L Leybaert

Affiliations

Department of Basic and Applied Medical Sciences (BAMS), Physiology Group, Ghent University, Ghent, Belgium.

Publications (39)

Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage.

Frontiers in pharmacology

Avec: Raghda Ramadan , Els Vromans , Dornatien Chuo Anang , Ines Goetschalckx , Delphine Hoorelbeke , Elke Decrock , Sarah Baatout , Luc Leybaert , An Aerts

RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes.

Cardiovascular research

Avec: Alessio Lissoni , Paco Hulpiau , Tânia Martins-Marques , Nan Wang , Geert Bultynck , Rainer Schulz , Katja Witschas , Henrique Girao , Maarten De Smet , Luc Leybaert

The role of connexin proteins and their channels in radiation-induced atherosclerosis.

Cellular and molecular life sciences : CMLS

Avec: Raghda Ramadan , Sarah Baatout , An Aerts , Luc Leybaert

Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning.

Basic research in cardiology

Avec: Christine Hirschhäuser , Alessio Lissoni , Philipp Maximilian Görge , Paul D Lampe , Jacqueline Heger , Klaus-Dieter Schlüter , Luc Leybaert , Rainer Schulz , Kerstin Boengler

Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma: A preclinical F98 glioblastoma rat model study.

PloS one

Avec: Valerie De Meulenaere , Ellen Bonte , Jeroen Verhoeven , Jean-Pierre Kalala Okito , Leen Pieters , Anne Vral , Olivier De Wever , Luc Leybaert , Ingeborg Goethals , Christian Vanhove , Benedicte Descamps , Karel Deblaere

Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity.

Cell death and differentiation

Avec: Layal Maatouk , Chenju Yi , Maria-Angeles Carrillo-de Sauvage , Anne-Claire Compagnion , Stéphane Hunot , Pascal Ezan , Etienne C Hirsch , Annette Koulakoff , Frank W Pfrieger , François Tronche , Luc Leybaert , Christian Giaume , Sheela Vyas

Connexin hemichannels and cell death as measures of bovine COC vitrification success.

Reproduction (Cambridge, England)

Avec: Katarzyna Joanna Szymańska , Nerea Ortiz-Escribano , Etienne Van den Abbeel , Ann Van Soom , Luc Leybaert

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock.

Scientific reports

Avec: Tinneke Delvaeye , Maarten A J De Smet , Stijn Verwaerde , Elke Decrock , Aleksandra Czekaj , Roosmarijn E Vandenbroucke , Kelly Lemeire , Amanda Gonçalves , Wim Declercq , Peter Vandenabeele , Dmitri V Krysko , Luc Leybaert

A new look at osteoarthritis: Threshold potentials and an analogy to hypocalcemia.

Frontiers in aging

Avec: P Van Gelder , E Audenaert , P Calders , L Leybaert

Vitrification negatively affects the Ca

Reproductive biomedicine online

Avec: Davina Bonte , Vanessa Thys , Petra De Sutter , Annekatrien Boel , Luc Leybaert , Björn Heindryckx

The calcium dynamics of human dental pulp stem cells stimulated with tricalcium silicate-based cements determine their differentiation and mineralization outcome.

Scientific reports

Avec: Elanagai Rathinam , Srinath Govindarajan , Sivaprakash Rajasekharan , Heidi Declercq , Dirk Elewaut , Peter De Coster , Luc Martens , Luc Leybaert

Astrocytic Connexin43 Channels as Candidate Targets in Epilepsy Treatment.

Biomolecules

Avec: Laura Walrave , Mathieu Vinken , Luc Leybaert , Ilse Smolders

IP3RPEP6, a novel peptide inhibitor of IP

Acta physiologica (Oxford, England)

Avec: Siyu Tao , Paco Hulpiau , Larry E Wagner , Katja Witschas , David I Yule , Geert Bultynck , Luc Leybaert

Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis.

