Alexis-Pierre Bemelmans

Affiliations

Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, 92265, Fontenay-aux-Roses, France.

Publications (32)

Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state.

Brain : a journal of neurology

Avec: Anastasie Maté de Gérando , Marie d'Orange , Emma Augustin , Charlène Joséphine , Gwénaelle Aurégan , Mylène Gaudin-Guérif , Martine Guillermier , Anne-Sophie Hérard , Lev Stimmer , Fanny Petit , Pauline Gipchtein , Caroline Jan , Carole Escartin , Erwan Selingue , Kévin Carvalho , David Blum , Emmanuel Brouillet , Philippe Hantraye , Marie-Claude Gaillard , Gilles Bonvento , Karine Cambon

Astrocytes close the mouse critical period for visual plasticity.

Science (New York, N.Y.)

Avec: Jérôme Ribot , Rachel Breton , Charles-Félix Calvo , Julien Moulard , Pascal Ezan , Jonathan Zapata , Kevin Samama , Matthieu Moreau , Valentin Sabatet , Florent Dingli , Damarys Loew , Chantal Milleret , Pierre Billuart , Glenn Dallérac , Nathalie Rouach

PKCδ-positive GABAergic neurons in the central amygdala exhibit tissue-type plasminogen activator: role in the control of anxiety.

Molecular psychiatry

Avec: Sara Douceau , Eloïse Lemarchand , Yannick Hommet , Laurent Lebouvier , Charlène Joséphine , Eric Maubert , Véronique Agin , Denis Vivien

Melanophages give rise to hyperreflective foci in AMD, a disease-progression marker.

Journal of neuroinflammation

Avec: Sebastien Augustin , Marion Lam , Sophie Lavalette , Anna Verschueren , Frédéric Blond , Valérie Forster , Lauriane Przegralek , Zhiguo He , Daniel Lewandowski , Serge Picaud , José-Alain Sahel , Thibaud Mathis , Michel Paques , Gilles Thuret , Xavier Guillonneau , Cécile Delarasse , Florian Sennlaub

Progenitors from the central nervous system drive neurogenesis in cancer.

Nature

Avec: Philippe Mauffrey , Nicolas Tchitchek , Vilma Barroca , Virginie Firlej , Yves Allory , Paul-Henri Roméo , Claire Magnon

Fast calcium transients in dendritic spines driven by extreme statistics.

PLoS biology

Avec: Kanishka Basnayake , David Mazaud , Alexis Bemelmans , Nathalie Rouach , Eduard Korkotian , David Holcman

Publisher Correction: Progenitors from the central nervous system drive neurogenesis in cancer.

Nature

Avec: Philippe Mauffrey , Nicolas Tchitchek , Vilma Barroca , Virginie Firlej , Yves Allory , Paul-Henri Roméo , Claire Magnon

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease.

Cell metabolism

Avec: Juliette Le Douce , Marianne Maugard , Julien Veran , Marco Matos , Pierrick Jégo , Pierre-Antoine Vigneron , Emilie Faivre , Xavier Toussay , Michel Vandenberghe , Yaël Balbastre , Juliette Piquet , Elvire Guiot , Nguyet Thuy Tran , Myriam Taverna , Stéphane Marinesco , Ayumi Koyanagi , Shigeki Furuya , Mylène Gaudin-Guérif , Sébastien Goutal , Aurélie Ghettas , Alain Pruvost , Marie-Claude Gaillard , Karine Cambon , Lev Stimmer , Véronique Sazdovitch , Charles Duyckaerts , Graham Knott , Anne-Sophie Hérard , Thierry Delzescaux , Philippe Hantraye , Emmanuel Brouillet , Bruno Cauli , Stéphane H R Oliet , Aude Panatier , Gilles Bonvento

The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models.

Biomolecules

Avec: Rachel Kelly , Andrew G Cairns , Jörgen Ådén , Fredrik Almqvist , Emmanuel Brouillet , Tommy Patton , Declan P McKernan , Eilís Dowd

THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency.

