science advances

Avec: P Mehrabi , R Bücker , G Bourenkov , H M Ginn , D von Stetten , H M Müller-Werkmeister , A Kuo , T Morizumi , B T Eger , W-L Ou , S Oghbaey , A Sarracini , J E Besaw , O Pare-Labrosse , S Meier , H Schikora , F Tellkamp , A Marx , D A Sherrell , D Axford , R L Owen , O P Ernst , E F Pai , E C Schulz , R J D Miller

A versatile approach to high-density microcrystals in lipidic cubic phase for room-temperature serial crystallography.

Journal of applied crystallography

Avec: James Birch , Tristan O C Kwan , Peter J Judge , Danny Axford , Pierre Aller , Agata Butryn , Rosana I Reis , Juan F Bada Juarez , Javier Vinals , Robin L Owen , Eriko Nango , Rie Tanaka , Kensuke Tono , Yasumasa Joti , Tomoyuki Tanaka , Shigeki Owada , Michihiro Sugahara , So Iwata , Allen M Orville , Anthony Watts , Isabel Moraes

Direct measurement of X-ray-induced heating of microcrystals.

Journal of synchrotron radiation

Avec: Anna J Warren , Danny Axford , Robin L Owen

Two states of a light-sensitive membrane protein captured at room temperature using thin-film sample mounts.

Acta crystallographica. Section D, Structural biology

Avec: Danny Axford , Peter J Judge , Juan F Bada Juarez , Tristan O C Kwan , James Birch , Javier Vinals , Anthony Watts , Isabel Moraes

Membrane protein crystallography in the era of modern structural biology.

Biochemical Society transactions

Avec: Tristan O C Kwan , Danny Axford , Isabel Moraes

Fixed Target Serial Data Collection at Diamond Light Source.

Journal of visualized experiments : JoVE

Avec: Sam Horrell , Danny Axford , Nicholas E Devenish , Ali Ebrahim , Michael A Hough , Darren A Sherrell , Selina L S Storm , Ivo Tews , Jonathan A R Worrall , Robin L Owen

Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization.

Nature communications

Avec: Juan F Bada Juarez , Peter J Judge , Suliman Adam , Danny Axford , Javier Vinals , James Birch , Tristan O C Kwan , Kin Kuan Hoi , Hsin-Yung Yen , Anthony Vial , Pierre-Emmanuel Milhiet , Carol V Robinson , Igor Schapiro , Isabel Moraes , Anthony Watts

Observation of Cation Chromophore Photoisomerization of a Fluorescent Protein Using Millisecond Synchrotron Serial Crystallography and Infrared Vibrational and Visible Spectroscopy.

The journal of physical chemistry. B

Avec: James M Baxter , Christopher D M Hutchison , Karim Maghlaoui , Violeta Cordon-Preciado , R Marc L Morgan , Pierre Aller , Agata Butryn , Danny Axford , Sam Horrell , Robin L Owen , Selina L S Storm , Nicholas E Devenish , Jasper J van Thor

Atomic structure of a nudivirus occlusion body protein determined from a 70-year-old crystal sample.

Nature communications

Avec: Jeremy R Keown , Adam D Crawshaw , Jose Trincao , Loïc Carrique , Richard J Gildea , Sam Horrell , Anna J Warren , Danny Axford , Robin Owen , Gwyndaf Evans , Annie Bézier , Peter Metcalf , Jonathan M Grimes

Comparing internal fixation constructs for scapular spine insufficiency fractures following reverse shoulder arthroplasty.

Journal of shoulder and elbow surgery

Avec: Francis S H Ting , Jason S Lockhart , David Axford , James A Johnson , Daniel G Langohr , George S Athwal

Non-Contact Universal Sample Presentation for Room Temperature Macromolecular Crystallography Using Acoustic Levitation.

Scientific reports

Avec: R H Morris , E R Dye , D Axford , M I Newton , J H Beale , P T Docker

Resolving polymorphs and radiation-driven effects in microcrystals using fixed-target serial synchrotron crystallography.

Acta crystallographica. Section D, Structural biology

Avec: Ali Ebrahim , Martin V Appleby , Danny Axford , John Beale , Tadeo Moreno-Chicano , Darren A Sherrell , Richard W Strange , Michael A Hough , Robin L Owen

High-throughput structures of protein-ligand complexes at room temperature using serial femtosecond crystallography.

IUCrJ

Avec: Tadeo Moreno-Chicano , Ali Ebrahim , Danny Axford , Martin V Appleby , John H Beale , Amanda K Chaplin , Helen M E Duyvesteyn , Reza A Ghiladi , Shigeki Owada , Darren A Sherrell , Richard W Strange , Hiroshi Sugimoto , Kensuke Tono , Jonathan A R Worrall , Robin L Owen , Michael A Hough

Dynamic adaptive X-ray optics. Part II. High-speed piezoelectric bimorph deformable Kirkpatrick-Baez mirrors for rapid variation of the 2D size and shape of X-ray beams.

