Des anomalies cutanées peuvent survenir en raison de troubles liés à la méthylation.
Anomalies cutanéesMéthylation de l'ADN
Prévention
5
#1
Comment prévenir les anomalies de méthylation ?
Une alimentation équilibrée et un mode de vie sain peuvent réduire les risques.
AlimentationMode de vie
#2
Le stress influence-t-il la méthylation ?
Oui, le stress chronique peut affecter les niveaux de méthylation de l'ADN.
StressMéthylation de l'ADN
#3
Les suppléments nutritionnels aident-ils ?
Certains suppléments, comme l'acide folique, peuvent soutenir une méthylation saine.
Suppléments nutritionnelsAcide folique
#4
L'exercice physique a-t-il un impact ?
Oui, l'exercice régulier peut influencer positivement la méthylation de l'ADN.
Exercice physiqueMéthylation de l'ADN
#5
Les habitudes de sommeil affectent-elles la méthylation ?
Un sommeil de qualité est crucial pour maintenir une méthylation adéquate.
SommeilMéthylation de l'ADN
Traitements
5
#1
Quels traitements ciblent la méthylation ?
Des agents déméthylants comme l'azacitidine sont utilisés pour traiter certains cancers.
Agents déméthylantsCancer
#2
La thérapie génique peut-elle corriger la méthylation ?
Oui, la thérapie génique vise à restaurer la méthylation normale dans certaines conditions.
Thérapie géniqueMéthylation de l'ADN
#3
Y a-t-il des traitements préventifs ?
Des interventions diététiques et des modifications du mode de vie peuvent aider à prévenir des anomalies.
PréventionMode de vie
#4
Les médicaments peuvent-ils influencer la méthylation ?
Oui, certains médicaments peuvent modifier les niveaux de méthylation de l'ADN.
MédicamentsMéthylation de l'ADN
#5
Comment la recherche avance-t-elle sur ce sujet ?
Des études cliniques explorent de nouvelles thérapies ciblant la méthylation pour diverses maladies.
Recherche cliniqueThérapies ciblées
Complications
5
#1
Quelles complications sont liées à la méthylation anormale ?
Des complications incluent le développement de cancers et de maladies auto-immunes.
CancersMaladies auto-immunes
#2
La 5-méthylcytosine est-elle liée à des troubles mentaux ?
Oui, des anomalies de méthylation peuvent contribuer à des troubles mentaux comme la dépression.
Troubles mentauxDépression
#3
Y a-t-il des risques de maladies cardiovasculaires ?
Des études suggèrent un lien entre la méthylation et les maladies cardiovasculaires.
Maladies cardiovasculairesMéthylation de l'ADN
#4
Les complications peuvent-elles être réversibles ?
Certaines complications peuvent être atténuées par des traitements ciblés et des changements de mode de vie.
Traitements ciblésMode de vie
#5
La 5-méthylcytosine affecte-t-elle la fertilité ?
Des modifications de méthylation peuvent influencer la fertilité et le développement embryonnaire.
FertilitéDéveloppement embryonnaire
Facteurs de risque
5
#1
Quels facteurs augmentent le risque de méthylation anormale ?
Des facteurs comme l'âge, l'alimentation et l'exposition à des toxines peuvent augmenter le risque.
ÂgeToxines
#2
Le tabagisme influence-t-il la méthylation ?
Oui, le tabagisme est associé à des modifications de la méthylation de l'ADN.
TabagismeMéthylation de l'ADN
#3
L'environnement joue-t-il un rôle ?
Oui, des facteurs environnementaux comme la pollution peuvent affecter la méthylation.
EnvironnementPollution
#4
Les antécédents familiaux influencent-ils le risque ?
Oui, des antécédents familiaux de maladies peuvent augmenter le risque de méthylation anormale.
Antécédents familiauxMaladies
#5
Le mode de vie a-t-il un impact sur la méthylation ?
Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent affecter la méthylation.