Neurobiology of disease

Avec: Audrey Vautheny , Charlotte Duwat , Gwennaëlle Aurégan , Charlène Joséphine , Anne-Sophie Hérard , Caroline Jan , Julien Mitja , Pauline Gipchtein , Marie-Claude Gaillard , Luc Buée , David Blum , Philippe Hantraye , Gilles Bonvento , Emmanuel Brouillet , Karine Cambon ,

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.

International journal of molecular sciences

Avec: Noémie Cresto , Camille Gardier , Marie-Claude Gaillard , Francesco Gubinelli , Pauline Roost , Daniela Molina , Charlène Josephine , Noëlle Dufour , Gwenaëlle Auregan , Martine Guillermier , Suéva Bernier , Caroline Jan , Pauline Gipchtein , Philippe Hantraye , Marie-Christine Chartier-Harlin , Gilles Bonvento , Nadja Van Camp , Jean-Marc Taymans , Karine Cambon , Géraldine Liot , Emmanuel Brouillet

Time-Course of Alterations in the Endocannabinoid System after Viral-Mediated Overexpression of α-Synuclein in the Rat Brain.

Molecules (Basel, Switzerland)

Avec: Rachel Kelly , Charlène Joséphine , Emmanuel Brouillet , Declan P McKernan , Eilís Dowd

Physiological synaptic activity and recognition memory require astroglial glutamine.

Nature communications

Avec: Giselle Cheung , Danijela Bataveljic , Josien Visser , Naresh Kumar , Julien Moulard , Glenn Dallérac , Daria Mozheiko , Astrid Rollenhagen , Pascal Ezan , Cédric Mongin , Oana Chever , Joachim Lübke , Isabelle Leray , Nathalie Rouach

Correction: Fast calcium transients in dendritic spines driven by extreme statistics.

PLoS biology

Avec: Kanishka Basnayake , David Mazaud , Alexis Bemelmans , Nathalie Rouach , Eduard Korkotian , David Holcman

A Single Cisterna Magna Injection of AAV Leads to Binaural Transduction in Mice.

Frontiers in cell and developmental biology

Avec: Fabian Blanc , Corentin Affortit , Charlène Joséphine , Jean-Luc Puel , Michel Mondain , Jing Wang

Astroglial Kir4.1 potassium channel deficit drives neuronal hyperexcitability and behavioral defects in Fragile X syndrome mouse model.

Nature communications

Avec: Danijela Bataveljic , Helena Pivonkova , Vidian de Concini , Betty Hébert , Pascal Ezan , Sylvain Briault , Jacques Pichon , Arnaud Menuet , Nathalie Rouach

Upregulation of astroglial connexin 30 impairs hippocampal synaptic activity and recognition memory.

PLoS biology

Avec: Eléonore Hardy , Julien Moulard , Augustin Walter , Pascal Ezan , Franck Mouthon , Mathieu Charvériat , Nathalie Rouach , Armelle Rancillac

The ribosome-associated protein RACK1 represses Kir4.1 translation in astrocytes and influences neuronal activity.

Cell reports

Avec: Marc Oudart , Katia Avila-Gutierrez , Clara Moch , Elena Dossi , Giampaolo Milior , Anne-Cécile Boulay , Mathis Gaudey , Julien Moulard , Bérangère Lombard , Damarys Loew , Nathalie Rouach , Clément Chapat , Martine Cohen-Salmon

The intellectual disability protein Oligophrenin-1 controls astrocyte morphology and migration.

Glia

Avec: Laure-Elise Pillet , Noémie Cresto , Yoann Saillour , Grégory Ghézali , Jean Livet , Thierry Bienvenu , Nathalie Rouach , Pierre Billuart

Nanoscale molecular architecture controls calcium diffusion and ER replenishment in dendritic spines.

Science advances

Avec: Kanishka Basnayake , David Mazaud , Lilia Kushnireva , Alexis Bemelmans , Nathalie Rouach , Eduard Korkotian , David Holcman

Local Translation in Perisynaptic Astrocytic Processes Is Specific and Changes after Fear Conditioning.

