Simonetta Gribaldo

Affiliations

Evolutionary Biology of the Microbial Cell, Institut Pasteur, CNRS-UMR 2001, Paris, France.

ORCID: https://orcid.org/0000-0002-7662-021X

Publications (41)

A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes.

Science (New York, N.Y.)

Avec: Dona Sleiman , Pierre Simon Garcia , Marion Lagune , Jerome Loc'h , Ahmed Haouz , Najwa Taib , Pascal Röthlisberger , Simonetta Gribaldo , Philippe Marlière , Pierre Alexandre Kaminski

The rise of diversity in metabolic platforms across the Candidate Phyla Radiation.

BMC biology

Avec: Alexander L Jaffe , Cindy J Castelle , Paula B Matheus Carnevali , Simonetta Gribaldo , Jillian F Banfield

Cryptosporulation in Kurthia spp. forces a rethinking of asporogenesis in Firmicutes.

Environmental microbiology

Avec: Mathilda Fatton , Sevasti Filippidou , Thomas Junier , Guillaume Cailleau , Matthieu Berge , Daniel Poppleton , Thorsten B Blum , Marek Kaminek , Adolfo Odriozola , Jochen Blom , Shannon L Johnson , Jan Pieter Abrahams , Patrick S Chain , Simonetta Gribaldo , Elitza I Tocheva , Benoît Zuber , Patrick H Viollier , Pilar Junier

The host-associated archaeome.

Nature reviews. Microbiology

Avec: Guillaume Borrel , Jean-François Brugère , Simonetta Gribaldo , Ruth A Schmitz , Christine Moissl-Eichinger

Autotransporters Drive Biofilm Formation and Autoaggregation in the Diderm Firmicute Veillonella parvula.

Journal of bacteriology

Avec: Nathalie Béchon , Alicia Jiménez-Fernández , Jerzy Witwinowski , Emilie Bierque , Najwa Taib , Thomas Cokelaer , Laurence Ma , Jean-Marc Ghigo , Simonetta Gribaldo , Christophe Beloin

One or two membranes? Diderm Firmicutes challenge the Gram-positive/Gram-negative divide.

Molecular microbiology

Avec: Daniela Megrian , Najwa Taib , Jerzy Witwinowski , Christophe Beloin , Simonetta Gribaldo

Growth temperature and chromatinization in archaea.

Nature microbiology

Avec: Antoine Hocher , Guillaume Borrel , Khaled Fadhlaoui , Jean-François Brugère , Simonetta Gribaldo , Tobias Warnecke

A dynamic, ring-forming MucB / RseB-like protein influences spore shape in Bacillus subtilis.

PLoS genetics

Avec: Johana Luhur , Helena Chan , Benson Kachappilly , Ahmed Mohamed , Cécile Morlot , Milena Awad , Dena Lyras , Najwa Taib , Simonetta Gribaldo , David Z Rudner , Christopher D A Rodrigues

An ancient divide in outer membrane tethering systems in bacteria suggests a mechanism for the diderm-to-monoderm transition.

Nature microbiology

Avec: Jerzy Witwinowski , Anna Sartori-Rupp , Najwa Taib , Nika Pende , To Nam Tham , Daniel Poppleton , Jean-Marc Ghigo , Christophe Beloin , Simonetta Gribaldo

The cell biology of archaea.

Nature microbiology

Avec: Marleen van Wolferen , Andre Arashiro Pulschen , Buzz Baum , Simonetta Gribaldo , Sonja-Verena Albers

Diversity and Evolution of Methane-Related Pathways in Archaea.

Annual review of microbiology

Avec: Pierre Simon Garcia , Simonetta Gribaldo , Guillaume Borrel

A compendium of viruses from methanogenic archaea reveals their diversity and adaptations to the gut environment.

Nature microbiology

Avec: Sofia Medvedeva , Guillaume Borrel , Mart Krupovic , Simonetta Gribaldo

Comparative genomic analysis of Methanimicrococcus blatticola provides insights into host adaptation in archaea and the evolution of methanogenesis.

ISME communications

Avec: Courtney M Thomas , Najwa Taib , Simonetta Gribaldo , Guillaume Borrel

Diversification of division mechanisms in endospore-forming bacteria revealed by analyses of peptidoglycan synthesis in Clostridioides difficile.

