questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Métalloprotéines
Protéines de liaison au fer
Protéines à fer non hème
Lipoxygénases
Arachidonate lipoxygenases
Arachidonate 5-lipoxygenase
Arachidonate 5-lipoxygenase : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Lipoxygenases
Leucotriènes
Imagerie par résonance magnétique
Inflammation
Tests génétiques
Mutations
Symptômes
5
Asthme
Réactions allergiques
Crise d'asthme
Oppression thoracique
Prévention
5
Prévention de l'asthme
Allergènes
Régime alimentaire
Inflammation
Gestion du stress
Méditation
Exercice physique
Fonction pulmonaire
Traitements
5
Inhibiteurs de la lipoxygénase
Asthme
Anti-inflammatoires
Médiateurs
Acides gras oméga-3
Antioxydants
Corticostéroïdes
Réponse immunitaire
Bronchodilatateurs
Voies respiratoires
Complications
5
Infections respiratoires
Hospitalisations
Inflammation chronique
Maladies cardiovasculaires
Asthme
Dommages pulmonaires
Qualité de vie
Activités physiques
Facteurs de risque
5
Antécédents familiaux
Pollution
Tabagisme
Complications respiratoires
Infections respiratoires
Crises d'asthme
Exposition professionnelle
Irritants
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"@type": "Question",
"name": "Comment diagnostiquer une dysfonction de l'enzyme ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins peuvent mesurer les niveaux de leucotriènes et d'autres biomarqueurs."
}
},
{
"@type": "Question",
"name": "Quels examens sont utilisés pour évaluer l'inflammation ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'échographie, l'IRM et les tests de laboratoire peuvent aider à évaluer l'inflammation."
}
},
{
"@type": "Question",
"name": "Y a-t-il des tests génétiques pour l'arachidonate 5-lipoxygenase ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques peuvent identifier des mutations affectant l'enzyme, mais ils sont rares."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent un problème avec cette enzyme ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme l'asthme, les allergies ou des maladies inflammatoires peuvent indiquer un problème."
}
},
{
"@type": "Question",
"name": "Comment évaluer l'activité de l'enzyme dans le corps ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests biochimiques mesurent l'activité de l'enzyme dans des échantillons de tissus ou de sang."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une surproduction de leucotriènes ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des crises d'asthme, des réactions allergiques et des inflammations chroniques."
}
},
{
"@type": "Question",
"name": "Comment l'inflammation se manifeste-t-elle ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'inflammation peut se manifester par des rougeurs, des douleurs, un gonflement et une chaleur locale."
}
},
{
"@type": "Question",
"name": "Y a-t-il des signes d'allergies liés à cette enzyme ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des démangeaisons, des éruptions cutanées et des difficultés respiratoires peuvent survenir."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont associés à l'asthme ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent la toux, la respiration sifflante, l'essoufflement et la pression thoracique."
}
},
{
"@type": "Question",
"name": "Comment reconnaître une crise d'asthme ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une crise d'asthme se manifeste par une respiration difficile, une toux persistante et une oppression thoracique."
}
},
{
"@type": "Question",
"name": "Comment prévenir les crises d'asthme ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les allergènes, utiliser des médicaments préventifs et suivre un plan d'action personnalisé."
}
},
{
"@type": "Question",
"name": "Y a-t-il des mesures diététiques à prendre ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en fruits, légumes et oméga-3 peut aider à réduire l'inflammation."
}
},
{
"@type": "Question",
"name": "Comment gérer le stress pour prévenir l'inflammation ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des techniques de gestion du stress comme la méditation et le yoga peuvent réduire l'inflammation."
}
},
{
"@type": "Question",
"name": "Quels exercices sont bénéfiques pour les asthmatiques ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des exercices modérés comme la marche ou la natation peuvent améliorer la fonction pulmonaire."
}
},
{
"@type": "Question",
"name": "Comment éviter les irritants environnementaux ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Évitez la fumée, la pollution et les produits chimiques irritants pour protéger vos voies respiratoires."
}
},
{
"@type": "Question",
"name": "Quels médicaments ciblent l'arachidonate 5-lipoxygenase ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les inhibiteurs de la lipoxygénase, comme le zileuton, sont utilisés pour traiter l'asthme."
}
},
{
"@type": "Question",
"name": "Comment les anti-inflammatoires aident-ils ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils réduisent l'inflammation en inhibant la production de leucotriènes et d'autres médiateurs."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements naturels disponibles ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des acides gras oméga-3 et des antioxydants peuvent aider à moduler l'inflammation."
}
},
{
"@type": "Question",
"name": "Quels sont les effets des corticostéroïdes ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les corticostéroïdes réduisent l'inflammation et la réponse immunitaire, soulageant les symptômes."
}
},
{
"@type": "Question",
"name": "Comment les bronchodilatateurs agissent-ils ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils dilatent les voies respiratoires, facilitant la respiration et réduisant les symptômes d'asthme."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec l'asthme ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des infections respiratoires, des crises d'asthme sévères et des hospitalisations."