Cell reports

Avec: Noémie Mazaré , Marc Oudart , Julien Moulard , Giselle Cheung , Romain Tortuyaux , Philippe Mailly , David Mazaud , Anne-Cécile Boulay , Corinne Blugeon , Laurent Jourdren , Stéphane Le Crom , Nathalie Rouach , Martine Cohen-Salmon

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo.

Neurobiology of disease

Avec: Noémie Cresto , Marie-Claude Gaillard , Camille Gardier , Francesco Gubinelli , Elsa Diguet , Déborah Bellet , Laurine Legroux , Julien Mitja , Gwenaëlle Auregan , Martine Guillermier , Charlène Josephine , Caroline Jan , Noëlle Dufour , Alain Joliot , Philippe Hantraye , Gilles Bonvento , Nicole Déglon , Karine Cambon , Géraldine Liot , Emmanuel Brouillet

Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns.

PLoS biology

Avec: Flora Vasile , Elena Dossi , Julien Moulard , Pascal Ezan , Laure Lecoin , Martine Cohen-Salmon , Philippe Mailly , Marc Le Bert , Isabelle Couillin , Alexis Bemelmans , Nathalie Rouach

Fine-tuning FAM161A gene augmentation therapy to restore retinal function.

EMBO molecular medicine

Avec: Yvan Arsenijevic , Ning Chang , Olivier Mercey , Younes El Fersioui , Hanna Koskiniemi-Kuendig , Caroline Joubert , Carlo Rivolta , Eyal Banin , Dror Sharon , Paul Guichard , Virginie Hamel , Corinne Kostic

Publisher Correction: Multicolor multiscale brain imaging with chromatic multiphoton serial microscopy.

Nature communications

Avec: Lamiae Abdeladim , Katherine S Matho , Solène Clavreul , Pierre Mahou , Jean-Marc Sintes , Xavier Solinas , Ignacio Arganda-Carreras , Stephen G Turney , Jeff W Lichtman , Anatole Chessel , Karine Loulier , Willy Supatto , Jean Livet , Emmanuel Beaurepaire

Multicolor multiscale brain imaging with chromatic multiphoton serial microscopy.

Nature communications

rAAV-Mediated Cochlear Gene Therapy: Prospects and Challenges for Clinical Application.

Journal of clinical medicine

Avec: Fabian Blanc , Michel Mondain , Corentin Affortit , Jean-Luc Puel , Jing Wang

Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing.

Science advances

Avec: Andry Andrianarivelo , Estefani Saint-Jour , Paula Pousinha , Sebastian P Fernandez , Anna Petitbon , Veronique De Smedt-Peyrusse , Nicolas Heck , Vanesa Ortiz , Marie-Charlotte Allichon , Vincent Kappès , Sandrine Betuing , Roman Walle , Ying Zhu , Charlène Joséphine , Gustavo Turecki , Naguib Mechawar , Jonathan A Javitch , Jocelyne Caboche , Pierre Trifilieff , Jacques Barik , Peter Vanhoutte

Intra-striatal infusion of the small molecule alpha-synuclein aggregator, FN075, does not enhance parkinsonism in a subclinical AAV-alpha-synuclein rat model.

The European journal of neuroscience

Avec: Tommy Patton , Giulia Comini , Kaushik Narasimhan , Andrew G Cairns , Jörgen Ådén , Fredrik Almqvist , Alexis Bemelmans , Emmanuel Brouillet , Declan P McKernan , Eilís Dowd

Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice.

Brain : a journal of neurology

Avec: Victoria Gomez-Murcia , Agathe Launay , Kévin Carvalho , Anaëlle Burgard , Céline Meriaux , Raphaëlle Caillierez , Sabiha Eddarkaoui , Devrim Kilinc , Dolores Siedlecki-Wullich , Mélanie Besegher , Séverine Bégard , Bryan Thiroux , Matthieu Jung , Ouada Nebie , Maxence Wisztorski , Nicole Déglon , Claire Montmasson , Malika Hamdane , Thibaud Lebouvier , Didier Vieau , Isabelle Fournier , Luc Buee , Sabine Lévi , Luisa V Lopes , Anne-Laurence Boutillier , Emilie Faivre , David Blum

Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology.