Mode de vieAlimentation
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "5-Méthyl-cytosine : Questions médicales les plus fréquentes",
"headline": "5-Méthyl-cytosine : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les 5-Méthyl-cytosine : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-03-31",
"dateModified": "2025-03-26",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "5-Méthyl-cytosine"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Cytosine",
"url": "https://questionsmedicales.fr/mesh/D003596",
"about": {
"@type": "MedicalCondition",
"name": "Cytosine",
"code": {
"@type": "MedicalCode",
"code": "D003596",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D03.383.742.698.421"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "5-Méthyl-cytosine",
"alternateName": "5-Methylcytosine",
"code": {
"@type": "MedicalCode",
"code": "D044503",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Yun-Gui Yang",
"url": "https://questionsmedicales.fr/author/Yun-Gui%20Yang",
"affiliation": {
"@type": "Organization",
"name": "CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China; Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: ygyang@big.ac.cn."
}
},
{
"@type": "Person",
"name": "Ying Yang",
"url": "https://questionsmedicales.fr/author/Ying%20Yang",
"affiliation": {
"@type": "Organization",
"name": "CAS Key Laboratory of Genomic and Precision Medicine, College of Futuer Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China."
}
},
{
"@type": "Person",
"name": "Qing Dai",
"url": "https://questionsmedicales.fr/author/Qing%20Dai",
"affiliation": {
"@type": "Organization",
"name": "Department of Chemistry, The University of Chicago, Chicago, IL 60637."
}
},
{
"@type": "Person",
"name": "Chuan He",
"url": "https://questionsmedicales.fr/author/Chuan%20He",
"affiliation": {
"@type": "Organization",
"name": "Department of Chemistry, The University of Chicago, Chicago, IL 60637."
}
},
{
"@type": "Person",
"name": "Bao-Fa Sun",
"url": "https://questionsmedicales.fr/author/Bao-Fa%20Sun",
"affiliation": {
"@type": "Organization",
"name": "CAS Key Laboratory of Genomic and Precision Medicine, College of Futuer Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Modeling Low Muscle Mass Screening in Hemodialysis Patients.",
"datePublished": "2022-10-21",
"url": "https://questionsmedicales.fr/article/36273447",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1159/000526866"
}
},
{
"@type": "ScholarlyArticle",
"name": "Fat-Free Mass Index as a Surrogate Marker of Appendicular Skeletal Muscle Mass Index for Low Muscle Mass Screening in Sarcopenia.",
"datePublished": "2022-09-28",
"url": "https://questionsmedicales.fr/article/36179769",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.jamda.2022.08.016"
}
},
{
"@type": "ScholarlyArticle",
"name": "The dilemma of recalling well-circumscribed masses in a screening population: A narrative literature review and exploration of Dutch screening practice.",
"datePublished": "2023-05-03",
"url": "https://questionsmedicales.fr/article/37169601",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.breast.2023.05.001"
}
},
{
"@type": "ScholarlyArticle",
"name": "Cost-effectiveness analysis of newborn screening by tandem mass spectrometry in Shenzhen, China: value and affordability of new screening technology.",
"datePublished": "2022-08-15",
"url": "https://questionsmedicales.fr/article/35971172",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s12913-022-08394-4"
}
},
{
"@type": "ScholarlyArticle",
"name": "The efficacy of mass screening for chronic obstructive pulmonary disease using screening questionnaires in a medical health check-up population.",
"datePublished": "2022-08-31",
"url": "https://questionsmedicales.fr/article/36057534",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.resinv.2022.07.005"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Composés hétérocycliques",
"item": "https://questionsmedicales.fr/mesh/D006571"
},
{
"@type": "ListItem",
"position": 3,
"name": "Composés hétéromonocycliques",
"item": "https://questionsmedicales.fr/mesh/D006573"
},
{
"@type": "ListItem",
"position": 4,
"name": "Pyrimidines",
"item": "https://questionsmedicales.fr/mesh/D011743"
},
{
"@type": "ListItem",
"position": 5,
"name": "Pyrimidinones",
"item": "https://questionsmedicales.fr/mesh/D011744"
},
{
"@type": "ListItem",
"position": 6,
"name": "Cytosine",
"item": "https://questionsmedicales.fr/mesh/D003596"
},
{
"@type": "ListItem",
"position": 7,
"name": "5-Méthyl-cytosine",