}
},
{
"@type": "Question",
"name": "Comment l'inflammation chronique affecte-t-elle la santé ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'inflammation chronique peut entraîner des maladies cardiovasculaires et des troubles métaboliques."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de développement d'allergies ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une exposition prolongée à des allergènes peut augmenter le risque de développer des allergies."
}
},
{
"@type": "Question",
"name": "Quels sont les effets à long terme de l'asthme non contrôlé ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'asthme non contrôlé peut entraîner des dommages pulmonaires permanents et une qualité de vie réduite."
}
},
{
"@type": "Question",
"name": "Comment l'asthme peut-il affecter la vie quotidienne ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'asthme peut limiter les activités physiques, affecter le sommeil et entraîner des absences scolaires ou professionnelles."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour l'asthme ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antécédents familiaux, l'exposition à des allergènes et la pollution sont des facteurs de risque."
}
},
{
"@type": "Question",
"name": "Comment le tabagisme influence-t-il l'asthme ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme aggrave les symptômes d'asthme et augmente le risque de complications respiratoires."
}
},
{
"@type": "Question",
"name": "Y a-t-il un lien entre l'obésité et l'asthme ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'obésité est un facteur de risque qui peut aggraver les symptômes et la gravité de l'asthme."
}
},
{
"@type": "Question",
"name": "Quels rôles jouent les infections respiratoires ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les infections respiratoires peuvent déclencher des crises d'asthme et aggraver l'inflammation."
}
},
{
"@type": "Question",
"name": "Comment l'exposition professionnelle affecte-t-elle l'asthme ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exposition à des irritants ou allergènes au travail peut augmenter le risque d'asthme professionnel."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 06/04/2025
Contenu vérifié selon les dernières recommandations médicales
7 publications dans cette catégorie
Affiliations :
Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt/Main, Germany.
6 publications dans cette catégorie
Affiliations :
Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt/Main, Germany.
6 publications dans cette catégorie
Affiliations :
Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Jena, Germany.
6 publications dans cette catégorie
Affiliations :
Department of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, D-10117 Berlin, Germany.
5 publications dans cette catégorie
Affiliations :
Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Jena, Germany.
Publications dans "Arachidonate 5-lipoxygenase" :
4 publications dans cette catégorie
Affiliations :
Department of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, D-10117 Berlin, Germany.
Publications dans "Arachidonate 5-lipoxygenase" :
4 publications dans cette catégorie
Affiliations :
Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
Publications dans "Arachidonate 5-lipoxygenase" :
4 publications dans cette catégorie
Affiliations :
Department of Integrative Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea.
Publications dans "Arachidonate 5-lipoxygenase" :
4 publications dans cette catégorie
Affiliations :
Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea. deokkun@konkuk.ac.kr.
Department of Integrative Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea. deokkun@konkuk.ac.kr.
Publications dans "Arachidonate 5-lipoxygenase" :
3 publications dans cette catégorie
Affiliations :
Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.
Publications dans "Arachidonate 5-lipoxygenase" :
3 publications dans cette catégorie
Affiliations :
Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.
Publications dans "Arachidonate 5-lipoxygenase" :
3 publications dans cette catégorie
Affiliations :
Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.
Publications dans "Arachidonate 5-lipoxygenase" :
3 publications dans cette catégorie
Affiliations :
Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan. Electronic address: toshiko@fhw.oka-pu.ac.jp.
Publications dans "Arachidonate 5-lipoxygenase" :
3 publications dans cette catégorie
Affiliations :
Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, 100730 People's Republic of China.
Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, 100005 People's Republic of China.
Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, 100730 People's Republic of China.
Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, 100005 People's Republic of China.
Publications dans "Arachidonate 5-lipoxygenase" :
3 publications dans cette catégorie
Affiliations :
Division of Clinical Pharmacology, Department of Pharmacology, and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232, United States.
Publications dans "Arachidonate 5-lipoxygenase" :
3 publications dans cette catégorie
Affiliations :
Institute for Clinical Pharmacology, Goethe University, Medical Faculty, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Publications dans "Arachidonate 5-lipoxygenase" :
3 publications dans cette catégorie
Affiliations :
Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany.
Publications dans "Arachidonate 5-lipoxygenase" :
3 publications dans cette catégorie
Affiliations :
Department of Biochemistry, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Publications dans "Arachidonate 5-lipoxygenase" :
2 publications dans cette catégorie
Affiliations :
Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.
Publications dans "Arachidonate 5-lipoxygenase" :
2 publications dans cette catégorie
Affiliations :
Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.
Publications dans "Arachidonate 5-lipoxygenase" :
Amblyopia is a disorder of neurodevelopment that occurs when there is discordant binocular visual experience during the first years of life. While treatments are effective in improving visual acuity, ...
Amblyopia is a neurodevelopmental disorder caused by abnormal visual experience in early life that affects 3-5% of the population. Amblyopia results in a host of monocular and binocular visual afferen...
Postural control is a complex skill based on the collaboration of dynamic sensory mechanisms, namely the visual, vestibular, and somatosensory systems....
