Metabolic engineering of Corynebacterium glutamicum for the production of glutaric acid, a C5 dicarboxylic acid platform chemical.

Codon Corynebacterium glutamicum / genetics DNA, Bacterial / genetics Dicarboxylic Acids / metabolism Fermentation Glucose / metabolism Glutarates / metabolism Lysine / metabolism Metabolic Engineering / methods Plasmids / genetics Pseudomonas putida / genetics Vasotocin / analogs & derivatives
Codon optimization Corynebacterium glutamicum Fed-batch fermentation Glutaric acid His(6)-tag L‐Lysine davTDBA

Journal

Metabolic engineering
ISSN: 1096-7184
Titre abrégé: Metab Eng
Pays: Belgium
ID NLM: 9815657

Informations de publication

Date de publication:
01 2019
Historique:
received: 30 03 2018
revised: 08 08 2018
accepted: 17 08 2018
pubmed: 26 8 2018
medline: 14 6 2019
entrez: 26 8 2018
Statut: ppublish

Résumé

Corynebacterium glutamicum was metabolically engineered for the production of glutaric acid, a C5 dicarboxylic acid that can be used as platform building block chemical for nylons and plasticizers. C. glutamicum gabT and gabD genes and Pseudomonas putida davT and davD genes encoding 5-aminovalerate transaminase and glutarate semialdehyde dehydrogenase, respectively, were examined in C. glutamicum for the construction of a glutaric acid biosynthesis pathway along with P. putida davB and davA genes encoding lysine 2-monooxygenase and delta-aminovaleramidase, respectively. The glutaric acid biosynthesis pathway constructed in recombinant C. glutamicum was engineered by examining strong synthetic promoters P

Identifiants

DOI: 10.1016/j.ymben.2018.08.007 PMID: 30144560
pubmed: 30144560
pii: S1096-7176(18)30137-X
doi: 10.1016/j.ymben.2018.08.007
pii:
doi:

Substances chimiques

Codon 0
DNA, Bacterial 0
Dicarboxylic Acids 0
Glutarates 0
vasotocin, Mpa(1)- 0
glutaric acid H849F7N00B
Glucose IY9XDZ35W2
Lysine K3Z4F929H6
Vasotocin W6S6URY8OF

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

99-109

Informations de copyright

Copyright © 2018 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

Auteurs

Hee Taek Kim (HT)

Bio-based Chemistry Research Center, Advanced Convergent Chemistry Division, Korea Research Institute of Chemical Technology, P.O. Box 107, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114 Republic of Korea.

Tae Uk Khang (TU)

Bio-based Chemistry Research Center, Advanced Convergent Chemistry Division, Korea Research Institute of Chemical Technology, P.O. Box 107, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114 Republic of Korea; Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

Kei-Anne Baritugo (KA)

Division of Chemical Engineering and Materials Science, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea.

Sung Min Hyun (SM)

Bio-based Chemistry Research Center, Advanced Convergent Chemistry Division, Korea Research Institute of Chemical Technology, P.O. Box 107, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114 Republic of Korea; Department of Biological and Chemical Engineering, Hongik University, 2639 Sejong-ro, Sinan-ri, Jochiwon-eup, Sejong-si 30016, Republic of Korea.

Kyoung Hee Kang (KH)

Bio-based Chemistry Research Center, Advanced Convergent Chemistry Division, Korea Research Institute of Chemical Technology, P.O. Box 107, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114 Republic of Korea.

Sol Hee Jung (SH)

Division of Chemical Engineering and Materials Science, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea.

Bong Keun Song (BK)

Bio-based Chemistry Research Center, Advanced Convergent Chemistry Division, Korea Research Institute of Chemical Technology, P.O. Box 107, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114 Republic of Korea.

Kyungmoon Park (K)

Department of Biological and Chemical Engineering, Hongik University, 2639 Sejong-ro, Sinan-ri, Jochiwon-eup, Sejong-si 30016, Republic of Korea.

Min-Kyu Oh (MK)

Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

Gi Bae Kim (GB)

Metabolic Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus program), KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.

Hyun Uk Kim (HU)

Department of Chemical and Biomolecular Engineering (BK21 Plus program), KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.

Sang Yup Lee (SY)

Metabolic Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus program), KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.

Si Jae Park (SJ)

Division of Chemical Engineering and Materials Science, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea. Electronic address: parksj93@ewha.ac.kr.

Jeong Chan Joo (JC)

Bio-based Chemistry Research Center, Advanced Convergent Chemistry Division, Korea Research Institute of Chemical Technology, P.O. Box 107, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114 Republic of Korea. Electronic address: jcjoo@krict.re.kr.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Codon › Metabolic engineering of Corynebacterium...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes irréguliers à Gram positif › Corynebacterium › Corynebacterium glutamicum › Metabolic engineering of Corynebacterium...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN bactérien › Metabolic engineering of Corynebacterium...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Diacides carboxyliques › Metabolic engineering of Corynebacterium...
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Fermentation › Metabolic engineering of Corynebacterium...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Metabolic engineering of Corynebacterium...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Diacides carboxyliques › Glutarates › Metabolic engineering of Corynebacterium...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Lysine › Metabolic engineering of Corynebacterium...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Génie métabolique › Metabolic engineering of Corynebacterium...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Plasmides › Metabolic engineering of Corynebacterium...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas putida › Metabolic engineering of Corynebacterium...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones post-hypophysaires › Vasotocine › Metabolic engineering of Corynebacterium...