Nature communications

Avec: Shailab Shrestha , Najwa Taib , Simonetta Gribaldo , Aimee Shen

Terrabacteria: redefining bacterial envelope diversity, biogenesis and evolution.

Nature reviews. Microbiology

Avec: Basile Beaud Benyahia , Najwa Taib , Christophe Beloin , Simonetta Gribaldo

A divide-and-conquer phylogenomic approach based on character supermatrices resolves early steps in the evolution of the Archaea.

BMC ecology and evolution

Avec: Monique Aouad , Jean-Pierre Flandrois , Frédéric Jauffrit , Manolo Gouy , Simonetta Gribaldo , Céline Brochier-Armanet

Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition.

Nature ecology & evolution

Avec: Najwa Taib , Daniela Megrian , Jerzy Witwinowski , Panagiotis Adam , Daniel Poppleton , Guillaume Borrel , Christophe Beloin , Simonetta Gribaldo

SepF is the FtsZ anchor in archaea, with features of an ancestral cell division system.

Nature communications

Avec: Nika Pende , Adrià Sogues , Daniela Megrian , Anna Sartori-Rupp , Patrick England , Hayk Palabikyan , Simon K-M R Rittmann , Martín Graña , Anne Marie Wehenkel , Pedro M Alzari , Simonetta Gribaldo

Spotlight on FtsZ-based cell division in Archaea.

Trends in microbiology

Avec: Solenne Ithurbide , Simonetta Gribaldo , Sonja-Verena Albers , Nika Pende

Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host.

eLife

Avec: Francesca D'Angelo , Elena Fernández-Fueyo , Pierre Simon Garcia , Helena Shomar , Martin Pelosse , Rita Rebelo Manuel , Ferhat Büke , Siyi Liu , Niels van den Broek , Nicolas Duraffourg , Carol de Ram , Martin Pabst , Emmanuelle Bouveret , Simonetta Gribaldo , Béatrice Py , Sandrine Ollagnier de Choudens , Frédéric Barras , Gregory Bokinsky

Factors shaping the abundance and diversity of the gut archaeome across the animal kingdom.

Nature communications

Avec: Courtney M Thomas , Elie Desmond-Le Quéméner , Simonetta Gribaldo , Guillaume Borrel

Components of iron-Sulfur cluster assembly machineries are robust phylogenetic markers to trace the origin of mitochondria and plastids.

PLoS biology

Avec: Pierre Simon Garcia , Frédéric Barras , Simonetta Gribaldo

An early origin of iron-sulfur cluster biosynthesis machineries before Earth oxygenation.

Nature ecology & evolution

Avec: Pierre Simon Garcia , Francesca D'Angelo , Sandrine Ollagnier de Choudens , Macha Dussouchaud , Emmanuelle Bouveret , Simonetta Gribaldo , Frédéric Barras

The SUF system: an ABC ATPase-dependent protein complex with a role in Fe-S cluster biogenesis.

Research in microbiology

Avec: Pierre Simon Garcia , Simonetta Gribaldo , Béatrice Py , Frédéric Barras

Wide diversity of methane and short-chain alkane metabolisms in uncultured archaea.

Nature microbiology

Avec: Guillaume Borrel , Panagiotis S Adam , Luke J McKay , Lin-Xing Chen , Isabel Natalia Sierra-García , Christian M K Sieber , Quentin Letourneur , Amine Ghozlane , Gary L Andersen , Wen-Jun Li , Steven J Hallam , Gerard Muyzer , Valéria Maia de Oliveira , William P Inskeep , Jillian F Banfield , Simonetta Gribaldo

An archaeal origin of the Wood-Ljungdahl H

Nature microbiology

Avec: Panagiotis S Adam , Guillaume Borrel , Simonetta Gribaldo

Histone variants in archaea and the evolution of combinatorial chromatin complexity.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Kathryn M Stevens , Jacob B Swadling , Antoine Hocher , Corinna Bang , Simonetta Gribaldo , Ruth A Schmitz , Tobias Warnecke

Single-Stranded DNA-Binding Proteins in the Archaea.

Methods in molecular biology (Clifton, N.J.)

