G Legube

Affiliations

Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Intégrative (CBI), UPS, CNRS, Toulouse, France. Electronic address: gaelle.legube@univ-tlse3.fr.

Publications (17)

Non-canonical DNA/RNA structures during Transcription-Coupled Double-Strand Break Repair: Roadblocks or Bona fide repair intermediates?

DNA repair

Avec: Nadine Puget , Kyle M Miller , Gaëlle Legube

Chromatin organization drives the search mechanism of nuclear factors.

Nature communications

Avec: Matteo Mazzocca , Alessia Loffreda , Emanuele Colombo , Tom Fillot , Daniela Gnani , Paola Falletta , Emanuele Monteleone , Serena Capozi , Edouard Bertrand , Gaelle Legube , Zeno Lavagnino , Carlo Tacchetti , Davide Mazza

R-loops as Janus-faced modulators of DNA repair.

Nature cell biology

Avec: Aline Marnef , Gaëlle Legube

Analyzing Homologous Recombination at a Genome-Wide Level.

Methods in molecular biology (Clifton, N.J.)

Avec: Coline Arnould , Vincent Rocher , Gaëlle Legube

Chromatin compartmentalization regulates the response to DNA damage.

Nature

Avec: Coline Arnould , Vincent Rocher , Florian Saur , Aldo S Bader , Fernando Muzzopappa , Sarah Collins , Emma Lesage , Benjamin Le Bozec , Nadine Puget , Thomas Clouaire , Thomas Mangeat , Raphael Mourad , Nadav Ahituv , Daan Noordermeer , Fabian Erdel , Martin Bushell , Aline Marnef , Gaëlle Legube

The Secret Life of Chromosome Loops upon DNA Double-Strand Break.

Journal of molecular biology

Avec: Coline Arnould , Gaëlle Legube

Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor.

Science advances

Avec: Jean Personnaz , Enzo Piccolo , Alizée Dortignac , Jason S Iacovoni , Jérôme Mariette , Vincent Rocher , Arnaud Polizzi , Aurélie Batut , Simon Deleruyelle , Lucas Bourdens , Océane Delos , Lucie Combes-Soia , Romain Paccoud , Elsa Moreau , Frédéric Martins , Thomas Clouaire , Fadila Benhamed , Alexandra Montagner , Walter Wahli , Robert F Schwabe , Armelle Yart , Isabelle Castan-Laurell , Justine Bertrand-Michel , Odile Burlet-Schiltz , Catherine Postic , Pierre-Damien Denechaud , Cédric Moro , Gaelle Legube , Chih-Hao Lee , Hervé Guillou , Philippe Valet , Cédric Dray , Jean-Philippe Pradère

Endogenous neuronal DNA double-strand breaks are not sufficient to drive brain aging and neurodegeneration.

bioRxiv : the preprint server for biology

Avec: Sarah Cohen , Laura Cheradame , Karishma J B Pratt , Sarah Collins , Ashlie Barillas , Annika Carlson , Vijay Ramani , Gaëlle Legube , Saul A Villeda , R Dyche Mullins , Bjoern Schwer

A Snapshot on the Cis Chromatin Response to DNA Double-Strand Breaks.

Trends in genetics : TIG

Avec: Thomas Clouaire , Gaëlle Legube

Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins.

Nature communications

Avec: Philippe E Mangeot , Valérie Risson , Floriane Fusil , Aline Marnef , Emilie Laurent , Juliana Blin , Virginie Mournetas , Emmanuelle Massouridès , Thibault J M Sohier , Antoine Corbin , Fabien Aubé , Marie Teixeira , Christian Pinset , Laurent Schaeffer , Gaëlle Legube , François-Loïc Cosset , Els Verhoeyen , Théophile Ohlmann , Emiliano P Ricci

Repair of DNA double-strand breaks in RNAPI- and RNAPII-transcribed loci.

DNA repair

Avec: E Lesage , T Clouaire , G Legube

Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism.