"item": "https://questionsmedicales.fr/mesh/D044503"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : 5-Méthyl-cytosine - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur 5-Méthyl-cytosine",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-12",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur 5-Méthyl-cytosine",
"description": "Comment détecte-t-on la 5-méthylcytosine ?\nQuels tests sont utilisés pour évaluer la méthylation ?\nLa 5-méthylcytosine est-elle mesurable dans le sang ?\nQuels biomarqueurs sont associés à la 5-méthylcytosine ?\nLa 5-méthylcytosine est-elle liée à des maladies ?",
"url": "https://questionsmedicales.fr/mesh/D044503?mesh_terms=Mass+Screening#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur 5-Méthyl-cytosine",
"description": "Quels symptômes sont liés à la méthylation anormale ?\nLa 5-méthylcytosine affecte-t-elle le comportement ?\nY a-t-il des signes cliniques de dysfonctionnement ?\nLa 5-méthylcytosine est-elle liée à des symptômes neurologiques ?\nPeut-on observer des symptômes cutanés ?",
"url": "https://questionsmedicales.fr/mesh/D044503?mesh_terms=Mass+Screening#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur 5-Méthyl-cytosine",
"description": "Comment prévenir les anomalies de méthylation ?\nLe stress influence-t-il la méthylation ?\nLes suppléments nutritionnels aident-ils ?\nL'exercice physique a-t-il un impact ?\nLes habitudes de sommeil affectent-elles la méthylation ?",
"url": "https://questionsmedicales.fr/mesh/D044503?mesh_terms=Mass+Screening#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur 5-Méthyl-cytosine",
"description": "Quels traitements ciblent la méthylation ?\nLa thérapie génique peut-elle corriger la méthylation ?\nY a-t-il des traitements préventifs ?\nLes médicaments peuvent-ils influencer la méthylation ?\nComment la recherche avance-t-elle sur ce sujet ?",
"url": "https://questionsmedicales.fr/mesh/D044503?mesh_terms=Mass+Screening#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur 5-Méthyl-cytosine",
"description": "Quelles complications sont liées à la méthylation anormale ?\nLa 5-méthylcytosine est-elle liée à des troubles mentaux ?\nY a-t-il des risques de maladies cardiovasculaires ?\nLes complications peuvent-elles être réversibles ?\nLa 5-méthylcytosine affecte-t-elle la fertilité ?",
"url": "https://questionsmedicales.fr/mesh/D044503?mesh_terms=Mass+Screening#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur 5-Méthyl-cytosine",
"description": "Quels facteurs augmentent le risque de méthylation anormale ?\nLe tabagisme influence-t-il la méthylation ?\nL'environnement joue-t-il un rôle ?\nLes antécédents familiaux influencent-ils le risque ?\nLe mode de vie a-t-il un impact sur la méthylation ?",
"url": "https://questionsmedicales.fr/mesh/D044503?mesh_terms=Mass+Screening#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment détecte-t-on la 5-méthylcytosine ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "La détection se fait par des techniques comme la bisulfite séquençage."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer la méthylation ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests comme le PCR en temps réel et le séquençage de nouvelle génération sont utilisés."
}
},
{
"@type": "Question",
"name": "La 5-méthylcytosine est-elle mesurable dans le sang ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des échantillons sanguins peuvent être analysés pour la méthylation de l'ADN."
}
},
{
"@type": "Question",
"name": "Quels biomarqueurs sont associés à la 5-méthylcytosine ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des biomarqueurs comme les gènes régulés par la méthylation peuvent être identifiés."
}
},
{
"@type": "Question",
"name": "La 5-méthylcytosine est-elle liée à des maladies ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle est associée à des maladies comme le cancer et des troubles neurologiques."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés à la méthylation anormale ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes peuvent inclure des troubles cognitifs et des anomalies de développement."
}
},
{
"@type": "Question",
"name": "La 5-méthylcytosine affecte-t-elle le comportement ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des modifications de la méthylation peuvent influencer le comportement et l'humeur."
}
},
{
"@type": "Question",
"name": "Y a-t-il des signes cliniques de dysfonctionnement ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes peuvent inclure des troubles métaboliques et des problèmes immunitaires."
}
},
{
"@type": "Question",
"name": "La 5-méthylcytosine est-elle liée à des symptômes neurologiques ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle est impliquée dans des maladies neurodégénératives et des troubles psychiatriques."