Journal of synchrotron radiation

Avec: Simon G Alcock , Ioana Theodora Nistea , Riccardo Signorato , Robin L Owen , Daniel Axford , John P Sutter , Andrew Foster , Kawal Sawhney

Data collection from crystals grown in microfluidic droplets.

Acta crystallographica. Section D, Structural biology

Avec: Gyorgy Babnigg , Darren Sherrell , Youngchang Kim , Jessica L Johnson , Boguslaw Nocek , Kemin Tan , Danny Axford , Hui Li , Lance Bigelow , Lukas Welk , Michael Endres , Robin L Owen , Andrzej Joachimiak

Does the osteoarthritic shoulder have altered rotator cuff vectors with increasing glenoid deformity? An in silico analysis.

Journal of shoulder and elbow surgery

Avec: Desmond J Bokor , Antonio Arenas-Miquelez , David Axford , Petra L Graham , Louis M Ferreira , George S Athwal , Sumit Raniga

Réseau de co-auteurs

Danny Axford 23 collaborations

Robin L Owen 19 collaborations

Ali Ebrahim 8 collaborations

Michael A Hough 8 collaborations

Jonathan A R Worrall 7 collaborations

Hiroshi Sugimoto 6 collaborations

Shigeki Owada 6 collaborations

Pierre Aller 5 collaborations

John H Beale 5 collaborations

Kensuke Tono 5 collaborations

Sam Horrell 5 collaborations

Darren A Sherrell 5 collaborations

Takehiko Tosha 4 collaborations

Ivo Tews 4 collaborations

Agata Butryn 4 collaborations

Selina L S Storm 4 collaborations

Allen M Orville 4 collaborations

Tadeo Moreno-Chicano 4 collaborations

Richard W Strange 4 collaborations

Tristan O C Kwan 4 collaborations

Isabel Moraes 4 collaborations

Amanda K Chaplin 3 collaborations

Bradley Davy 3 collaborations

Nicholas E Devenish 3 collaborations

Gwyndaf Evans 3 collaborations

Richard J Gildea 3 collaborations

Helen M E Duyvesteyn 3 collaborations

Martin V Appleby 3 collaborations

James Birch 3 collaborations

Peter J Judge 3 collaborations

Juan F Bada Juarez 3 collaborations

Javier Vinals 3 collaborations

Anthony Watts 3 collaborations

Marina Lučić 2 collaborations

Michael T Wilson 2 collaborations

Gabriel Leen 2 collaborations

Rie Tanaka 2 collaborations

Graeme Winter 2 collaborations

Reza A Ghiladi 2 collaborations

David von Stetten 2 collaborations

Neil G Paterson 2 collaborations

Daniel Axford 2 collaborations

John Beale 2 collaborations

Anna J Warren 2 collaborations

David Axford 2 collaborations

George S Athwal 2 collaborations

Dimitri A Svistunenko 1 collaboration

Florian S N Dworkowski 1 collaboration

Philipp S Simon 1 collaboration

Philip Hinchliffe 1 collaboration

Ramzi N Massad 1 collaboration

Catherine L Tooke 1 collaboration

Isabel Bogacz 1 collaboration

In-Sik Kim 1 collaboration

Asmit Bhowmick 1 collaboration

Aaron S Brewster 1 collaboration

Jürgen Brem 1 collaboration

Jos J A G Kamps 1 collaboration

Pauline A Lang 1 collaboration

Patrick Rabe 1 collaboration

Julien Orlans 1 collaboration

Tiankun Zhou 1 collaboration

Frances A Houle 1 collaboration

Nicholas K Sauter 1 collaboration

Christopher J Schofield 1 collaboration

James Spencer 1 collaboration

Vittal K Yachandra 1 collaboration

Junko Yano 1 collaboration

Jan F Kern 1 collaboration

James Beilsten-Edmands 1 collaboration

James Sandy 1 collaboration

Juan Sanchez-Weatherby 1 collaboration

C David Owen 1 collaboration

Petra Lukacik 1 collaboration

Claire Strain-Damerell 1 collaboration

Martin A Walsh 1 collaboration

Leiah M Carey 1 collaboration

R Bruce Doak 1 collaboration

Robert W Henning 1 collaboration

Diana C F Monteiro 1 collaboration

Dean A Myles 1 collaboration

Megan L Straw 1 collaboration

Vukica Šrajer 1 collaboration

Martin Trebbin 1 collaboration

Kevin L Weiss 1 collaboration

Flora Meilleur 1 collaboration

Jake A Hill 1 collaboration

Yvonne Nyathi 1 collaboration

Godfrey S Beddard 1 collaboration

Arwen R Pearson 1 collaboration

Helen M Ginn 1 collaboration

Briony A Yorke 1 collaboration

Anastasya Shilova 1 collaboration

Tamar Skaist Mehlman 1 collaboration

Justin T Biel 1 collaboration

Syeda Maryam Azeem 1 collaboration

Elliot R Nelson 1 collaboration