A literature survey regarding postural stability in strabismus and amblyopia was conducted using databases in order to collect data for a narrative review of published reports and available literature...
The results of the literature survey were analyzed to provide an overview of the current knowledge of postural stability in strabismus and amblyopia. The results revealed that although postural contro...
Binocular vision is imperative for the maturation and preservation of balance control in children, as balance performance is reduced in strabismus and/or amblyopia....
Published studies of amblyopia include only patients with visual acuity (VA) worse than 20/40 in one or both eyes. The purpose of this study is to evaluate patients diagnosed and treated as amblyopic ...
Retrospective clinical cohort study....
Setting: Institutional practice....
All patients diagnosed with amblyopia at Boston Children's Hospital between 2010 and 2014....
VA better than 20/40 but not correctable to 20/20 in one or both eyes; age 2 to 12 years....
Demographics, VA, baseline characteristics....
Resolution, defined as VA 20/20 in both eyes; stereopsis at the last follow-up....
Of 2311 patients reviewed, 464 (20.1%) had subthreshold amblyopia. A majority (61.7%) had an amblyogenic factor, most commonly anisometropia (32.8%). Patients were followed for a median of 3.1 years; ...
Patients with subthreshold amblyopia represent a sizeable cohort in real-world amblyopia practice. When offered treatment, half achieved 20/20 vision in both eyes with improved stereopsis as well. Fur...
The treatment of unilateral amblyopia involves refractive adaptation, occlusion therapy or penalization with atropine drops. However, in recent years, the use of binocular digital therapy has shown pr...
This systematic review was conducted in accordance to PRISMA statement. Electronic literature was thoroughly searched for articles published between 2013 and May 2024, in the following electronic data...
Twenty RCTs, including 1769 patients, were incorporated into this systematic review. Twelve different types of binocular amblyopia treatments were identified and categorized into two main types. The f...
Binocular amblyopia treatment has shown promising results in addressing unilateral anisometropic, strabismic or mixed type of amblyopia. Nevertheless, further randomized controlled trials are essentia...
Standard-of-care assessment for children with amblyopia includes measuring amblyopic eye best-corrected visual acuity (AE BCVA) with the fellow eye occluded. By definition, this abolishes the interocu...
Cross-sectional study....
Dichoptic and monocular AE BCVA of children aged 6-12 years (42 with amblyopia, 24 with recovered normal AE BCVA, 30 control) were measured. Stereoacuity, suppression, eye-hand coordination, and readi...
Overall, 81% of amblyopic children had worse dichoptic than monocular AE BCVA (mean difference=0.15±0.11 logMAR; P < .0001), and 71% of children with recovered normal AE BCVA had worse dichoptic than ...
Dichoptic AE BCVA deficits were worse than monocular AE BCVA deficits and were associated with reduced stereoacuity and suppression, consistent with the hypothesis that binocular dysfunction plays a r...
To compare amblyopia treatment outcomes between patients with neurodevelopmental disorders and their typically developing peers....
Of 2,311 patients diagnosed with amblyopia between 2010 and 2014 at Boston Children's Hospital, 460 met inclusion criteria (age 2-12 with anisometropic, strabismic, or mixed amblyopia [interocular dif...
The DD group (n = 54) and TD group (n = 406) were similar in demographics, amblyogenic risk factors, baseline visual measures, prescribed therapy, and adherence (P ≥ 0.10). Between-visit follow-up tim...
Patients with DD and those with TD responded similarly to amblyopia therapy; however, follow-up intervals were longer in patients with DD and correlated with the likelihood of persistent amblyopia, su...
To determine whether deficits in manual dexterity in children with amblyopia improve after binocular amblyopia treatment and whether improvements are related to age at treatment, baseline sensory stat...
Manual dexterity (Movement Assessment Battery for Children-2), visual acuity, fusion, suppression, and stereoacuity were measured at baseline and after 4-8 weeks of binocular amblyopia in 134 children...
Baseline manual dexterity standard scores of amblyopic children were significantly below those of controls in both the younger (8.81 ± 0.33 vs 11.80 ± 0.60 [P < 0.0001]) and older groups (7.19 ± 0.34 ...
To compare the macular and papillary parameters on optical coherence tomography (OCT) between the amblyopic eye and the healthy eye in subjects with unilateral strabismic or anisometropic amblyopia....
This is a cross-sectional and comparative study carried out over two years, from April 1, 2019, to March 31, 2021. We included patients aged over 5years, followed for unilateral amblyopia, free of any...
We collected 50 patients, 29 children, and 21 adults, with a mean age of 19.8years. Amblyopia was secondary to anisometropia in 40 patients and strabismus in 10 patients. Analysis of macular tomograph...
Amblyopia is accompanied by thickening of the peripapillary retinal fibers without macular repercussions. However, larger prospective studies are needed to confirm these results....
To determine the optical coherence tomography angiography (OCTA) parameters including foveal avascular zone (FAZ) and vessel density (VD) in the amblyopic eyes compared with the fellow sound eyes and ...