Avec: Najwa Taib , Simonetta Gribaldo , Stuart A MacNeill

A Comprehensive Evolutionary Scenario of Cell Division and Associated Processes in the Firmicutes.

Molecular biology and evolution

Avec: Pierre S Garcia , Wandrille Duchemin , Jean-Pierre Flandrois , Simonetta Gribaldo , Christophe Grangeasse , Céline Brochier-Armanet

Roadmap for naming uncultivated Archaea and Bacteria.

Nature microbiology

Avec: Alison E Murray , John Freudenstein , Simonetta Gribaldo , Roland Hatzenpichler , Philip Hugenholtz , Peter Kämpfer , Konstantinos T Konstantinidis , Christopher E Lane , R Thane Papke , Donovan H Parks , Ramon Rossello-Mora , Matthew B Stott , Iain C Sutcliffe , J Cameron Thrash , Stephanus N Venter , William B Whitman , Silvia G Acinas , Rudolf I Amann , Karthik Anantharaman , Jean Armengaud , Brett J Baker , Roman A Barco , Helge B Bode , Eric S Boyd , Carrie L Brady , Paul Carini , Patrick S G Chain , Daniel R Colman , Kristen M DeAngelis , Maria Asuncion de Los Rios , Paulina Estrada-de Los Santos , Christopher A Dunlap , Jonathan A Eisen , David Emerson , Thijs J G Ettema , Damien Eveillard , Peter R Girguis , Ute Hentschel , James T Hollibaugh , Laura A Hug , William P Inskeep , Elena P Ivanova , Hans-Peter Klenk , Wen-Jun Li , Karen G Lloyd , Frank E Löffler , Thulani P Makhalanyane , Duane P Moser , Takuro Nunoura , Marike Palmer , Victor Parro , Carlos Pedrós-Alió , Alexander J Probst , Theo H M Smits , Andrew D Steen , Emma T Steenkamp , Anja Spang , Frank J Stewart , James M Tiedje , Peter Vandamme , Michael Wagner , Feng-Ping Wang , Pablo Yarza , Brian P Hedlund , Anna-Louise Reysenbach

A catalogue of 1,167 genomes from the human gut archaeome.

Nature microbiology

Avec: Cynthia Maria Chibani , Alexander Mahnert , Guillaume Borrel , Alexandre Almeida , Almut Werner , Jean-François Brugère , Simonetta Gribaldo , Robert D Finn , Ruth A Schmitz , Christine Moissl-Eichinger

Localization and functional characterization of the alternative oxidase in Naegleria.

The Journal of eukaryotic microbiology

Avec: Diego Cantoni , Ashley Osborne , Najwa Taib , Gary Thompson , Rubén Martín-Escolano , Eleanna Kazana , Elizabeth Edrich , Ian R Brown , Simonetta Gribaldo , Campbell W Gourlay , Anastasios D Tsaousis

Genetic Screens Identify Additional Genes Implicated in Envelope Remodeling during the Engulfment Stage of Bacillus subtilis Sporulation.

mBio

Avec: Helena Chan , Najwa Taib , Michael C Gilmore , Ahmed M T Mohamed , Kieran Hanna , Johana Luhur , Hieu Nguyen , Elham Hafiz , Felipe Cava , Simonetta Gribaldo , David Rudner , Christopher D A Rodrigues

Ancient origin and constrained evolution of the division and cell wall gene cluster in Bacteria.

Nature microbiology

Avec: Daniela Megrian , Najwa Taib , Alexander L Jaffe , Jillian F Banfield , Simonetta Gribaldo

Analyses of cell wall synthesis in

bioRxiv : the preprint server for biology

Avec: Shailab Shrestha , Najwa Taib , Simonetta Gribaldo , Aimee Shen

Dual function of OmpM as outer membrane tether and nutrient uptake channel in diderm Firmicutes.

Nature communications

Avec: Augustinas Silale , Yiling Zhu , Jerzy Witwinowski , Robert E Smith , Kahlan E Newman , Satya P Bhamidimarri , Arnaud Baslé , Syma Khalid , Christophe Beloin , Simonetta Gribaldo , Bert van den Berg

Proteins containing photosynthetic reaction centre domains modulate FtsZ-based archaeal cell division.