JCI insight

Avec: Marijke De Bock , Maarten De Smet , Stijn Verwaerde , Hanane Tahiri , Steffi Schumacher , Valérie Van Haver , Katja Witschas , Christian Steinhäuser , Nathalie Rouach , Roosmarijn E Vandenbroucke , Luc Leybaert

Connexin 43 in Mitochondria: What Do We Really Know About Its Function?

Frontiers in physiology

Avec: Kerstin Boengler , Luc Leybaert , Marisol Ruiz-Meana , Rainer Schulz

Inhibiting astrocyte connexin-43 hemichannels blocks radiation-induced vesicular VEGF-A release and blood-brain barrier dysfunction.

Glia

Avec: Steffi Schumacher , Hanane Tahiri , Pascal Ezan , Nathalie Rouach , Katja Witschas , Luc Leybaert

Baselining physiological parameters in three muscles across three equine breeds. What can we learn from the horse?

Frontiers in physiology

Avec: Carmen Vidal Moreno de Vega , Constance de Meeûs d'Argenteuil , Berit Boshuizen , Lorie De Mare , Yannick Gansemans , Filip Van Nieuwerburgh , Dieter Deforce , Klara Goethals , Ward De Spiegelaere , Luc Leybaert , Elisabeth-Lidwien J M M Verdegaal , Cathérine Delesalle

Connexins and pannexins in Alzheimer's disease.

Neuroscience letters

Avec: Christian Giaume , Juan C Sáez , Weihong Song , Luc Leybaert , Christian C Naus

Comparison of Shifts in Skeletal Muscle Plasticity Parameters in Horses in Three Different Muscles, in Answer to 8 Weeks of Harness Training.

Frontiers in veterinary science

Avec: Constance de Meeûs d'Argenteuil , Berit Boshuizen , Carmen Vidal Moreno de Vega , Luc Leybaert , Lorie de Maré , Klara Goethals , Ward De Spiegelaere , Maarten Oosterlinck , Cathérine Delesalle

X‑irradiation induces acute and early term inflammatory responses in atherosclerosis‑prone ApoE‑/‑ mice and in endothelial cells.

Molecular medicine reports

Avec: Raghda Ramadan , Michaël Claessens , Ellen Cocquyt , Mohamed Mysara , Elke Decrock , Sarah Baatout , An Aerts , Luc Leybaert

Preservation of connexin 43 and transzonal projections in isolated bovine pre-antral follicles before and following vitrification.

Journal of assisted reproduction and genetics

Avec: Anniek Bus , Katarzyna Szymanska , Isabel Pintelon , Jo L M R Leroy , Luc Leybaert , Peter E J Bols

Targeting connexins with Gap27 during cold storage of the human donor uterus protects against cell death.

PloS one

Avec: Katarzyna J Szymanska , Menekse Göker , Melissa Bol , Jo Van Dorpe , Steven Weyers , Luc Leybaert

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability.

The Journal of clinical investigation

Avec: Maarten Aj De Smet , Alessio Lissoni , Timur Nezlobinsky , Nan Wang , Eef Dries , Marta Pérez-Hernández , Xianming Lin , Matthew Amoni , Tim Vervliet , Katja Witschas , Eli Rothenberg , Geert Bultynck , Rainer Schulz , Alexander V Panfilov , Mario Delmar , Karin R Sipido , Luc Leybaert

The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells.

Channels (Austin, Tex.)

Avec: Dieter V Van de Sande , Ivan Kopljar , Alaerts Maaike , Ard Teisman , David J Gallacher , Loeys Bart , Dirk J Snyders , Luc Leybaert , Hua Rong Lu , Alain J Labro

Cx43 Hemichannel and Panx1 Channel Modulation by Gap19 and

International journal of molecular sciences

Avec: Alessio Lissoni , Siyu Tao , Rosalie Allewaert , Katja Witschas , Luc Leybaert

Dynamics of training and acute exercise-induced shifts in muscular glucose transporter (GLUT) 4, 8, and 12 expression in locomotion versus posture muscles in healthy horses.