}
},
{
"@type": "Question",
"name": "Peut-on observer des symptômes cutanés ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies cutanées peuvent survenir en raison de troubles liés à la méthylation."
}
},
{
"@type": "Question",
"name": "Comment prévenir les anomalies de méthylation ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et un mode de vie sain peuvent réduire les risques."
}
},
{
"@type": "Question",
"name": "Le stress influence-t-il la méthylation ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter les niveaux de méthylation de l'ADN."
}
},
{
"@type": "Question",
"name": "Les suppléments nutritionnels aident-ils ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains suppléments, comme l'acide folique, peuvent soutenir une méthylation saine."
}
},
{
"@type": "Question",
"name": "L'exercice physique a-t-il un impact ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut influencer positivement la méthylation de l'ADN."
}
},
{
"@type": "Question",
"name": "Les habitudes de sommeil affectent-elles la méthylation ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un sommeil de qualité est crucial pour maintenir une méthylation adéquate."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent la méthylation ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des agents déméthylants comme l'azacitidine sont utilisés pour traiter certains cancers."
}
},
{
"@type": "Question",
"name": "La thérapie génique peut-elle corriger la méthylation ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la thérapie génique vise à restaurer la méthylation normale dans certaines conditions."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements préventifs ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des interventions diététiques et des modifications du mode de vie peuvent aider à prévenir des anomalies."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils influencer la méthylation ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent modifier les niveaux de méthylation de l'ADN."
}
},
{
"@type": "Question",
"name": "Comment la recherche avance-t-elle sur ce sujet ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études cliniques explorent de nouvelles thérapies ciblant la méthylation pour diverses maladies."
}
},
{
"@type": "Question",
"name": "Quelles complications sont liées à la méthylation anormale ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent le développement de cancers et de maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "La 5-méthylcytosine est-elle liée à des troubles mentaux ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anomalies de méthylation peuvent contribuer à des troubles mentaux comme la dépression."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de maladies cardiovasculaires ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études suggèrent un lien entre la méthylation et les maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Les complications peuvent-elles être réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être atténuées par des traitements ciblés et des changements de mode de vie."
}
},
{
"@type": "Question",
"name": "La 5-méthylcytosine affecte-t-elle la fertilité ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des modifications de méthylation peuvent influencer la fertilité et le développement embryonnaire."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de méthylation anormale ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme l'âge, l'alimentation et l'exposition à des toxines peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Le tabagisme influence-t-il la méthylation ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme est associé à des modifications de la méthylation de l'ADN."
}
},
{
"@type": "Question",
"name": "L'environnement joue-t-il un rôle ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des facteurs environnementaux comme la pollution peuvent affecter la méthylation."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies peuvent augmenter le risque de méthylation anormale."
}
},
{
"@type": "Question",
"name": "Le mode de vie a-t-il un impact sur la méthylation ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent affecter la méthylation."
}
}
]
}
]
}
CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China; Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: ygyang@big.ac.cn.
CAS Key Laboratory of Genomic and Precision Medicine, College of Futuer Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
CAS Key Laboratory of Genomic and Precision Medicine, College of Futuer Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China.
CAS Key Laboratory of Genomic and Precision Medicine, College of Futuer Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
EMBL-Australia Collaborating Group, Department of Genome Sciences, John Curtin School of Medical Research, Australian National University, Canberra, 2601, Australian Captial Territory, Australia. thomas.preiss@anu.edu.au.
Victor Chang Cardiac Research Institute, Sydney, New South Wales, 2010, Australia. thomas.preiss@anu.edu.au.
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. huangy@sibcb.ac.cn.
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Tongji Hospital, Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200092, China.
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Computed tomography (CT) can accurately measure muscle mass, which is necessary for diagnosing sarcopenia, even in dialysis patients. However, CT-based screening for such patients is challenging, espe...
Hemodialysis patients (n = 619) who had undergone abdominal CT screening were divided into the development (n = 441) and validation (n = 178) groups. PMI was manually measured using abdominal CT image...
Of all subjects, 226 (37%) were diagnosed with low muscle mass using PMI. A predictive model for low muscle mass was calculated using ten variables: each grip strength, sex, height, dry weight, primar...