Neurobiology of disease

Avec: Charlotte Duwat , Pauline Léal , Audrey Vautheny , Gwennaëlle Aurégan , Charlène Joséphine , Marie-Claude Gaillard , Anne-Sophie Hérard , Caroline Jan , Pauline Gipchtein , Julien Mitja , Stéphane Fouquet , Marie-Laure Niepon , Philippe Hantraye , Emmanuel Brouillet , Gilles Bonvento , Karine Cambon ,

Retinal damage promotes mitochondrial transfer in the visual system of a mouse model of Leber hereditary optic neuropathy.

Neurobiology of disease

Avec: Pascal Ezan , Eléonore Hardy , Alexis Bemelmans , Magali Taiel , Elena Dossi , Nathalie Rouach

Réseau de co-auteurs

Nathalie Rouach 12 collaborations

Emmanuel Brouillet 9 collaborations

Charlène Joséphine 7 collaborations

Philippe Hantraye 6 collaborations

Marie-Claude Gaillard 6 collaborations

Gilles Bonvento 6 collaborations

Karine Cambon 6 collaborations

Julien Moulard 6 collaborations

Pascal Ezan 6 collaborations

Alexis Bemelmans 6 collaborations

Caroline Jan 5 collaborations

Anne-Sophie Hérard 4 collaborations

Pauline Gipchtein 4 collaborations

David Mazaud 4 collaborations

Martine Guillermier 3 collaborations

David Blum 3 collaborations

Kanishka Basnayake 3 collaborations

Eduard Korkotian 3 collaborations

David Holcman 3 collaborations

Declan P McKernan 3 collaborations

Eilís Dowd 3 collaborations

Julien Mitja 3 collaborations

Noémie Cresto 3 collaborations

Elena Dossi 3 collaborations

Martine Cohen-Salmon 3 collaborations

Jean Livet 3 collaborations

Mylène Gaudin-Guérif 2 collaborations

Lev Stimmer 2 collaborations

Kévin Carvalho 2 collaborations

Damarys Loew 2 collaborations

Pierre Billuart 2 collaborations

Glenn Dallérac 2 collaborations

Philippe Mauffrey 2 collaborations

Nicolas Tchitchek 2 collaborations

Vilma Barroca 2 collaborations

Virginie Firlej 2 collaborations

Yves Allory 2 collaborations

Paul-Henri Roméo 2 collaborations

Claire Magnon 2 collaborations

Emilie Faivre 2 collaborations

Rachel Kelly 2 collaborations

Andrew G Cairns 2 collaborations

Jörgen Ådén 2 collaborations

Fredrik Almqvist 2 collaborations

Tommy Patton 2 collaborations

Audrey Vautheny 2 collaborations

Charlotte Duwat 2 collaborations

Gwennaëlle Aurégan 2 collaborations

Camille Gardier 2 collaborations

Francesco Gubinelli 2 collaborations

Charlène Josephine 2 collaborations

Noëlle Dufour 2 collaborations

Gwenaëlle Auregan 2 collaborations

Géraldine Liot 2 collaborations

Giselle Cheung 2 collaborations

Danijela Bataveljic 2 collaborations

Fabian Blanc 2 collaborations

Corentin Affortit 2 collaborations

Jean-Luc Puel 2 collaborations

Michel Mondain 2 collaborations

Jing Wang 2 collaborations

Eléonore Hardy 2 collaborations

Marc Oudart 2 collaborations

Anne-Cécile Boulay 2 collaborations

Philippe Mailly 2 collaborations

Nicole Déglon 2 collaborations

Lamiae Abdeladim 2 collaborations

Katherine S Matho 2 collaborations

Solène Clavreul 2 collaborations

Pierre Mahou 2 collaborations

Jean-Marc Sintes 2 collaborations

Xavier Solinas 2 collaborations