Frontiers in physiology

Avec: Carmen Vidal Moreno de Vega , Diete Lemmens , Constance de Meeûs d'Argenteuil , Berit Boshuizen , Lorie de Maré , Luc Leybaert , Klara Goethals , Jean Eduardo de Oliveira , Guilherme Hosotani , Dieter Deforce , Filip Van Nieuwerburgh , Lindsey Devisscher , Cathérine Delesalle

Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function.

Scientific reports

Avec: Raghda Ramadan , Els Vromans , Dornatien Chuo Anang , Elke Decrock , Mohamed Mysara , Pieter Monsieurs , Sarah Baatout , Luc Leybaert , An Aerts

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke.

The Journal of experimental medicine

Avec: Moises Freitas-Andrade , Nan Wang , John F Bechberger , Marijke De Bock , Paul D Lampe , Luc Leybaert , Christian C Naus

Glial Connexins and Pannexins in the Healthy and Diseased Brain.

Physiological reviews

Avec: Christian Giaume , Christian C Naus , Juan C Sáez , Luc Leybaert

Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse model.

Molecular human reproduction

Avec: M Ferrer-Buitrago , L Tilleman , V Thys , A Hachem , A Boel , F Van Nieuwerburgh , D Deforce , L Leybaert , P De Sutter , J Parrington , B Heindryckx

Cx43 channels and signaling via IP

Cell death & disease

Avec: Delphine Hoorelbeke , Elke Decrock , Maarten De Smet , Marijke De Bock , Benedicte Descamps , Valérie Van Haver , Tinneke Delvaeye , Dmitri V Krysko , Christian Vanhove , Geert Bultynck , Luc Leybaert

Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia.

Trends in molecular medicine

Avec: Tania Martins-Marques , Derek J Hausenloy , Joost P G Sluijter , Luc Leybaert , Henrique Girao

Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating.

International journal of molecular sciences

Avec: Alessio Lissoni , Nan Wang , Timur Nezlobinskii , Maarten De Smet , Alexander V Panfilov , Nele Vandersickel , Luc Leybaert , Katja Witschas

An improved F98 glioblastoma rat model to evaluate novel treatment strategies incorporating the standard of care.

PloS one

Avec: Velislava Zoteva , Valerie De Meulenaere , Marthe De Boeck , Christian Vanhove , Luc Leybaert , Robrecht Raedt , Leen Pieters , Anne Vral , Tom Boterberg , Karel Deblaere

Integrating and optimizing tonabersat in standard glioblastoma therapy: A preclinical study.

PloS one

Avec: Velislava Zoteva , Valerie De Meulenaere , Christian Vanhove , Luc Leybaert , Robrecht Raedt , Leen Pieters , Anne Vral , Tom Boterberg , Karel Deblaere

Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments.

The Journal of clinical investigation

Avec: Luc Leybaert , Maarten Aj De Smet , Alessio Lissoni , Rosalie Allewaert , H Llewelyn Roderick , Geert Bultynck , Mario Delmar , Karin R Sipido , Katja Witschas

Assisted oocyte activation does not overcome recurrent embryo developmental problems.

Human reproduction (Oxford, England)

Avec: A Cardona Barberán , D Bonte , A Boel , V Thys , R Paredis , F Machtelinckx , P De Sutter , I De Croo , L Leybaert , D Stoop , P Coucke , F Vanden Meerschaut , B Heindryckx

Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells.

Open biology

Avec: Tania Martins-Marques , Katja Witschas , Ilda Ribeiro , Mónica Zuzarte , Steve Catarino , Teresa Ribeiro-Rodrigues , Francisco Caramelo , Trond Aasen , Isabel Marques Carreira , Lino Goncalves , Luc Leybaert , Henrique Girao

High rate of detected variants in male

Human reproduction open

Avec: Arantxa Cardona Barberán , Ramesh Reddy Guggilla , Cora Colenbier , Emma Van der Velden , Andrei Rybouchkin , Dominic Stoop , Luc Leybaert , Paul Coucke , Sofie Symoens , Annekatrien Boel , Frauke Vanden Meerschaut , Björn Heindryckx