Nature microbiology

Avec: Phillip Nußbaum , Danguole Kureisaite-Ciziene , Dom Bellini , Chris van der Does , Marko Kojic , Najwa Taib , Anna Yeates , Maxime Tourte , Simonetta Gribaldo , Martin Loose , Jan Löwe , Sonja-Verena Albers

When iron and sulfur met on an anoxic planet and eventually made clusters essential for life.

Biochimica et biophysica acta. Molecular cell research

Avec: Pierre Simon Garcia , Simonetta Gribaldo , Frédéric Barras

The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking.

Nature communications

Avec: Kyrie P Grasekamp , Basile Beaud Benyahia , Najwa Taib , Bianca Audrain , Benjamin Bardiaux , Yannick Rossez , Nadia Izadi-Pruneyre , Maylis Lejeune , Xavier Trivelli , Zina Chouit , Yann Guerardel , Jean-Marc Ghigo , Simonetta Gribaldo , Christophe Beloin

Borg extrachromosomal elements of methane-oxidizing archaea have conserved and expressed genetic repertoires.

Nature communications

Avec: Marie C Schoelmerich , Lynn Ly , Jacob West-Roberts , Ling-Dong Shi , Cong Shen , Nikhil S Malvankar , Najwa Taib , Simonetta Gribaldo , Ben J Woodcroft , Christopher W Schadt , Basem Al-Shayeb , Xiaoguang Dai , Christopher Mozsary , Scott Hickey , Christine He , John Beaulaurier , Sissel Juul , Rohan Sachdeva , Jillian F Banfield

Stable coexistence between an archaeal virus and the dominant methanogen of the human gut.

Nature communications

Avec: Diana P Baquero , Sofia Medvedeva , Camille Martin-Gallausiaux , Nika Pende , Anna Sartori-Rupp , Stéphane Tachon , Thierry Pedron , Laurent Debarbieux , Guillaume Borrel , Simonetta Gribaldo , Mart Krupovic