Ignacio Arganda-Carreras 2 collaborations

Stephen G Turney 2 collaborations

Jeff W Lichtman 2 collaborations

Anatole Chessel 2 collaborations

Karine Loulier 2 collaborations

Willy Supatto 2 collaborations

Emmanuel Beaurepaire 2 collaborations

Anastasie Maté de Gérando 1 collaboration

Marie d'Orange 1 collaboration

Emma Augustin 1 collaboration

Gwénaelle Aurégan 1 collaboration

Fanny Petit 1 collaboration

Carole Escartin 1 collaboration

Erwan Selingue 1 collaboration

Jérôme Ribot 1 collaboration

Rachel Breton 1 collaboration

Charles-Félix Calvo 1 collaboration

Jonathan Zapata 1 collaboration

Kevin Samama 1 collaboration

Matthieu Moreau 1 collaboration

Valentin Sabatet 1 collaboration

Florent Dingli 1 collaboration

Chantal Milleret 1 collaboration

Sara Douceau 1 collaboration

Eloïse Lemarchand 1 collaboration

Yannick Hommet 1 collaboration

Laurent Lebouvier 1 collaboration

Eric Maubert 1 collaboration

Véronique Agin 1 collaboration

Denis Vivien 1 collaboration

Sebastien Augustin 1 collaboration

Marion Lam 1 collaboration

Sophie Lavalette 1 collaboration

Anna Verschueren 1 collaboration

Frédéric Blond 1 collaboration

Valérie Forster 1 collaboration

Lauriane Przegralek 1 collaboration

Zhiguo He 1 collaboration

Daniel Lewandowski 1 collaboration

Serge Picaud 1 collaboration

José-Alain Sahel 1 collaboration

Thibaud Mathis 1 collaboration

Michel Paques 1 collaboration

Gilles Thuret 1 collaboration

Xavier Guillonneau 1 collaboration

Cécile Delarasse 1 collaboration

Florian Sennlaub 1 collaboration

Juliette Le Douce 1 collaboration

Marianne Maugard 1 collaboration

Julien Veran 1 collaboration

Marco Matos 1 collaboration

Pierrick Jégo 1 collaboration

Pierre-Antoine Vigneron 1 collaboration

Xavier Toussay 1 collaboration

Michel Vandenberghe 1 collaboration

Yaël Balbastre 1 collaboration

Juliette Piquet 1 collaboration

Elvire Guiot 1 collaboration

Nguyet Thuy Tran 1 collaboration

Myriam Taverna 1 collaboration

Stéphane Marinesco 1 collaboration

Ayumi Koyanagi 1 collaboration

Shigeki Furuya 1 collaboration

Sébastien Goutal 1 collaboration

Aurélie Ghettas 1 collaboration

Alain Pruvost 1 collaboration

Véronique Sazdovitch 1 collaboration

Charles Duyckaerts 1 collaboration

Graham Knott 1 collaboration

Thierry Delzescaux 1 collaboration

Bruno Cauli 1 collaboration

Stéphane H R Oliet 1 collaboration

Aude Panatier 1 collaboration

Luc Buée 1 collaboration

Pauline Roost 1 collaboration

Daniela Molina 1 collaboration

Suéva Bernier 1 collaboration

Marie-Christine Chartier-Harlin 1 collaboration

Nadja Van Camp 1 collaboration

Jean-Marc Taymans 1 collaboration

Josien Visser 1 collaboration

Naresh Kumar 1 collaboration

Daria Mozheiko 1 collaboration

Astrid Rollenhagen 1 collaboration

Cédric Mongin 1 collaboration

Oana Chever 1 collaboration

Joachim Lübke 1 collaboration

Isabelle Leray 1 collaboration

Helena Pivonkova 1 collaboration

Vidian de Concini 1 collaboration

Betty Hébert 1 collaboration

Sylvain Briault 1 collaboration