Réseau de co-auteurs

Luc Leybaert 36 collaborations

Katja Witschas 9 collaborations

Alessio Lissoni 6 collaborations

Elke Decrock 5 collaborations

Geert Bultynck 5 collaborations

Raghda Ramadan 4 collaborations

Sarah Baatout 4 collaborations

An Aerts 4 collaborations

Nan Wang 4 collaborations

Rainer Schulz 4 collaborations

Maarten De Smet 4 collaborations

Christian Vanhove 4 collaborations

Henrique Girao 3 collaborations

Valerie De Meulenaere 3 collaborations

Leen Pieters 3 collaborations

Anne Vral 3 collaborations

Karel Deblaere 3 collaborations

Christian Giaume 3 collaborations

Marijke De Bock 3 collaborations

Carmen Vidal Moreno de Vega 3 collaborations

Constance de Meeûs d'Argenteuil 3 collaborations

Berit Boshuizen 3 collaborations

Klara Goethals 3 collaborations

Cathérine Delesalle 3 collaborations

Christian C Naus 3 collaborations

Els Vromans 2 collaborations

Dornatien Chuo Anang 2 collaborations

Delphine Hoorelbeke 2 collaborations

Paco Hulpiau 2 collaborations

Paul D Lampe 2 collaborations

Kerstin Boengler 2 collaborations

Benedicte Descamps 2 collaborations

Pascal Ezan 2 collaborations

Tinneke Delvaeye 2 collaborations

Stijn Verwaerde 2 collaborations

Roosmarijn E Vandenbroucke 2 collaborations

Dmitri V Krysko 2 collaborations

Annekatrien Boel 2 collaborations

Björn Heindryckx 2 collaborations

Siyu Tao 2 collaborations

Hanane Tahiri 2 collaborations

Steffi Schumacher 2 collaborations

Valérie Van Haver 2 collaborations

Nathalie Rouach 2 collaborations

Filip Van Nieuwerburgh 2 collaborations

Dieter Deforce 2 collaborations

Ward De Spiegelaere 2 collaborations

Juan C Sáez 2 collaborations

Lorie de Maré 2 collaborations

Mohamed Mysara 2 collaborations

Maarten Aj De Smet 2 collaborations

Alexander V Panfilov 2 collaborations

Mario Delmar 2 collaborations

Karin R Sipido 2 collaborations

Rosalie Allewaert 2 collaborations

V Thys 2 collaborations

A Boel 2 collaborations

P De Sutter 2 collaborations

B Heindryckx 2 collaborations

Tania Martins-Marques 2 collaborations

Velislava Zoteva 2 collaborations

Robrecht Raedt 2 collaborations

Tom Boterberg 2 collaborations

Ines Goetschalckx 1 collaboration

Tânia Martins-Marques 1 collaboration

Christine Hirschhäuser 1 collaboration

Philipp Maximilian Görge 1 collaboration

Jacqueline Heger 1 collaboration

Klaus-Dieter Schlüter 1 collaboration

Ellen Bonte 1 collaboration

Jeroen Verhoeven 1 collaboration

Jean-Pierre Kalala Okito 1 collaboration

Olivier De Wever 1 collaboration

Ingeborg Goethals 1 collaboration

Layal Maatouk 1 collaboration

Chenju Yi 1 collaboration

Maria-Angeles Carrillo-de Sauvage 1 collaboration

Anne-Claire Compagnion 1 collaboration

Stéphane Hunot 1 collaboration

Etienne C Hirsch 1 collaboration

Annette Koulakoff 1 collaboration

Frank W Pfrieger 1 collaboration

François Tronche 1 collaboration

Sheela Vyas 1 collaboration

Katarzyna Joanna Szymańska 1 collaboration

Nerea Ortiz-Escribano 1 collaboration

Etienne Van den Abbeel 1 collaboration

Ann Van Soom 1 collaboration

Maarten A J De Smet 1 collaboration

Aleksandra Czekaj 1 collaboration

Kelly Lemeire 1 collaboration

Amanda Gonçalves 1 collaboration

Wim Declercq 1 collaboration