Réseau de co-auteurs

Najwa Taib 17 collaborations

Guillaume Borrel 11 collaborations

Pierre Simon Garcia 7 collaborations

Christophe Beloin 7 collaborations

Jerzy Witwinowski 5 collaborations

Frédéric Barras 5 collaborations

Jillian F Banfield 4 collaborations

Daniela Megrian 4 collaborations

Nika Pende 4 collaborations

Daniel Poppleton 3 collaborations

Jean-François Brugère 3 collaborations

Ruth A Schmitz 3 collaborations

Jean-Marc Ghigo 3 collaborations

Anna Sartori-Rupp 3 collaborations

Sonja-Verena Albers 3 collaborations

Alexander L Jaffe 2 collaborations

Christine Moissl-Eichinger 2 collaborations

Antoine Hocher 2 collaborations

Tobias Warnecke 2 collaborations

Johana Luhur 2 collaborations

Helena Chan 2 collaborations

Christopher D A Rodrigues 2 collaborations

Sofia Medvedeva 2 collaborations

Mart Krupovic 2 collaborations

Courtney M Thomas 2 collaborations

Shailab Shrestha 2 collaborations

Aimee Shen 2 collaborations

Basile Beaud Benyahia 2 collaborations

Jean-Pierre Flandrois 2 collaborations

Céline Brochier-Armanet 2 collaborations

Francesca D'Angelo 2 collaborations

Emmanuelle Bouveret 2 collaborations

Béatrice Py 2 collaborations

Sandrine Ollagnier de Choudens 2 collaborations

Panagiotis S Adam 2 collaborations

Wen-Jun Li 2 collaborations

William P Inskeep 2 collaborations

Dona Sleiman 1 collaboration

Marion Lagune 1 collaboration

Jerome Loc'h 1 collaboration

Ahmed Haouz 1 collaboration

Pascal Röthlisberger 1 collaboration

Philippe Marlière 1 collaboration

Pierre Alexandre Kaminski 1 collaboration

Cindy J Castelle 1 collaboration

Paula B Matheus Carnevali 1 collaboration

Mathilda Fatton 1 collaboration

Sevasti Filippidou 1 collaboration

Thomas Junier 1 collaboration

Guillaume Cailleau 1 collaboration

Matthieu Berge 1 collaboration

Thorsten B Blum 1 collaboration

Marek Kaminek 1 collaboration

Adolfo Odriozola 1 collaboration

Jochen Blom 1 collaboration

Shannon L Johnson 1 collaboration

Jan Pieter Abrahams 1 collaboration

Patrick S Chain 1 collaboration

Elitza I Tocheva 1 collaboration

Benoît Zuber 1 collaboration

Patrick H Viollier 1 collaboration

Pilar Junier 1 collaboration

Nathalie Béchon 1 collaboration

Alicia Jiménez-Fernández 1 collaboration

Emilie Bierque 1 collaboration

Thomas Cokelaer 1 collaboration

Laurence Ma 1 collaboration

Khaled Fadhlaoui 1 collaboration

Benson Kachappilly 1 collaboration

Ahmed Mohamed 1 collaboration

Cécile Morlot 1 collaboration

Milena Awad 1 collaboration

Dena Lyras 1 collaboration

David Z Rudner 1 collaboration

To Nam Tham 1 collaboration

Marleen van Wolferen 1 collaboration

Andre Arashiro Pulschen 1 collaboration

Buzz Baum 1 collaboration

Monique Aouad 1 collaboration

Frédéric Jauffrit 1 collaboration

Manolo Gouy 1 collaboration

Panagiotis Adam 1 collaboration

Adrià Sogues 1 collaboration

Patrick England 1 collaboration

Hayk Palabikyan 1 collaboration

Simon K-M R Rittmann 1 collaboration

Martín Graña 1 collaboration

Anne Marie Wehenkel 1 collaboration

Pedro M Alzari 1 collaboration

Solenne Ithurbide 1 collaboration

Elena Fernández-Fueyo 1 collaboration

Helena Shomar 1 collaboration

Martin Pelosse 1 collaboration

Rita Rebelo Manuel 1 collaboration

Ferhat Büke 1 collaboration

Siyi Liu 1 collaboration

Niels van den Broek 1 collaboration

Nicolas Duraffourg 1 collaboration

Carol de Ram 1 collaboration

Martin Pabst 1 collaboration

Gregory Bokinsky 1 collaboration

Elie Desmond-Le Quéméner 1 collaboration

Macha Dussouchaud 1 collaboration

Luke J McKay 1 collaboration

Lin-Xing Chen 1 collaboration

Isabel Natalia Sierra-García 1 collaboration

Christian M K Sieber 1 collaboration

Quentin Letourneur 1 collaboration

Amine Ghozlane 1 collaboration

Gary L Andersen 1 collaboration

Steven J Hallam 1 collaboration

Gerard Muyzer 1 collaboration

Valéria Maia de Oliveira 1 collaboration

Kathryn M Stevens 1 collaboration

Jacob B Swadling 1 collaboration

Corinna Bang 1 collaboration

Stuart A MacNeill 1 collaboration

Pierre S Garcia 1 collaboration

Wandrille Duchemin 1 collaboration

Christophe Grangeasse 1 collaboration

Alison E Murray 1 collaboration

John Freudenstein 1 collaboration

Roland Hatzenpichler 1 collaboration