Sakib Hossain 1 collaboration

Louise Dunnett 1 collaboration

Alice Douangamath 1 collaboration

Romain Talon 1 collaboration

Helen Orins 1 collaboration

Frank von Delft 1 collaboration

Daniel A Keedy 1 collaboration

Rachel Bolton 1 collaboration

Moritz M Machelett 1 collaboration

Jack Stubbs 1 collaboration

Nicolas Caramello 1 collaboration

Lucrezia Catapano 1 collaboration

Martin Malý 1 collaboration

Matthew J Rodrigues 1 collaboration

Charlotte Cordery 1 collaboration

Graham J Tizzard 1 collaboration

Fraser MacMillan 1 collaboration

Sylvain Engilberge 1 collaboration

Jeremy S Webb 1 collaboration

Mike Zubkov 1 collaboration

Simon Coles 1 collaboration

Eric Mathieu 1 collaboration

Roberto A Steiner 1 collaboration

Garib Murshudov 1 collaboration

Tobias E Schrader 1 collaboration

Antoine Royant 1 collaboration

Ferdous Sohel 1 collaboration

Vida Abedi 1 collaboration

Ye Zhu 1 collaboration

Ramin Zand 1 collaboration

Ebrahim Barkoudah 1 collaboration

Troy Krupica 1 collaboration

Kingsley Iheasirim 1 collaboration

Umesh M Sharma 1 collaboration

Sagar B Dugani 1 collaboration

Paul Y Takahashi 1 collaboration

Sumit Bhagra 1 collaboration

Mohammad H Murad 1 collaboration

Gustavo Saposnik 1 collaboration

Mohammed Yousufuddin 1 collaboration

Markus Gerstel 1 collaboration

Melanie Vollmar 1 collaboration

Katherine E McAuley 1 collaboration

Ralf Flaig 1 collaboration

Alun W Ashton 1 collaboration

David R Hall 1 collaboration

Peter Docker 1 collaboration

P Mehrabi 1 collaboration

R Bücker 1 collaboration

G Bourenkov 1 collaboration

H M Ginn 1 collaboration

D von Stetten 1 collaboration

H M Müller-Werkmeister 1 collaboration

A Kuo 1 collaboration

T Morizumi 1 collaboration

B T Eger 1 collaboration

W-L Ou 1 collaboration

S Oghbaey 1 collaboration

A Sarracini 1 collaboration

J E Besaw 1 collaboration

O Pare-Labrosse 1 collaboration

S Meier 1 collaboration

H Schikora 1 collaboration

F Tellkamp 1 collaboration

A Marx 1 collaboration

D A Sherrell 1 collaboration

R L Owen 1 collaboration

O P Ernst 1 collaboration

E F Pai 1 collaboration

E C Schulz 1 collaboration

R J D Miller 1 collaboration

Rosana I Reis 1 collaboration

Eriko Nango 1 collaboration

Yasumasa Joti 1 collaboration

Tomoyuki Tanaka 1 collaboration

Michihiro Sugahara 1 collaboration

So Iwata 1 collaboration

Suliman Adam 1 collaboration

Kin Kuan Hoi 1 collaboration

Hsin-Yung Yen 1 collaboration

Anthony Vial 1 collaboration

Pierre-Emmanuel Milhiet 1 collaboration

Carol V Robinson 1 collaboration

Igor Schapiro 1 collaboration

James M Baxter 1 collaboration

Christopher D M Hutchison 1 collaboration

Karim Maghlaoui 1 collaboration

Violeta Cordon-Preciado 1 collaboration

R Marc L Morgan 1 collaboration

Jasper J van Thor 1 collaboration

Jeremy R Keown 1 collaboration

Adam D Crawshaw 1 collaboration

Jose Trincao 1 collaboration

Loïc Carrique 1 collaboration

Robin Owen 1 collaboration

Annie Bézier 1 collaboration

Peter Metcalf 1 collaboration

Jonathan M Grimes 1 collaboration

Francis S H Ting 1 collaboration

Jason S Lockhart 1 collaboration

James A Johnson 1 collaboration

Daniel G Langohr 1 collaboration

R H Morris 1 collaboration

E R Dye 1 collaboration

M I Newton 1 collaboration

J H Beale 1 collaboration

P T Docker 1 collaboration

Simon G Alcock 1 collaboration

Ioana Theodora Nistea 1 collaboration

Riccardo Signorato 1 collaboration

John P Sutter 1 collaboration

Andrew Foster 1 collaboration

Kawal Sawhney 1 collaboration

Gyorgy Babnigg 1 collaboration

Darren Sherrell 1 collaboration

Youngchang Kim 1 collaboration

Jessica L Johnson 1 collaboration

Boguslaw Nocek 1 collaboration

Kemin Tan 1 collaboration

Hui Li 1 collaboration

Lance Bigelow 1 collaboration

Lukas Welk 1 collaboration

Michael Endres 1 collaboration

Andrzej Joachimiak 1 collaboration

Desmond J Bokor 1 collaboration

Antonio Arenas-Miquelez 1 collaboration

Petra L Graham 1 collaboration

Louis M Ferreira 1 collaboration

Sumit Raniga 1 collaboration