Jacques Pichon 1 collaboration

Arnaud Menuet 1 collaboration

Augustin Walter 1 collaboration

Franck Mouthon 1 collaboration

Mathieu Charvériat 1 collaboration

Armelle Rancillac 1 collaboration

Katia Avila-Gutierrez 1 collaboration

Clara Moch 1 collaboration

Giampaolo Milior 1 collaboration

Mathis Gaudey 1 collaboration

Bérangère Lombard 1 collaboration

Clément Chapat 1 collaboration

Laure-Elise Pillet 1 collaboration

Yoann Saillour 1 collaboration

Grégory Ghézali 1 collaboration

Thierry Bienvenu 1 collaboration

Lilia Kushnireva 1 collaboration

Noémie Mazaré 1 collaboration

Romain Tortuyaux 1 collaboration

Corinne Blugeon 1 collaboration

Laurent Jourdren 1 collaboration

Stéphane Le Crom 1 collaboration

Elsa Diguet 1 collaboration

Déborah Bellet 1 collaboration

Laurine Legroux 1 collaboration

Alain Joliot 1 collaboration

Flora Vasile 1 collaboration

Laure Lecoin 1 collaboration

Marc Le Bert 1 collaboration

Isabelle Couillin 1 collaboration

Yvan Arsenijevic 1 collaboration

Ning Chang 1 collaboration

Olivier Mercey 1 collaboration

Younes El Fersioui 1 collaboration

Hanna Koskiniemi-Kuendig 1 collaboration

Caroline Joubert 1 collaboration

Carlo Rivolta 1 collaboration

Eyal Banin 1 collaboration

Dror Sharon 1 collaboration

Paul Guichard 1 collaboration

Virginie Hamel 1 collaboration

Corinne Kostic 1 collaboration

Andry Andrianarivelo 1 collaboration

Estefani Saint-Jour 1 collaboration

Paula Pousinha 1 collaboration

Sebastian P Fernandez 1 collaboration

Anna Petitbon 1 collaboration

Veronique De Smedt-Peyrusse 1 collaboration

Nicolas Heck 1 collaboration

Vanesa Ortiz 1 collaboration

Marie-Charlotte Allichon 1 collaboration

Vincent Kappès 1 collaboration

Sandrine Betuing 1 collaboration

Roman Walle 1 collaboration

Ying Zhu 1 collaboration

Gustavo Turecki 1 collaboration

Naguib Mechawar 1 collaboration

Jonathan A Javitch 1 collaboration

Jocelyne Caboche 1 collaboration

Pierre Trifilieff 1 collaboration

Jacques Barik 1 collaboration

Peter Vanhoutte 1 collaboration

Giulia Comini 1 collaboration

Kaushik Narasimhan 1 collaboration

Victoria Gomez-Murcia 1 collaboration

Agathe Launay 1 collaboration

Anaëlle Burgard 1 collaboration

Céline Meriaux 1 collaboration

Raphaëlle Caillierez 1 collaboration

Sabiha Eddarkaoui 1 collaboration

Devrim Kilinc 1 collaboration

Dolores Siedlecki-Wullich 1 collaboration

Mélanie Besegher 1 collaboration

Séverine Bégard 1 collaboration

Bryan Thiroux 1 collaboration

Matthieu Jung 1 collaboration

Ouada Nebie 1 collaboration

Maxence Wisztorski 1 collaboration

Claire Montmasson 1 collaboration

Malika Hamdane 1 collaboration

Thibaud Lebouvier 1 collaboration

Didier Vieau 1 collaboration

Isabelle Fournier 1 collaboration

Luc Buee 1 collaboration

Sabine Lévi 1 collaboration

Luisa V Lopes 1 collaboration

Anne-Laurence Boutillier 1 collaboration

Pauline Léal 1 collaboration

Stéphane Fouquet 1 collaboration

Marie-Laure Niepon 1 collaboration

Magali Taiel 1 collaboration