Philip Hugenholtz 1 collaboration

Peter Kämpfer 1 collaboration

Konstantinos T Konstantinidis 1 collaboration

Christopher E Lane 1 collaboration

R Thane Papke 1 collaboration

Donovan H Parks 1 collaboration

Ramon Rossello-Mora 1 collaboration

Matthew B Stott 1 collaboration

Iain C Sutcliffe 1 collaboration

J Cameron Thrash 1 collaboration

Stephanus N Venter 1 collaboration

William B Whitman 1 collaboration

Silvia G Acinas 1 collaboration

Rudolf I Amann 1 collaboration

Karthik Anantharaman 1 collaboration

Jean Armengaud 1 collaboration

Brett J Baker 1 collaboration

Roman A Barco 1 collaboration

Helge B Bode 1 collaboration

Eric S Boyd 1 collaboration

Carrie L Brady 1 collaboration

Paul Carini 1 collaboration

Patrick S G Chain 1 collaboration

Daniel R Colman 1 collaboration

Kristen M DeAngelis 1 collaboration

Maria Asuncion de Los Rios 1 collaboration

Paulina Estrada-de Los Santos 1 collaboration

Christopher A Dunlap 1 collaboration

Jonathan A Eisen 1 collaboration

David Emerson 1 collaboration

Thijs J G Ettema 1 collaboration

Damien Eveillard 1 collaboration

Peter R Girguis 1 collaboration

Ute Hentschel 1 collaboration

James T Hollibaugh 1 collaboration

Laura A Hug 1 collaboration

Elena P Ivanova 1 collaboration

Hans-Peter Klenk 1 collaboration

Karen G Lloyd 1 collaboration

Frank E Löffler 1 collaboration

Thulani P Makhalanyane 1 collaboration

Duane P Moser 1 collaboration

Takuro Nunoura 1 collaboration

Marike Palmer 1 collaboration

Victor Parro 1 collaboration

Carlos Pedrós-Alió 1 collaboration

Alexander J Probst 1 collaboration

Theo H M Smits 1 collaboration

Andrew D Steen 1 collaboration

Emma T Steenkamp 1 collaboration

Anja Spang 1 collaboration

Frank J Stewart 1 collaboration

James M Tiedje 1 collaboration

Peter Vandamme 1 collaboration

Michael Wagner 1 collaboration

Feng-Ping Wang 1 collaboration

Pablo Yarza 1 collaboration

Brian P Hedlund 1 collaboration

Anna-Louise Reysenbach 1 collaboration

Cynthia Maria Chibani 1 collaboration

Alexander Mahnert 1 collaboration

Alexandre Almeida 1 collaboration

Almut Werner 1 collaboration

Robert D Finn 1 collaboration

Diego Cantoni 1 collaboration

Ashley Osborne 1 collaboration

Gary Thompson 1 collaboration

Rubén Martín-Escolano 1 collaboration

Eleanna Kazana 1 collaboration

Elizabeth Edrich 1 collaboration

Ian R Brown 1 collaboration

Campbell W Gourlay 1 collaboration

Anastasios D Tsaousis 1 collaboration

Michael C Gilmore 1 collaboration

Ahmed M T Mohamed 1 collaboration

Kieran Hanna 1 collaboration

Hieu Nguyen 1 collaboration

Elham Hafiz 1 collaboration

Felipe Cava 1 collaboration

David Rudner 1 collaboration

Augustinas Silale 1 collaboration

Yiling Zhu 1 collaboration

Robert E Smith 1 collaboration

Kahlan E Newman 1 collaboration

Satya P Bhamidimarri 1 collaboration

Arnaud Baslé 1 collaboration

Syma Khalid 1 collaboration

Bert van den Berg 1 collaboration

Phillip Nußbaum 1 collaboration

Danguole Kureisaite-Ciziene 1 collaboration

Dom Bellini 1 collaboration

Chris van der Does 1 collaboration

Marko Kojic 1 collaboration

Anna Yeates 1 collaboration

Maxime Tourte 1 collaboration

Martin Loose 1 collaboration

Jan Löwe 1 collaboration

Kyrie P Grasekamp 1 collaboration

Bianca Audrain 1 collaboration

Benjamin Bardiaux 1 collaboration

Yannick Rossez 1 collaboration

Nadia Izadi-Pruneyre 1 collaboration

Maylis Lejeune 1 collaboration

Xavier Trivelli 1 collaboration

Zina Chouit 1 collaboration

Yann Guerardel 1 collaboration

Marie C Schoelmerich 1 collaboration

Lynn Ly 1 collaboration

Jacob West-Roberts 1 collaboration

Ling-Dong Shi 1 collaboration

Cong Shen 1 collaboration

Nikhil S Malvankar 1 collaboration

Ben J Woodcroft 1 collaboration

Christopher W Schadt 1 collaboration

Basem Al-Shayeb 1 collaboration

Xiaoguang Dai 1 collaboration

Christopher Mozsary 1 collaboration

Scott Hickey 1 collaboration

Christine He 1 collaboration

John Beaulaurier 1 collaboration

Sissel Juul 1 collaboration

Rohan Sachdeva 1 collaboration

Diana P Baquero 1 collaboration

Camille Martin-Gallausiaux 1 collaboration

Stéphane Tachon 1 collaboration

Thierry Pedron 1 collaboration

Laurent Debarbieux 1 collaboration