Des anomalies cutanées peuvent survenir en raison de troubles liés à la méthylation.
Anomalies cutanéesMéthylation de l'ADN
Prévention
5
#1
Comment prévenir les anomalies de méthylation ?
Une alimentation équilibrée et un mode de vie sain peuvent réduire les risques.
AlimentationMode de vie
#2
Le stress influence-t-il la méthylation ?
Oui, le stress chronique peut affecter les niveaux de méthylation de l'ADN.
StressMéthylation de l'ADN
#3
Les suppléments nutritionnels aident-ils ?
Certains suppléments, comme l'acide folique, peuvent soutenir une méthylation saine.
Suppléments nutritionnelsAcide folique
#4
L'exercice physique a-t-il un impact ?
Oui, l'exercice régulier peut influencer positivement la méthylation de l'ADN.
Exercice physiqueMéthylation de l'ADN
#5
Les habitudes de sommeil affectent-elles la méthylation ?
Un sommeil de qualité est crucial pour maintenir une méthylation adéquate.
SommeilMéthylation de l'ADN
Traitements
5
#1
Quels traitements ciblent la méthylation ?
Des agents déméthylants comme l'azacitidine sont utilisés pour traiter certains cancers.
Agents déméthylantsCancer
#2
La thérapie génique peut-elle corriger la méthylation ?
Oui, la thérapie génique vise à restaurer la méthylation normale dans certaines conditions.
Thérapie géniqueMéthylation de l'ADN
#3
Y a-t-il des traitements préventifs ?
Des interventions diététiques et des modifications du mode de vie peuvent aider à prévenir des anomalies.
PréventionMode de vie
#4
Les médicaments peuvent-ils influencer la méthylation ?
Oui, certains médicaments peuvent modifier les niveaux de méthylation de l'ADN.
MédicamentsMéthylation de l'ADN
#5
Comment la recherche avance-t-elle sur ce sujet ?
Des études cliniques explorent de nouvelles thérapies ciblant la méthylation pour diverses maladies.
Recherche cliniqueThérapies ciblées
Complications
5
#1
Quelles complications sont liées à la méthylation anormale ?
Des complications incluent le développement de cancers et de maladies auto-immunes.
CancersMaladies auto-immunes
#2
La 5-méthylcytosine est-elle liée à des troubles mentaux ?
Oui, des anomalies de méthylation peuvent contribuer à des troubles mentaux comme la dépression.
Troubles mentauxDépression
#3
Y a-t-il des risques de maladies cardiovasculaires ?
Des études suggèrent un lien entre la méthylation et les maladies cardiovasculaires.
Maladies cardiovasculairesMéthylation de l'ADN
#4
Les complications peuvent-elles être réversibles ?
Certaines complications peuvent être atténuées par des traitements ciblés et des changements de mode de vie.
Traitements ciblésMode de vie
#5
La 5-méthylcytosine affecte-t-elle la fertilité ?
Des modifications de méthylation peuvent influencer la fertilité et le développement embryonnaire.
FertilitéDéveloppement embryonnaire
Facteurs de risque
5
#1
Quels facteurs augmentent le risque de méthylation anormale ?
Des facteurs comme l'âge, l'alimentation et l'exposition à des toxines peuvent augmenter le risque.
ÂgeToxines
#2
Le tabagisme influence-t-il la méthylation ?
Oui, le tabagisme est associé à des modifications de la méthylation de l'ADN.
TabagismeMéthylation de l'ADN
#3
L'environnement joue-t-il un rôle ?
Oui, des facteurs environnementaux comme la pollution peuvent affecter la méthylation.
EnvironnementPollution
#4
Les antécédents familiaux influencent-ils le risque ?
Oui, des antécédents familiaux de maladies peuvent augmenter le risque de méthylation anormale.
Antécédents familiauxMaladies
#5
Le mode de vie a-t-il un impact sur la méthylation ?
Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent affecter la méthylation.
Mode de vieAlimentation
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CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China; Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: ygyang@big.ac.cn.
CAS Key Laboratory of Genomic and Precision Medicine, College of Futuer Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
CAS Key Laboratory of Genomic and Precision Medicine, College of Futuer Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China.
CAS Key Laboratory of Genomic and Precision Medicine, College of Futuer Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
EMBL-Australia Collaborating Group, Department of Genome Sciences, John Curtin School of Medical Research, Australian National University, Canberra, 2601, Australian Captial Territory, Australia. thomas.preiss@anu.edu.au.
Victor Chang Cardiac Research Institute, Sydney, New South Wales, 2010, Australia. thomas.preiss@anu.edu.au.
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. huangy@sibcb.ac.cn.
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Tongji Hospital, Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200092, China.
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
The Maastricht VI/Florence Consensus and Chinese National Consensus Report provide comprehensive guidelines for treating...
Chinese medical staff attending gastrointestinal conferences across various regions were selected for this study. The questionnaire included: 1. the number of patients with peptic ulcer bleeding in ho...
Across all levels of Chinese hospitals, the urea breath test was the most commonly used method for detecting...