The EMBO journal

Avec: Ilaria Gritti , Veronica Basso , Darawan Rinchai , Federica Corigliano , Silvia Pivetti , Marco Gaviraghi , Dalia Rosano , Davide Mazza , Sara Barozzi , Marco Roncador , Giovanni Parmigiani , Gaelle Legube , Dario Parazzoli , Davide Cittaro , Davide Bedognetti , Anna Mondino , Simona Segalla , Giovanni Tonon

A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair.

Genes & development

Avec: Aline Marnef , Anne-Laure Finoux , Coline Arnould , Emmanuelle Guillou , Virginie Daburon , Vincent Rocher , Thomas Mangeat , Philippe E Mangeot , Emiliano P Ricci , Gaëlle Legube

Loop extrusion as a mechanism for formation of DNA damage repair foci.

Nature

Avec: Coline Arnould , Vincent Rocher , Anne-Laure Finoux , Thomas Clouaire , Kevin Li , Felix Zhou , Pierre Caron , Philippe E Mangeot , Emiliano P Ricci , Raphaël Mourad , James E Haber , Daan Noordermeer , Gaëlle Legube

Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox.

Frontiers in molecular biosciences

Avec: Alexandra C Vítor , Pablo Huertas , Gaëlle Legube , Sérgio F de Almeida

A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrid accumulation.

Nature communications

Avec: S Cohen , A Guenolé , I Lazar , A Marnef , T Clouaire , D V Vernekar , N Puget , V Rocher , C Arnould , M Aguirrebengoa , M Genais , N Firmin , R A Shamanna , R Mourad , V A Bohr , V Borde , G Legube

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells.

Molecular cell

Avec: Florian J Groelly , Rebecca A Dagg , Michalis Petropoulos , Giacomo G Rossetti , Birbal Prasad , Andreas Panagopoulos , Teressa Paulsen , Angeliki Karamichali , Samuel E Jones , Fena Ochs , Vasilis S Dionellis , Emilia Puig Lombardi , Matthieu J Miossec , Helen Lockstone , Gaëlle Legube , Andrew N Blackford , Matthias Altmeyer , Thanos D Halazonetis , Madalena Tarsounas