Peter Vandenabeele 1 collaboration

P Van Gelder 1 collaboration

E Audenaert 1 collaboration

P Calders 1 collaboration

Davina Bonte 1 collaboration

Vanessa Thys 1 collaboration

Petra De Sutter 1 collaboration

Elanagai Rathinam 1 collaboration

Srinath Govindarajan 1 collaboration

Sivaprakash Rajasekharan 1 collaboration

Heidi Declercq 1 collaboration

Dirk Elewaut 1 collaboration

Peter De Coster 1 collaboration

Luc Martens 1 collaboration

Laura Walrave 1 collaboration

Mathieu Vinken 1 collaboration

Ilse Smolders 1 collaboration

Larry E Wagner 1 collaboration

David I Yule 1 collaboration

Christian Steinhäuser 1 collaboration

Marisol Ruiz-Meana 1 collaboration

Lorie De Mare 1 collaboration

Yannick Gansemans 1 collaboration

Elisabeth-Lidwien J M M Verdegaal 1 collaboration

Weihong Song 1 collaboration

Maarten Oosterlinck 1 collaboration

Michaël Claessens 1 collaboration

Ellen Cocquyt 1 collaboration

Anniek Bus 1 collaboration

Katarzyna Szymanska 1 collaboration

Isabel Pintelon 1 collaboration

Jo L M R Leroy 1 collaboration

Peter E J Bols 1 collaboration

Katarzyna J Szymanska 1 collaboration

Menekse Göker 1 collaboration

Melissa Bol 1 collaboration

Jo Van Dorpe 1 collaboration

Steven Weyers 1 collaboration

Timur Nezlobinsky 1 collaboration

Eef Dries 1 collaboration

Marta Pérez-Hernández 1 collaboration

Xianming Lin 1 collaboration

Matthew Amoni 1 collaboration

Tim Vervliet 1 collaboration

Eli Rothenberg 1 collaboration

Dieter V Van de Sande 1 collaboration

Ivan Kopljar 1 collaboration

Alaerts Maaike 1 collaboration

Ard Teisman 1 collaboration

David J Gallacher 1 collaboration

Loeys Bart 1 collaboration

Dirk J Snyders 1 collaboration

Hua Rong Lu 1 collaboration

Alain J Labro 1 collaboration

Diete Lemmens 1 collaboration

Jean Eduardo de Oliveira 1 collaboration

Guilherme Hosotani 1 collaboration

Lindsey Devisscher 1 collaboration

Pieter Monsieurs 1 collaboration

Moises Freitas-Andrade 1 collaboration

John F Bechberger 1 collaboration

M Ferrer-Buitrago 1 collaboration

L Tilleman 1 collaboration

A Hachem 1 collaboration

F Van Nieuwerburgh 1 collaboration

D Deforce 1 collaboration

J Parrington 1 collaboration

Derek J Hausenloy 1 collaboration

Joost P G Sluijter 1 collaboration

Timur Nezlobinskii 1 collaboration

Nele Vandersickel 1 collaboration

Marthe De Boeck 1 collaboration

H Llewelyn Roderick 1 collaboration

A Cardona Barberán 1 collaboration

D Bonte 1 collaboration

R Paredis 1 collaboration

F Machtelinckx 1 collaboration

I De Croo 1 collaboration

D Stoop 1 collaboration

P Coucke 1 collaboration

F Vanden Meerschaut 1 collaboration

Ilda Ribeiro 1 collaboration

Mónica Zuzarte 1 collaboration

Steve Catarino 1 collaboration

Teresa Ribeiro-Rodrigues 1 collaboration

Francisco Caramelo 1 collaboration

Trond Aasen 1 collaboration

Isabel Marques Carreira 1 collaboration

Lino Goncalves 1 collaboration

Arantxa Cardona Barberán 1 collaboration

Ramesh Reddy Guggilla 1 collaboration

Cora Colenbier 1 collaboration

Emma Van der Velden 1 collaboration

Andrei Rybouchkin 1 collaboration

Dominic Stoop 1 collaboration

Paul Coucke 1 collaboration

Sofie Symoens 1 collaboration

Frauke Vanden Meerschaut 1 collaboration