There is a need for an enhanced understanding of and adherence to guidelines for...
The use of gonad contact shielding (GCS) in radiology departments has varied across countries, possibly because, until recently, there was no agreed consensus with mixed evidence supporting its use. T...
An online survey was sent via email to potential participants through the Society of Medical Radiographers Malta (SRM) as well as social media posts on local radiography pages. Descriptive and inferen...
Almost half of the registered radiographers working in radiology departments in Malta (n = 101/203) completed the survey (49.7 % response rate). 61.4 % of participating radiographers indicated they 'o...
Some misconceptions and uncertainties among radiographers concerning the benefits and risks of using GCS were noted. Local radiology departments should look into their protocols and assess the need fo...
Residents experience the longest working hours among physicians. Thus, it would be beneficial to perform a nationwide survey in Japan on residents' long work hours and the background factors promoting...
The survey was sent to 924 hospitals. The physicians' general attributes, work hours and conditions, and employers' foundational entities were explored. Multiple logistic regression analysis was perfo...
Of the 4306 resident physicians who responded, 67% had ≥ 60 in-hospital hours/week and 27% had ≥ 80 h/week; 51% were on-call ≥ four times/month. Many of them hoped for increased remuneration. Addition...
Understanding the factors that increase the likelihood of residents working very long hours could aid in making targeted changes to address the specific concerns. Moreover, reducing working hours to a...
With the rapid development of science and technology, the trend of low age myopia is becoming increasingly significant. The latest national survey done by the Chinese government found that more than 8...
Breastfeeding provides the optimal nutrition for infants and offers numerous benefits for both mother and child. The World Health Organisation recommends exclusive breastfeeding during the first 6 mon...
In this prospective, questionnaire-based study conducted between 2020 and 2022, primiparous women were asked to complete three questionnaires at three defined survey time points (routine prepartum pre...
A total of 140 women were included and returned all three questionnaires. Fifty-eight percent performed breastfeeding exclusively at least until their baby had reached the age of 6 months, whereas 20%...
Breastfeeding behaviour and duration are influenced by multiple factors. Although certain sociodemographic factors are unalterable, comprehensive prepartum knowledge transfer and postpartum midwifery ...
The study was retrospectively registered at the German Clinical Trials Register (Deutsches Register Klinischer Studien, DRKS) on 6 December 2022 (DRKS00030763)....
Hairdresser dystonia is one of the occupational dystonias and task-specific movement disorders occurring as a result of long-term repetitive cutting with scissors. The task-specific dystonia manifests...
Microplastics (MPs) can enter the body via plastic products. Given modern plastic exposure, we seek to assess MP exposure in large populations through epidemiological tools. In this quasi-experimental...
Patient feedback is an important way for healthcare providers to understand patient experience and improve the quality of care effectively and facilitate patient-centered care in the healthcare system...
Attendances aged 18 or above from all public hospitals with AEDs during 16-30 June 2016 were targeted and a cross-sectional telephone survey was conducted using AEEQ. Preliminary AEEQ consisted of 92 ...
A total of 512 patients were recruited with a response rate of 54% and a mean age of 53.2 years old. The exploratory factor analysis suggested removing 7 items due to weak factor loadings and high cro...
The AEEQ is a valid and reliable instrument to evaluate the AED service which helps to build the engagement platform for promoting patient-centered care between patients and frontline healthcare profe...
COVID-19 affected mental health and wellbeing. Research is needed to assess its impact using validated tools. The study assessed the content validity, reliability and dimensionality of a multidimensio...
An online questionnaire collected data in the second half of 2020 from adults in different countries. The questionnaire included nine sections assessing: COVID-19 experience and sociodemographic profi...
The overall CVI = 0.83 with lower values for the memory items. Cronbach α for the memory items = 0.94 and ICC = 0.71. Cronbach α for PTSD items was 0.93 and ICC = 0.89. Test-retest scores varied by se...
The questionnaire has good content validity and can be used to assess the impact of the pandemic in cross-sectional studies especially as individual items. The PSI and self-care strategies need revisi...
Many interstitial lung diseases (ILDs) have clear causal relationships with environmental and occupational exposures. Exposure identification can assist with diagnosis, understanding disease pathogene...
This scoping review aimed to summarise the available evidence relating to ILD exposure assessment questionnaires, identify research gaps and inform the content for a future single evidence-based ILD q...
A scoping review based on Arksey and O'Malley's methodological framework was conducted....
Any questionnaire that elicited exposures specific to ILD was included. A modified COSMIN Risk of Bias Framework was used to assess quality....
Relevant articles were identified from MEDLINE and EMBASE up to 23 July 2023....
22 exposure questionnaires were identified, including 15 generally pertaining to ILD, along with several disease-specific questionnaires for hypersensitivity pneumonitis (n=4), chronic beryllium disea...
Designing a robust ILD-specific questionnaire should include an evidence-based and relevance-based approach to exposure derivation, with clinicians and patients involved in its development and tested ...