Réseau de co-auteurs

Gaëlle Legube 12 collaborations

Coline Arnould 5 collaborations

Vincent Rocher 5 collaborations

Aline Marnef 4 collaborations

Thomas Clouaire 4 collaborations

Gaelle Legube 3 collaborations

Philippe E Mangeot 3 collaborations

Emiliano P Ricci 3 collaborations

Nadine Puget 2 collaborations

Davide Mazza 2 collaborations

Sarah Collins 2 collaborations

Thomas Mangeat 2 collaborations

Daan Noordermeer 2 collaborations

T Clouaire 2 collaborations

Anne-Laure Finoux 2 collaborations

Kyle M Miller 1 collaboration

Matteo Mazzocca 1 collaboration

Alessia Loffreda 1 collaboration

Emanuele Colombo 1 collaboration

Tom Fillot 1 collaboration

Daniela Gnani 1 collaboration

Paola Falletta 1 collaboration

Emanuele Monteleone 1 collaboration

Serena Capozi 1 collaboration

Edouard Bertrand 1 collaboration

Zeno Lavagnino 1 collaboration

Carlo Tacchetti 1 collaboration

Florian Saur 1 collaboration

Aldo S Bader 1 collaboration

Fernando Muzzopappa 1 collaboration

Emma Lesage 1 collaboration

Benjamin Le Bozec 1 collaboration

Raphael Mourad 1 collaboration

Nadav Ahituv 1 collaboration

Fabian Erdel 1 collaboration

Martin Bushell 1 collaboration

Jean Personnaz 1 collaboration

Enzo Piccolo 1 collaboration

Alizée Dortignac 1 collaboration

Jason S Iacovoni 1 collaboration

Jérôme Mariette 1 collaboration

Arnaud Polizzi 1 collaboration

Aurélie Batut 1 collaboration

Simon Deleruyelle 1 collaboration

Lucas Bourdens 1 collaboration

Océane Delos 1 collaboration

Lucie Combes-Soia 1 collaboration

Romain Paccoud 1 collaboration

Elsa Moreau 1 collaboration

Frédéric Martins 1 collaboration

Fadila Benhamed 1 collaboration

Alexandra Montagner 1 collaboration

Walter Wahli 1 collaboration

Robert F Schwabe 1 collaboration

Armelle Yart 1 collaboration

Isabelle Castan-Laurell 1 collaboration

Justine Bertrand-Michel 1 collaboration

Odile Burlet-Schiltz 1 collaboration

Catherine Postic 1 collaboration

Pierre-Damien Denechaud 1 collaboration

Cédric Moro 1 collaboration

Chih-Hao Lee 1 collaboration

Hervé Guillou 1 collaboration

Philippe Valet 1 collaboration

Cédric Dray 1 collaboration

Jean-Philippe Pradère 1 collaboration

Sarah Cohen 1 collaboration

Laura Cheradame 1 collaboration

Karishma J B Pratt 1 collaboration

Ashlie Barillas 1 collaboration

Annika Carlson 1 collaboration

Vijay Ramani 1 collaboration

Saul A Villeda 1 collaboration

R Dyche Mullins 1 collaboration

Bjoern Schwer 1 collaboration

Valérie Risson 1 collaboration

Floriane Fusil 1 collaboration

Emilie Laurent 1 collaboration

Juliana Blin 1 collaboration

Virginie Mournetas 1 collaboration

Emmanuelle Massouridès 1 collaboration

Thibault J M Sohier 1 collaboration

Antoine Corbin 1 collaboration

Fabien Aubé 1 collaboration

Marie Teixeira 1 collaboration

Christian Pinset 1 collaboration

Laurent Schaeffer 1 collaboration

François-Loïc Cosset 1 collaboration

Els Verhoeyen 1 collaboration

Théophile Ohlmann 1 collaboration

E Lesage 1 collaboration

Ilaria Gritti 1 collaboration

Veronica Basso 1 collaboration

Darawan Rinchai 1 collaboration

Federica Corigliano 1 collaboration

Silvia Pivetti 1 collaboration

Marco Gaviraghi 1 collaboration

Dalia Rosano 1 collaboration

Sara Barozzi 1 collaboration

Marco Roncador 1 collaboration

Giovanni Parmigiani 1 collaboration

Dario Parazzoli 1 collaboration

Davide Cittaro 1 collaboration

Davide Bedognetti 1 collaboration

Anna Mondino 1 collaboration

Simona Segalla 1 collaboration

Giovanni Tonon 1 collaboration

Emmanuelle Guillou 1 collaboration

Virginie Daburon 1 collaboration

Kevin Li 1 collaboration

Felix Zhou 1 collaboration

Pierre Caron 1 collaboration

Raphaël Mourad 1 collaboration

James E Haber 1 collaboration

Alexandra C Vítor 1 collaboration

Pablo Huertas 1 collaboration

Sérgio F de Almeida 1 collaboration

S Cohen 1 collaboration

A Guenolé 1 collaboration

I Lazar 1 collaboration

A Marnef 1 collaboration

D V Vernekar 1 collaboration

N Puget 1 collaboration

V Rocher 1 collaboration

C Arnould 1 collaboration

M Aguirrebengoa 1 collaboration

M Genais 1 collaboration

N Firmin 1 collaboration

R A Shamanna 1 collaboration

R Mourad 1 collaboration

V A Bohr 1 collaboration

V Borde 1 collaboration

Florian J Groelly 1 collaboration

Rebecca A Dagg 1 collaboration

Michalis Petropoulos 1 collaboration

Giacomo G Rossetti 1 collaboration

Birbal Prasad 1 collaboration

Andreas Panagopoulos 1 collaboration

Teressa Paulsen 1 collaboration

Angeliki Karamichali 1 collaboration

Samuel E Jones 1 collaboration

Fena Ochs 1 collaboration

Vasilis S Dionellis 1 collaboration

Emilia Puig Lombardi 1 collaboration

Matthieu J Miossec 1 collaboration

Helen Lockstone 1 collaboration

Andrew N Blackford 1 collaboration

Matthias Altmeyer 1 collaboration

Thanos D Halazonetis 1 collaboration

Madalena Tarsounas 1 collaboration