Our results facilitate skeletal muscle screening in hemodialysis patients, assisting in sarcopenia prophylaxis and intervention decisions....
We aimed to examine the relationship between the fat-free mass index (FFMI; FFM/height...
Cross-sectional study....
This study included 1313 adults (women, 33.6%) aged 40-87 years (mean age, 55 ± 10 years) from the WASEDA'S Health Study....
Body composition was measured using multifrequency BIA and DXA. Low muscle mass was defined according to the criteria of the Asian Working Group for Sarcopenia 2019....
BIA-measured FFMI showed strong positive correlations with both BIA- (r = 0.96) and DXA-measured (r = 0.95) ASMIs. Similarly, in the subgroup analysis according to age and obesity, the FFMI was correl...
The FFMI showed a strong positive correlation with BIA- and DXA-measured ASMIs, regardless of age and obesity. The FFMI could be a useful simple surrogate marker of the ASMI for low muscle mass screen...
In Dutch breast cancer screening, solitary, new or growing well-circumscribed masses should be recalled for further assessment. This results in cancers detected but also in false positive recalls, esp...
A systematic literature search was performed using PubMed. In addition, follow-up data were retrieved on all 8860 recalled women in a Dutch screening region from 2014 to 2019....
Based on 15 articles identified in the literature search, we found that probably benign well-circumscribed masses that were kept under surveillance had a positive predictive value (PPV) of 0-2%. New o...
To recognize malignancies presenting as well-circumscribed masses, identifying solitary, new or growing lesions is key. This information is missing at initial screening since prior examinations are no...
Newborn screening (NBS) can prevent inborn errors of metabolism (IEMs), which may cause long-term disability and even death in newborns. However, in China, tandem mass spectrometry (MS/MS) screening h...
A Markov model was built to estimate the cost and quality-adjusted life-years (QALYs) of different screening programs. We compared PKU screening using traditional immunofluorescence (IF) with the othe...
The incremental cost-effectiveness ratio (ICER) of detecting all 12 IEMs in the national program is 277,823 RMB per QALY, below three times per capita GDP in Shenzhen. MS/MS screening in Shenzhen can ...
We conclude that the newborn screening using MS/MS in Shenzhen is cost-effective, and the budget affordable for the Shenzhen government. Two concepts for selecting the IEMs to be detected are also pre...
Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease, highlighting the need for efficient screening strategies to identify patients with COPD. However, there is little e...
In this cross-sectional study, we originally investigated the efficacy of mass screening for COPD among community residents in the aforementioned region using two COPD screening questionnaires....
From July 2018 through January 2019, 688 participants were enrolled. COPD was diagnosed using the Global Initiative for the Chronic Obstructive Lung Disease criteria. Twenty-one patients were newly di...
Mass screening for COPD using screening questionnaires, particularly the COPD-PS questionnaire, might be useful to identify the early stages of COPD in a medical health check-up population....
Although the study design for identifying specific disease associations using a health insurance database has been well-established, few studies explore unknown comorbidities. We conducted a series of...
Gastric cancer is an inflammation-related cancer triggered by Helicobacter pylori infection. Understanding of the natural disease course has prompted the hypothesis that gastric cancer can be prevente...
The early detection of symptoms and rapid testing are the basis of an efficient screening strategy to control COVID-19 transmission. The olfactory dysfunction is one of the most prevalent symptom and ...
The main goal of this study was to examine the relationship between exposure to mass media health campaign massages and the uptake of non-communicable diseases (NCDs) screening services in Ghana and w...
Updated data on the seroprevalences of hepatitis B and C viruses (HBV, HCV) are required to enable the adaptation of control strategies. In this study, we aimed to: (i) estimate the seroprevalences of...
From October 2020 to October 2022, a mass screening campaign was conducted in 10 cities across Burkina Faso. Individuals of all ages and genders who consented to participate were screened for viral ma...
A total of 15,650 participants were enrolled in the study. Of these, 51.4% were women and the age range was from 1 to 97 years. All participants were screened for HBsAg and 7,507 were also screened fo...
The prevalence of HBV and HCV infections remains high in Burkina Faso. Prevention strategies, including initial mass screening with rapid diagnostic tests and vaccination, need to be intensified....